Our lab is interested in the molecular events that control gene expression during animal development. Using muscle (cardiac, skeletal and smooth) as model systems, we study transcriptional, epigenetic and microRNA (miRNA)-mediated post-transcriptional regulation of gene expression. We apply a variety of developmental, molecular, cellular, biochemical, genetic and physiological approaches, including transgenic and knockout mouse models in our lab.
The heart is the “heart” of life. Heart disease is the number one cause of mortality and morbidity world wide. Congenital heart disease occurs in one of every one hundred live births and is the most common human birth defect. Discovery of the genetic control and molecular mechanisms of heart development is an important prerequisite to develop novel therapies for human cardiovascular disease.