Harvard Catalyst Profiles

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Item TypeName
Academic Article Turning on a dimer: new insights into MLL chimeras.
Academic Article The pu.1 promoter drives myeloid gene expression in zebrafish.
Academic Article Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family.
Academic Article Zebrafish myelopoiesis and blood cell development.
Academic Article NOTCH and PI3K-AKT pathways intertwined.
Academic Article The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.
Academic Article Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo.
Academic Article Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish.
Academic Article DNA microarrays in the diagnosis and management of acute lymphoblastic leukemia.
Academic Article Fishing for cancer models.
Academic Article Zebrafish as a powerful vertebrate model system for in vivo studies of cell death.
Academic Article Activating FLT3 mutations in CD117/KIT(+) T-cell acute lymphoblastic leukemias.
Academic Article TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors.
Academic Article Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia.
Academic Article Gene expression profiling in T-cell acute lymphoblastic leukemia.
Academic Article CD34+ cell selection is required to assess HOXA9 expression levels in patients with myelodysplastic syndrome.
Academic Article A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors.
Academic Article FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors.
Academic Article Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio).
Academic Article Lessons from transgenic zebrafish expressing the green fluorescent protein (GFP) in the myeloid lineage.
Academic Article Hyperdiploidy plus nonamplified MYCN confers a favorable prognosis in children 12 to 18 months old with disseminated neuroblastoma: a Pediatric Oncology Group study.
Academic Article Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia.
Academic Article SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein.
Academic Article T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.
Academic Article Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.
Academic Article mll ortholog containing functional domains of human MLL is expressed throughout the zebrafish lifespan and in haematopoietic tissues.
Academic Article Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation.
Academic Article Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia.
Academic Article Small molecules thwart crash and burn.
Academic Article Zebrafish as a model for myelopoiesis during embryogenesis.
Academic Article The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish.
Academic Article NOTCH1-induced T-cell leukemia in transgenic zebrafish.
Academic Article cpsf1 is required for definitive HSC survival in zebrafish.
Academic Article Development of the peripheral sympathetic nervous system in zebrafish.
Academic Article NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis.
Academic Article Myelopoiesis in the zebrafish, Danio rerio.
Academic Article Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis.
Academic Article Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia.
Academic Article Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53.
Academic Article Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation.
Academic Article Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish.
Academic Article Inactivation of LEF1 in T-cell acute lymphoblastic leukemia.
Academic Article Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency.
Academic Article Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia.
Academic Article Molecular Pathogenesis of MDS.
Academic Article NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.
Academic Article Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
Concept Gene Expression Regulation, Neoplastic
Concept Gene Expression Regulation, Enzymologic
Concept Gene Expression Regulation, Developmental
Concept Gene Expression Regulation
Concept Gene Expression Regulation, Leukemic
Academic Article The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia.
Academic Article Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors.
Academic Article Ribonucleoprotein HNRNPA2B1 interacts with and regulates oncogenic KRAS in pancreatic ductal adenocarcinoma cells.
Academic Article The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1.
Academic Article Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.
Academic Article A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing.
Academic Article Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.
Academic Article Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia.
Academic Article Small genomic insertions form enhancers that misregulate oncogenes.
Academic Article APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL.
Academic Article Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia.
Academic Article LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis.
Search Criteria
  • Gene Expression Regulation
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.