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Yeast Swd2 is essential because of antagonism between Set1 histone methyltransferase complex and APT (associated with Pta1) termination factor.
The role of cotranscriptional histone methylations.
Dimethylation of H3K4 by Set1 recruits the Set3 histone deacetylase complex to 5' transcribed regions.
H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway.
Systematic dissection of roles for chromatin regulators in a yeast stress response.
Feedback control of Set1 protein levels is important for proper H3K4 methylation patterns.
Determinants of Histone H3K4 Methylation Patterns.
The Set1 N-terminal domain and Swd2 interact with RNA polymerase II CTD to recruit COMPASS.
Histone Lysine N Methyltransferase