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One or more keywords matched the following items that are connected to Engelman, Alan
Item TypeName
Academic Article A mutation in integrase can compensate for mutations in the simian immunodeficiency virus att site.
Academic Article Wild-type levels of nuclear localization and human immunodeficiency virus type 1 replication in the absence of the central DNA flap.
Academic Article Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking.
Academic Article Characterization of a replication-defective human immunodeficiency virus type 1 att site mutant that is blocked after the 3' processing step of retroviral integration.
Academic Article Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration.
Academic Article Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase.
Academic Article Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication.
Academic Article Structure-based mutagenesis of the human immunodeficiency virus type 1 DNA attachment site: effects on integration and cDNA synthesis.
Academic Article Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1.
Academic Article Identification of host proteins required for HIV infection through a functional genomic screen.
Academic Article Genetic analyses of conserved residues in the carboxyl-terminal domain of human immunodeficiency virus type 1 integrase.
Academic Article Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication.
Academic Article An integration-defective U5 deletion mutant of human immunodeficiency virus type 1 reverts by eliminating additional long terminal repeat sequences.
Academic Article Genetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase.
Academic Article A rapid in vitro assay for HIV DNA integration.
Academic Article A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75.
Academic Article HIV-1 DNA integration: mechanism of viral DNA cleavage and DNA strand transfer.
Academic Article Human immunodeficiency virus type 1 replication in the absence of integrase-mediated dna recombination: definition of permissive and nonpermissive T-cell lines.
Academic Article Requirements for capsid-binding and an effector function in TRIMCyp-mediated restriction of HIV-1.
Academic Article A soluble active mutant of HIV-1 integrase: involvement of both the core and carboxyl-terminal domains in multimerization.
Academic Article The structural biology of HIV-1: mechanistic and therapeutic insights.
Academic Article HIV DNA is heavily uracilated, which protects it from autointegration.
Academic Article Correlation of recombinant integrase activity and functional preintegration complex formation during acute infection by replication-defective integrase mutant human immunodeficiency virus.
Academic Article Simian virus 40-based replication of catalytically inactive human immunodeficiency virus type 1 integrase mutants in nonpermissive T cells and monocyte-derived macrophages.
Academic Article Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.
Academic Article Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect.
Academic Article Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase.
Academic Article Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors.
Academic Article The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.
Academic Article Viral latency and potential eradication of HIV-1.
Academic Article Lys-34, dispensable for integrase catalysis, is required for preintegration complex function and human immunodeficiency virus type 1 replication.
Academic Article Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import.
Concept Virus Replication
Academic Article The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.
Academic Article Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.
Academic Article Structural basis for nuclear import of splicing factors by human Transportin 3.
Academic Article The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.
Academic Article Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74.
Academic Article Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus Passage In Vivo.
Academic Article Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro.
Grant LEDGF-Integrase Structural Biology
Academic Article Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration.
Academic Article A HTRF based competitive binding assay for screening specific inhibitors of HIV-1 capsid assembly targeting the C-Terminal domain of capsid.
Academic Article HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains.
Search Criteria
  • Virus Replication
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.