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One or more keywords matched the following properties of Brugnara, Carlo
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overview Ion transport across biological membranes plays a crucial role in several physiological and pathological processes. My research has been focused on the study of the transport systems mediating transport of Na and K across the membrane of erythrocytes. My studies have addressed the issue of how these transporters induce cellular dehydration in sickle cell disease and whether we can use the knowledge gained from the study of these systems to develop new therapeutic approaches for sickle cell anemia. This approach is relevant to the pathogenesis and potential therapy of this disease because it is known that dehydration of sickle erythrocytes promotes sickling and may have a major role in the vascular complications of this disease. My clinical laboratory-based research has been focused on the use of hematological parameters to assess the balance between iron availability and erythropoiesis. We have described the appearance of functional iron deficiency in normal subjects treated with recombinant human erythropoietin (r-HuEPO) based on the particular flow cytometric characteristics of erythrocytes and reticulocytes. We have shown the clinical value of reticulocyte parameters in the setting of r-HuEPO use and in the diagnosis of iron deficiency in children.
One or more keywords matched the following items that are connected to Brugnara, Carlo
Item TypeName
Academic Article Use of recombinant human erythropoietin outside the setting of uremia.
Academic Article Iron deficiency and erythropoiesis: new diagnostic approaches.
Academic Article Erythropoietin, iron, and erythropoiesis.
Academic Article Reticulocyte cellular indices: a new approach in the diagnosis of anemias and monitoring of erythropoietic function.
Academic Article Reticulocyte hemoglobin: an integrated parameter for evaluation of erythropoietic activity.
Academic Article Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI.
Academic Article Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts.
Academic Article Quantitative trait loci for baseline erythroid traits.
Academic Article Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo.
Academic Article Red blood cell regeneration induced by subcutaneous recombinant erythropoietin: iron-deficient erythropoiesis in iron-replete subjects.
Academic Article Use of erythropoiesis stimulating agents and intravenous iron for cancer and treatment-related anaemia: the need for predictors and indicators of effectiveness has not abated.
Academic Article Efficacy of different dosing regimens for recombinant human erythropoietin in a simulated perisurgical setting: the importance of iron availability in optimizing response.
Academic Article Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts.
Academic Article Foxo3 is required for the regulation of oxidative stress in erythropoiesis.
Academic Article Effects of subcutaneous recombinant human erythropoietin in normal subjects: development of decreased reticulocyte hemoglobin content and iron-deficient erythropoiesis.
Academic Article Automated reticulocyte counting: state of the art and clinical applications in the evaluation of erythropoiesis.
Academic Article A novel method utilising markers of altered erythropoiesis for the detection of recombinant human erythropoietin abuse in athletes.
Concept Erythropoiesis
Academic Article Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice.
Academic Article FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis.
Academic Article Positive Iron Balance in Chronic Kidney Disease: How Much is Too Much and How to Tell?
Search Criteria
  • Erythropoiesis
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.