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One or more keywords matched the following items that are connected to Mantzoros, Christos
Item TypeName
Academic Article Evidence for leptin binding to proteins in serum of rodents and humans: modulation with obesity.
Academic Article The Val81 missense mutation of the melanocortin 3 receptor gene, but not the 1908c/T nucleotide polymorphism in lamin A/C gene, is associated with hyperleptinemia and hyperinsulinemia in obese Greek caucasians.
Academic Article Leptin: its role in obesity and beyond.
Academic Article Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides.
Academic Article Diabetes and risk of endometrial cancer: a population-based prospective cohort study.
Academic Article Role of leptin in reproduction.
Academic Article The role of leptin and hypothalamic neuropeptides in energy homeostasis: update on leptin in obesity.
Academic Article Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity.
Academic Article Adiponectin and resistin are associated with risk for myelodysplastic syndrome, independently from the insulin-like growth factor-I (IGF-I) system.
Academic Article Walnut consumption increases satiation but has no effect on insulin resistance or the metabolic profile over a 4-day period.
Academic Article Ciliary neurotrophic factorAx15 alters energy homeostasis, decreases body weight, and improves metabolic control in diet-induced obese and UCP1-DTA mice.
Academic Article Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa.
Academic Article Peptide YY levels are elevated after gastric bypass surgery.
Academic Article Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice.
Academic Article Human leptin levels are pulsatile and inversely related to pituitary-adrenal function.
Academic Article Conicity index as a predictor of blood pressure levels, insulin and triglyceride concentrations of healthy premenopausal women.
Academic Article The role of leptin in human obesity and disease: a review of current evidence.
Academic Article The emerging role of leptin in humans.
Academic Article Hormonal, lifestyle, and dietary factors in relation to leptin among elderly men.
Academic Article Cardiovascular abnormalities in transgenic mice with reduced brown fat: an animal model of human obesity.
Academic Article Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case-control study.
Academic Article Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice.
Academic Article The role of the fat mass and obesity associated gene (FTO) in breast cancer risk.
Academic Article Leptin hormonal kinetics in the fed state: effects of adiposity, age, and gender on endogenous leptin production and clearance rates.
Academic Article Recombinant methionyl human leptin administration to achieve high physiologic or pharmacologic leptin levels does not alter circulating inflammatory marker levels in humans with leptin sufficiency or excess.
Academic Article Regulation of mouse hepatic genes in response to diet induced obesity, insulin resistance and fasting induced weight reduction.
Academic Article Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies.
Academic Article Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects.
Academic Article FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise.
Academic Article Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical training.
Academic Article Low circulating adiponectin and resistin, but not leptin, levels are associated with multiple myeloma risk: a case-control study.
Academic Article Management of the metabolic syndrome and type 2 diabetes through lifestyle modification.
Academic Article Circulating adiponectin levels and expression of adiponectin receptors in relation to lung cancer: two case-control studies.
Academic Article Relationship between serum adiponectin and prostate cancer grade.
Academic Article Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet.
Academic Article Efficacy of metreleptin in obese patients with type 2 diabetes: cellular and molecular pathways underlying leptin tolerance.
Academic Article Leptin: in search of role(s) in human physiology and pathophysiology.
Academic Article Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance.
Academic Article Dietary fibers and glycemic load, obesity, and plasma adiponectin levels in women with type 2 diabetes.
Academic Article Linking hepatic transcriptional changes to high-fat diet induced physiology for diabetes-prone and obese-resistant mice.
Academic Article Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels.
Academic Article Obesity, eating disorders and restrained eating: is leptin the missing link?
Academic Article Energy homeostasis, obesity and eating disorders: recent advances in endocrinology.
Academic Article Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence.
Academic Article Circulating resistin in lean, obese, and insulin-resistant mouse models: lack of association with insulinemia and glycemia.
Academic Article Adiponectin receptor expression in human malignant tissues.
Academic Article Insulin resistance: the clinical spectrum.
Academic Article Genetic variation within IL18 is associated with insulin levels, insulin resistance and postprandial measures.
Academic Article Insulin resistance in relation to melanoma risk.
Academic Article The role of adiponectin in cancer: a review of current evidence.
Academic Article Effect of birth weight and maternal smoking on cord blood leptin concentrations of full-term and preterm newborns.
Academic Article Circulating insulin concentrations, smoking, and alcohol intake are important independent predictors of leptin in young healthy men.
Academic Article Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female mice.
Academic Article Editorial: leptin as a therapeutic agent--trials and tribulations.
Academic Article Leptin concentrations in the polycystic ovary syndrome.
Academic Article Predictors of sex hormone levels among the elderly: a study in Greece.
Academic Article Sex differences in circulating human leptin pulse amplitude: clinical implications.
Academic Article Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study.
Academic Article Adiponectin and cancer: a systematic review.
Academic Article Association of maternal short sleep duration with adiposity and cardiometabolic status at 3 years postpartum.
Academic Article Pharmacokinetics of recombinant methionyl human leptin after subcutaneous administration: variation of concentration-dependent parameters according to assay.
Academic Article Gene expression of PPARgamma and PGC-1alpha in human omental and subcutaneous adipose tissues is related to insulin resistance markers and mediates beneficial effects of physical training.
Academic Article Soluble leptin receptor and leptin are associated with baseline adiposity and metabolic risk factors, and predict adiposity, metabolic syndrome, and glucose levels at 2-year follow-up: the Cyprus Metabolism Prospective Cohort Study.
Academic Article Adiponectin: a link between obesity and cancer.
Academic Article Low adiponectin levels are associated with renal cell carcinoma: a case-control study.
Academic Article Total and high-molecular-weight adiponectin and resistin in relation to the risk for type 2 diabetes in women.
Academic Article Leptin in reproduction.
Academic Article Circulating adiponectin and leptin in relation to myelodysplastic syndrome: a case-control study.
Academic Article Altered levels of adiponectin and adiponectin receptors may underlie the effect of ciliary neurotrophic factor (CNTF) to enhance insulin sensitivity in diet-induced obese mice.
Academic Article A brief history of insulin resistance: from the first insulin radioimmunoassay to selectively targeting protein kinase C pathways.
Academic Article Independent circadian and sleep/wake regulation of adipokines and glucose in humans.
Academic Article Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.
Academic Article The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability.
Academic Article Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations.
Academic Article Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications.
Academic Article Breast-feeding, adipokines, and childhood obesity.
Academic Article Narrative review: the role of leptin in human physiology: emerging clinical applications.
Academic Article Leptin in human physiology and therapeutics.
Academic Article Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study.
Academic Article Selective PPAR? modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice.
Academic Article Advances in adipokines.
Concept Anti-Obesity Agents
Concept Obesity
Concept Obesity, Morbid
Concept Obesity, Abdominal
Academic Article Differential associations of leptin with adiposity across early childhood.
Academic Article Gender and body mass index modify the effect of increasing amounts of caffeinated coffee on postprandial glucose and insulin concentrations; a randomized, controlled, clinical trial.
Academic Article Effect of different amounts of coffee on dietary intake and appetite of normal-weight and overweight/obese individuals.
Academic Article Irisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans.
Academic Article Higher fetuin-A, lower adiponectin and free leptin levels mediate effects of excess body weight on insulin resistance and risk for myelodysplastic syndrome.
Academic Article Gender dimorphism and lack of day/night variation or effects of energy deprivation on undercarboxylated osteocalcin levels in humans.
Academic Article Diet patterns, adipokines, and metabolism: where are we and what is next?
Academic Article Irisin in patients with nonalcoholic fatty liver disease.
Academic Article Detailed assessments of childhood adversity enhance prediction of central obesity independent of gender, race, adult psychosocial risk and health behaviors.
Academic Article Irisin in humans: recent advances and questions for future research.
Academic Article Cord blood levels of osteopontin as a phenotype marker of gestational age and neonatal morbidities.
Academic Article Obesity and thyroid cancer: epidemiologic associations and underlying mechanisms.
Academic Article Cohort profile: project viva.
Academic Article Omentin-1 levels are reduced by pharmacologic doses of leptin, but remain unaffected by energy deprivation and display no day-night variation.
Academic Article Effects of a 1-year exercise and lifestyle intervention on irisin, adipokines, and inflammatory markers in obese children.
Academic Article Implication of circulating irisin levels with brown adipose tissue and sarcopenia in humans.
Academic Article 20 years of leptin: role of leptin in human reproductive disorders.
Academic Article Stress- and PTSD-associated obesity and metabolic dysfunction: a growing problem requiring further research and novel treatments.
Academic Article 20 years of leptin: from the discovery of the leptin gene to leptin in our therapeutic armamentarium.
Academic Article Leptin in autoimmune diseases.
Academic Article From leptin to other adipokines in health and disease: facts and expectations at the beginning of the 21st century.
Academic Article Posttraumatic stress disorder, alone or additively with early life adversity, is associated with obesity and cardiometabolic risk.
Academic Article Intracellular leptin signaling following effective weight loss.
Academic Article Leptin applications in 2015: what have we learned about leptin and obesity?
Academic Article Effect of an intensive lifestyle intervention on atrial fibrillation risk in individuals with type 2 diabetes: the Look AHEAD randomized trial.
Academic Article Lack of mature lymphocytes results in obese but metabolically healthy mice when fed a high-fat diet.
Academic Article Prediagnosis Plasma Adiponectin in Relation to Colorectal Cancer Risk According to KRAS Mutation Status.
Academic Article Metabolic health and weight: Understanding metabolically unhealthy normal weight or metabolically healthy obese patients.
Academic Article Self-reported eating speed in relation to non-alcoholic fatty liver disease in adults.
Academic Article Guidelines on vitamin D replacement in bariatric surgery: Identification and systematic appraisal.
Academic Article Hypovitaminosis D in bariatric surgery: A systematic review of observational studies.
Academic Article Central nervous system regulation of eating: Insights from human brain imaging.
Academic Article Ciliary neurotrophic factor upregulates follistatin and Pak1, causes overexpression of muscle differentiation related genes and downregulation of established atrophy mediators in skeletal muscle.
Academic Article Lorcaserin Administration Decreases Activation of Brain Centers in Response to Food Cues and These Emotion- and Salience-Related Changes Correlate With Weight Loss Effects: A 4-Week-Long Randomized, Placebo-Controlled, Double-Blind Clinical Trial.
Grant Peripheral and Central Interactions in Energy Balance
Grant Leptin Signaling in Humans
Grant Adipokine physiology
Grant The Role of Leptin in the Maintenance of a Reduced Body Weight
Grant Role of leptin in the neuroendocrine response to fasting
Academic Article Leptin administration in physiological or pharmacological doses does not alter circulating irisin levels in humans.
Academic Article Activin A and follistatin in patients with nonalcoholic fatty liver disease.
Academic Article Methylsulfonylmethane (MSM), an organosulfur compound, is effective against obesity-induced metabolic disorders in mice.
Academic Article Adipose tissue, obesity and non-alcoholic fatty liver disease.
Academic Article A novel MC4R deletion coexisting with FTO and MC1R gene variants, causes severe early onset obesity.
Academic Article Adiponectin administration prevents weight gain and glycemic profile changes in diet-induced obese immune deficient Rag1-/- mice lacking mature lymphocytes.
Academic Article Obese individuals with more components of the metabolic syndrome and/or prediabetes demonstrate decreased activation of reward-related brain centers in response to food cues in both the fed and fasting states: a preliminary fMRI study.
Academic Article Research advances in metabolism 2016.
Academic Article Adherence to the Mediterranean diet during pregnancy and offspring adiposity and cardiometabolic traits in childhood.
Academic Article A prospective evaluation of clinical and genetic predictors of weight changes in breast cancer survivors.
Academic Article Treating prediabetes in the obese: are GLP-1 analogues the answer?
Academic Article Physiology and role of irisin in glucose homeostasis.
Academic Article Adiponectin, lipids and atherosclerosis.
Academic Article Walnut consumption increases activation of the insula to highly desirable food cues: A randomized, double-blind, placebo-controlled, cross-over fMRI study.
Academic Article Current child, but not maternal, snoring is bi-directionally related to adiposity and cardiometabolic risk markers: A cross-sectional and a prospective cohort analysis.
Academic Article ASGE EndoVators Summit: Defining the role and value of endoscopic therapies in obesity management.
Academic Article ASGE EndoVators Summit: Defining the role and value of endoscopic therapies in obesity management.
Academic Article Associations of maternal and cord blood adipokines with offspring adiposity in Project Viva: is there an interaction with child age?
Academic Article Obesity as a risk factor for Alzheimer's disease: weighing the evidence.
Academic Article Irisin and leptin concentrations in relation to obesity, and developing type 2 diabetes: A cross sectional and a prospective case-control study nested in the Normative Aging Study.
Academic Article Adipose tissue and reproductive health.
Academic Article Obesity as a Disease.
Academic Article Inflammation: A key player linking obesity with malignancies.
Academic Article Obese individuals with type 2 diabetes demonstrate decreased activation of the salience-related insula and increased activation of the emotion/salience-related amygdala to visual food cues compared to non-obese individuals with diabetes: A preliminary study.
Academic Article Classic and Novel Adipocytokines at the Intersection of Obesity and Cancer: Diagnostic and Therapeutic Strategies.
Academic Article Follistatins in glucose regulation in healthy and obese individuals.
Academic Article Pharmacotherapy of obesity: Available medications and drugs under investigation.
Academic Article Leptin trajectories from birth to mid-childhood and cardio-metabolic health in early adolescence.
Academic Article Obesity and cancer risk: Emerging biological mechanisms and perspectives.
Academic Article GEOFFREY HARRIS PRIZE LECTURE 2018: Novel pathways regulating neuroendocrine function, energy homeostasis and metabolism in humans.
Academic Article Research developments in metabolism 2018.
Academic Article Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics.
Academic Article Obesity: seize the day, fight the fat.
Academic Article Lorcaserin treatment decreases body weight and reduces cardiometabolic risk factors in obese adults: A six-month, randomized, placebo-controlled, double-blind clinical trial.
Academic Article Of mice and men: Why progress in the pharmacological management of obesity is slower than anticipated and what could be done about it?
Academic Article Mechanisms underlying the cardiometabolic protective effect of walnut consumption in obese people: A cross-over, randomized, double-blind, controlled inpatient physiology study.
Academic Article Of mice and men: incretin actions in the central nervous system.
Academic Article Longer-term liraglutide administration at the highest dose approved for obesity increases reward-related orbitofrontal cortex activation in response to food cues: Implications for plateauing weight loss in response to anti-obesity therapies.
Academic Article Will medications that mimic gut hormones or target their receptors eventually replace bariatric surgery?
Academic Article Cord Leptin is Associated with Neuropsychomotor Development in Childhood.
Academic Article Short-term treatment with high dose liraglutide improves lipid and lipoprotein profile and changes hormonal mediators of lipid metabolism in obese patients with no overt type 2 diabetes mellitus: a randomized, placebo-controlled, cross-over, double-blind clinical trial.
Academic Article Circulating levels of gastrointestinal hormones in response to the most common types of bariatric surgery and predictive value for weight loss over one year: Evidence from two independent trials.
Academic Article Targeted Analysis of Three Hormonal Systems Identifies Molecules Associated with the Presence and Severity of NAFLD.
Academic Article Metabolism updates: new directions, techniques, and exciting research that is broadening the horizons.
Academic Article Adiponectin and leptin in the diagnosis and therapy of NAFLD.
Academic Article Variants in ADIPOQ gene are linked to adiponectin levels and lung function in young males independent of obesity.
Academic Article Sex specific effect of ATPase inhibitory factor 1 on body weight: studies in high fat diet induced obese mice and genetic association studies in humans.
Academic Article Metabolic regulation of activins in healthy individuals and in obese patients undergoing bariatric surgery.
Academic Article The effect of excess body fat on female and male reproduction.
Academic Article Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality, in a cohort of patients with COVID-19 in the Bronx, New York.
Academic Article Commentary: Phosphodiesterase 4 inhibitors as potential adjunct treatment targeting the cytokine storm in COVID-19.
Academic Article Covid-19 and Disparities in Nutrition and Obesity.
Academic Article Intensive Weight Loss Intervention and Cancer Risk in Adults with Type 2 Diabetes: Analysis of the Look AHEAD Randomized Clinical Trial.
Academic Article Mediterranean diet as a nutritional approach for COVID-19.
Academic Article Commentary: COVID-19 and obesity pandemics converge into a syndemic requiring urgent and multidisciplinary action.
Academic Article Leptin alters energy intake and fat mass but not energy expenditure in lean subjects.
Academic Article Fasting oxyntomodulin, glicentin, and gastric inhibitory polypeptide levels are associated with activation of reward- and attention-related brain centres in response to visual food cues in adults with obesity: A cross-sectional functional MRI study.
Academic Article Branched-Chain Amino Acids in relation to food preferences and insulin resistance in obese subjects consuming walnuts: A cross-over, randomized, double-blind, placebo-controlled inpatient physiology study.
Academic Article Leptin in Leanness and Obesity: JACC State-of-the-Art Review.
Academic Article Preparing for the NASH epidemic: A call to action.
Academic Article The presence of NAFLD influences the transition of metabolically healthy to metabolically unhealthy obesity and the ten-year cardiovascular disease risk: a population-based cohort study.
Academic Article Novel Non-invasive Approaches to the Treatment of Obesity: From Pharmacotherapy to Gene Therapy.
Academic Article Serum adipokine levels in patients with type 1 diabetes are associated with degree of obesity but only resistin is independently associated with atherosclerosis markers.
Search Criteria
  • Obesity
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.