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One or more keywords matched the following items that are connected to Evans, Christopher
Item TypeName
Academic Article Gene transfer approaches to the healing of bone and cartilage.
Academic Article Synovial fibroblasts spread rheumatoid arthritis to unaffected joints.
Academic Article Gene therapies for osteoarthritis.
Academic Article Development of gene-based therapies for cartilage repair.
Academic Article Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees.
Academic Article Altered relative expression of BMPs and BMP inhibitors in cartilaginous areas of human fractures progressing towards nonunion.
Academic Article Role of NF-kappaB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals.
Academic Article Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model.
Academic Article Regional and cellular localisation of BMPs and their inhibitors' expression in human fractures.
Academic Article Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines.
Academic Article Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage.
Academic Article Major biological obstacles for persistent cell-based regeneration of articular cartilage.
Academic Article Gene transfer to articular chondrocytes with recombinant adenovirus.
Academic Article Gene delivery to cartilage defects using coagulated bone marrow aspirate.
Academic Article In vitro gene transfer to chondrocytes and synovial fibroblasts by adenoviral vectors.
Academic Article [Gene therapy for osteoarticular disorders].
Academic Article Experimental arthritis induced by intraarticular injection of allogenic cartilaginous particles into rabbit knees.
Academic Article Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus.
Academic Article Adenovirus-mediated gene transfer of glutamine: fructose-6-phosphate amidotransferase antagonizes the effects of interleukin-1beta on rat chondrocytes.
Academic Article The role of nitric oxide in proteoglycan turnover by bovine articular cartilage organ cultures.
Concept Cartilage, Articular
Concept Cartilage
Concept Cartilage Diseases
Academic Article Cycloheximide inhibits the induction of collagenase mRNA in chondrocytes exposed to synovial factors or recombinant interleukin-1.
Academic Article The biochemical and histological effects of artificial ligament wear particles: in vitro and in vivo studies.
Academic Article Synovial activation of chondrocytes: evidence for complex cytokine interactions.
Academic Article Characterisation of chondrocyte activation in response to cytokines synthesised by a synovial cell line.
Academic Article Protein kinase C and chondrocyte activation.
Academic Article Nitric oxide and proteoglycan turnover in rabbit articular cartilage.
Academic Article Chondrocyte activation in response to factor(s) produced by a continuous line of lapine synovial fibroblasts.
Academic Article Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide.
Academic Article Protein phosphorylation and metalloproteinase synthesis by lapine articular chondrocytes.
Academic Article Induction of collagenase mRNA in lapine articular chondrocytes by synovial factors and interleukin-1.
Academic Article [Possibilities of gene therapy in traumatic and degenerative articular lesions. Current status of experimental and initial clinical applications].
Academic Article Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects.
Academic Article Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws.
Academic Article Intermittent sub-ambient interstitial hydrostatic pressure as a potential mechanical stimulator for chondrocyte metabolism.
Academic Article Evidence that responses of articular chondrocytes to interleukin-1 and basic fibroblast growth factor are not mediated by protein kinase C.
Academic Article The synovial activation of chondrocytes: evidence for complex cytokine interactions involving a possible novel factor.
Academic Article Chondrocyte activation by a putative interleukin-1 derived from lapine polymorphonuclear leukocytes.
Academic Article Transfer of genes to chondrocytic cells of the lumbar spine. Proposal for a treatment strategy of spinal disorders by local gene therapy.
Academic Article Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: prolyl hydroxylase as a possible target.
Academic Article Chondrocyte activation by interleukin-1: synergism with fibroblast growth factor and phorbol myristate acetate.
Academic Article Comparison of the nitric oxide synthase inhibitors methylarginine and aminoguanidine as prophylactic and therapeutic agents in rat adjuvant arthritis.
Academic Article Enhanced endocytosis by aging chondrocytes and fibroblasts.
Academic Article The natural history of the anterior cruciate ligament-deficient knee. Changes in synovial fluid cytokine and keratan sulfate concentrations.
Academic Article Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: a feasibility study.
Academic Article Chondrocyte activation by interleukin-1: analysis of the synergistic properties of fibroblast growth factor and phorbol myristate acetate.
Academic Article Altered patterns of protein phosphorylation in articular chondrocytes treated with interleukin-1 or synovial cytokines.
Academic Article Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy.
Academic Article Inhibition of transforming growth factor beta production by nitric oxide-treated chondrocytes: implications for matrix synthesis.
Academic Article Using gene therapy to protect and restore cartilage.
Academic Article Inhibition of cartilage destruction by double gene transfer of IL-1Ra and IL-10 involves the activin pathway.
Academic Article Nitric oxide and cartilage metabolism.
Academic Article Potential treatment of osteoarthritis by gene therapy.
Academic Article Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model.
Academic Article [TGF-beta-1 gene transfer in joint cartilage cells. Stimulating effect in extracellular matrix synthesis].
Academic Article The synovial production of collagenase and chondrocyte activating factors in response to cobalt.
Academic Article Nitric oxide in osteoarthritis.
Academic Article Insulinlike growth factor-I gene therapy applications for cartilage repair.
Academic Article Interaction of strain and interleukin-1 in articular cartilage: effects on proteoglycan synthesis in chondrocytes.
Academic Article Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function.
Academic Article Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy.
Academic Article Constitutive intra-articular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis.
Academic Article Nitric oxide and its role in orthopaedic disease.
Academic Article Nitric oxide and energy production in articular chondrocytes.
Academic Article Human IL-1Ra gene transfer into human synovial fibroblasts is chondroprotective.
Academic Article Gene transfer of cytokine inhibitors into human synovial fibroblasts in the SCID mouse model.
Academic Article Gene therapy of arthritis.
Academic Article Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees.
Academic Article GAG-augmented polysaccharide hydrogel: a novel biocompatible and biodegradable material to support chondrogenesis.
Academic Article Cartilage injury and repair.
Academic Article Gene therapy for meniscal injury: enhanced synthesis of proteoglycan and collagen by meniscal cells transduced with a TGFbeta(1)gene.
Academic Article Cyclic tensile stress exerts antiinflammatory actions on chondrocytes by inhibiting inducible nitric oxide synthase.
Academic Article Cyclic tensile strain acts as an antagonist of IL-1 beta actions in chondrocytes.
Academic Article [Gene transfer in the treatment of arthritis].
Academic Article Gene transfer of p53 to arthritic joints stimulates synovial apoptosis and inhibits inflammation.
Academic Article Articular responses to purified cartilage proteoglycans.
Academic Article Retrovirally transduced bone marrow stromal cells isolated from a mouse model of human osteogenesis imperfecta (oim) persist in bone and retain the ability to form cartilage and bone after extended passaging.
Academic Article Increased matrix synthesis following adenoviral transfer of a transforming growth factor beta1 gene into articular chondrocytes.
Academic Article Differences in nitric oxide production by superficial and deep human articular chondrocytes: implications for proteoglycan turnover in inflammatory joint diseases.
Academic Article Nitric oxide inhibits chondrocyte response to IGF-I: inhibition of IGF-IRbeta tyrosine phosphorylation.
Academic Article An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints.
Academic Article Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1.
Academic Article Adenoviral mediated delivery of FAS ligand to arthritic joints causes extensive apoptosis in the synovial lining.
Academic Article Direct adenovirus-mediated IGF-I gene transduction of synovium induces persisting synovial fluid IGF-I ligand elevations.
Academic Article Modulation of chondrocyte proteoglycan synthesis by endogeneously produced nitric oxide.
Academic Article Effects of Dexamethasone on Mesenchymal Stromal Cell Chondrogenesis and Aggrecanase Activity: Comparison of Agarose and Self-Assembling Peptide Scaffolds.
Academic Article Observations on the senescence of cells derived from articular cartilage.
Academic Article Binding of the bone-seeking agent 99mTc-1-hydroxyethylidene-1,1-diphosphonic acid to cartilage and collagen in vitro and its stimulation by Er3+ and low pH.
Academic Article Neutral proteinases secreted by chondrocytes and activated macrophages in vitro.
Academic Article Gene therapy approaches to regenerating the musculoskeletal system.
Academic Article Drug delivery to chondrocytes.
Grant Novel, Rapidly Translatable Technologies for Healing Long Bone Segmental Defects
Grant Healing of Segmental Defects of Bone by Gene Transfer
Grant CLINICAL TRIAL OF GENE THERAPY FOR ARTHRITIS
Academic Article Intra-articular dexamethasone to inhibit the development of post-traumatic osteoarthritis.
Academic Article Release of neutral proteinases from mononuclear phagocytes and synovial cells in response to cartilaginous wear particles in vitro.
Academic Article State of art and limitations in genetic engineering to induce stable chondrogenic phenotype.
Academic Article Gene Therapy to Enhance Bone and Cartilage Repair in Orthopaedic Surgery.
Academic Article Catering to chondrocytes.
Academic Article Different types of cartilage neotissue fabricated from collagen hydrogels and mesenchymal stromal cells via SOX9, TGFB1 or BMP2 gene transfer.
Search Criteria
  • Cartilage
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.