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overview Our lab is interested in the molecular events that control gene expression during animal development. Using muscle (cardiac, skeletal and smooth) as model systems, we study transcriptional, epigenetic and microRNA (miRNA)-mediated post-transcriptional regulation of gene expression. We apply a variety of developmental, molecular, cellular, biochemical, genetic and physiological approaches, including transgenic and knockout mouse models in our lab. The heart is the “heart” of life. Heart disease is the number one cause of mortality and morbidity world wide. Congenital heart disease occurs in one of every one hundred live births and is the most common human birth defect. Discovery of the genetic control and molecular mechanisms of heart development is an important prerequisite to develop novel therapies for human cardiovascular disease.
One or more keywords matched the following items that are connected to Wang, Da-Zhi
Item TypeName
Academic Article The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation.
Academic Article Potentiation of serum response factor activity by a family of myocardin-related transcription factors.
Academic Article Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes.
Academic Article Myocardin is a master regulator of smooth muscle gene expression.
Academic Article Myocardin is sufficient and necessary for cardiac gene expression in Xenopus.
Academic Article Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies.
Academic Article Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor.
Academic Article A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection.
Academic Article Modulation of cardiac growth and development by HOP, an unusual homeodomain protein.
Academic Article The BMP pathway acts to directly regulate Tbx20 in the developing heart.
Academic Article MicroRNAs in heart development.
Academic Article Application of microRNA in cardiac and skeletal muscle disease gene therapy.
Academic Article "RISCing" the heart: In vivo identification of cardiac microRNA targets by RISCome.
Academic Article DOT1L regulates dystrophin expression and is critical for cardiac function.
Academic Article Myocardin marks the earliest cardiac gene expression and plays an important role in heart development.
Academic Article Control of smooth muscle development by the myocardin family of transcriptional coactivators.
Academic Article Myocardin induces cardiomyocyte hypertrophy.
Academic Article MicroRNAs in skeletal and cardiac muscle development.
Academic Article MicroRNAs in cardiac remodeling and disease.
Academic Article Bone morphogenetic protein signaling modulates myocardin transactivation of cardiac genes.
Academic Article The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice.
Academic Article Acetylation of myocardin is required for the activation of cardiac and smooth muscle genes.
Academic Article Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression.
Academic Article Synergistic activation of cardiac genes by myocardin and Tbx5.
Concept Myocardium
Academic Article MicroRNAs in cardiac regeneration and cardiovascular disease.
Academic Article miR-22 in cardiac remodeling and disease.
Academic Article Trbp regulates heart function through microRNA-mediated Sox6 repression.
Grant Transcriptional control of cardiac development
Academic Article Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts.
Academic Article Loss of microRNA-22 prevents high-fat diet induced dyslipidemia and increases energy expenditure without affecting cardiac hypertrophy.
Search Criteria
  • Myocardium
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.