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Item TypeName
Academic Article Antiviral drug resistance in herpes simplex virus.
Academic Article Translational recoding induced by G-rich mRNA sequences that form unusual structures.
Academic Article Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus.
Academic Article The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases.
Academic Article A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus.
Academic Article The role of herpes simplex virus ICP27 in the regulation of UL24 gene expression by differential polyadenylation.
Academic Article High-frequency phenotypic reversion and pathogenicity of an acyclovir-resistant herpes simplex virus mutant.
Academic Article Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant.
Academic Article Identification of crucial hydrogen-bonding residues for the interaction of herpes simplex virus DNA polymerase subunits via peptide display, mutational, and calorimetric approaches.
Academic Article ND10 protein PML is recruited to herpes simplex virus type 1 prereplicative sites and replication compartments in the presence of viral DNA polymerase.
Academic Article Effect of immunization on herpes simplex virus type 1 latent infection in the trigeminal ganglion.
Academic Article A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance.
Academic Article Latent herpes simplex virus infection of sensory neurons alters neuronal gene expression.
Academic Article Herpes simplex virus 1 microRNAs expressed abundantly during latent infection are not essential for latency in mouse trigeminal ganglia.
Academic Article Engineered herpes simplex virus DNA polymerase point mutants: the most highly conserved region shared among alpha-like DNA polymerases is involved in substrate recognition.
Academic Article Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene.
Academic Article A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice.
Academic Article Examination of the roles of transcription factor Sp1-binding sites and an octamer motif in trans induction of the herpes simplex virus thymidine kinase gene.
Academic Article The herpes simplex virus processivity factor, UL42, binds DNA as a monomer.
Academic Article Genetic analysis of temperature-sensitive mutants of HSV-1: the combined use of complementation and physical mapping for cistron assignment.
Academic Article Mutations that specifically impair the DNA binding activity of the herpes simplex virus protein UL42.
Academic Article Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus.
Academic Article MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs.
Academic Article Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus.
Academic Article Prediction and identification of herpes simplex virus 1-encoded microRNAs.
Academic Article Expanded spectrum of viral therapy in the treatment of nervous system tumors.
Academic Article Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity.
Academic Article Secondary structure and structure-activity relationships of peptides corresponding to the subunit interface of herpes simplex virus DNA polymerase.
Academic Article Persistent elevated expression of cytokine transcripts in ganglia latently infected with herpes simplex virus in the absence of ganglionic replication or reactivation.
Academic Article Low levels of herpes simplex virus thymidine- thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model.
Academic Article Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin.
Academic Article Demonstration of circularization of herpes simplex virus DNA following infection using pulsed field gel electrophoresis.
Academic Article Functional analysis of the herpes simplex virus UL42 protein.
Academic Article Mutational analysis of DNA polymerase substrate recognition and subunit interactions using herpes simplex virus as prototype.
Academic Article Importance of the herpes simplex virus UL24 gene for productive ganglionic infection in mice.
Academic Article Translational compensation of a frameshift mutation affecting herpes simplex virus thymidine kinase is sufficient to permit reactivation from latency.
Academic Article ICP27 selectively regulates the cytoplasmic localization of a subset of viral transcripts in herpes simplex virus type 1-infected cells.
Academic Article Heterogeneity of a herpes simplex virus clinical isolate exhibiting resistance to acyclovir and foscarnet.
Academic Article Induction of transcription by a viral regulatory protein depends on the relative strengths of functional TATA boxes.
Academic Article Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment.
Academic Article Experimental therapy of human glioma by means of a genetically engineered virus mutant.
Academic Article Isolation and characterization of herpes simplex virus mutants containing engineered mutations at the DNA polymerase locus.
Academic Article Inhibitors of the sodium potassium ATPase that impair herpes simplex virus replication identified via a chemical screening approach.
Academic Article Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.
Academic Article An unusual internal ribosome entry site in the herpes simplex virus thymidine kinase gene.
Academic Article Herpes simplex virus 1 immediate-early and early gene expression during reactivation from latency under conditions that prevent infectious virus production.
Academic Article Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection.
Academic Article Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants that retain susceptibility to acyclovir.
Academic Article Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.
Academic Article The pre-NH(2)-terminal domain of the herpes simplex virus 1 DNA polymerase catalytic subunit is required for efficient viral replication.
Academic Article Herpes simplex viruses: mechanisms of DNA replication.
Academic Article Analysis of the transcript of the herpes simplex virus DNA polymerase gene provides evidence that polymerase expression is inefficient at the level of translation.
Academic Article The positively charged surface of herpes simplex virus UL42 mediates DNA binding.
Academic Article Mutations that increase DNA binding by the processivity factor of herpes simplex virus affect virus production and DNA replication fidelity.
Academic Article A genetic approach to promoter recognition during trans induction of viral gene expression.
Academic Article Initiator elements and regulated expression of the herpes simplex virus thymidine kinase gene.
Academic Article Specific inhibition of herpes simplex virus DNA polymerase by helical peptides corresponding to the subunit interface.
Academic Article Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors.
Academic Article Biochemical and genetic analysis of acyclovir-resistant mutants of herpes simplex virus type 1.
Academic Article Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.
Academic Article Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir.
Academic Article Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain.
Academic Article Herpes simplex virus processivity factor UL42 imparts increased DNA-binding specificity to the viral DNA polymerase and decreased dissociation from primer-template without reducing the elongation rate.
Academic Article Binding of herpes simplex virus-1 US11 to specific RNA sequences.
Academic Article The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase.
Academic Article Neither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virus.
Academic Article Effects of substitutions of arginine residues on the basic surface of herpes simplex virus UL42 support a role for DNA binding in processive DNA synthesis.
Academic Article A net +1 frameshift permits synthesis of thymidine kinase from a drug-resistant herpes simplex virus mutant.
Academic Article The extreme C terminus of herpes simplex virus DNA polymerase is crucial for functional interaction with processivity factor UL42 and for viral replication.
Academic Article CNS tumor therapy by attenuated herpes simplex viruses.
Academic Article Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis.
Academic Article Correct intranuclear localization of herpes simplex virus DNA polymerase requires the viral ICP8 DNA-binding protein.
Academic Article Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity?
Academic Article Mutations in the herpes simplex virus major DNA-binding protein gene leading to altered sensitivity to DNA polymerase inhibitors.
Academic Article A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate.
Academic Article Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine.
Academic Article Generation of genetic diversity in herpes simplex virus: an antimutator phenotype maps to the DNA polymerase locus.
Academic Article Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase.
Academic Article Temporal regulation of herpes simplex virus type 1 UL24 mRNA expression via differential polyadenylation.
Academic Article Enzymatic activities of overexpressed herpes simplex virus DNA polymerase purified from recombinant baculovirus-infected insect cells.
Academic Article A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells.
Academic Article Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.
Academic Article Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site.
Academic Article Mutation within the herpes simplex virus DNA polymerase gene conferring resistance to (R)-9-(3,4-dihydroxybutyl)guanine.
Academic Article Virucidal activity of a GT-rich oligonucleotide against herpes simplex virus mediated by glycoprotein B.
Academic Article Interactions of herpes simplex virus type 1 with ND10 and recruitment of PML to replication compartments.
Academic Article Identification, localization, and regulation of expression of the UL24 protein of herpes simplex virus type 1.
Academic Article Promoter domains required for expression of plasmid-borne copies of the herpes simplex virus thymidine kinase gene in virus-infected mouse fibroblasts and microinjected frog oocytes.
Academic Article Alternate utilization of two regulatory domains within the Moloney murine sarcoma virus long terminal repeat.
Academic Article The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency.
Academic Article Quantification and analysis of thymidine kinase expression from acyclovir-resistant G-string insertion and deletion mutants in herpes simplex virus-infected cells.
Academic Article Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia.
Academic Article The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity.
Academic Article In vivo fitness and virulence of a drug-resistant herpes simplex virus 1 mutant.
Academic Article Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons.
Academic Article Herpes simplex virus mutants resistant to arabinosyladenine in the presence of deoxycoformycin.
Academic Article Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency.
Academic Article ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells.
Academic Article A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency.
Academic Article Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2.
Academic Article Net -1 frameshifting on a noncanonical sequence in a herpes simplex virus drug-resistant mutant is stimulated by nonstop mRNA.
Academic Article Genetics of herpes simplex virus.
Academic Article Structural organization and unusual codon usage in the DNA polymerase gene from herpes simplex virus type 1.
Academic Article Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex viral genome during establishment of latent infection.
Academic Article Gene transfer to sensory neurons using herpes virus vectors.
Academic Article Identification of a small molecule that inhibits herpes simplex virus DNA Polymerase subunit interactions and viral replication.
Academic Article Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants.
Academic Article A novel functional domain of an alpha-like DNA polymerase. The binding site on the herpes simplex virus polymerase for the viral UL42 protein.
Academic Article Restricted expression of herpes simplex virus lytic genes during establishment of latent infection by thymidine kinase-negative mutant viruses.
Academic Article Expression of extremely low levels of thymidine kinase from an acyclovir-resistant herpes simplex virus mutant supports reactivation from latently infected mouse trigeminal ganglia.
Academic Article Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1.
Academic Article Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants.
Academic Article A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture.
Academic Article Herpes simplex virus is equipped with RNA- and protein-based mechanisms to repress expression of ATRX, an effector of intrinsic immunity.
Academic Article Acyclovir-resistant, pathogenic herpesviruses.
Academic Article Translational regulation of herpes simplex virus DNA polymerase.
Academic Article Unusual regulation of expression of the herpes simplex virus DNA polymerase gene.
Academic Article Low-level expression and reversion both contribute to reactivation of herpes simplex virus drug-resistant mutants with mutations on homopolymeric sequences in thymidine kinase.
Academic Article Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication.
Academic Article Inhibition of translation by a short element in the 5' leader of the herpes simplex virus 1 DNA polymerase transcript.
Academic Article Effect of an amber mutation in the herpes simplex virus thymidine kinase gene on polypeptide synthesis and stability.
Academic Article Structural and functional organization of herpes simplex virus DNA polymerase investigated by limited proteolysis.
Academic Article Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia.
Academic Article Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene.
Academic Article General aspects of virus drug resistance with special reference to herpes simplex virus.
Academic Article Conformational changes induced in herpes simplex virus DNA polymerase upon DNA binding.
Academic Article Regulation of neighboring gene expression by the herpes simplex virus type 1 thymidine kinase gene.
Concept Herpes Simplex Virus Vaccines
Concept Simplexvirus
Academic Article Common and new acyclovir resistant herpes simplex virus-1 mutants causing bilateral recurrent herpetic keratitis in an immunocompetent patient.
Academic Article Roles of conserved residues within the pre-NH2-terminal domain of herpes simplex virus 1 DNA polymerase in replication and latency in mice.
Academic Article Expression of herpes simplex virus 1 microRNAs in cell culture models of quiescent and latent infection.
Academic Article A neuron-specific host microRNA targets herpes simplex virus-1 ICP0 expression and promotes latency.
Academic Article HIV integrase inhibitors block replication of alpha-, beta-, and gammaherpesviruses.
Academic Article History and genomic sequence analysis of the herpes simplex virus 1 KOS and KOS1.1 sub-strains.
Grant Antagonizing miRNAs in a strategy to cure HSV latency
Grant VIral and host mechanisms that tilt the HSV lytic/latent balance
Grant Mechanisms Regulating HSV TK Expression During Infection
Grant COMBINED APPROACH TO TARGETED ANTIHERPESVIRUS DRUGS
Grant Mechanism of Latency of Herpes Simplex Virus
Grant Molecular Genetics of HSV DNA Polymerase Gene
Academic Article Mutations Inactivating Herpes Simplex Virus 1 MicroRNA miR-H2 Do Not Detectably Increase ICP0 Gene Expression in Infected Cultured Cells or Mouse Trigeminal Ganglia.
Grant Molecular Genetics of HSV DNA Polymerase Gene
Academic Article Herpes Simplex Virus 1 DNA Polymerase RNase H Activity Acts in a 3'-to-5' Direction and Is Dependent on the 3'-to-5' Exonuclease Active Site.
Grant Structural studies of herpesvirus DNA polymerases
Academic Article Herpes Simplex Virus 1 Lytic Infection Blocks MicroRNA (miRNA) Biogenesis at the Stage of Nuclear Export of Pre-miRNAs.
Academic Article Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity.
Academic Article Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency.
Search Criteria
  • Simplexvirus
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.