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Item TypeName
Academic Article Immune control of HIV: the obstacles of HLA and viral diversity.
Academic Article Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.
Academic Article Identification of overlapping HLA class I-restricted cytotoxic T cell epitopes in a conserved region of the human immunodeficiency virus type 1 envelope glycoprotein: definition of minimum epitopes and analysis of the effects of sequence variation.
Academic Article Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay.
Academic Article Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II.
Academic Article Stimulation of human cytotoxic T cells with HIV-1-derived peptides presented by recombinant HLA-A2 peptide complexes.
Academic Article CD8+ cells in human immunodeficiency virus type I pathogenesis: cytolytic and noncytolytic inhibition of viral replication.
Academic Article Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection.
Academic Article Efficient processing of the immunodominant, HLA-A*0201-restricted human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitope despite multiple variations in the epitope flanking sequences.
Academic Article Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A.
Academic Article Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.
Academic Article HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering.
Academic Article Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles.
Academic Article Unusual polymorphisms in human immunodeficiency virus type 1 associated with nonprogressive infection.
Academic Article Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.
Academic Article HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection.
Academic Article Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides.
Academic Article HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response.
Academic Article Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif.
Academic Article Mother-to-child transmission of HIV infection and CTL escape through HLA-A2-SLYNTVATL epitope sequence variation.
Academic Article Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers.
Academic Article Identification of HLA-A11-restricted HIV-1-specific cytotoxic T-lymphocyte epitopes in China.
Academic Article Detection of a vigorous HIV-1-specific cytotoxic T lymphocyte response in cerebrospinal fluid from infected persons with AIDS dementia complex.
Academic Article HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells.
Academic Article Portable flanking sequences modulate CTL epitope processing.
Academic Article HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.
Academic Article Lack of strong immune selection pressure by the immunodominant, HLA-A*0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection.
Academic Article Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
Academic Article HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control.
Academic Article Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes.
Academic Article CD8+ T-cell responses to different HIV proteins have discordant associations with viral load.
Academic Article Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I alleles.
Academic Article Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing child.
Academic Article Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads.
Academic Article HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers.
Academic Article Central role of reverting mutations in HLA associations with human immunodeficiency virus set point.
Academic Article Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers.
Academic Article The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design.
Academic Article Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes release gamma interferon, tumor necrosis factor alpha (TNF-alpha), and TNF-beta when they encounter their target antigens.
Academic Article Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV.
Academic Article Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1.
Academic Article Epitope specificity of MHC restricted cytotoxic T lymphocytes induced by candidate HIV-1 vaccine.
Academic Article Degenerate and promiscuous recognition by CTL of peptides presented by the MHC class I A3-like superfamily: implications for vaccine development.
Academic Article HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C.
Academic Article High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control.
Academic Article TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection.
Academic Article De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection.
Academic Article CD4+ human immunodeficiency virus type 1 (HIV-1) envelope-specific cytotoxic T lymphocytes derived from the peripheral blood cells of an HIV-1-infected individual.
Academic Article Lack of viral escape and defective in vivo activation of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes in rapidly progressive infection.
Academic Article Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid.
Academic Article HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition.
Academic Article Adaptation of HIV-1 to human leukocyte antigen class I.
Academic Article Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa.
Academic Article Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality.
Academic Article Overlapping epitopes in human immunodeficiency virus type 1 gp120 presented by HLA A, B, and C molecules: effects of viral variation on cytotoxic T-lymphocyte recognition.
Academic Article Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities.
Academic Article Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.
Academic Article HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory.
Academic Article Extensive HLA class I allele promiscuity among viral CTL epitopes.
Academic Article Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipients.
Academic Article A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells.
Academic Article HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load.
Academic Article Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection.
Academic Article Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes.
Academic Article HIV evolution: CTL escape mutation and reversion after transmission.
Academic Article Major histocompatibility complex class I-intercellular adhesion molecule-1 association on the surface of target cells: implications for antigen presentation to cytotoxic T lymphocytes.
Academic Article Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters.
Academic Article Recognition of the highly conserved YMDD region in the human immunodeficiency virus type 1 reverse transcriptase by HLA-A2-restricted cytotoxic T lymphocytes from an asymptomatic long-term nonprogressor.
Academic Article Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope.
Academic Article Preferential CTL targeting of Gag is associated with relative viral control in long-term surviving HIV-1 infected former plasma donors from China.
Academic Article Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa.
Academic Article T cell receptor cross-recognition of an HIV-1 CD8+ T cell epitope presented by closely related alleles from the HLA-A3 superfamily.
Academic Article Elite control of HIV infection: implications for vaccine design.
Academic Article HIV control through a single nucleotide on the HLA-B locus.
Academic Article Induction of a major histocompatibility complex class I-restricted cytotoxic T-lymphocyte response to a highly conserved region of human immunodeficiency virus type 1 (HIV-1) gp120 in seronegative humans immunized with a candidate HIV-1 vaccine.
Academic Article Founder effects in the assessment of HIV polymorphisms and HLA allele associations.
Academic Article Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1.
Academic Article Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes.
Academic Article Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control.
Academic Article Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection.
Academic Article HIV type 1-specific cytotoxic T lymphocytes stimulate HLA class I and intercellular adhesion molecule type 1 expression and increase beta 2-microglobulin levels in vitro.
Academic Article Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes.
Academic Article HIV and HLA class I: an evolving relationship.
Academic Article Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone.
Academic Article Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving.
Academic Article HLA-B57-restricted cytotoxic T-lymphocyte activity in a single infected subject toward two optimal epitopes, one of which is entirely contained within the other.
Academic Article Rapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by elispot and intracellular cytokine staining assays.
Academic Article A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition.
Academic Article CD8 epitope escape and reversion in acute HCV infection.
Academic Article Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.
Academic Article Targeting of a CD8 T cell env epitope presented by HLA A-B*5802 is associated with markers of HIV disease progression and lack of selection pressure
Academic Article Recognition of two overlapping CTL epitopes in HIV-1 p17 by CTL from a long-term nonprogressing HIV-1-infected individual.
Academic Article Evolution and transmission of stable CTL escape mutations in HIV infection.
Academic Article Characterization of a novel respiratory syncytial virus-specific human cytotoxic T-lymphocyte epitope.
Academic Article Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein.
Academic Article Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection.
Academic Article Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection.
Academic Article Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection.
Academic Article Rare HLA drive additional HIV evolution compared to more frequent alleles.
Academic Article Impaired CTL recognition of cells latently infected with Kaposi's sarcoma-associated herpes virus.
Academic Article Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
Academic Article Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection.
Academic Article Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection.
Academic Article HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins.
Academic Article HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release.
Academic Article Presentation of endogenous peptides to MHC class I-restricted cytotoxic T lymphocytes in transport deletion mutant T2 cells.
Academic Article A novel immunodominant CD8+ T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected Thais.
Academic Article Immunopathogenesis and immunotherapy in AIDS virus infections.
Academic Article Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity.
Academic Article Co-operative additive effects between HLA alleles in control of HIV-1.
Academic Article Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.
Academic Article Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians.
Academic Article High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection.
Academic Article HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation.
Academic Article HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1.
Academic Article HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1.
Academic Article Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection.
Academic Article Additive contribution of HLA class I alleles in the immune control of HIV-1 infection.
Academic Article Widespread impact of HLA restriction on immune control and escape pathways of HIV-1.
Academic Article HIV-1 reverse transcriptase is a target for cytotoxic T lymphocytes in infected individuals.
Academic Article Replicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rate.
Academic Article Factors associated with viral rebound in HIV-1-infected individuals enrolled in a therapeutic HIV-1 gag vaccine trial.
Academic Article Attenuation of multiple Nef functions in HIV-1 elite controllers.
Academic Article Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1.
Academic Article Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.
Academic Article Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms.
Academic Article Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans.
Academic Article T cell receptor usage and fine specificity of human immunodeficiency virus 1-specific cytotoxic T lymphocyte clones: analysis of quasispecies recognition reveals a dominant response directed against a minor in vivo variant.
Academic Article Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes.
Academic Article Recognition of a defined region within p24 Gag by CD8+ T cells during primary HIV-1 infection in individuals expressing protective HLA class I alleles
Academic Article Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses.
Academic Article Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype.
Academic Article Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes.
Academic Article Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1.
Academic Article The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
Academic Article Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals.
Academic Article Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design.
Academic Article Cytotoxic T-lymphocyte cross-reactivity among different human immunodeficiency virus type 1 clades: implications for vaccine development.
Academic Article HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load.
Academic Article Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses.
Academic Article Immunogenetics of spontaneous control of HIV.
Concept HLA Antigens
Concept HLA-B Antigens
Concept HLA-B7 Antigen
Concept HLA-A Antigens
Concept HLA-DR1 Antigen
Concept HLA-A3 Antigen
Concept HLA-DQ Antigens
Concept HLA-DR Antigens
Concept HLA-A2 Antigen
Concept HLA-A1 Antigen
Concept HLA-B8 Antigen
Concept HLA-B27 Antigen
Concept HLA-C Antigens
Academic Article Association of HLA-DRB1-restricted CD4? T cell responses with HIV immune control.
Academic Article HLA-A*68:02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective.
Academic Article Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes.
Academic Article Nef-specific CD8+ T cell responses contribute to HIV-1 immune control.
Academic Article HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01.
Academic Article Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease.
Academic Article Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection.
Academic Article The complex and specific pMHC interactions with diverse HIV-1 TCR clonotypes reveal a structural basis for alterations in CTL function.
Academic Article LILRB2 interaction with HLA class I correlates with control of HIV-1 infection.
Academic Article Genotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic.
Academic Article HIV subtype influences HLA-B*07:02-associated HIV disease outcome.
Academic Article Paradigm-violating HLA Class II-restricted CD8 T-cells in HIV-infection.
Academic Article Differences in Immunodominant Patterns and HLA-DRB1 Restriction Characteristics in HIV-specific CD4 T-cell Responses between Clade B and C Infection.
Academic Article Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure.
Academic Article Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence.
Academic Article CD8+ TCR Bias and Immunodominance in HIV-1 Infection.
Academic Article High frequency of transmitted HIV-1 Gag HLA class I-driven immune escape variants but minimal immune selection over the first year of clade C infection.
Academic Article Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection.
Academic Article Correction for Thobakgale et al., Impact of HLA in Mother and Child on Disease Progression of Pediatric Human Immunodeficiency Virus Type 1 Infection.
Academic Article Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load.
Academic Article Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa.
Academic Article Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences.
Academic Article HIV-1 Vpu Mediates HLA-C Downregulation.
Academic Article CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles.
Academic Article Lower Viral Loads and Slower CD4+ T-Cell Count Decline in MRKAd5 HIV-1 Vaccinees Expressing Disease-Susceptible HLA-B*58:02.
Grant Acute HIV Infection: Implications for vaccine design
Grant HLA Typing and Epitope Mapping Relative to HIV Vaccine Design
Grant Pathogenesis of Clade C HIV Infection
Grant HIV 1 specific T cell clones
Academic Article HLA-C levels impact natural killer cell subset distribution and function.
Academic Article Crystal structure of HLA-B*5801, a protective HLA allele for HIV-1 infection.
Academic Article Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion.
Academic Article Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller.
Academic Article HLA-B*57 and IFNL4-Related Polymorphisms Are Associated With Protection Against HIV-1 Disease Progression in Controllers.
Academic Article Crystal structure of HLA-B*5801 with a TW10 HIV Gag epitope reveals a novel mode of peptide presentation.
Academic Article HLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection.
Academic Article Role of HIV-specific CD8+ T cells in pediatric HIV cure strategies after widespread early viral escape.
Academic Article Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.
Academic Article T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable.
Academic Article Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1.
Academic Article Engineering modular intracellular protein sensor-actuator devices.
Academic Article Structural topology defines protective CD8+ T cell epitopes in the HIV proteome.
Academic Article Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity.
Academic Article Structure-guided T cell vaccine design for SARS-CoV-2 variants and sarbecoviruses.
Academic Article HLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV.
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  • HLA A Antigens
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.