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One or more keywords matched the following items that are connected to Evans, Christopher
Item TypeName
Academic Article Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis.
Academic Article Arthritis: is the cure in your genes?
Academic Article Gene therapies for osteoarthritis.
Academic Article Clinical trials in the gene therapy of arthritis.
Academic Article Role of NF-kappaB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals.
Academic Article Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model.
Academic Article Gene therapy for arthritis: principles and clinical practice.
Academic Article Gene transfer to human joints: progress toward a gene therapy of arthritis.
Academic Article In vivo gene delivery to synovium by lentiviral vectors.
Academic Article Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis.
Academic Article Interleukin-1beta and tumor necrosis factor alpha inhibit chondrogenesis by human mesenchymal stem cells through NF-kappaB-dependent pathways.
Academic Article Transgene persistence and cell turnover in the diarthrodial joint: implications for gene therapy of chronic joint diseases.
Academic Article Lentiviral-mediated gene delivery to synovium: potent intra-articular expression with amplification by inflammation.
Academic Article Novel biological approaches to the intra-articular treatment of osteoarthritis.
Academic Article A simple, lanthanide-based method to enhance the transduction efficiency of adenovirus vectors.
Academic Article In vitro gene transfer to chondrocytes and synovial fibroblasts by adenoviral vectors.
Academic Article Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus.
Academic Article Adenovirus-mediated gene transfer of glutamine: fructose-6-phosphate amidotransferase antagonizes the effects of interleukin-1beta on rat chondrocytes.
Academic Article A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer.
Academic Article The role of nitric oxide in proteoglycan turnover by bovine articular cartilage organ cultures.
Concept Interleukin-8
Concept Interleukin-17
Concept Interleukin-1beta
Concept Interleukin-4
Concept Interleukin-23
Concept Interleukin-6
Concept Interleukin 1 Receptor Antagonist Protein
Concept Interleukin-10
Concept Receptors, Interleukin-1
Concept Interleukins
Concept Interleukin-1
Academic Article Cycloheximide inhibits the induction of collagenase mRNA in chondrocytes exposed to synovial factors or recombinant interleukin-1.
Academic Article The biochemical and histological effects of artificial ligament wear particles: in vitro and in vivo studies.
Academic Article Synovial activation of chondrocytes: evidence for complex cytokine interactions.
Academic Article Interleukin-1 receptor antagonist suppresses neurotrophin response in injured rat brain.
Academic Article Synovial fluid cytokine concentrations as possible prognostic indicators in the ACL-deficient knee.
Academic Article [The effect of cytokines on regeneration results of compressed nerve roots and transsected peripheral nerves].
Academic Article Nitric oxide and proteoglycan turnover in rabbit articular cartilage.
Academic Article Joint efforts: tackling arthritis using gene therapy. First International Meeting on the Gene Therapy of Arthritis and Related Disorders. Bethesda, MD, USA, 2-3 December 1998.
Academic Article Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide.
Academic Article Protein phosphorylation and metalloproteinase synthesis by lapine articular chondrocytes.
Academic Article Interleukin-1 and synovial protein kinase C: identification of a novel, 35 kDa cytosolic substrate.
Academic Article Induction of collagenase mRNA in lapine articular chondrocytes by synovial factors and interleukin-1.
Academic Article [In vitro transfer of genes in spinal tissue].
Academic Article Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects.
Academic Article Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws.
Academic Article Synovial protein kinase C and its apparent insensitivity to interleukin-1.
Academic Article Evidence that responses of articular chondrocytes to interleukin-1 and basic fibroblast growth factor are not mediated by protein kinase C.
Academic Article The synovial activation of chondrocytes: evidence for complex cytokine interactions involving a possible novel factor.
Academic Article Chondrocyte activation by a putative interleukin-1 derived from lapine polymorphonuclear leukocytes.
Academic Article Transfer of genes to chondrocytic cells of the lumbar spine. Proposal for a treatment strategy of spinal disorders by local gene therapy.
Academic Article Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: prolyl hydroxylase as a possible target.
Academic Article Studies on the autocrine activation of a synovial cell line.
Academic Article The promise of a new clinical trial--intra-articular IL-1 receptor antagonist.
Academic Article Chondrocyte activation by interleukin-1: synergism with fibroblast growth factor and phorbol myristate acetate.
Academic Article Chondrocyte activation by interleukin-1: analysis of the synergistic properties of fibroblast growth factor and phorbol myristate acetate.
Academic Article Altered patterns of protein phosphorylation in articular chondrocytes treated with interleukin-1 or synovial cytokines.
Academic Article Inducible synthesis of collagenase and other neutral metalloproteinases by cells of aortic origin.
Academic Article Nitric oxide synthesis and its regulation by rabbit synoviocytes.
Academic Article Herniated cervical intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2.
Academic Article Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy.
Academic Article Interleukin-1 alpha as an autocrine regulator in rabbit synovial fibroblasts.
Academic Article Inhibition of transforming growth factor beta production by nitric oxide-treated chondrocytes: implications for matrix synthesis.
Academic Article Approaches to enhancing the retroviral transduction of human synoviocytes.
Academic Article The interleukin-1 receptor antagonist and its delivery by gene transfer.
Academic Article Inhibition of cartilage destruction by double gene transfer of IL-1Ra and IL-10 involves the activin pathway.
Academic Article Toward a biochemical understanding of human intervertebral disc degeneration and herniation. Contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases.
Academic Article The induction of IL-1 by freeze-dried ethylene oxide-treated bone-patellar tendon-bone allograft wear particles: an in vitro study.
Academic Article Interaction of strain and interleukin-1 in articular cartilage: effects on proteoglycan synthesis in chondrocytes.
Academic Article Gene therapy for osteoporosis: evaluation in a murine ovariectomy model.
Academic Article Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy.
Academic Article Prolonged systemic expression of human IL-1 receptor antagonist (hIL-1ra) in mice reconstituted with hematopoietic cells transduced with a retrovirus carrying the hIL-1ra cDNA.
Academic Article Constitutive intra-articular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis.
Academic Article Getting genes into human synovium.
Academic Article Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2.
Academic Article Osteoarthritis gene therapy.
Academic Article [Perspectives in gene therapy in rheumatic and degenerative diseases of the spine and joints].
Academic Article Nitric oxide and energy production in articular chondrocytes.
Academic Article Neurophysiologic changes in lumbar nerve root inflammation in the rat after treatment with cytokine inhibitors. Evidence for a role of interleukin-1.
Academic Article Constitutive systemic expression of IL-1Ra or soluble TNF receptor by genetically modified hematopoietic cells suppresses LPS induction of IL-6 and IL-10.
Academic Article Human IL-1Ra gene transfer into human synovial fibroblasts is chondroprotective.
Academic Article Generation of nitric oxide by lapine meniscal cells and its effect on matrix metabolism: stimulation of collagen production by arginine.
Academic Article Gene transfer of cytokine inhibitors into human synovial fibroblasts in the SCID mouse model.
Academic Article Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees.
Academic Article Cyclic tensile stress exerts antiinflammatory actions on chondrocytes by inhibiting inducible nitric oxide synthase.
Academic Article Cyclic tensile strain acts as an antagonist of IL-1 beta actions in chondrocytes.
Academic Article Effect of growth factors on the proliferation of ligament fibroblasts from skeletally mature rabbits.
Academic Article Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4.
Academic Article Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene.
Academic Article Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis.
Academic Article [In vitro transduction of human osteoblast cell populations with retroviral vectors].
Academic Article Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4.
Academic Article Gene transfer of p53 to arthritic joints stimulates synovial apoptosis and inhibits inflammation.
Academic Article IL-1Ra and vIL-10 gene transfer using retroviral vectors ameliorates particle-associated inflammation in the murine air pouch model.
Academic Article Suppression of intra-articular responses to interleukin-1 by transfer of the interleukin-1 receptor antagonist gene to synovium.
Academic Article Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer.
Academic Article Nitric oxide inhibits chondrocyte response to IGF-I: inhibition of IGF-IRbeta tyrosine phosphorylation.
Academic Article Viral IL-10 gene transfer inhibits DTH responses to soluble antigens: evidence for involvement of genetically modified dendritic cells and macrophages.
Academic Article Adenoviral transduction of human osteoblastic cell cultures: a new perspective for gene therapy of bone diseases.
Academic Article Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1.
Academic Article Gene therapy approaches for treating rheumatoid arthritis.
Academic Article Effects of cytokine gene therapy on particulate-induced inflammation in the murine air pouch.
Academic Article Modulation of chondrocyte proteoglycan synthesis by endogeneously produced nitric oxide.
Academic Article Leukoregulin, a T cell-derived cytokine, induces IL-8 gene expression and secretion in human skin fibroblasts. Demonstration and secretion in human skin fibroblasts. Demonstration of enhanced NF-kappa B binding and NF-kappa B-driven promoter activity.
Academic Article TNFa and IL-1ß influence the differentiation and migration of murine MSCs independently of the NF-?B pathway.
Grant DELIVERY OF THERAPEUTIC GENES TO HUMAN RHEUMATOID JOINTS
Grant MECHANISMS OF CHONDROCYTE ACTIVATION IN ARTHRITIS
Grant Delivery of Therapeutic Genes to Osteoarthritic Joints
Grant INTERLEUKIN-1 &SIGNAL TRANSDUCTION IN SYNOVIOCYTES
Grant CLINICAL TRIAL OF GENE THERAPY FOR ARTHRITIS
Academic Article Autologous Conditioned Serum.
Academic Article Self-Complementary Adeno-Associated Virus-Mediated Interleukin-1 Receptor Antagonist Gene Delivery for the Treatment of Osteoarthritis: Test of Efficacy in an Equine Model.
Academic Article Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model.
Academic Article Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice.
Search Criteria
  • Interleukins
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.