Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following properties of Wang, Da-Zhi
overview Our lab is interested in the molecular events that control gene expression during animal development. Using muscle (cardiac, skeletal and smooth) as model systems, we study transcriptional, epigenetic and microRNA (miRNA)-mediated post-transcriptional regulation of gene expression. We apply a variety of developmental, molecular, cellular, biochemical, genetic and physiological approaches, including transgenic and knockout mouse models in our lab. The heart is the “heart” of life. Heart disease is the number one cause of mortality and morbidity world wide. Congenital heart disease occurs in one of every one hundred live births and is the most common human birth defect. Discovery of the genetic control and molecular mechanisms of heart development is an important prerequisite to develop novel therapies for human cardiovascular disease.
One or more keywords matched the following items that are connected to Wang, Da-Zhi
Item TypeName
Academic Article The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation.
Academic Article miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation.
Academic Article Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy.
Academic Article Muscling through the microRNA world.
Academic Article The emerging role of microRNAs as a therapeutic target for cardiovascular disease.
Academic Article Taking microRNAs to heart.
Academic Article MicroRNAs in cardiac development and remodeling.
Academic Article microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7.
Academic Article Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects.
Academic Article MicroRNAs in heart development.
Academic Article Application of microRNA in cardiac and skeletal muscle disease gene therapy.
Academic Article "RISCing" the heart: In vivo identification of cardiac microRNA targets by RISCome.
Academic Article microRNAs in cardiovascular development.
Academic Article Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure.
Academic Article 'CArG'ing for microRNAs.
Academic Article Determination of miRNA targets in skeletal muscle cells.
Academic Article MicroRNAs in cardiomyocyte development.
Academic Article MicroRNAs in skeletal and cardiac muscle development.
Academic Article MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice.
Academic Article MicroRNAs in cardiac remodeling and disease.
Academic Article microRNAs and muscle disorders.
Academic Article Induction of microRNA-1 by myocardin in smooth muscle cells inhibits cell proliferation.
Academic Article Transgenic overexpression of miR-133a in skeletal muscle.
Academic Article Smooth(ing) muscle differentiation by microRNAs.
Academic Article Micro or mega: how important are microRNAs in muscle?
Concept MicroRNAs
Academic Article mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts.
Academic Article MicroRNA-22 regulates cardiac hypertrophy and remodeling in response to stress.
Academic Article MicroRNAs in cardiac regeneration and cardiovascular disease.
Academic Article Loss of MicroRNA-155 protects the heart from pathological cardiac hypertrophy.
Academic Article Crystallin-aB regulates skeletal muscle homeostasis via modulation of argonaute2 activity.
Academic Article Non-Coding RNAs Including miRNAs and lncRNAs in Cardiovascular Biology and Disease.
Academic Article miR-22 in cardiac remodeling and disease.
Academic Article Trbp regulates heart function through microRNA-mediated Sox6 repression.
Academic Article Noncoding RNAs, Emerging Regulators of Skeletal Muscle Development and Diseases.
Academic Article Mystery of Trbp, tale of a RBP in the miRNA pathway.
Academic Article The myriad essential roles of microRNAs in cardiovascular homeostasis and disease.
Grant MicroRNAs, cardiac development and function
Grant Therapeutic applications of miRNAs in myocardial and cardiac regeneration
Academic Article Poly(C)-binding protein 1 (Pcbp1) regulates skeletal muscle differentiation by modulating microRNA processing in myoblasts.
Grant MicroRNAs, cardiac function and cardiomyopathy
Academic Article Loss of microRNA-22 prevents high-fat diet induced dyslipidemia and increases energy expenditure without affecting cardiac hypertrophy.
Academic Article miR-22 in Smooth Muscle Cells: A Potential Therapy for Cardiovascular Disease.
Grant Epsin in Angiogenesis and Vascular Remodeling
Academic Article Non-coding RNA in Ischemic and Non-ischemic Cardiomyopathy.
Academic Article Regulation of Skeletal Muscle by microRNAs.
Academic Article LncEGFL7OS regulates human angiogenesis by interacting with MAX at the EGFL7/miR-126 locus.
Academic Article Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction.
Grant CD45-mediated endothelial-to-mesenchymal transition in cardiovascular disease
Academic Article Deletion of miRNA-22 Induces Cardiac Hypertrophy in Females but Attenuates Obesogenic Diet-Mediated Metabolic Disorders.
Academic Article Tiny Regulators of Massive Tissue: MicroRNAs in Skeletal Muscle Development, Myopathies, and Cancer Cachexia.
Academic Article miRNA-22 deletion limits white adipose expansion and activates brown fat to attenuate high-fat diet-induced fat mass accumulation.
Academic Article Transient exposure to miR-203 enhances the differentiation capacity of established pluripotent stem cells.
Search Criteria
  • MicroRNAs
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.