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CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids.
Synthesis of dideoxymycobactin antigens presented by CD1a reveals T cell fine specificity for natural lipopeptide structures.
Human CD1a deficiency is common and genetically regulated.
Cutting Edge: CD1a tetramers and dextramers identify human lipopeptide-specific T cells ex vivo.
Total Synthesis of Mycobacterium tuberculosis Dideoxymycobactin-838 and Stereoisomers: Diverse CD1a-Restricted T Cells Display a Common Hierarchy of Lipopeptide Recognition.