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One or more keywords matched the following items that are connected to Florez, Jose
Item TypeName
Academic Article TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program.
Academic Article Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals.
Academic Article Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
Academic Article High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people.
Academic Article Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity.
Academic Article Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program.
Academic Article Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
Academic Article Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism.
Academic Article Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?
Academic Article The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program.
Academic Article Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.
Academic Article TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study.
Academic Article Genetic modulation of lipid profiles following lifestyle modification or metformin treatment: the Diabetes Prevention Program.
Academic Article Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program.
Academic Article Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.
Academic Article Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study.
Academic Article The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits.
Academic Article New susceptibility loci associated with kidney disease in type 1 diabetes.
Academic Article Genetic susceptibility to type 2 diabetes and implications for therapy.
Academic Article Association testing of previously reported variants in a large case-control meta-analysis of diabetic nephropathy.
Academic Article Personalized genetic risk counseling to motivate diabetes prevention: a randomized trial.
Academic Article Association testing of TCF7L2 polymorphisms with type 2 diabetes in multi-ethnic youth.
Academic Article Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP × environment regression coefficients.
Academic Article New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Academic Article Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program.
Academic Article The Krüppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people.
Academic Article The prevention of type 2 diabetes.
Academic Article Variants in MTNR1B influence fasting glucose levels.
Academic Article Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource.
Academic Article The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program.
Academic Article Strong association of socioeconomic status with genetic ancestry in Latinos: implications for admixture studies of type 2 diabetes.
Academic Article Novel genetic findings applied to the clinic in type 2 diabetes.
Academic Article Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.
Academic Article Association of the SLC30A8 missense polymorphism R325W with proinsulin levels at baseline and after lifestyle, metformin or troglitazone intervention in the Diabetes Prevention Program.
Academic Article Genetic architecture of type 2 diabetes: recent progress and clinical implications.
Academic Article The clinical application of genetic testing in type 2 diabetes: a patient and physician survey.
Academic Article Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
Academic Article Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems.
Academic Article Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.
Academic Article Impact of literacy and numeracy on motivation for behavior change after diabetes genetic risk testing.
Academic Article Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
Academic Article The new type 2 diabetes gene TCF7L2.
Academic Article Genomics of type 2 diabetes mellitus: implications for the clinician.
Academic Article Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes.
Academic Article Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes.
Academic Article The genetics of type 2 diabetes: what have we learned from GWAS?
Academic Article A genome-wide association search for type 2 diabetes genes in African Americans.
Academic Article Consistent directions of effect for established type 2 diabetes risk variants across populations: the population architecture using Genomics and Epidemiology (PAGE) Consortium.
Academic Article Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
Academic Article A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
Academic Article Impact of common variation in bone-related genes on type 2 diabetes and related traits.
Academic Article TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program.
Academic Article Genetic counseling as a tool for type 2 diabetes prevention: a genetic counseling framework for common polygenetic disorders.
Academic Article Genetic susceptibility to type 2 diabetes and implications for antidiabetic therapy.
Academic Article Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism.
Academic Article Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study.
Academic Article Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes, and coronary heart disease.
Academic Article Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
Academic Article Design of a randomized trial of diabetes genetic risk testing to motivate behavior change: the Genetic Counseling/lifestyle Change (GC/LC) Study for Diabetes Prevention.
Academic Article Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes.
Academic Article Genome-wide association with diabetes-related traits in the Framingham Heart Study.
Academic Article A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.
Academic Article Phenotypic consequences of the peroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism: the weight of the evidence in genetic association studies.
Academic Article Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes.
Academic Article Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone.
Academic Article Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program.
Academic Article The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.
Academic Article Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.
Academic Article Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people.
Academic Article A genetic link between type 2 diabetes and prostate cancer.
Academic Article Genotype score in addition to common risk factors for prediction of type 2 diabetes.
Academic Article Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans.
Concept Diabetes Mellitus, Type 1
Concept Diabetes Mellitus, Type 2
Academic Article The cancer-associated FGFR4-G388R polymorphism enhances pancreatic insulin secretion and modifies the risk of diabetes.
Academic Article Lack of interaction of beta-cell-function-associated variants with hypertension on change in fasting glucose and diabetes risk: the Framingham Offspring Study.
Academic Article Case records of the Massachusetts General Hospital. Case 17-2013. A 56-year-old woman with poorly controlled diabetes mellitus and fatigue.
Academic Article Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects.
Academic Article Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus.
Academic Article 2-Aminoadipic acid is a biomarker for diabetes risk.
Academic Article Variation at the melanocortin 4 receptor gene and response to weight-loss interventions in the diabetes prevention program.
Academic Article Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes.
Academic Article Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes.
Academic Article Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study.
Academic Article Insights from monogenic diabetes and glycemic treatment goals for common types of diabetes.
Academic Article Genetic risk of progression to type 2 diabetes and response to intensive lifestyle or metformin in prediabetic women with and without a history of gestational diabetes mellitus.
Academic Article Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
Academic Article Common variation at PPARGC1A/B and change in body composition and metabolic traits following preventive interventions: the Diabetes Prevention Program.
Academic Article Circulating natriuretic peptide concentrations reflect changes in insulin sensitivity over time in the Diabetes Prevention Program.
Academic Article An update on the pharmacogenomics of metformin: progress, problems and potential.
Academic Article The influence of rare genetic variation in SLC30A8 on diabetes incidence and ß-cell function.
Academic Article Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.
Academic Article Polygenic type 2 diabetes prediction at the limit of common variant detection.
Academic Article Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population.
Academic Article Metabolite traits and genetic risk provide complementary information for the prediction of future type 2 diabetes.
Academic Article Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.
Academic Article Metformin pharmacogenomics: current status and future directions.
Academic Article It's not black and white: individualizing metformin treatment in type 2 diabetes.
Academic Article Differences in pancreatic volume, fat content, and fat density measured by multidetector-row computed tomography according to the duration of diabetes.
Academic Article Pathways targeted by antidiabetes drugs are enriched for multiple genes associated with type 2 diabetes risk.
Academic Article Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
Academic Article Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in mice and humans.
Academic Article Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
Academic Article The study to understand the genetics of the acute response to metformin and glipizide in humans (SUGAR-MGH): design of a pharmacogenetic resource for type 2 diabetes.
Academic Article Association of a 62 Variants Type 2 Diabetes Genetic Risk Score With Markers of Subclinical Atherosclerosis: A Transethnic, Multicenter Study.
Academic Article Therapeutic Challenges in Diabetes Prevention: We Have Not Found the "Exercise Pill".
Academic Article Steroid Sex Hormones, Sex Hormone-Binding Globulin, and Diabetes Incidence in the Diabetes Prevention Program.
Academic Article Genetic Predisposition to Weight Loss and Regain With Lifestyle Intervention: Analyses From the Diabetes Prevention Program and the Look AHEAD Randomized Controlled Trials.
Academic Article Genetic Evidence for a Causal Role of Obesity in Diabetic Kidney Disease.
Academic Article Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
Academic Article Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants.
Academic Article Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.
Academic Article Found in Translation: A Type 1 Diabetes Genetic Risk Score Applied to Clinical Diagnosis.
Academic Article Metabolite Profiles of Diabetes Incidence and Intervention Response in the Diabetes Prevention Program.
Academic Article Type 2 Diabetes Genetic Predisposition, Obesity, and All-Cause Mortality Risk in the U.S.: A Multiethnic Analysis.
Academic Article Catechol-O-methyltransferase association with hemoglobin A1c.
Academic Article The (in)famous GWAS P-value threshold revisited and updated for low-frequency variants.
Academic Article Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.
Academic Article Leveraging Genetics to Advance Type 2 Diabetes Prevention.
Academic Article The genetic architecture of type 2 diabetes.
Academic Article Type 2 diabetes: genetic data sharing to advance complex disease research.
Academic Article Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.
Academic Article The Genetic Landscape of Renal Complications in Type 1 Diabetes.
Academic Article Prospective functional classification of all possible missense variants in PPARG.
Academic Article Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.
Academic Article Genetics of Diabetic Kidney Disease.
Academic Article Pharmacogenetics in type 2 diabetes: precision medicine or discovery tool?
Academic Article Genetically Driven Hyperglycemia Increases Risk of Coronary Artery Disease Separately From Type 2 Diabetes.
Academic Article A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
Academic Article Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease.
Academic Article An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.
Academic Article Variation in Maturity-Onset Diabetes of the Young Genes Influence Response to Interventions for Diabetes Prevention.
Academic Article Mining the Genome for Therapeutic Targets.
Academic Article Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.
Academic Article The pharmacogenetics of metformin.
Academic Article A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes.
Academic Article Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.
Academic Article Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
Academic Article Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees.
Academic Article TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH).
Academic Article Precision medicine in diabetes: an opportunity for clinical translation.
Academic Article Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity.
Academic Article Metabolomics insights into early type 2 diabetes pathogenesis and detection in individuals with normal fasting glucose.
Academic Article A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.
Academic Article Mexican Carriers of the HNF1A p.E508K Variant Do Not Experience an Enhanced Response to Sulfonylureas.
Academic Article Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.
Academic Article A Global Overview of Precision Medicine in Type 2 Diabetes.
Academic Article Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis.
Academic Article Genetic Determinants of Glycemic Traits and the Risk of Gestational Diabetes Mellitus.
Academic Article Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.
Academic Article Genetic Ancestry Markers and Difference in A1c Between African American and White in the Diabetes Prevention Program.
Academic Article The SLC16A11 risk haplotype is associated with decreased insulin action, higher transaminases and large-size adipocytes.
Grant Center for Identification and Study of Individuals with Atypical Diabetes Mellitus
Academic Article Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Academic Article Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals.
Academic Article Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis.
Academic Article Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen.
Academic Article Metabolite Profiles of Incident Diabetes and Heterogeneity of Treatment Effect in the Diabetes Prevention Program.
Academic Article Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors.
Academic Article Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose.
Academic Article Genetics of diabetes mellitus and diabetes complications.
Academic Article A Polygenic Score for Type 2 Diabetes Risk Is Associated With Both the Acute and Sustained Response to Sulfonylureas.
Academic Article Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis.
Academic Article Sequencing cell-free fetal DNA in pregnant women with GCK-MODY: a proof-of-concept study.
Search Criteria
  • Diabetes Mellitus Type 2
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.