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One or more keywords matched the following properties of Goldstein, Jill
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overview Introduction: I have had a long-standing interest in sex differences in the brain and the roles of steroid hormones, genes, and markers of immune function in understanding sex differences in psychiatric disorders and their comorbidity with general medicine. I believe that an understanding of these pathways will provide knowledge for the development of novel sex-dependent therapeutic discovery. For >30 years at Harvard, I have been working with colleagues that span Harvard schools and departments and other collaborative institutions that integrate fields of study, methods of analysis, and levels of study from basic to clinical to tackle issues of sex differences in medicine and women's health. Relatively little is known about how sex differences in healthy brain development may or may not deviate in producing pathology and the impact on treatment. Further, clinical decisions based on research are primarily based on data from males that are often inappropriate for females, even for disorders (like depression) in which women predominate. Given the gap between the clinical and scientific importance of studying sex effects in medicine and the relative paucity of studies on these issues, the history of my work has contributed to moving this field forward. History of Research: My laboratory, called the Clinical Neuroscience Laboratory of Sex Differences in the Brain, has been ongoing for >25 years (http://cnl-sd.mgh.harvard.edu). Our team consists of an interdisciplinary group of investigators, integrating structural and functional MRI studies, psychophysiology, steroid hormones, markers of immune function, genetics, and collaborative efforts with preclinical investigators modeling steroid hormones, genes, immune function, and the brain. The first disorder of interest was schizophrenia, a devastating illness for which men have a higher risk than women. Although in the 1980’s, the prevailing ideology was that it was similar in men and women, my team was instrumental in demonstrating that men have a significantly higher risk than women, the causes for which begin during mid-gestation, a key period of the sexual differentiation of the brain. Our studies of sex differences in cognitive functions identified specific domains in which women compared with men had relative preservation of function, i.e. language, executive functions, verbal memory, and olfaction. Using structural and functional MRI, my team identified brain abnormalities in schizophrenia in regions associated with sex differences in cognitive and affective functions. These brain regions, rich in gonadal hormone receptors, led to studies with basic neuroscience colleagues to map out prenatal stress and immune mechanisms associated with the dysregulation of the sexual differentiation of the brain during mid-gestation. We further demonstrated similar causal pathways for understanding sex differences in the risk for major depressive disorder, but for which women have a significantly higher risk than men. Over the last 15 years, the lab has focused on sex differences in major depression and why it is highly comorbid with cardiovascular disease and risk for Alzheimer’s disease later in life. We continue to take a lifespan approach to understanding sex differences in the shared causes of these disorders of the heart and brain. Included in this work, I oversee a unique prenatal cohort study in which subjects have prospective data from pregnancy through their 60’s, including brain imaging, allowing us to investigate in a human population the fetal programming of adult onset disorders, a topic primarily studied in animals. Our work has contributed to identifying fetal stress-immune biomarkers that disrupt the sexual differentiation of the brain and that are retained and expressed in adulthood as sex differences in deficits in stress response circuitry, major depression, and comorbid physiologic and cardiac dysfunction. In 2018, I launched the Innovation Center on Sex Differences in Medicine (ICON), a collaborative effort between Massachusetts General Hospital and the Harvard T. H. Chan School of Public Health, partnering with WomenAgainstAlzheimers (http://icon.mgh.harvard.edu). ICON consists of collaborators across departments, fields and methodologies bringing together psychiatry, OB-GYN, cardiology, neurology, and public health. ICON’s primary mission is to leverage fundamental discoveries “from cells to society” about sex differences in the brain and heart into strategies to develop sex-dependent therapeutics and target them early for prevention. In addition, we are invested in educating the next generation of scientists, clinicians, and the public about sex differences in medicine and advocating for these issues at the national and global levels. In 2020, ICON was designated an NIH Specialized Center of Research Excellence (SCORE) for Sex Differences in Medicine, one of only 8 in the country. Finally, I have spent my career educating the next generation of scientists and clinicians to study sex differences in health and disease across disciplines and methods and providing resources for their careers in women’s health and sex differences in medicine. In the service of this for >15 years, I have been the PI of a Harvard-wide junior faculty training program (ORWH-NICHD K12 HD051959-06) called Building Interdisciplinary Careers in Women's Health (BIRCWH) with ours targeted to "Hormones and Genes in Women's Health: From Bench to Bedside". With a translational focus, BIRCWH is training the next generation to investigate sex differences in medicine, and/or women's health specifically, and incorporate the knowledge into their academic and clinical careers in medicine.
One or more keywords matched the following items that are connected to Goldstein, Jill
Item TypeName
Award or Honor Receipt Award for Exploratory Seminar on “Unexplored Sex Differences in Cardiovascular Disease”
Academic Article Genetic heterogeneity may in part explain sex differences in the familial risk for schizophrenia.
Academic Article Sex differences in language dysfunction in schizophrenia.
Academic Article Impact of normal sexual dimorphisms on sex differences in structural brain abnormalities in schizophrenia assessed by magnetic resonance imaging.
Academic Article Sex differences in prefrontal cortical brain activity during fMRI of auditory verbal working memory.
Academic Article Sex differences in stress response circuitry activation dependent on female hormonal cycle.
Academic Article Sex, hormones and affective arousal circuitry dysfunction in schizophrenia.
Academic Article Images in neuroscience. Brain development, XI: sexual dimorphism.
Academic Article Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging.
Academic Article Sex differences in clinical response to olanzapine compared with haloperidol.
Academic Article Hypothalamic abnormalities in schizophrenia: sex effects and genetic vulnerability.
Academic Article Neuroanatomic substrates of sex differences in language dysfunction in schizophrenia: a pilot study.
Academic Article Fear conditioning and extinction: influence of sex and menstrual cycle in healthy humans.
Academic Article Sex differences in the neurobiology of fear conditioning and extinction: a preliminary fMRI study of shared sex differences with stress-arousal circuitry.
Academic Article Sex differences in the familial transmission of schizophrenia.
Academic Article Covariance modeling of MRI brain volumes in memory circuitry in schizophrenia: Sex differences are critical.
Academic Article Impact of fetal versus perinatal hypoxia on sex differences in childhood outcomes: developmental timing matters.
Academic Article Sex differences in schizophrenia.
Academic Article Volumetric parcellation methodology of the human hypothalamus in neuroimaging: normative data and sex differences.
Academic Article Are there sex differences in neuropsychological functions among patients with schizophrenia?
Academic Article Sex differences in neuropsychological function in non-psychotic relatives of schizophrenic probands.
Academic Article Sex and brain abnormalities in schizophrenia: fact or fiction?
Academic Article Sex-specific rates of transmission of psychosis in the New England high-risk family study.
Academic Article Sex differences in olfactory identification and Wisconsin Card Sorting performance in schizophrenia: relationship to attention and verbal ability.
Concept Sex Characteristics
Academic Article Sex-dependent pathophysiology as predictors of comorbidity of major depressive disorder and cardiovascular disease.
Academic Article Sex differences in the genetic risk for schizophrenia: history of the evidence for sex-specific and sex-dependent effects.
Academic Article Disruption of fetal hormonal programming (prenatal stress) implicates shared risk for sex differences in depression and cardiovascular disease.
Academic Article Fetal hormonal programming of sex differences in depression: linking women's mental health with sex differences in the brain across the lifespan.
Academic Article Sex differences, hormones, and fMRI stress response circuitry deficits in psychoses.
Grant Fetal Hormonal Programming of Sex Differences in Aging of the Memory Circuitry
Grant Gender and Brain Abnormalities in Schizophrenia
Grant SEX AND ATTENTION IN SCHIZOPHRENIA--APPLICATION OF FMRI
Grant Hormones and Genes in Women's Health: From Bench to Bedside
Grant Sex, Hormones and GABA in Stress Induced Anhedonia in Depression
Grant Fetal Antecedents to Sex Differences in Depression: A Translational Approach
Academic Article Impact of Sex and Menopausal Status on Episodic Memory Circuitry in Early Midlife.
Grant Fetal Hormonal Programming of Sex Differences in Aging of the Memory Circuitry (Phase II)
Academic Article Brain activity and connectivity in response to negative affective stimuli: Impact of dysphoric mood and sex across diagnoses.
Academic Article Sex differences in episodic memory in early midlife: impact of reproductive aging.
Academic Article Reorganization of Functional Networks in Verbal Working Memory Circuitry in Early Midlife: The Impact of Sex and Menopausal Status.
Academic Article Prenatal stress-immune programming of sex differences in comorbidity of depression and obesity/metabolic syndrome.
Grant Prenatal Immune Programming of Sex Differences in Dysregulation of Emotion Processing in Midlife
Academic Article Impact of Prenatal Stress on Offspring Psychopathology and Comorbidity With General Medicine Later in Life.
Academic Article Sex and Gender Differences Research Design for Basic, Clinical, and Population Studies: Essentials for Investigators.
Academic Article Understanding the impact of sex and gender in Alzheimer's disease: A call to action.
Grant Aging of Emotion Circuitry: Impact of Sex, Depression, and Fetal Immune Origins
Academic Article Sex differences in major depression and comorbidity of cardiometabolic disorders: impact of prenatal stress and immune exposures.
Academic Article Sex Differences in the Prenatal Programming of Adult Metabolic Syndrome by Maternal Androgens.
Award or Honor Receipt Founder and Executive Director of the Innovation Center on Sex Differences in Medicine
Academic Article Impact of sex and reproductive status on memory circuitry structure and function in early midlife using structural covariance analysis.
Academic Article Impact of adrenal hormones, reproductive aging, and major depression on memory circuitry decline in early midlife.
Grant Impact of Depression on Alzheimer's disease: Prenatal Immune Origins and Shared Impact of Sex
Academic Article Maternal Bacterial Infection During Pregnancy and Offspring Risk of Psychotic Disorders: Variation by Severity of Infection and Offspring Sex.
Academic Article Impact of BDNF and sex on maintaining intact memory function in early midlife.
Grant Sex Differences in Major Depression: Impact of Prenatal Stress-Immune and Autonomic Dysregulation
Academic Article Sex Differences in Disorders of the Brain and Heart-A Global Crisis of Multimorbidity and Novel Opportunity.
Academic Article Sex Differences in Hemoglobin A1c Levels Related to the Comorbidity of Obesity and Depression.
Academic Article Impact of prenatal maternal cytokine exposure on sex differences in brain circuitry regulating stress in offspring 45 years later.
Search Criteria
  • Sex Differences
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.