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overview My research involves elucidating mechanisms underlying the pathogenesis of sleep apnea, with particular foci on ventilatory instability and sleep apnea in patients with heart failure. I am currently investigating the mechanisms responsible for the emergence of oscillations in breathing, and working to develop a clinically-applicable means to measure ventilatory instability and the other traits responsible for sleep apnea. I further aim to establish the mechanisms underlying several promising treatments for sleep apnea, that will ultimately provide ways to predict responders to treatment.
One or more keywords matched the following items that are connected to Sands, Scott
Item TypeName
Academic Article Mechanism underlying accelerated arterial oxygen desaturation during recurrent apnea.
Academic Article Increased peripheral chemosensitivity via dopaminergic manipulation promotes respiratory instability in lambs.
Academic Article Upper airway collapsibility and patterns of flow limitation at constant end-expiratory lung volume.
Academic Article Model-based characterization of ventilatory stability using spontaneous breathing.
Academic Article Phenotypes of patients with mild to moderate obstructive sleep apnoea as confirmed by cluster analysis.
Academic Article Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea.
Academic Article A simplified method for determining phenotypic traits in patients with obstructive sleep apnea.
Academic Article A model analysis of arterial oxygen desaturation during apnea in preterm infants.
Academic Article A model investigation of the impact of ventilation-perfusion mismatch on oxygenation during apnea in preterm infants.
Academic Article Continuous positive airway pressure reduces loop gain and resolves periodic central apneas in the lamb.
Academic Article A dynamic model for assessing the impact of diffusing capacity on arterial oxygenation during apnea.
Academic Article Acetazolamide attenuates the ventilatory response to arousal in patients with obstructive sleep apnea.
Concept Sleep Apnea Syndromes
Concept Sleep Apnea, Obstructive
Concept Apnea
Concept Sleep Apnea, Central
Academic Article Clinical consequences of altered chemoreflex control.
Academic Article Adapting our approach to treatment-emergent central sleep apnea.
Academic Article Impaired blood pressure control in children with obstructive sleep apnea.
Academic Article Acoustic pharyngometry measurement of minimal cross-sectional airway area is a significant independent predictor of moderate-to-severe obstructive sleep apnea.
Academic Article Does pressure affect performance? Continuous positive airway pressure for sleep-disordered breathing in heart failure.
Academic Article Long-term changes in blood pressure control in elementary school-aged children with sleep-disordered breathing.
Academic Article Long-term changes in heart rate variability in elementary school-aged children with sleep-disordered breathing.
Academic Article The classical Starling resistor model often does not predict inspiratory airflow patterns in the human upper airway.
Academic Article Does my bed partner have OSA? There's an app for that!
Academic Article Acetazolamide attenuates Hunter-Cheyne-Stokes breathing but augments the hypercapnic ventilatory response in patients with heart failure.
Academic Article Reply 2.
Academic Article Influence of pharyngeal muscle activity on inspiratory negative effort dependence in the human upper airway.
Academic Article Response to, ‘‘The unnormalized spectral indices of heart rate variability should be presented in conjunction with normalized versions of the same variables’’.
Academic Article Obstructive sleep apnea in older adults is a distinctly different physiological phenotype.
Academic Article Effects of hyperoxia and hypoxia on the physiological traits responsible for obstructive sleep apnoea.
Academic Article Enhanced upper-airway muscle responsiveness is a distinct feature of overweight/obese individuals without sleep apnea.
Academic Article Quantifying the ventilatory control contribution to sleep apnoea using polysomnography.
Academic Article Clinical predictors of the respiratory arousal threshold in patients with obstructive sleep apnea.
Academic Article An Integrative Model of Physiological Traits Can be Used to Predict Obstructive Sleep Apnea and Response to Non Positive Airway Pressure Therapy.
Academic Article Test of the Starling resistor model in the human upper airway during sleep.
Academic Article Central sleep apnoea in congestive heart failure.
Academic Article Evaluation of the role of lung volume and airway size and shape in supine-predominant obstructive sleep apnoea patients.
Academic Article Congestive heart failure and central sleep apnea.
Academic Article Clinical Use of Loop Gain Measures to Determine Continuous Positive Airway Pressure Efficacy in Patients with Complex Sleep Apnea. A Pilot Study.
Academic Article Tube Law of the Pharyngeal Airway in Sleeping Patients with Obstructive Sleep Apnea.
Academic Article Congestive Heart Failure and Central Sleep Apnea.
Academic Article Desipramine Increases Genioglossus Activity and Reduces Upper Airway Collapsibility during Non-REM Sleep in Healthy Subjects.
Academic Article Desipramine improves upper airway collapsibility and reduces OSA severity in patients with minimal muscle compensation.
Academic Article The Effect of Donepezil on Arousal Threshold and Apnea-Hypopnea Index. A Randomized, Double-Blind, Cross-Over Study.
Academic Article Pathogenesis of central and complex sleep apnoea.
Academic Article The Combination of Supplemental Oxygen and a Hypnotic Markedly Improves Obstructive Sleep Apnea in Patients with a Mild to Moderate Upper Airway Collapsibility.
Academic Article Effects of Tiagabine on Slow Wave Sleep and Arousal Threshold in Patients with Obstructive Sleep Apnea.
Academic Article Upper-Airway Collapsibility and Loop Gain Predict the Response to Oral Appliance Therapy in Patients with Obstructive Sleep Apnea.
Academic Article Reply: Is the Muscle the Only Potential Target of Desipramine in Obstructive Sleep Apnea Syndrome?
Academic Article Differences in respiratory arousal threshold in Caucasian and Chinese patients with obstructive sleep apnoea.
Academic Article Effect of Sleeping Position on Upper Airway Patency in Obstructive Sleep Apnea Is Determined by the Pharyngeal Structure Causing Collapse.
Academic Article Effects of Tiagabine on Slow Wave Sleep and Arousal Threshold in Patients With Obstructive Sleep Apnea.
Academic Article Estimation of Pharyngeal Collapsibility During Sleep by Peak Inspiratory Airflow.
Academic Article Response to a combination of oxygen and a hypnotic as treatment for obstructive sleep apnoea is predicted by a patient's therapeutic CPAP requirement.
Academic Article Therapeutic CPAP Level Predicts Upper Airway Collapsibility in Patients With Obstructive Sleep Apnea.
Academic Article Loop Gain Predicts the Response to Upper Airway Surgery in Patients With Obstructive Sleep Apnea.
Academic Article Airflow Shape Is Associated With the Pharyngeal Structure Causing OSA.
Academic Article Physiology-Based Modeling May Predict Surgical Treatment Outcome for Obstructive Sleep Apnea.
Academic Article The relationship between partial upper-airway obstruction and inter-breath transition period during sleep.
Academic Article Predicting epiglottic collapse in patients with obstructive sleep apnoea.
Academic Article Stable Breathing in Patients With Obstructive Sleep Apnea Is Associated With Increased Effort but Not Lowered Metabolic Rate.
Academic Article Dynamic loop gain increases upon adopting the supine body position during sleep in patients with obstructive sleep apnoea.
Academic Article Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men.
Academic Article Measuring Loop Gain via Home Sleep Testing in Patients with Obstructive Sleep Apnea.
Academic Article Quantifying the Arousal Threshold Using Polysomnography in Obstructive Sleep Apnea.
Academic Article Phenotyping Pharyngeal Pathophysiology using Polysomnography in Patients with Obstructive Sleep Apnea.
Academic Article Palatal prolapse as a signature of expiratory flow limitation and inspiratory palatal collapse in patients with obstructive sleep apnoea.
Academic Article Ventilatory control sensitivity in patients with obstructive sleep apnea is sleep stage dependent.
Academic Article Prevalence, Associated Clinical Features, and Impact on Continuous Positive Airway Pressure Use of a Low Respiratory Arousal Threshold Among Male United States Veterans With Obstructive Sleep Apnea.
Academic Article Breath-holding as a means to estimate the loop gain contribution to obstructive sleep apnoea.
Academic Article Retropalatal and retroglossal airway compliance in patients with obstructive sleep apnea.
Academic Article Neural memory of the genioglossus muscle during sleep is stage-dependent in healthy subjects and obstructive sleep apnoea patients.
Academic Article Identifying obstructive sleep apnoea patients responsive to supplemental oxygen therapy.
Academic Article Daytime loop gain is elevated in obstructive sleep apnea but not reduced by CPAP treatment.
Academic Article Apnea-Hypopnea Event Duration Predicts Mortality in Men and Women in the Sleep Heart Health Study.
Academic Article The hypoxic burden of sleep apnoea predicts cardiovascular disease-related mortality: the Osteoporotic Fractures in Men Study and the Sleep Heart Health Study.
Academic Article The Combination of Atomoxetine and Oxybutynin Greatly Reduces Obstructive Sleep Apnea Severity. A Randomized, Placebo-controlled, Double-Blind Crossover Trial.
Academic Article Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans.
Academic Article Validating an Algorithm for Automatic Scoring of Inspiratory Flow Limitation Within a Range of Recording Settings.
Academic Article Is there a threshold that triggers cortical arousals in obstructive sleep apnea.
Academic Article Reply to Patel and Althouse: Robust Methods Are Needed to Evaluate the Pharmacologic Treatment of Obstructive Sleep Apnea.
Academic Article Quantifying the magnitude of pharyngeal obstruction during sleep using airflow shape.
Academic Article Exposure to mild intermittent hypoxia increases loop gain and the arousal threshold in participants with obstructive sleep apnoea.
Academic Article More Than the Sum of the Respiratory Events: Personalized Medicine Approaches for Obstructive Sleep Apnea.
Academic Article The hypoxic burden: a novel sleep apnoea severity metric and a predictor of cardiovascular mortality-Reply to 'The hypoxic burden: also known as the desaturation severity parameter'.
Academic Article Hypoxic burden captures sleep apnoea-specific nocturnal hypoxaemia.
Academic Article The Effect of Upper Airway Surgery on Loop Gain in Obstructive Sleep Apnea.
Grant A Novel Pharmacological Therapy for Obstructive Sleep Apnea
Academic Article Polysomnographic Endotyping to Select Patients with Obstructive Sleep Apnea for Oral Appliances.
Academic Article The physiological phenotype of obstructive sleep apnea differs between Caucasian and Chinese patients.
Academic Article Sex differences in obstructive sleep apnea phenotypes, the multi-ethnic study of atherosclerosis.
Academic Article Predicting sleep apnea responses to oral appliance therapy using polysomnographic airflow.
Academic Article Physiological Traits and Adherence to Obstructive Sleep Apnea Treatment in Patients with Stroke.
Academic Article The Sleep Apnea-Specific Hypoxic Burden Predicts Incident Heart Failure.
Academic Article Effect of Venlafaxine on Apnea-Hypopnea Index in Patients With Sleep Apnea: A Randomized, Double-Blind Crossover Study.
Academic Article Interhemispheric sleep depth coherence predicts driving safety in sleep apnea.
Academic Article Angiotensin II-Type I Receptor Antagonism Does Not Influence the Chemoreceptor Reflex or Hypoxia-Induced Central Sleep Apnea in Men.
Search Criteria
  • Apnea
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.