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Item TypeName
Academic Article Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load.
Academic Article Strong cytotoxic T cell and weak neutralizing antibody responses in a subset of persons with stable nonprogressing HIV type 1 infection.
Academic Article Levels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy.
Academic Article Analysis of successful immune responses in persons infected with hepatitis C virus.
Academic Article Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children.
Academic Article Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay.
Academic Article Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles.
Academic Article Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection.
Academic Article Monocyte chemoattractant protein-2 (CC chemokine ligand 8) inhibits replication of human immunodeficiency virus type 1 via CC chemokine receptor 5.
Academic Article Progress in defining CD4 helper cell responses in chronic viral infections.
Academic Article Longitudinal and cross-sectional analysis of cytotoxic T lymphocyte responses and their relationship to vertical human immunodeficiency virus transmission. ARIEL Project Investigators.
Academic Article STI and beyond: the prospects of boosting anti-HIV immune responses.
Academic Article Absence of biologically important Kaposi sarcoma-associated herpesvirus gene products and virus-specific cellular immune responses in multiple myeloma.
Academic Article Identification of type-specific cytotoxic T lymphocyte responses to homologous viral proteins in laboratory workers accidentally infected with HIV-1.
Academic Article Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides.
Academic Article HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response.
Academic Article Synergistic inhibition of human immunodeficiency virus type 1 (HIV-1) replication in vitro by recombinant soluble CD4 and 3'-azido-3'-deoxythymidine.
Academic Article CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control.
Academic Article Detection of a vigorous HIV-1-specific cytotoxic T lymphocyte response in cerebrospinal fluid from infected persons with AIDS dementia complex.
Academic Article Modulation of host immune responses by clinically relevant human DNA and RNA viruses.
Academic Article Can immune responses to human immunodeficiency virus be preserved, enhanced, or restored?
Academic Article HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells.
Academic Article Association between HIV Type 1-specific T cell responses and CD4+ T cell counts or CD4+:CD8+ T cell ratios in HIV Type 1 subtype B infection in China.
Academic Article Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia.
Academic Article Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection.
Academic Article Lack of strong immune selection pressure by the immunodominant, HLA-A*0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection.
Academic Article The role of CD4+ T cell help and CD40 ligand in the in vitro expansion of HIV-1-specific memory cytotoxic CD8+ T cell responses.
Academic Article Reconstitution of virus-specific CD4 proliferative responses in pediatric HIV-1 infection.
Academic Article Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution.
Academic Article Hepatitis C virus-specific cytolytic T lymphocyte and T helper cell responses in seronegative persons.
Academic Article CD8+ T-cell responses to different HIV proteins have discordant associations with viral load.
Academic Article IL-8 responsiveness defines a subset of CD8 T cells poised to kill.
Academic Article Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing child.
Academic Article T lymphocyte responses in HIV-1 infection: implications for vaccine development.
Academic Article Cytotoxic T-lymphocyte (CTL) responses directed against regulatory and accessory proteins in HIV-1 infection.
Academic Article Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences.
Academic Article Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice.
Academic Article The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design.
Academic Article Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy.
Academic Article HIV-1-specific cytotoxic T lymphocyte response in healthy, long-term nonprogressing seropositive persons.
Academic Article The cytotoxic T-lymphocyte response in HIV-1 infection.
Academic Article Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses.
Academic Article High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control.
Academic Article Proliferative capacity of epitope-specific CD8 T cell responses is inversely related to viral load in chronic HIV-1 infection
Academic Article De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection.
Academic Article HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus.
Academic Article Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals.
Academic Article Characteristics of the intrahepatic cytotoxic T lymphocyte response in chronic hepatitis C virus infection.
Academic Article Discordant Efficacy of HIV-Specific Cd8+ T Cell Responses Is Determined by Protein-Specificity
Academic Article Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities.
Academic Article CD8+ T lymphocyte responses target functionally important regions of Protease and Integrase in HIV-1 infected subjects.
Academic Article Human immunodeficiency virus type 1-hepatitis C virus coinfection: intraindividual comparison of cellular immune responses against two persistent viruses.
Academic Article Increased detection of HIV-specific T cell responses by combination of central sequences with comparable immunogenicity.
Academic Article Definition of the viral targets of protective HIV-1-specific T cell responses.
Academic Article High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control.
Academic Article Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes.
Academic Article Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection.
Academic Article Detection of diverse hepatitis C virus (HCV)-specific cytotoxic T lymphocytes in peripheral blood of infected persons by screening for responses to all translated proteins of HCV.
Academic Article Increased sequence diversity coverage improves detection of HIV-specific T cell responses.
Academic Article Induction of a major histocompatibility complex class I-restricted cytotoxic T-lymphocyte response to a highly conserved region of human immunodeficiency virus type 1 (HIV-1) gp120 in seronegative humans immunized with a candidate HIV-1 vaccine.
Academic Article Inter-clade cross-reactivity of HIV-1-specific T cell responses in human immunodeficiency virus type 1 infection in China.
Academic Article Loss of HIV-1-specific T-cell responses associated with very rapid HIV-1 disease progression.
Academic Article Detection of HIV type 1 gag-specific CD4(+) T cell responses in acutely infected infants.
Academic Article Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1.
Academic Article CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription.
Academic Article Factors predicting discordant virological and immunological responses to antiretroviral therapy in HIV-1 clade C infected Zulu/Xhosa in South Africa.
Academic Article Improved CD4 lymphocyte outgrowth in response to effective antiretroviral therapy.
Academic Article The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses.
Academic Article Neutralizing antibodies to adenovirus serotype 5 vaccine vectors are directed primarily against the adenovirus hexon protein.
Academic Article Impaired HCV-specific T cell responses and recurrent HCV in HIV coinfection
Academic Article Multiple effector functions mediated by human immunodeficiency virus-specific CD4(+) T-cell clones.
Academic Article Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection.
Academic Article Viremia control despite escape from a rapid and potent autologous neutralizing antibody response after therapy cessation in an HIV-1-infected individual.
Academic Article Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins.
Academic Article Differential targeting and shifts in the immunodominance of Epstein-Barr virus--specific CD8 and CD4 T cell responses during acute and persistent infection.
Academic Article A novel immunodominant CD8+ T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected Thais.
Academic Article HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome.
Academic Article Broad specificity of virus-specific CD4+ T-helper-cell responses in resolved hepatitis C virus infection.
Academic Article Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.
Academic Article Augmentation of HIV-1-specific T helper cell responses in chronic HIV-1 infection by therapeutic immunization.
Academic Article Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection.
Academic Article Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection.
Academic Article Regulatory T cell frequencies do not correlate with breadth or magnitude of HIV-1-specific T cell responses.
Academic Article Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians.
Academic Article High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection.
Academic Article Human immunodeficiency virus type 1 specific cytotoxic T lymphocyte responses in Chinese infected with HIV-1 B'/C Recombinant (CRF07_BC).
Academic Article HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation.
Academic Article HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell function.
Academic Article HIV-specific CD4 T cell responses to different viral proteins have discordant associations with viral load and clinical outcome.
Academic Article HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1.
Academic Article Frequent and strong antibody-mediated natural killer cell activation in response to HIV-1 Env in individuals with chronic HIV-1 infection.
Academic Article Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells.
Academic Article Increased Sequence Diversity Coverage Improves Detection of HIV-Specific T Cell Responses
Academic Article Retroviral Immunology: Immune Response and Restoration
Academic Article Effective T cell responses select HIV-1 mutants and slow disease progression. 81(12):6742-51. Epub 2007 Apr 4
Academic Article Differential immunogenicity of HIV-1 clade C proteins in eliciting CD8+ and CD4+ cell responses.
Academic Article Cytotoxic T lymphocytes in human immunodeficiency virus infection: responses to structural proteins.
Academic Article T cell receptor usage and fine specificity of human immunodeficiency virus 1-specific cytotoxic T lymphocyte clones: analysis of quasispecies recognition reveals a dominant response directed against a minor in vivo variant.
Academic Article Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses.
Academic Article Comprehensive screening reveals strong and broadly directed human immunodeficiency virus type 1-specific CD8 responses in perinatally infected children.
Academic Article The immune response to AIDS virus infection: good, bad, or both?
Academic Article Relative dominance of Env-gp41-specific cytotoxic T lymphocytes responses in HIV-1 advanced infection.
Academic Article Liver-derived CTL in hepatitis C virus infection: breadth and specificity of responses in a cohort of persons with chronic infection.
Academic Article Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responses.
Academic Article High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level.
Academic Article Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses.
Concept Dose-Response Relationship, Drug
Concept Dose-Response Relationship, Immunologic
Concept Epidemics
Academic Article Association of HLA-DRB1-restricted CD4? T cell responses with HIV immune control.
Academic Article HLA-A*68:02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective.
Academic Article Nef-specific CD8+ T cell responses contribute to HIV-1 immune control.
Academic Article The T-cell response to HIV.
Academic Article Genotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic.
Academic Article Profiling human antibody responses by integrated single-cell analysis.
Academic Article Differences in Immunodominant Patterns and HLA-DRB1 Restriction Characteristics in HIV-specific CD4 T-cell Responses between Clade B and C Infection.
Academic Article Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection.
Academic Article Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract.
Academic Article Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers.
Academic Article Population-Level Immune-Mediated Adaptation in HIV-1 Polymerase during the North American Epidemic.
Academic Article HIV-1 Antibody Neutralization Breadth Is Associated with Enhanced HIV-Specific CD4+ T Cell Responses.
Academic Article Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control.
Grant Therapeutic Vaccination for HIV Using VEE Vectors
Grant CELL-MEDIATED IMMUNITY IN HEPATITIS C VIRUS INFECTION
Grant Acute HIV Infection: Implications for vaccine design
Grant IMMUNE CONTROL OF HIV REPLICATION
Grant HIV-1-specific CD4 Cells in Disease Pathogenesis
Grant Immune Control and Evasion during Acute HCV Infection
Grant Pathogenesis of Clade C HIV Infection
Grant Inhibition of HIV 1 Replication by Cytotoxic Lymphocytes
Grant Pathogenesis of Clade C HIV Infection
Grant Harvard University Center for AIDS Research
Grant HIV 1 SPECIFIC T CELL CLONES
Grant IMMUNE RECONSTITUTION IN AIDS VIRUS INFECTIONS
Grant HIV 1 SPECIFIC IMMUNITY AND MATERNAL-FETAL TRANSMISSION
Grant HIV 1 specific T cell clones
Grant LIVE ATTENUATED MULTIPLY DELETED HIV-1 VACCINE FOR AIDS
Grant PATHOGENESIS AND TREATMENT OF ACUTE HIV INFECTION
Academic Article Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals.
Academic Article Analysis of Major Histocompatibility Complex-Bound HIV Peptides Identified from Various Cell Types Reveals Common Nested Peptides and Novel T Cell Responses.
Grant Molecular networks of HIV-specific CD4 T cell help to B cells
Academic Article T-cell responses targeting HIV Nef uniquely correlate with infected cell frequencies after long-term antiretroviral therapy.
Academic Article High-resolution definition of humoral immune response correlates of effective immunity against HIV.
Academic Article Frequencies of Circulating Th1-Biased T Follicular Helper Cells in Acute HIV-1 Infection Correlate with the Development of HIV-Specific Antibody Responses and Lower Set Point Viral Load.
Academic Article Recommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting.
Academic Article Evolution and Diversity of Immune Responses during Acute HIV Infection.
Academic Article Dendritic cells focus CTL responses toward highly conserved and topologically important HIV-1 epitopes.
Academic Article HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses.
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  • Response
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.