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Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition.
Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage.
Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance.
The BRCA1-?11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin.
CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer.