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overview Dr. De Gruttola's research activities focus on developments of statistical methods required for appropriate public health response to the AIDS epidemic. The aspects of the epidemic on which he has worked include transmission of the Human Immunodeficiency Virus (HIV), natural history of infection with HIV, and clinical research on AIDS therapies. This work involves not only statistical methodology, but also public health surveillance systems, medical issues surrounding HIV infection, and concerns of communities most affected by the epidemic. The goals include forecasting future AIDS incidence, developing strategies for clinical research on HIV infection, and evaluating the public health impact of antiviral treatment. The statistical issues on which Dr. De Gruttola has been engaged include evaluating the degree to which the treatment response of markers of HIV infection constitute adequate evidence for clinical efficacy. He has also worked on projections of AIDS incidence using data from the New York City Health Department. A special focus of this work was estimation of the risk that children of HIV-infected mothers would develop AIDS in the first 10 years of life using data combined from a variety of sources.
One or more keywords matched the following items that are connected to De Gruttola, Victor
Item TypeName
Academic Article Assessment of non-response bias in a probability household survey of male same-gender sexual behavior.
Academic Article Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study.
Academic Article Editorial commentary: network epidemic models: assumptions and interpretations.
Academic Article Response to zidovudine/didanosine-containing combination antiretroviral therapy among HIV-1 subtype C-infected adults in Botswana: two-year outcomes from a randomized clinical trial.
Academic Article Immunophenotypic markers and antiretroviral therapy (IMART): T cell activation and maturation help predict treatment response.
Academic Article Controlling the HIV epidemic, without a vaccine!
Academic Article Association of efavirenz hypersusceptibility with virologic response in ACTG 368, a randomized trial of abacavir (ABC) in combination with efavirenz (EFV) and indinavir (IDV) in HIV-infected subjects with prior nucleoside analog experience.
Academic Article Adherence to antiretroviral therapy, virological response, and time to resistance in the Dakar cohort.
Academic Article Initiatives for developing and comparing genotype interpretation systems: external validation of existing systems for didanosine against virological response.
Academic Article The relation between baseline HIV drug resistance and response to antiretroviral therapy: re-analysis of retrospective and prospective studies using a standardized data analysis plan.
Academic Article HIV-1 subtype C-infected individuals maintaining high viral load as potential targets for the "test-and-treat" approach to reduce HIV transmission.
Concept Epidemics
Academic Article Patterns of plasma human immunodeficiency virus type 1 RNA response to antiretroviral therapy.
Academic Article Can the Heterosexual HIV Epidemic be Eliminated in South Africa Using Combination Prevention? A Modeling Analysis.
Grant Methods for Long-Term Follow-Up of HIV-Infected Patients
Grant Methods to Advance the HIV Prevention Research Agenda
Academic Article Efficient Hybrid EM for Linear and Nonlinear Mixed Effects Models with Censored Response.
Academic Article Sampling dynamic networks with application to investigation of HIV epidemic drivers.
Academic Article Viral load and response to treatment of HIV.
Academic Article A model for the AIDS epidemic in Mexico: short-term projections.
Academic Article Envelope following responses predict speech-in-noise performance in normal-hearing listeners.
Search Criteria
  • Epidemic
  • Response
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.