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One or more keywords matched the following items that are connected to Coen, Donald
Item TypeName
Academic Article Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44.
Academic Article The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: relationship to the structure of alpha-like DNA polymerases.
Academic Article Identification of crucial hydrogen-bonding residues for the interaction of herpes simplex virus DNA polymerase subunits via peptide display, mutational, and calorimetric approaches.
Academic Article Linear diffusion on DNA despite high-affinity binding by a DNA polymerase processivity factor.
Academic Article ND10 protein PML is recruited to herpes simplex virus type 1 prereplicative sites and replication compartments in the presence of viral DNA polymerase.
Academic Article A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance.
Academic Article Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase.
Academic Article Engineered herpes simplex virus DNA polymerase point mutants: the most highly conserved region shared among alpha-like DNA polymerases is involved in substrate recognition.
Academic Article Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion.
Academic Article A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice.
Academic Article Antiviral drug resistance.
Academic Article Enzymatic amplification of DNA by PCR: standard procedures and optimization.
Academic Article Analysis of the association of the human cytomegalovirus DNA polymerase subunit UL44 with the viral DNA replication factor UL84.
Academic Article The herpes simplex virus processivity factor, UL42, binds DNA as a monomer.
Academic Article Genetic analysis of temperature-sensitive mutants of HSV-1: the combined use of complementation and physical mapping for cistron assignment.
Academic Article Mutations that specifically impair the DNA binding activity of the herpes simplex virus protein UL42.
Academic Article Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus.
Academic Article Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity.
Academic Article Secondary structure and structure-activity relationships of peptides corresponding to the subunit interface of herpes simplex virus DNA polymerase.
Academic Article The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus.
Academic Article Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin.
Academic Article Functional analysis of the herpes simplex virus UL42 protein.
Academic Article Mutational analysis of DNA polymerase substrate recognition and subunit interactions using herpes simplex virus as prototype.
Academic Article Isolation and characterization of herpes simplex virus mutants containing engineered mutations at the DNA polymerase locus.
Academic Article Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.
Academic Article Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.
Academic Article The pre-NH(2)-terminal domain of the herpes simplex virus 1 DNA polymerase catalytic subunit is required for efficient viral replication.
Academic Article Herpes simplex viruses: mechanisms of DNA replication.
Academic Article Interaction of the human cytomegalovirus uracil DNA glycosylase UL114 with the viral DNA polymerase catalytic subunit UL54.
Academic Article Analysis of the transcript of the herpes simplex virus DNA polymerase gene provides evidence that polymerase expression is inefficient at the level of translation.
Academic Article The positively charged surface of herpes simplex virus UL42 mediates DNA binding.
Academic Article Mutations that increase DNA binding by the processivity factor of herpes simplex virus affect virus production and DNA replication fidelity.
Academic Article Specific inhibition of herpes simplex virus DNA polymerase by helical peptides corresponding to the subunit interface.
Academic Article Biochemical and genetic analysis of acyclovir-resistant mutants of herpes simplex virus type 1.
Academic Article Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain.
Academic Article Herpes simplex virus processivity factor UL42 imparts increased DNA-binding specificity to the viral DNA polymerase and decreased dissociation from primer-template without reducing the elongation rate.
Academic Article Residues of human cytomegalovirus DNA polymerase catalytic subunit UL54 that are necessary and sufficient for interaction with the accessory protein UL44.
Academic Article The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase.
Academic Article Effects of substitutions of arginine residues on the basic surface of herpes simplex virus UL42 support a role for DNA binding in processive DNA synthesis.
Academic Article The extreme C terminus of herpes simplex virus DNA polymerase is crucial for functional interaction with processivity factor UL42 and for viral replication.
Academic Article Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis.
Academic Article Correct intranuclear localization of herpes simplex virus DNA polymerase requires the viral ICP8 DNA-binding protein.
Academic Article Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity?
Academic Article Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine.
Academic Article Generation of genetic diversity in herpes simplex virus: an antimutator phenotype maps to the DNA polymerase locus.
Academic Article Enzymatic activities of overexpressed herpes simplex virus DNA polymerase purified from recombinant baculovirus-infected insect cells.
Academic Article The human cytomegalovirus UL44 C clamp wraps around DNA.
Academic Article The carboxy-terminal segment of the human cytomegalovirus DNA polymerase accessory subunit UL44 is crucial for viral replication.
Academic Article Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.
Academic Article Mutation within the herpes simplex virus DNA polymerase gene conferring resistance to (R)-9-(3,4-dihydroxybutyl)guanine.
Academic Article Specific residues in the connector loop of the human cytomegalovirus DNA polymerase accessory protein UL44 are crucial for interaction with the UL54 catalytic subunit.
Academic Article The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity.
Academic Article Herpes simplex virus mutants resistant to arabinosyladenine in the presence of deoxycoformycin.
Academic Article Genetics of herpes simplex virus.
Academic Article Structural organization and unusual codon usage in the DNA polymerase gene from herpes simplex virus type 1.
Academic Article Identification of a small molecule that inhibits herpes simplex virus DNA Polymerase subunit interactions and viral replication.
Academic Article Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1.
Academic Article Translational regulation of herpes simplex virus DNA polymerase.
Academic Article Unusual regulation of expression of the herpes simplex virus DNA polymerase gene.
Academic Article Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication.
Academic Article Inhibition of translation by a short element in the 5' leader of the herpes simplex virus 1 DNA polymerase transcript.
Academic Article Structural and functional organization of herpes simplex virus DNA polymerase investigated by limited proteolysis.
Academic Article A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives.
Academic Article Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene.
Academic Article General aspects of virus drug resistance with special reference to herpes simplex virus.
Concept DNA-Directed DNA Polymerase
Academic Article Roles of conserved residues within the pre-NH2-terminal domain of herpes simplex virus 1 DNA polymerase in replication and latency in mice.
Academic Article Dynamic and nucleolin-dependent localization of human cytomegalovirus UL84 to the periphery of viral replication compartments and nucleoli.
Academic Article Mechanism of ganciclovir-induced chain termination revealed by resistant viral polymerase mutants with reduced exonuclease activity.
Academic Article Potency and Stereoselectivity of Cyclopropavir Triphosphate Action on Human Cytomegalovirus DNA Polymerase.
Grant Molecular Genetics of HSV DNA Polymerase Gene
Academic Article A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions.
Grant Molecular Genetics of HSV DNA Polymerase Gene
Academic Article Herpes Simplex Virus 1 DNA Polymerase RNase H Activity Acts in a 3'-to-5' Direction and Is Dependent on the 3'-to-5' Exonuclease Active Site.
Academic Article HSV-1 DNA polymerase 3'-5' exonuclease-deficient mutant D368A exhibits severely reduced viral DNA synthesis and polymerase expression.
Grant Structural studies of herpesvirus DNA polymerases
Academic Article Resistance to a Nucleoside Analog Antiviral Drug from More Rapid Extension of Drug-Containing Primers.
Search Criteria
  • DNA Directed DNA Polymerase
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.