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Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability.
MDC1 is a mediator of the mammalian DNA damage checkpoint.
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
53BP1, a mediator of the DNA damage checkpoint.
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.
Direct DNA binding by Brca1.
The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients.
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage.
Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation.
ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency.
Cancer. BRCA2 enters the fray.
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.
BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly.
BRCA1 as tumor suppressor: lord without its RING?
NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.
Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.