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One or more keywords matched the following items that are connected to Henske, Elizabeth
Item TypeName
Academic Article Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions.
Academic Article Tuberous sclerosis-associated renal cell carcinoma. Clinical, pathological, and genetic features.
Academic Article Renal cell carcinoma in children with diffuse cystic hyperplasia of the kidneys.
Academic Article Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B.
Academic Article Renal angiomyolipomas, cysts, and cancer in tuberous sclerosis complex.
Academic Article The expression of hamartin, the product of the TSC1 gene, in normal human tissues and in TSC1- and TSC2-linked angiomyolipomas.
Academic Article Comprehensive mutational analysis of the TSC1 gene: observations on frequency of mutation, associated features, and nonpenetrance.
Academic Article The spectrum of mutations in TSC1 and TSC2 in women with tuberous sclerosis and lymphangiomyomatosis.
Academic Article The genetic basis of kidney cancer: why is tuberous sclerosis complex often overlooked?
Academic Article Malignant tumors of the kidney, brain, and soft tissues in children and young adults with the tuberous sclerosis complex.
Academic Article Chromosome 16 loss of heterozygosity in tuberous sclerosis and sporadic lymphangiomyomatosis.
Academic Article Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma.
Academic Article Mutational analysis of the tuberous sclerosis gene TSC2 in patients with pulmonary lymphangioleiomyomatosis.
Academic Article Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a metastatic mechanism.
Academic Article Apparent renal cell carcinomas in tuberous sclerosis are heterogeneous: the identification of malignant epithelioid angiomyolipoma.
Academic Article Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles.
Academic Article The role of tuberin in cellular differentiation: are B-Raf and MAPK involved?
Academic Article Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53.
Academic Article Tuberous sclerosis and the kidney: from mesenchyme to epithelium, and beyond.
Academic Article mTOR activation, lymphangiogenesis, and estrogen-mediated cell survival: the "perfect storm" of pro-metastatic factors in LAM pathogenesis.
Academic Article Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis.
Academic Article The tuberous sclerosis complex.
Academic Article Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells.
Academic Article Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease.
Academic Article Mammalian target of rapamycin signaling and autophagy: roles in lymphangioleiomyomatosis therapy.
Academic Article Estrogen-induced activation of mammalian target of rapamycin is mediated via tuberin and the small GTPase Ras homologue enriched in brain.
Academic Article Tuberous sclerosis complex and lymphangioleiomyomatosis: miles to go, promises to keep.
Academic Article Autophagy: an 'Achilles' heel of tumorigenesis in TSC and LAM.
Academic Article Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1.
Academic Article A novel missense mutation in the GTPase activating protein homology region of TSC2 in two large families with tuberous sclerosis complex.
Academic Article Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent.
Academic Article Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.
Academic Article Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis.
Academic Article Selective alterations in glutamate and GABA receptor subunit mRNA expression in dysplastic neurons and giant cells of cortical tubers.
Academic Article Cosmid contigs spanning 9q34 including the candidate region for TSC1.
Academic Article A 5.4-Mb continuous pulsed-field gel electrophoresis map of human 9q34.1 between ABL and D9S114, including the tuberous sclerosis (TSC1) region.
Academic Article Metastasis of benign tumor cells in tuberous sclerosis complex.
Academic Article Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1.
Academic Article Real-time monitoring of tumorigenesis, dissemination, & drug response in a preclinical model of lymphangioleiomyomatosis/tuberous sclerosis complex.
Academic Article Expression of wild type and mutant TSC2, but not TSC1, causes an increase in the G1 fraction of the cell cycle in HEK293 cells.
Academic Article Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration.
Academic Article Frequent progesterone receptor immunoreactivity in tuberous sclerosis-associated renal angiomyolipomas.
Academic Article Tuberous sclerosis-associated lesions of the kidney, brain, and skin are angiogenic neoplasms.
Academic Article Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors.
Academic Article Evidence that lymphangiomyomatosis is caused by TSC2 mutations: chromosome 16p13 loss of heterozygosity in angiomyolipomas and lymph nodes from women with lymphangiomyomatosis.
Academic Article Pulmonary lymphangioleiomyomatosis in a man.
Academic Article Mutational analysis of the von hippel lindau gene in clear cell renal carcinomas from tuberous sclerosis complex patients.
Academic Article TORC1 activation and autophagy inhibition: opposing forces in Rheb-driven tumorigenesis.
Academic Article The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe.
Academic Article The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway.
Academic Article Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways.
Academic Article Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner.
Academic Article New developments in the neurobiology of the tuberous sclerosis complex.
Academic Article Renal angiomyolipomas from patients with sporadic lymphangiomyomatosis contain both neoplastic and non-neoplastic vascular structures.
Academic Article Faslodex inhibits estradiol-induced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis.
Academic Article Aberrant cellular differentiation and migration in renal and pulmonary tuberous sclerosis complex.
Academic Article The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions.
Academic Article Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34.
Academic Article Loss of heterozygosity in the tuberous sclerosis (TSC2) region of chromosome band 16p13 occurs in sporadic as well as TSC-associated renal angiomyolipomas.
Academic Article A high-resolution linkage map of human 9q34.1.
Academic Article A radiation-reduced hybrid cell line containing 5 Mb/17 cM of human DNA from 9q34.
Academic Article The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development.
Academic Article MicroRNA-21 is induced by rapamycin in a model of tuberous sclerosis (TSC) and lymphangioleiomyomatosis (LAM).
Concept Tuberous Sclerosis
Academic Article The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.
Academic Article Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.
Academic Article Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.
Academic Article Tuberous sclerosis complex, mTOR, and the kidney: report of an NIDDK-sponsored workshop.
Academic Article Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells.
Academic Article Renal cell carcinoma in tuberous sclerosis complex.
Academic Article High-throughput drug screen identifies chelerythrine as a selective inducer of death in a TSC2-null setting.
Academic Article Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex.
Academic Article Tuberous sclerosis complex 2 loss increases lysophosphatidylcholine synthesis in lymphangioleiomyomatosis.
Academic Article Targeted deletion of Tsc1 causes fatal cardiomyocyte hyperplasia independently of afterload.
Academic Article Therapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: a paradigm shift.
Academic Article Tuberous sclerosis complex.
Academic Article Exosomes mediate the acquisition of the disease phenotypes by cells with normal genome in tuberous sclerosis complex.
Academic Article Evidence Supporting a Lymphatic Endothelium Origin for Angiomyolipoma, a TSC2(-) Tumor Related to Lymphangioleiomyomatosis.
Academic Article Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference.
Academic Article Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development.
Grant Mechanisms of Renal Tumorigenesis in Tuberous Sclerosis
Grant Induction of Oncogenic mircoRNA by rapamycin: Role in TSC Therapy
Grant Roles of Tuberin (TSC2), Hamartin (TSC1), and Rheb in Renal Cyst Pathogenesis
Grant Summit on Drug Discovery in Tuberous Sclerosis Complex and Related Disorders
Grant Regulation of Estrogen Signaling by Tuberin and Rheb
Grant Molecular Basis of Lymphangiomyomatosis
Grant The Lymphangioleiomyomatosis (LAM)Genome Atlas
Grant Roles of autophagy-mediated pathways in the pathogenesis and treatment of TSC
Grant The Molecular and Genetic Pathogenesis of LAM
Academic Article Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization.
Academic Article New developments in the genetics and pathogenesis of tumours in tuberous sclerosis complex.
Academic Article Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis.
Academic Article Aberrant SYK Kinase Signaling Is Essential for Tumorigenesis Induced by TSC2 Inactivation.
Academic Article Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R.
Academic Article p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.
Mentoring - Current Student Opportunity Tuberous Sclerosis (TSC): Basic and Translational Research in a Multi-Disciplinary Environment
Mentoring - Current Student Opportunity Genetic Disease: Tuberous sclerosis complex (TSC) pathogenesis
Academic Article mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability.
Academic Article Notch transactivates Rheb to maintain the multipotency of TSC-null cells.
Grant The Metabolic Pathogenesis of Chromophobe Renal Cell Carcinoma
Academic Article TSC2 regulates microRNA biogenesis via mTORC1 and GSK3ß.
Academic Article TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy.
Academic Article Pulmonary manifestations in tuberous sclerosis complex.
Academic Article Renal disease in tuberous sclerosis complex: pathogenesis and therapy.
Academic Article Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis.
Academic Article Serum endostatin levels are associated with diffusion capacity and with tuberous sclerosis- associated lymphangioleiomyomatosis.
Grant Pathogenic Mechanisms of Pulmonary Lymphangioleiomyomatosis
Academic Article The Codon 72 TP53 Polymorphism Contributes to TSC Tumorigenesis through the Notch-Nodal Axis.
Academic Article Allosteric and ATP-Competitive Inhibitors of mTOR Effectively Suppress Tumor Progression-Associated Epithelial-Mesenchymal Transition in the Kidneys of Tsc2+/- Mice.
Academic Article Generalised mosaicism for TSC2 mutation in isolated lymphangioleiomyomatosis.
Academic Article Alterations in Polyamine Metabolism in Patients With Lymphangioleiomyomatosis and Tuberous Sclerosis Complex 2-Deficient Cells.
Academic Article Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor ß (RARß).
Academic Article Immunotherapy for Lymphangioleiomyomatosis and Tuberous Sclerosis: Progress and Future Directions.
Academic Article Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion.
Academic Article IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex.
Academic Article Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex.
Academic Article Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex.
Academic Article TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism.
Academic Article Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells.
Academic Article Renal Cell Carcinoma in Tuberous Sclerosis Complex.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.