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One or more keywords matched the following properties of Giovannucci, Edward
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overview My primary research efforts focus on how nutritional, hormonal, and genetic factors are related to various malignancies, especially those of the prostate and large bowel. Much of this work is based on the Nurses' Health Study, the Health Professionals Follow-Up Study and the Physicians' Health Study cohorts. For prostate cancer, my work has centered on the role of specific antioxidants, particularly lycopene, and on the potentially deleterious effects of diets high in calcium and dietary fat. In addition to establishing risk factors, we have been interested in understanding etiologic mechanisms that will help provide a solid scientific rationale for preventive strategies. Specifically, I have studied how nutritional factors influence prostate cancer through modulating levels of insulin-like growth factors (IGFs) and binding proteins, insulin, vitamin D metabolites, and steroid hormones. More recently, our work has examined the role of obesity and energy balance in the progression of prostate cancer. Regarding colorectal cancer, our work in the Nurses' Health Study and Health Professionals Follow-Up Study has established specific modifiable risk factors that contribute to over 70% of colorectal cancers. We have helped establish several factors that increase risk of colorectal cancer, including central obesity, physical inactivity, smoking, and diets high in red and processed meats. We have also hypothesized and demonstrated that some of these factors increase risk through higher insulin and IGF levels. We have also identified potential protective micronutrients, including vitamin D, folate, calcium and vitamin B6. We are testing the efficacy of some of these potentially protective agents, including folic acid, vitamin D, and vitamin B6 in randomized intervention trials. Finally, we have undertaken the collection of tumor tissue blocks for prostate cancer and colorectal cancer and precursor lesions (adenomas) within the Nurses' Health Study, Physicians' Health Study, and Health Professionals Follow-Up Study. With these specimens, we are identifying specific somatic molecular alterations in tumors. These alterations have been shown to have powerful influences on survival. We are now linking specific nutritional and lifestyle exposures to the probability of possessing certain of these tissue markers among those who develop cancer. Ultimately, we plan to provide the most comprehensive examination of the relations of dietary and other modifiable factors, hormonal factors, genetic susceptibility, and specific molecular endpoints in tumors. The great strength of our unique approach is to have updated and integrated data on all these factors, over up to a 30 year time period. My research work is mostly funded through the National Institutes of Health (R01's, R21's, R03's, P01), all from the National Cancer Institute. I also have funding from the American Institute of Cancer Research. My major teaching effort has been as an instructor in two courses, Cancer Epidemiology and Nutritional Epidemiology of Cancer at the Harvard School of Public Health. I do not have clinical duties.
preferred title Professor of Nutrition and Epidemiology
One or more keywords matched the following items that are connected to Giovannucci, Edward
Item TypeName
Academic Article What causes prostate cancer? A brief summary of the epidemiology.
Academic Article Dietary iron, zinc, and calcium and the risk of lung cancer.
Academic Article The epidemiology of vitamin D and colorectal cancer: recent findings.
Academic Article A prospective study of alcohol, smoking, caffeine, and the risk of duodenal ulcer in men.
Academic Article Alcohol intake and colorectal cancer: a comparison of approaches for including repeated measures of alcohol consumption.
Academic Article Commentary. On the epidemiology of influenza: reply to Radonovich et al.
Academic Article Vitamin D: epidemiology of cardiovascular risks and events.
Academic Article Risk of bladder cancer by geographic region in a U.S. cohort of male health professionals.
Academic Article Commentary: Lifestyle factors and colorectal cancer microsatellite instability--molecular pathological epidemiology science, based on unique tumour principle.
Academic Article Genetic variation in the toll-like receptor 4 and prostate cancer incidence and mortality.
Academic Article Epidemiology of vitamin D and colorectal cancer.
Academic Article Interdisciplinary education to integrate pathology and epidemiology: towards molecular and population-level health science.
Academic Article On the epidemiology of influenza.
Academic Article Ogino et Al. Respond to "the 21st century epidemiologist".
Academic Article The epidemiology of sex steroid hormones and their signaling and metabolic pathways in the etiology of prostate cancer.
Academic Article The epidemiology of vitamin D and cancer incidence and mortality: a review (United States).
Academic Article Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field.
Academic Article Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease.
Academic Article Epidemiology of vitamin D and colorectal cancer: casual or causal link?
Academic Article Reproducibility and validity of a self-administered physical activity questionnaire for male health professionals.
Concept Epidemiology
Concept Molecular Epidemiology
Academic Article Plasma antioxidants, genetic variation in SOD2, CAT, GPX1, GPX4, and prostate cancer survival.
Academic Article Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology.
Academic Article Progress and opportunities in molecular pathological epidemiology of colorectal premalignant lesions.
Academic Article Proceedings of the second international molecular pathological epidemiology (MPE) meeting.
Academic Article The high prevalence of undiagnosed prostate cancer at autopsy: implications for epidemiology and treatment of prostate cancer in the Prostate-specific Antigen-era.
Academic Article Molecular pathological epidemiology gives clues to paradoxical findings.
Academic Article Integration of molecular pathology, epidemiology and social science for global precision medicine.
Academic Article Review Article: The Role of Molecular Pathological Epidemiology in the Study of Neoplastic and Non-neoplastic Diseases in the Era of Precision Medicine.
Academic Article Colorectal Cancer Epidemiology in the Nurses' Health Study.
Academic Article The use and interpretation of anthropometric measures in cancer epidemiology: A perspective from the world cancer research fund international continuous update project.
Academic Article E-cigarettes and Urologic Health: A Collaborative Review of Toxicology, Epidemiology, and Potential Risks.
Academic Article Dietary Patterns and Risk of Colorectal Cancer: Analysis by Tumor Location and Molecular Subtypes.
Academic Article Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status.
Academic Article Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor.
Academic Article Utility of inverse probability weighting in molecular pathological epidemiology.
Academic Article Substitution analysis in nutritional epidemiology: proceed with caution.
Grant Impact of screening and diagnostic intensity on the study of prostate cancer epidemiology
Academic Article Night-Shift Work Duration and Risk of Colorectal Cancer According to IRS1 and IRS2 Expression.
Academic Article Nutritional epidemiology and cancer: A Tale of Two Cities.
Academic Article Nutritional epidemiology: forest, trees and leaves.
Search Criteria
  • Epidemiology
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.