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Item TypeName
Academic Article Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load.
Academic Article Immune control of HIV: the obstacles of HLA and viral diversity.
Academic Article Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.
Academic Article Identification of overlapping HLA class I-restricted cytotoxic T cell epitopes in a conserved region of the human immunodeficiency virus type 1 envelope glycoprotein: definition of minimum epitopes and analysis of the effects of sequence variation.
Academic Article Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children.
Academic Article Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay.
Academic Article Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II.
Academic Article Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection.
Academic Article Enhanced inhibition of human immunodeficiency virus type 1 by Met-stromal-derived factor 1beta correlates with down-modulation of CXCR4.
Academic Article Efficient processing of the immunodominant, HLA-A*0201-restricted human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitope despite multiple variations in the epitope flanking sequences.
Academic Article Vpr is preferentially targeted by CTL during HIV-1 infection.
Academic Article Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A.
Academic Article HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering.
Academic Article Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells.
Academic Article Unusual polymorphisms in human immunodeficiency virus type 1 associated with nonprogressive infection.
Academic Article Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.
Academic Article HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection.
Academic Article Identification of type-specific cytotoxic T lymphocyte responses to homologous viral proteins in laboratory workers accidentally infected with HIV-1.
Academic Article Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells.
Academic Article Rev activity determines sensitivity of HIV-1-infected primary T cells to CTL killing.
Academic Article Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides.
Academic Article Mother-to-child transmission of HIV infection and CTL escape through HLA-A2-SLYNTVATL epitope sequence variation.
Academic Article CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control.
Academic Article Identification of HLA-A11-restricted HIV-1-specific cytotoxic T-lymphocyte epitopes in China.
Academic Article Human immunodeficiency virus type 1 populations in blood and semen.
Academic Article Detection of a vigorous HIV-1-specific cytotoxic T lymphocyte response in cerebrospinal fluid from infected persons with AIDS dementia complex.
Academic Article HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells.
Academic Article Portable flanking sequences modulate CTL epitope processing.
Academic Article Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia.
Academic Article Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection.
Academic Article Immunological and virological analyses of persons infected by human immunodeficiency virus type 1 while participating in trials of recombinant gp120 subunit vaccines.
Academic Article Type 2 Bias of T cells expanded from the blood of melanoma patients switched to type 1 by IL-12p70 mRNA-transfected dendritic cells.
Academic Article Reconstitution of virus-specific CD4 proliferative responses in pediatric HIV-1 infection.
Academic Article Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution.
Academic Article Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
Academic Article Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I alleles.
Academic Article Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins.
Academic Article Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities.
Academic Article Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing child.
Academic Article Central role of reverting mutations in HLA associations with human immunodeficiency virus set point.
Academic Article Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences.
Academic Article The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design.
Academic Article HIV-1-specific cytotoxic T lymphocyte response in healthy, long-term nonprogressing seropositive persons.
Academic Article Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes release gamma interferon, tumor necrosis factor alpha (TNF-alpha), and TNF-beta when they encounter their target antigens.
Academic Article Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV.
Academic Article Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire.
Academic Article Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1.
Academic Article Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes.
Academic Article Epitope specificity of MHC restricted cytotoxic T lymphocytes induced by candidate HIV-1 vaccine.
Academic Article The cytotoxic T-lymphocyte response in HIV-1 infection.
Academic Article Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding.
Academic Article Cytotoxic T-cell epitopes in HIV/SIV infection.
Academic Article HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus.
Academic Article Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells.
Academic Article Decreased CXCR3+ CD8 T cells in advanced human immunodeficiency virus infection suggest that a homing defect contributes to cytotoxic T-lymphocyte dysfunction.
Academic Article Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid.
Academic Article Human leukocyte antigen-specific polymorphisms in HIV-1 Gag and their association with viral load in chronic untreated infection.
Academic Article Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection.
Academic Article Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality.
Academic Article Characteristics of the intrahepatic cytotoxic T lymphocyte response in chronic hepatitis C virus infection.
Academic Article An optimal viral peptide recognized by CD8+ T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein.
Academic Article Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.
Academic Article Extensive HLA class I allele promiscuity among viral CTL epitopes.
Academic Article Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes.
Academic Article Increased detection of HIV-specific T cell responses by combination of central sequences with comparable immunogenicity.
Academic Article Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipients.
Academic Article HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load.
Academic Article Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection.
Academic Article Definition of the viral targets of protective HIV-1-specific T cell responses.
Academic Article Increased sequence diversity coverage improves detection of HIV-specific T cell responses.
Academic Article HIV evolution: CTL escape mutation and reversion after transmission.
Academic Article Recognition of the highly conserved YMDD region in the human immunodeficiency virus type 1 reverse transcriptase by HLA-A2-restricted cytotoxic T lymphocytes from an asymptomatic long-term nonprogressor.
Academic Article Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope.
Academic Article Preferential CTL targeting of Gag is associated with relative viral control in long-term surviving HIV-1 infected former plasma donors from China.
Academic Article Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa.
Academic Article Induction of a major histocompatibility complex class I-restricted cytotoxic T-lymphocyte response to a highly conserved region of human immunodeficiency virus type 1 (HIV-1) gp120 in seronegative humans immunized with a candidate HIV-1 vaccine.
Academic Article Loss of HIV-1-specific T-cell responses associated with very rapid HIV-1 disease progression.
Academic Article Functional and genetic analysis of coreceptor usage by dualtropic HIV-1 subtype C isolates.
Academic Article An epitope-selective, transporter associated with antigen presentation (TAP)-1/2-independent pathway and a more general TAP-1/2-dependent antigen-processing pathway allow recognition of the HIV-1 envelope glycoprotein by CD8+ CTL.
Academic Article Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone.
Academic Article HLA-B57-restricted cytotoxic T-lymphocyte activity in a single infected subject toward two optimal epitopes, one of which is entirely contained within the other.
Academic Article Rapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by elispot and intracellular cytokine staining assays.
Academic Article A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition.
Academic Article CD8 epitope escape and reversion in acute HCV infection.
Academic Article Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.
Academic Article Recognition of two overlapping CTL epitopes in HIV-1 p17 by CTL from a long-term nonprogressing HIV-1-infected individual.
Academic Article Multiple effector functions mediated by human immunodeficiency virus-specific CD4(+) T-cell clones.
Academic Article Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection.
Academic Article Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection.
Academic Article Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
Academic Article Viremia control despite escape from a rapid and potent autologous neutralizing antibody response after therapy cessation in an HIV-1-infected individual.
Academic Article Differential targeting and shifts in the immunodominance of Epstein-Barr virus--specific CD8 and CD4 T cell responses during acute and persistent infection.
Academic Article Transmission and long-term stability of compensated CD8 escape mutations.
Academic Article HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins.
Academic Article Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness.
Academic Article HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release.
Academic Article Presentation of endogenous peptides to MHC class I-restricted cytotoxic T lymphocytes in transport deletion mutant T2 cells.
Academic Article A novel immunodominant CD8+ T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected Thais.
Academic Article Broad specificity of virus-specific CD4+ T-helper-cell responses in resolved hepatitis C virus infection.
Academic Article Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.
Academic Article Persistent recognition of autologous virus by high-avidity CD8 T cells in chronic, progressive human immunodeficiency virus type 1 infection.
Academic Article Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.
Academic Article Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians.
Academic Article Limited sequence evolution within persistently targeted CD8 epitopes in chronic human immunodeficiency virus type 1 infection.
Academic Article Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1.
Academic Article Persistence of attenuated rev genes in a human immunodeficiency virus type 1-infected asymptomatic individual.
Academic Article Characterization of full-length hepatitis C virus genotype 4 sequences.
Academic Article Random T-cell receptor recruitment in human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells from genetically identical twins infected with the same HIV-1 strain.
Academic Article Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis.
Academic Article Cytotoxic T lymphocytes in human immunodeficiency virus infection: responses to structural proteins.
Academic Article T cell receptor usage and fine specificity of human immunodeficiency virus 1-specific cytotoxic T lymphocyte clones: analysis of quasispecies recognition reveals a dominant response directed against a minor in vivo variant.
Academic Article Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes.
Academic Article Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses.
Academic Article Comprehensive screening reveals strong and broadly directed human immunodeficiency virus type 1-specific CD8 responses in perinatally infected children.
Academic Article Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype.
Academic Article Relative dominance of Env-gp41-specific cytotoxic T lymphocytes responses in HIV-1 advanced infection.
Academic Article Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design.
Academic Article Cytotoxic T-lymphocyte cross-reactivity among different human immunodeficiency virus type 1 clades: implications for vaccine development.
Academic Article Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responses.
Academic Article HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load.
Academic Article Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses.
Academic Article Inhibition of cytotoxicity and cytokine release of CD8+ HIV-specific cytotoxic T lymphocytes by pentoxifylline.
Concept Amino Acid Sequence
Academic Article Nef-specific CD8+ T cell responses contribute to HIV-1 immune control.
Academic Article Genotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic.
Academic Article A cell-intrinsic inhibitor of HIV-1 reverse transcription in CD4(+) T cells from elite controllers.
Academic Article Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma.
Academic Article CD8+ TCR Bias and Immunodominance in HIV-1 Infection.
Academic Article Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.