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One or more keywords matched the following properties of Czeisler, Charles
overview My laboratory research is focused on understanding the neurobiology of the human circadian pacemaker, located in the suprachiasmatic nucleus (SCN) of the hypothalamus, and its interaction with the sleep homeostat, and on applying that knowledge to clinical medicine and occupational health. We are examining the role of the pineal hormone melatonin in the organization of sleep and circadian rhythms. We are investigating the physiological mechanism underlying photic resetting of the human circadian pacemaker, having shown that some blind people without sight can retain normal circadian responsiveness to light. We are now investigating how the timing, duration, intensity and wavelength of light affects its circadian resetting capacity, which is mediated through intrinsically photosensitive retinal ganglion cells containing the novel photopigment melanopsin. Current research is aimed at functional determination of the photoreceptor(s) responsible for circadian vision in humans, on adaptation of circadian photoreceptors and on the after-effects of entrainment on circadian period in humans. We are investigating how circadian and homeostatic processes interact to regulate sleep and neurobiological function during wakefulness. Other ongoing research in the lab includes examining novel wakefulness- and sleep-promoting countermeasures, the effect of exercise on the circadian pacemaker, fMRI of the sleep deprived brain, the influence of aging on sleep and circadian rhythms, the influence of chronic sleep restriction on human performance, the influence of space flight on sleep and circadian rhythms and the application of our research to night workers-including medical residents and police-through the work of the Sleep Matters Initiative at Brigham Health.
One or more keywords matched the following items that are connected to Czeisler, Charles
Item TypeName
Mentoring - Completed Student Project Duration-response Characteristics of Light Resetting of the Human Circadian Pacemaker
Academic Article Low-dose repeated caffeine administration for circadian-phase-dependent performance degradation during extended wakefulness.
Academic Article Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression.
Academic Article Absence of circadian phase resetting in response to bright light behind the knees.
Academic Article A phase response curve to single bright light pulses in human subjects.
Academic Article Sensitivity of the human circadian pacemaker to moderately bright light.
Academic Article Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertness.
Academic Article Is there an intrinsic period of the circadian clock? Response.
Academic Article Adaptation of human pineal melatonin suppression by recent photic history.
Academic Article Human phase response curve to a 1 h pulse of bright white light.
Academic Article Response: moonlight and circadian rhythms.
Academic Article Spectral responses of the human circadian system depend on the irradiance and duration of exposure to light.
Academic Article Commentary: the human circadian response to light--strong and weak resetting.
Academic Article Human responses to bright light of different durations.
Academic Article Acute effects of bright light exposure on cortisol levels.
Academic Article Armodafinil for treatment of excessive sleepiness associated with shift work disorder: a randomized controlled study.
Academic Article Melatonin rhythm observed throughout a three-cycle bright-light stimulus designed to reset the human circadian pacemaker.
Academic Article Human phase response curve to a single 6.5 h pulse of short-wavelength light.
Academic Article Dose-response relationships for resetting of human circadian clock by light.
Academic Article Melanopsin and rod-cone photoreceptors play different roles in mediating pupillary light responses during exposure to continuous light in humans.
Concept Dose-Response Relationship, Drug
Concept Dose-Response Relationship, Radiation
Grant Treatment of Circadian Sleep Disorders with Bright Light
Grant Sleep Disorders Management, Health and Safety in Police
Grant Sleep, Aging and Circadian Rhythm Disorders
Grant Desensitization of Circadian Responses to Light
Grant Multi-Center Trial of Limiting PGY2&3 Resident Work Hours on Patient Safety-CCC
Grant Mechanism Underlying the Effects of Blue Light in Humans
Grant Disrupted Sleep in the Elderly: Circadian Etiology
Grant Adaptation of Circadian Responses to Light Treatment
Grant Photic and Nonphotic Input to the Human Circadian System
Grant Sensitization of Human Circadian Responses to Light
Academic Article An Exploration of the Temporal Dynamics of Circadian Resetting Responses to Short- and Long-Duration Light Exposures: Cross-Species Consistencies and Differences.
Academic Article Rapid suppression of bone formation marker in response to sleep restriction and circadian disruption in men.
Academic Article Estimating Representative Group Intrinsic Circadian Period from Illuminance-Response Curve Data.
Academic Article Characterizing the temporal Dynamics of Melatonin and Cortisol Changes in Response to Nocturnal Light Exposure.
Grant Sleep, Aging and Circadian Rhythm Disorders
Grant Sleep, Aging and Circadian Rhythm Disorders
Grant Sleep, Aging and Circadian Rhythm Disorders
Search Criteria
  • Epidemic
  • Response
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.