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One or more keywords matched the following items that are connected to Armstrong, Scott
Item TypeName
Academic Article Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis.
Academic Article FLT3 as a therapeutic target in childhood acute leukemia.
Academic Article Polycomb repressive complex 2 is required for MLL-AF9 leukemia.
Academic Article Comparison of human genomics and genetic models of cancer to identify novel therapeutic targets.
Academic Article Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation.
Academic Article FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.
Academic Article NCI first International Workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the committee on the biological considerations of hematological relapse following allogeneic stem cell transplantation unrelated to graft-versus-tumor effects: state of the science.
Academic Article H3K79 methylation profiles define murine and human MLL-AF4 leukemias.
Academic Article The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML.
Academic Article MLL translocations, histone modifications and leukaemia stem-cell development.
Academic Article Genomewide identification of prednisolone-responsive genes in acute lymphoblastic leukemia cells.
Academic Article EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs.
Academic Article Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.
Academic Article Targeting epigenetic programs in MLL-rearranged leukemias.
Academic Article Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains.
Academic Article mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.
Academic Article Linking miRNA regulation to BCR-ABL expression: the next dimension.
Academic Article Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia.
Academic Article DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions.
Academic Article MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia.
Academic Article MLL-rearranged B lymphoblastic leukemias selectively express the immunoregulatory carbohydrate-binding protein galectin-1.
Concept Gene Expression Regulation, Neoplastic
Concept Gene Expression Regulation, Enzymologic
Concept Gene Expression Regulation, Developmental
Concept Gene Expression Regulation
Concept Gene Expression Regulation, Leukemic
Academic Article DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier.
Academic Article AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.
Academic Article Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.
Academic Article DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
Academic Article Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Academic Article Structure-guided DOT1L probe optimization by label-free ligand displacement.
Academic Article Mediator kinase inhibition further activates super-enhancer-associated genes in AML.
Academic Article JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors.
Academic Article Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia.
Academic Article A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.
Academic Article Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs.
Academic Article Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.
Academic Article Loss of BAP1 function leads to EZH2-dependent transformation.
Academic Article The role of DOT1L in the maintenance of leukemia gene expression.
Academic Article Genomic dark matter sheds light on EVI1-driven leukemia.
Academic Article Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond.
Academic Article The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.
Academic Article NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis.
Academic Article Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling.
Academic Article Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting.
Academic Article ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia.
Academic Article Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations.
Academic Article Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells.
Academic Article Role and regulation of phospholipase D signalling.
Search Criteria
  • Gene Expression Regulation
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.