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One or more keywords matched the following items that are connected to Gardella, Thomas
Item TypeName
Academic Article Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors.
Academic Article Zinc(II)-mediated enhancement of the agonist activity of histidine-substituted parathyroid hormone(1-14) analogues.
Academic Article The history of parathyroid hormone and its receptor: structure-based design of parathyroid hormone analogues.
Academic Article Evaluating the signal transduction mechanism of the parathyroid hormone 1 receptor. Effect of receptor-G-protein interaction on the ligand binding mechanism and receptor conformation.
Academic Article Mutational analysis of the receptor-activating region of human parathyroid hormone.
Academic Article The carboxy-terminus of parathyroid hormone is essential for hormone processing and secretion.
Academic Article Selective and nonselective inverse agonists for constitutively active type-1 parathyroid hormone receptors: evidence for altered receptor conformations.
Academic Article The (1-14) fragment of parathyroid hormone (PTH) activates intact and amino-terminally truncated PTH-1 receptors.
Academic Article Interaction of PTH and PTHrP with their receptors.
Academic Article Residues in the membrane-spanning and extracellular loop regions of the parathyroid hormone (PTH)-2 receptor determine signaling selectivity for PTH and PTH-related peptide.
Academic Article Residue 19 of the parathyroid hormone: structural consequences.
Academic Article Amino-terminal parathyroid hormone fragment analogs containing alpha,alpha-di-alkyl amino acids at positions 1 and 3.
Academic Article Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin. Evidence for a common pattern of ligand-receptor interaction.
Academic Article Constitutive activation of the cyclic adenosine 3',5'-monophosphate signaling pathway by parathyroid hormone (PTH)/PTH-related peptide receptors mutated at the two loci for Jansen's metaphyseal chondrodysplasia.
Academic Article Residue 19 of the parathyroid hormone (PTH) modulates ligand interaction with the juxtamembrane region of the PTH-1 receptor.
Academic Article Parathyroid hormone (PTH)-(1-14) and -(1-11) analogs conformationally constrained by alpha-aminoisobutyric acid mediate full agonist responses via the juxtamembrane region of the PTH-1 receptor.
Academic Article Enhanced activity in parathyroid hormone-(1-14) and -(1-11): novel peptides for probing ligand-receptor interactions.
Academic Article Functional evidence for an intramolecular side chain interaction between residues 6 and 10 of receptor-bound parathyroid hormone analogues.
Academic Article Full-length chicken parathyroid hormone. Biosynthesis in Escherichia coli and analysis of biologic activity.
Academic Article Structure based design of parathyroid hormone analogs.
Academic Article Receptors for PTH and PTHrP: their biological importance and functional properties.
Academic Article Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective parathyroid hormone analogs.
Academic Article Novel parathyroid hormone (PTH) antagonists that bind to the juxtamembrane portion of the PTH/PTH-related protein receptor.
Academic Article Backbone-methylated analogues of the principle receptor binding region of human parathyroid hormone. Evidence for binding to both the N-terminal extracellular domain and extracellular loop region.
Academic Article Converting parathyroid hormone-related peptide (PTHrP) into a potent PTH-2 receptor agonist.
Academic Article Homolog-scanning mutagenesis of the parathyroid hormone (PTH) receptor reveals PTH-(1-34) binding determinants in the third extracellular loop.
Academic Article Minimization of parathyroid hormone. Novel amino-terminal parathyroid hormone fragments with enhanced potency in activating the type-1 parathyroid hormone receptor.
Academic Article Tuberoinfundibular peptide 39 binds to the parathyroid hormone (PTH)/PTH-related peptide receptor, but functions as an antagonist.
Academic Article Chemistry as an expanding resource in protein science: fully synthetic and fully active human parathyroid hormone-related protein (1-141).
Academic Article Evidence for a ligand interaction site at the amino-terminus of the parathyroid hormone (PTH)/PTH-related protein receptor from cross-linking and mutational studies.
Academic Article Role of amino acid side chains in region 17-31 of parathyroid hormone (PTH) in binding to the PTH receptor.
Academic Article Studies of the N-terminal region of a parathyroid hormone-related peptide (1-36) analog: receptor subtype-selective agonists, antagonists, and photochemical cross-linking agents.
Academic Article Molecular properties of the PTH/PTHrP receptor.
Academic Article Toward parathyroid hormone minimization: conformational studies of cyclic PTH(1-14) analogues.
Academic Article Cooperative interaction of arginine-19 and the N-terminal signaling domain in the affinity and potency of parathyroid hormone.
Academic Article C-terminal analogues of parathyroid hormone: effect of C-terminus function on helical structure, stability, and bioactivity.
Academic Article Role of the extracellular regions of the parathyroid hormone (PTH)/PTH-related peptide receptor in hormone binding.
Academic Article The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34).
Academic Article Mutation of the signal peptide-encoding region of the preproparathyroid hormone gene in familial isolated hypoparathyroidism.
Academic Article Identification of a contact site for residue 19 of parathyroid hormone (PTH) and PTH-related protein analogs in transmembrane domain two of the type 1 PTH receptor.
Academic Article Amino-terminal modifications of human parathyroid hormone (PTH) selectively alter phospholipase C signaling via the type 1 PTH receptor: implications for design of signal-specific PTH ligands.
Academic Article Autoactivation of type-1 parathyroid hormone receptors containing a tethered ligand.
Academic Article Parathyroid hormone and parathyroid hormone-related peptide, and their receptors.
Academic Article Identification of determinants of inverse agonism in a constitutively active parathyroid hormone/parathyroid hormone-related peptide receptor by photoaffinity cross-linking and mutational analysis.
Academic Article Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations.
Academic Article Sustained cyclic AMP production by parathyroid hormone receptor endocytosis.
Academic Article Progress, paradox, and potential: parathyroid hormone research over five decades.
Academic Article Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH.
Academic Article Non-canonical signaling of the PTH receptor.
Academic Article Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation.
Academic Article Expression of human parathyroid hormone-(1-84) in Escherichia coli as a factor X-cleavable fusion protein.
Academic Article Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor.
Academic Article Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues.
Academic Article Transmembrane residues of the parathyroid hormone (PTH)/PTH-related peptide receptor that specifically affect binding and signaling by agonist ligands.
Academic Article Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides.
Academic Article Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm.
Academic Article Determinants of [Arg2]PTH-(1-34) binding and signaling in the transmembrane region of the parathyroid hormone receptor.
Academic Article Multiple sites of contact between the carboxyl-terminal binding domain of PTHrP-(1--36) analogs and the amino-terminal extracellular domain of the PTH/PTHrP receptor identified by photoaffinity cross-linking.
Academic Article Retromer terminates the generation of cAMP by internalized PTH receptors.
Academic Article Parathyroid hormone (PTH)-PTH-related peptide hybrid peptides reveal functional interactions between the 1-14 and 15-34 domains of the ligand.
Academic Article Analysis of parathyroid hormone's principal receptor-binding region by site-directed mutagenesis and analog design.
Academic Article The hydrophobic residues phenylalanine 184 and leucine 187 in the type-1 parathyroid hormone (PTH) receptor functionally interact with the amino-terminal portion of PTH-(1-34).
Concept Receptors, Parathyroid Hormone
Concept Parathyroid Hormone-Related Protein
Concept Receptor, Parathyroid Hormone, Type 2
Concept Parathyroid Hormone
Concept Receptor, Parathyroid Hormone, Type 1
Academic Article Backbone modification of a polypeptide drug alters duration of action in vivo.
Academic Article Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase.
Academic Article Actions of the small molecule ligands SW106 and AH-3960 on the type-1 parathyroid hormone receptor.
Academic Article International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors.
Academic Article A Homozygous [Cys25]PTH(1-84) Mutation That Impairs PTH/PTHrP Receptor Activation Defines a Novel Form of Hypoparathyroidism.
Academic Article PTH receptor-1 signalling-mechanistic insights and therapeutic prospects.
Academic Article Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling.
Academic Article Diphtheria Toxin- and GFP-Based Mouse Models of Acquired Hypoparathyroidism and Treatment With a Long-Acting Parathyroid Hormone Analog.
Academic Article Pharmacodynamic Actions of a Long-Acting PTH Analog (LA-PTH) in Thyroparathyroidectomized (TPTX) Rats and Normal Monkeys.
Grant MUTANT ANALYSIS OF HUMAN PARATHYROID HORMONE
Grant Hormonal Control of Calcium Metabolism
Academic Article SIKs control osteocyte responses to parathyroid hormone.
Academic Article Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist.
Academic Article Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1-34) Peptide Fragment.
Academic Article Jansen Metaphyseal Chondrodysplasia due to Heterozygous H223R-PTH1R Mutations With or Without Overt Hypercalcemia.
Academic Article Studies of the N-Terminal Region of a Parathyroid Hormone-Related Peptide(1-36) Analog: Receptor Subtype-Selective Agonists, Antagonists, and Photochemical Cross-Linking Agents1.
Academic Article Knockin mouse with mutant Ga11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors.
Academic Article Corrigendum: SIKs control osteocyte responses to parathyroid hormone.
Academic Article Tuberoinfundibular Peptide 39 Binds to the Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor, but Functions as an Antagonist**This work was supported by grants from the NIH, NIDDK (DK-11794), the Swedish Foundation for International Cooperation in Research and Higher Education (to K.B.J.), and the Deutsche Forschungsgemeinschaft (JO 315/1-2; to M.R.J.).
Academic Article Development of Potent, Protease-Resistant Agonists of the Parathyroid Hormone Receptor with Broad ß Residue Distribution.
Academic Article Progression of Mineral Ion Abnormalities in Patients With Jansen Metaphyseal Chondrodysplasia.
Academic Article Calcium fluxes at the bone/plasma interface: Acute effects of parathyroid hormone (PTH) and targeted deletion of PTH/PTH-related peptide (PTHrP) receptor in the osteocytes.
Academic Article Parathyroid hormone(1-34) and its analogs differentially modulate osteoblastic Rankl expression via PKA/SIK2/SIK3 and PP1/PP2A-CRTC3 signaling.
Academic Article Receptor selectivity from minimal backbone modification of a polypeptide agonist.
Grant PTH Inverse Agonists as Therapy for Jansen?s Disease
Academic Article Structure and dynamics of the active human parathyroid hormone receptor-1.
Academic Article Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling.
Academic Article Use of Backbone Modification To Enlarge the Spatiotemporal Diversity of Parathyroid Hormone Receptor-1 Signaling via Biased Agonism.
Academic Article PTH/PTHrP Receptor Signaling, Allostery, and Structures.
Academic Article Improved GPCR ligands from nanobody tethering.
Academic Article Allosteric interactions in the parathyroid hormone GPCR-arrestin complex formation.
Search Criteria
  • Parathyroid Hormone
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.