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Item TypeName
Academic Article Non-gingival soft tissue growths after allogeneic marrow transplantation.
Academic Article A phase II study of BTI-322, a monoclonal anti-CD2 antibody, for treatment of steroid-resistant acute graft-versus-host disease.
Academic Article Development and validation of a scale to measure symptoms of chronic graft-versus-host disease.
Academic Article Interleukin-1 blockade does not prevent acute graft-versus-host disease: results of a randomized, double-blind, placebo-controlled trial of interleukin-1 receptor antagonist in allogeneic bone marrow transplantation.
Academic Article Optimistic expectations and survival after hematopoietic stem cell transplantation.
Academic Article Randomized trial of CD8+ T-cell depletion in the prevention of graft-versus-host disease associated with donor lymphocyte infusion.
Academic Article Infliximab use in patients with severe graft-versus-host disease and other emerging risk factors of non-Candida invasive fungal infections in allogeneic hematopoietic stem cell transplant recipients: a cohort study.
Academic Article Comparative outcome of nonmyeloablative and myeloablative allogeneic hematopoietic cell transplantation for patients older than 50 years of age.
Academic Article The graft-versus-leukemia effects of allogeneic cell therapy.
Academic Article Unrelated donor bone marrow transplantation for chronic myelogenous leukemia: a decision analysis.
Academic Article Predicting costs of stem-cell transplantation.
Academic Article A novel rapid single nucleotide polymorphism (SNP)-based method for assessment of hematopoietic chimerism after allogeneic stem cell transplantation.
Academic Article Donor immunization with pneumococcal conjugate vaccine and early protective antibody responses following allogeneic hematopoietic cell transplantation.
Academic Article Comparable outcome with T-cell-depleted unrelated-donor versus related-donor allogeneic bone marrow transplantation.
Academic Article Partial CD8+ T-cell depletion of allogeneic peripheral blood stem cell transplantation is insufficient to prevent graft-versus-host disease.
Academic Article Mucositis after allogeneic hematopoietic stem cell transplantation: a cohort study of methotrexate- and non-methotrexate-containing graft-versus-host disease prophylaxis regimens.
Academic Article Blood and Marrow Transplant Clinical Trials Network State of the Science Symposium 2007.
Academic Article Adoptive immunotherapy with donor mononuclear cell infusions to treat relapse of acute leukemia or myelodysplasia after allogeneic bone marrow transplantation.
Academic Article A multicenter, randomized, double-blind comparison of different doses of intravenous immunoglobulin for prevention of graft-versus-host disease and infection after allogeneic bone marrow transplantation.
Academic Article Allogeneic bone marrow transplantation for chronic myelogenous leukemia: comparative analysis of unrelated versus matched sibling donor transplantation.
Academic Article Impact of conditioning regimen intensity on outcome of allogeneic hematopoietic cell transplantation for advanced acute myelogenous leukemia and myelodysplastic syndrome.
Academic Article Seroprotective titers against 2009 H1N1 influenza A virus after vaccination in allogeneic hematopoietic stem cell transplantation recipients.
Academic Article T-cell depletion in GVHD: less is more?
Academic Article Idiopathic thrombocytopenic purpura following allogeneic bone marrow transplantation--treatment with anti-D immunoglobulin.
Academic Article The costs and cost-effectiveness of unrelated donor bone marrow transplantation for chronic phase chronic myelogenous leukemia.
Academic Article Long-term follow-up of patients who achieved complete remission after donor leukocyte infusions.
Academic Article Graft-versus-tumor induction with donor leukocyte infusions as primary therapy for patients with malignancies.
Academic Article Establishment of complete and mixed donor chimerism after allogeneic lymphohematopoietic transplantation: recommendations from a workshop at the 2001 Tandem Meetings of the International Bone Marrow Transplant Registry and the American Society of Blood and Marrow Transplantation.
Academic Article Improved survival in lymphoma patients receiving sirolimus for graft-versus-host disease prophylaxis after allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning.
Academic Article Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials.
Academic Article Stem cell transplantation-harnessing of graft-versus-malignancy.
Academic Article Comparison of multiple immunization schedules for Haemophilus influenzae type b-conjugate and tetanus toxoid vaccines following bone marrow transplantation.
Academic Article Allogeneic transplantation with reduced-intensity conditioning for Hodgkin and non-Hodgkin lymphoma: importance of histology for outcome.
Academic Article Comparison of Tacrolimus and Sirolimus (Tac/Sir) versus Tacrolimus, Sirolimus, and mini-methotrexate (Tac/Sir/MTX) as acute graft-versus-host disease prophylaxis after reduced-intensity conditioning allogeneic peripheral blood stem cell transplantation.
Academic Article Iron overload in hematologic malignancies and outcome of allogeneic hematopoietic stem cell transplantation.
Academic Article A large single-center experience with allogeneic stem-cell transplantation for peripheral T-cell non-Hodgkin lymphoma and advanced mycosis fungoides/Sezary syndrome.
Academic Article Hyperlipidemia and statin use after allogeneic hematopoietic stem cell transplantation.
Academic Article Diverse patterns of T-cell response against multiple newly identified human Y chromosome-encoded minor histocompatibility epitopes.
Academic Article Classifying cytogenetics in patients with acute myelogenous leukemia in complete remission undergoing allogeneic transplantation: a Center for International Blood and Marrow Transplant Research study.
Academic Article Sirolimus and thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation.
Academic Article Prolonged erythroid aplasia after major ABO-mismatched transplantation for chronic myelogenous leukemia.
Academic Article A phase I/II double-blind, placebo-controlled study of recombinant human interleukin-11 for mucositis and acute GVHD prevention in allogeneic stem cell transplantation.
Academic Article Prognostic implications of declining plasma gelsolin levels after allogeneic stem cell transplantation.
Academic Article Voriconazole and sirolimus coadministration after allogeneic hematopoietic stem cell transplantation.
Academic Article Oral epithelial dysplasia and squamous cell carcinoma following allogeneic hematopoietic stem cell transplantation: clinical presentation and treatment outcomes.
Academic Article Recovery after stem-cell transplantation for hematologic diseases.
Academic Article Antibody response to DBY minor histocompatibility antigen is induced after allogeneic stem cell transplantation and in healthy female donors.
Academic Article Safety and efficacy of denileukin diftitox in patients with steroid-refractory acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Academic Article Extended follow-up of patients treated with imatinib mesylate (gleevec) for chronic myelogenous leukemia relapse after allogeneic transplantation: durable cytogenetic remission and conversion to complete donor chimerism without graft-versus-host disease.
Academic Article Predictors of improved progression-free survival after nonmyeloablative allogeneic stem cell transplantation for advanced chronic lymphocytic leukemia.
Academic Article High levels of B-cell activating factor in patients with active chronic graft-versus-host disease.
Academic Article Clinical practice. Long-term care after hematopoietic-cell transplantation in adults.
Academic Article Engraftment of autologous and allogeneic marrow HPCs after myeloablative therapy.
Academic Article A prognostic score for patients with acute leukemia or myelodysplastic syndromes undergoing allogeneic stem cell transplantation.
Academic Article The role of allogeneic stem cell transplantation for CML in the tyrosine kinase inhibitor era.
Academic Article Erythroid-lineage-specific engraftment in patients with severe hemoglobinopathy following allogeneic hematopoietic stem cell transplantation.
Academic Article The impact of geographic proximity to transplant center on outcomes after allogeneic hematopoietic stem cell transplantation.
Academic Article Pre-transplantation iron chelation in patients with MDS or acute leukemia and iron overload undergoing myeloablative allo-SCT.
Academic Article Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute graft-versus-host disease after marrow transplantation from unrelated donors.
Academic Article Costs of allogeneic hematopoietic cell transplantation with high-dose regimens.
Academic Article Severity of chronic graft-versus-host disease: association with treatment-related mortality and relapse.
Academic Article HLA-identical sibling allogeneic transplants versus chemotherapy in acute myelogenous leukemia with t(8;21) in first complete remission: collaborative study between the German AML Intergroup and CIBMTR.
Academic Article Sibling versus unrelated donor allogeneic hematopoietic cell transplantation for chronic myelogenous leukemia: refined HLA matching reveals more graft-versus-host disease but not less relapse.
Academic Article Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation.
Academic Article (90)Y-ibritumomab tiuxetan followed by reduced-intensity conditioning and allo-SCT in patients with advanced follicular lymphoma.
Academic Article Sirolimus, tacrolimus, and low-dose methotrexate as graft-versus-host disease prophylaxis in related and unrelated donor reduced-intensity conditioning allogeneic peripheral blood stem cell transplantation.
Academic Article The impact of soluble tumor necrosis factor receptor etanercept on the treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation.
Academic Article Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease.
Academic Article Bortezomib, tacrolimus, and methotrexate for prophylaxis of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation from HLA-mismatched unrelated donors.
Academic Article Sirolimus immunosuppression for graft-versus-host disease prophylaxis and therapy: an update.
Academic Article Risk factors for acute GVHD and survival after hematopoietic cell transplantation.
Academic Article Allogeneic hematopoietic cell transplantation for advanced polycythemia vera and essential thrombocythemia.
Academic Article Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation.
Academic Article Infusion of donor peripheral blood mononuclear cells to treat relapse after transplantation for chronic myelogenous leukemia.
Academic Article Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age.
Academic Article Sirolimus for GVHD prophylaxis in allogeneic stem cell transplantation.
Academic Article Relationship of Bcl-2 expression with apoptosis and proliferation in colonic graft versus host disease.
Academic Article Phase III study comparing methotrexate and tacrolimus (prograf, FK506) with methotrexate and cyclosporine for graft-versus-host disease prophylaxis after HLA-identical sibling bone marrow transplantation.
Academic Article Risk factors for cytomegalovirus reactivation after CD6+ T-cell-depleted allogeneic bone marrow transplantation.
Academic Article Guillain-Barré syndrome following allogeneic bone marrow transplantation.
Academic Article Prognostic factors for early severe pulmonary complications after hematopoietic stem cell transplantation.
Academic Article Allogeneic cell therapy for patients who relapse after autologous stem cell transplantation.
Academic Article A survey of diagnosis, management, and grading of chronic GVHD.
Academic Article Peripheral blood stem cells for allogeneic transplantation: a review.
Academic Article Prior rituximab correlates with less acute graft-versus-host disease and better survival in B-cell lymphoma patients who received allogeneic peripheral blood stem cell transplantation.
Academic Article Safety of posaconazole and sirolimus coadministration in allogeneic hematopoietic stem cell transplants.
Academic Article NCI First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.
Academic Article Combined CD4 T-cell and antibody response to human minor histocompatibility antigen DBY after allogeneic stem-cell transplantation.
Academic Article Autologous haemopoietic stem-cell transplantation followed by allogeneic or autologous haemopoietic stem-cell transplantation in patients with multiple myeloma (BMT CTN 0102): a phase 3 biological assignment trial.
Academic Article Minor histocompatibility antigen DBY elicits a coordinated B and T cell response after allogeneic stem cell transplantation.
Academic Article A disease risk index for patients undergoing allogeneic stem cell transplantation.
Academic Article Recovery of B-cell homeostasis after rituximab in chronic graft-versus-host disease.
Academic Article Effect of stem cell source on outcomes after unrelated donor transplantation in severe aplastic anemia.
Academic Article Allogeneic stem cell transplantation for aplastic anemia.
Academic Article Long-term follow-up of reduced-intensity allogeneic stem cell transplantation for chronic lymphocytic leukemia: prognostic model to predict outcome.
Academic Article Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation.
Academic Article Sirolimus is associated with veno-occlusive disease of the liver after myeloablative allogeneic stem cell transplantation.
Academic Article Iron overload in patients with acute leukemia or MDS undergoing myeloablative stem cell transplantation.
Academic Article Cord-blood hematopoietic stem cell transplant confers an increased risk for human herpesvirus-6-associated acute limbic encephalitis: a cohort analysis.
Academic Article Use of recombinant human erythropoietin in allogeneic bone marrow transplant donor/recipient pairs.
Academic Article Quality of life following bone marrow transplantation: findings from a multicentre study.
Academic Article Donor mononuclear cell infusions as therapy for B-cell lymphoproliferative disorder following allogeneic bone marrow transplant.
Academic Article FK506 (Tacrolimus) monotherapy for prevention of graft-versus-host disease after histocompatible sibling allogenic bone marrow transplantation.
Academic Article Immune reconstitution after double umbilical cord blood stem cell transplantation: comparison with unrelated peripheral blood stem cell transplantation.
Academic Article Improved survival for patients with acute myelogenous leukemia.
Academic Article Prior gemtuzumab ozogamicin exposure significantly increases the risk of veno-occlusive disease in patients who undergo myeloablative allogeneic stem cell transplantation.
Academic Article Donor immunization with Haemophilus influenzae type b (HIB)-conjugate vaccine in allogeneic bone marrow transplantation.
Academic Article Sirolimus-based graft-versus-host disease prophylaxis protects against cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation: a cohort analysis.
Academic Article Current and future approaches for control of graft-versus-host disease.
Academic Article The outcome of full-intensity and reduced-intensity conditioning matched sibling or unrelated donor transplantation in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia in first and second complete remission.
Academic Article ABO incompatibility as an adverse risk factor for survival after allogeneic bone marrow transplantation.
Academic Article Impact of cytogenetics on outcome of de novo and therapy-related AML and MDS after allogeneic transplantation.
Academic Article Novel drugs for the prevention and treatment of acute GVHD.
Concept Transplantation, Homologous
Academic Article Ocular graft-versus-host disease: a review.
Academic Article KIR ligand incompatibility is not associated with relapse reduction after double umbilical cord blood transplantation.
Academic Article Busulfan dose intensity and outcomes in reduced-intensity allogeneic peripheral blood stem cell transplantation for myelodysplastic syndrome or acute myeloid leukemia.
Academic Article ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death.
Academic Article Multicenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation.
Academic Article Outcomes of allogeneic hematopoietic cell transplantation in patients with dyskeratosis congenita.
Academic Article Rituximab prophylaxis prevents corticosteroid-requiring chronic GVHD after allogeneic peripheral blood stem cell transplantation: results of a phase 2 trial.
Academic Article Outcomes in patients age 70 or older undergoing allogeneic hematopoietic stem cell transplantation for hematologic malignancies.
Academic Article Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.
Academic Article Reduced-intensity hematopoietic cell transplantation for patients with primary myelofibrosis: a cohort analysis from the center for international blood and marrow transplant research.
Academic Article BK virus disease after allogeneic stem cell transplantation: a cohort analysis.
Academic Article Post-transplantation B cell activating factor and B cell recovery before onset of chronic graft-versus-host disease.
Academic Article Steroid-refractory acute graft-versus-host disease: is there an effective therapy?
Academic Article Factors associated with bronchiolitis obliterans syndrome and chronic graft-versus-host disease after allogeneic hematopoietic cell transplantation.
Academic Article Validation and refinement of the Disease Risk Index for allogeneic stem cell transplantation.
Academic Article Allotransplantation for patients age =40 years with non-Hodgkin lymphoma: encouraging progression-free survival.
Academic Article Tacrolimus/sirolimus vs tacrolimus/methotrexate as GVHD prophylaxis after matched, related donor allogeneic HCT.
Academic Article Hematopoietic stem cell transplantation donor sources in the 21st century: choosing the ideal donor when a perfect match does not exist.
Academic Article Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation.
Academic Article Donor chimerism early after reduced-intensity conditioning hematopoietic stem cell transplantation predicts relapse and survival.
Academic Article Characterization of oral involvement in acute graft-versus-host disease.
Academic Article Sequential infusion of donor-derived dendritic cells with donor lymphocyte infusion for relapsed hematologic cancers after allogeneic hematopoietic stem cell transplantation.
Academic Article Outcomes and management strategies for graft failure after umbilical cord blood transplantation.
Academic Article Phase I trial of maintenance sorafenib after allogeneic hematopoietic stem cell transplantation for fms-like tyrosine kinase 3 internal tandem duplication acute myeloid leukemia.
Academic Article Myelodysplastic syndrome evolving from aplastic anemia treated with immunosuppressive therapy: efficacy of hematopoietic stem cell transplantation.
Academic Article Long-term survival after transplantation of unrelated donor peripheral blood or bone marrow hematopoietic cells for hematologic malignancy.
Academic Article Absolute lymphocyte count recovery after allogeneic hematopoietic stem cell transplantation predicts clinical outcome.
Academic Article The utility of routine chest radiography in the initial evaluation of adult patients with febrile neutropenia patients undergoing HSCT.
Academic Article Angiogenic cytokines are antibody targets during graft-versus-leukemia reactions.
Academic Article Center for International Blood and Marrow Transplant Research chronic graft-versus-host disease risk score predicts mortality in an independent validation cohort.
Academic Article Impact of Chronic Graft-versus-Host Disease on Late Relapse and Survival on 7,489 Patients after Myeloablative Allogeneic Hematopoietic Cell Transplantation for Leukemia.
Academic Article A refined risk score for acute graft-versus-host disease that predicts response to initial therapy, survival, and transplant-related mortality.
Academic Article Phase II Trial of Tandem High-Dose Chemotherapy with Autologous Stem Cell Transplantation Followed by Reduced-Intensity Allogeneic Stem Cell Transplantation for Patients with High-Risk Lymphoma.
Academic Article Efficacy of immune suppression tapering in treating relapse after reduced intensity allogeneic stem cell transplantation.
Academic Article A Bortezomib-Based Regimen Offers Promising Survival and Graft-versus-Host Disease Prophylaxis in Myeloablative HLA-Mismatched and Unrelated Donor Transplantation: A Phase II Trial.
Academic Article Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD.
Academic Article The addition of sirolimus to the graft-versus-host disease prophylaxis regimen in reduced intensity allogeneic stem cell transplantation for lymphoma: a multicentre randomized trial.
Academic Article Improved Treatment-Related Mortality and Overall Survival of Patients with Grade IV Acute GVHD in the Modern Years.
Academic Article Infused total nucleated cell dose is a better predictor of transplant outcomes than CD34+ cell number in reduced-intensity mobilized peripheral blood allogeneic hematopoietic cell transplantation.
Academic Article Circulating T follicular helper cells with increased function during chronic graft-versus-host disease.
Academic Article Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: a CIBMTR analysis.
Academic Article Allogeneic transplantation is not superior to chemotherapy in most patients over 40 years of age with Philadelphia-negative acute lymphoblastic leukemia in first remission.
Academic Article Ipilimumab for Patients with Relapse after Allogeneic Transplantation.
Academic Article Does FLT3 mutation impact survival after hematopoietic stem cell transplantation for acute myeloid leukemia? A Center for International Blood and Marrow Transplant Research (CIBMTR) analysis.
Academic Article A phase I study of CD25/regulatory T-cell-depleted donor lymphocyte infusion for relapse after allogeneic stem cell transplantation.
Academic Article Next-generation sequencing-based detection of circulating tumour DNA After allogeneic stem cell transplantation for lymphoma.
Academic Article Plasma biomarkers of risk for death in a multicenter phase 3 trial with uniform transplant characteristics post-allogeneic HCT.
Academic Article Haematopoietic cell transplantation with and without sorafenib maintenance for patients with FLT3-ITD acute myeloid leukaemia in first complete remission.
Academic Article Heavy/light chain ratio normalization prior to transplant is of independent prognostic significance in multiple myeloma: a BMT CTN 0102 correlative study.
Academic Article Safety and efficacy of allogeneic hematopoietic stem cell transplant after PD-1 blockade in relapsed/refractory lymphoma.
Academic Article Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation.
Academic Article Management of refractory autoimmune hemolytic anemia via allogeneic stem cell transplantation.
Academic Article Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-ß production.
Academic Article Improved survival after acute graft-versus-host disease diagnosis in the modern era.
Academic Article Venous thromboembolism is associated with graft-versus-host disease and increased non-relapse mortality after allogeneic hematopoietic stem cell transplantation.
Academic Article Donor-engrafted CHIP is common among stem cell transplant recipients with unexplained cytopenias.
Academic Article Antibodies targeting surface membrane antigens in patients with chronic graft-versus-host disease.
Academic Article Outcomes after Allogeneic Stem Cell Transplantation in Patients with Double-Hit and Double-Expressor Lymphoma.
Academic Article Bortezomib-based immunosuppression after reduced-intensity conditioning hematopoietic stem cell transplantation: randomized phase II results.
Academic Article Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.
Academic Article Phase 1 clinical trial evaluating abatacept in patients with steroid-refractory chronic graft-versus-host disease.
Academic Article Final results from a defibrotide treatment-IND study for patients with hepatic veno-occlusive disease/sinusoidal obstruction syndrome.
Academic Article Safety and immunogenicity of conjugate quadrivalent meningococcal vaccination after hematopoietic cell transplantation.
Academic Article Cytomegalovirus Infection Among Cord Blood Allogeneic Transplantation Recipients: Low Incidence of Cytomegalovirus Events without High-Dose Valacyclovir Prophylaxis.
Academic Article Upper gastrointestinal acute graft-versus-host disease adds minimal prognostic value in isolation or with other graft-versus-host disease symptoms as currently diagnosed and treated.
Academic Article Early Clinical Predictors of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Myeloablative Stem Cell Transplantation.
Academic Article Comparative Analysis of Calcineurin Inhibitor-Based Methotrexate and Mycophenolate Mofetil-Containing Regimens for Prevention of Graft-versus-Host Disease after Reduced-Intensity Conditioning Allogeneic Transplantation.
Academic Article Allogeneic Hematopoietic Cell Transplantation in Patients Aged 50Years or Older with Severe Aplastic Anemia.
Academic Article Inferior Outcomes with Cyclosporine and Mycophenolate Mofetil after Myeloablative Allogeneic Hematopoietic Cell Transplantation.
Academic Article Effect of Sirolimus on Immune Reconstitution Following Myeloablative Allogeneic Stem Cell Transplantation: An Ancillary Analysis of a Randomized Controlled Trial Comparing Tacrolimus/Sirolimus and Tacrolimus/Methotrexate (Blood and Marrow Transplant Clinical Trials Network/BMT CTN 0402).
Academic Article Prognostic Score and Cytogenetic Risk Classification for Chronic Lymphocytic Leukemia Patients: Center for International Blood and Marrow Transplant Research Report.
Academic Article Recurrent genetic HLA loss in AML relapsed after matched unrelated allogeneic hematopoietic cell transplantation.
Academic Article Allogeneic Stem Cell Transplantation Provides Durable Remission in Patients with Primary Mediastinal Large B Cell Lymphoma.
Academic Article Choice of conditioning regimens for bone marrow transplantation in severe aplastic anemia.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.