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The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.
A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth.
Unregulated ARF6 activation in epithelial cysts generates hyperactive signaling endosomes and disrupts morphogenesis.
Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes.
Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells.
Proto-Oncogene Proteins c-bcl-2
Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness.
Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo.
Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer.
Clinical evaluation of BCL-2/XL levels pre- and post- HER2-targeted therapy.
Proto Oncogene Proteins c bcl 6