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One or more keywords matched the following properties of Duda, Dan
keywords Metastasis
keywords Liver Cancers
overview Current Research Goals Over the last decade and a half, I have built a productive Liver Cancer Research Program within the Steele Laboratories for Tumor Biology. The translational goal of this program is to increase the durability of response to the most effective available therapies. The approach is to identify new cellular and molecular mechanisms of local and metastatic tumor progression and treatment resistance and validate them as new targets for combination therapies for these cancers. To this end, my group is studying the activity of antiangiogenic drugs, antifibrotic drugs or radiotherapy approaches in combination with immunotherapy. In preclinical studies, we are employing models that reproduce the hallmarks of human cancers (i.e., genetically engineered models of primary hepatocellular carcinoma and cholangiocarcinoma, and metastatic pancreatic, breast and prostate carcinomas). In parallel, in clinical studies in cancer patients, we are conducting correlative studies of biomarkers of response to the same approaches. My research efforts are currently supported by grants from Federal sources – US Department of Defense (DoD) and National Cancer Institute (NCI) – and Foundations, and by agreements with commercial partners. Track Record and Service I have authored over 240 publications so far, of which 140+ are original reports, including in basic research journals such as Nature, Nature Medicine, Nature Biotechnology, Nature Genetics, Cell, Cancer Cell, Science Translational Medicine, Gut and Hepatology as well as in clinical journals such as the Journal of Clinical Oncology, npj Precision Oncology and JAMA Oncology. Over the last 2 decades, I have been invited to present our results at over 200 local, national and international meetings, including in Grand Rounds (Harvard, Mayo Clinic, Yale, Fred Hutchinson Cancer Center), Plenary and State-of-the-art Talks (AACR, ISSCR, IASGO) and several Keynote Lectures. For my work, I have received multiple awards, including from the AACR, Cancer Research Institute (CRI), IASGO, and MGH. I became an Honorary Member of the Academy of Medical Sciences of Romania in 2012, and was elected Member of the College of Fellows of the American Institute for Medical and Biomedical Engineering (AIMBE) in 2020. I have been serving as chartered or ad-hoc Member, and Chair or co-Chair of US NCI, American Cancer Society (ACS), US Department of Defense (DOD), and Belgium FWO Med4 panels since 2012. I am a Founding Editor of the journal Surgery, Gastroenterology and Oncology, a Senior Associate Editor of the International Journal of Radiation Oncology*Biology*Physics, and an Editorial Board member for several other journals, including Clinical & Translational Radiation Oncology, Journal of Hepatocellular Carcinoma and Cancers. Since 2015, I am serving as the Secretary General of the IASGO. In addition, I am a member of the American Association for the Study of Liver Diseases (AASLD) Liver Fibrosis Special Interest Group and of the NCI Hepatobiliary Task Force for Immuno-Oncology Biomarkers. Teaching I am teaching tumor biology and translational oncology through daily supervision of postdoctoral research fellows, and graduate and undergraduate students (50+ in the last 15 years). As a passionate supporter of the IASGO’s mission to globalize the best medical practice and knowledge all over the world. I have been coordinating, teaching and directing Postgraduate Courses in 28 countries in Asia, Europe, Africa and the Americas, since 2013. I have also taught nationally in ASTRO and RTOG translational meetings for residents and clinicians and locally in the MIT-HMS HST Program since 2005. In addition, I am coordinating a research exchange student program with University of Muenster, Germany since 2015, and directing the Annual Course titled “Methods in Biomedical Engineering, Tumor Biology and Immunology” at MGH since 2004. Education and Academic Appointments I obtained a DMD from the University of Medicine Iasi, Romania in 1993, and then earned a PhD in Medical Sciences (Gastrointestinal Surgery) from Tohoku University Graduate School of Medicine, Sendai, Japan in 2001. After graduation, I pursued postdoctoral training with Professor Rakesh K. Jain in the Steele Laboratories for Tumor Biology, Department of Radiation Oncology, MGH and Harvard Medical School in Boston. I became a Junior Faculty member at Harvard (Instructor) in 2004, and then rose through the ranks to Full Investigator at MGH Research Institute in 2016 and Associate Professor of Tumor Biology (Radiation Oncology) in 2012. In 2016, I was appointed as the Director of Translational Research in Gastrointestinal Radiation Oncology at MGH. In 2020, I received the honorary degree "Doctor Honoris Causa" from the University of Medicine Iasi, Romania, my Alma Mater. (For more information, see full CV at: https://steelelabs.mgh.harvard.edu/data/research_statements/2/Duda_HMS_CV.pdf)
One or more keywords matched the following items that are connected to Duda, Dan
Item TypeName
Award or Honor Receipt Scholar-in-Training Award
Award or Honor Receipt Career Development Award for Cancer Research in Angiogenesis
Award or Honor Receipt Postdoctoral Fellowship
Academic Article Gene therapy for pancreatic cancer based on genetic characterization of the disease.
Academic Article Oncolytic replication-competent adenovirus suppresses tumor angiogenesis through preserved E1A region.
Academic Article Differential transplantability of tumor-associated stromal cells.
Academic Article VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects.
Academic Article Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells.
Academic Article Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines.
Academic Article Role of bone marrow-derived cells in tumor angiogenesis and treatment.
Academic Article Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients.
Academic Article VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation.
Academic Article Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers.
Academic Article Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus.
Academic Article Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study.
Academic Article Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide.
Academic Article Pleiotropy of tissue-specific growth factors: from neurons to vessels via the bone marrow.
Academic Article Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma.
Academic Article Is vasculogenesis crucial for the regrowth of irradiated tumours?
Academic Article Safety, Efficacy, and Biomarker Exploration in a Phase II Study of Bevacizumab, Oxaliplatin, and Gemcitabine in Recurrent Müllerian Carcinoma.
Academic Article Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo.
Academic Article Malignant cells facilitate lung metastasis by bringing their own soil.
Academic Article Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy.
Academic Article Angiogenesis in brain tumours.
Academic Article Antiangiogenic agents for the treatment of glioblastoma.
Academic Article A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients.
Academic Article American Association for Cancer Research 98th Annual Meeting. Angiogenesis and anti-angiogenesis in cancer.
Academic Article Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.
Academic Article Lessons from phase III clinical trials on anti-VEGF therapy for cancer.
Academic Article Direct in vitro evidence and in vivo analysis of the antiangiogenesis effects of interleukin 12.
Academic Article Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis.
Academic Article A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer.
Academic Article Direct evidence for lineage-dependent effects of bone marrow stromal cells on tumor progression.
Academic Article Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors?
Academic Article Efficacy, safety, pharmacokinetics, and biomarkers of cediranib monotherapy in advanced hepatocellular carcinoma: a phase II study.
Academic Article An isolated tumor perfusion model in mice.
Academic Article Going beyond systemic fluoropyrimidines with radiation therapy for rectal cancer: what should be the priority?
Academic Article C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells.
Academic Article VEGFR1-activity-independent metastasis formation.
Academic Article Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer.
Academic Article Phase I study of cetuximab, irinotecan, and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer.
Academic Article VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer.
Academic Article Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer.
Academic Article A transient parabiosis skin transplantation model in mice.
Academic Article Gene therapy for pancreatic cancer using an adenovirus vector encoding soluble flt-1 vascular endothelial growth factor receptor.
Academic Article The antiangiogenesis effect of interleukin 12 during early growth of human pancreatic cancer in SCID mice.
Academic Article Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials.
Academic Article Development of sunitinib in hepatocellular carcinoma: rationale, early clinical experience, and correlative studies.
Academic Article Exploratory analysis of early toxicity of sunitinib in advanced hepatocellular carcinoma patients: kinetics and potential biomarker value.
Academic Article Normalization of the vasculature for treatment of cancer and other diseases.
Academic Article Changes in biomarkers of inflammation and angiogenesis during androgen deprivation therapy for prostate cancer.
Academic Article Vascular normalization as an emerging strategy to enhance cancer immunotherapy.
Academic Article Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice.
Academic Article Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models.
Academic Article Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas.
Academic Article The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma.
Academic Article Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors.
Academic Article Targeted therapy in rectal cancer.
Academic Article Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.
Academic Article AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.
Academic Article Premetastatic lung "niche": is vascular endothelial growth factor receptor 1 activation required?
Academic Article Antiangiogenesis and drug delivery to tumors: bench to bedside and back.
Academic Article Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study.
Academic Article Biomarkers of antiangiogenic therapy: how do we move from candidate biomarkers to valid biomarkers?
Academic Article Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice.
Academic Article Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape.
Academic Article HCC and angiogenesis: possible targets and future directions.
Academic Article An exploratory study of inflammatory cytokines as prognostic biomarkers in patients with ductal pancreatic adenocarcinoma.
Academic Article Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.
Academic Article Biomarkers of response and resistance to antiangiogenic therapy.
Academic Article Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation.
Academic Article In vivo evaluation of the early events associated with liver metastasis of circulating cancer cells.
Academic Article Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer.
Academic Article CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?
Academic Article Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy.
Academic Article Studying primary tumor-associated fibroblast involvement in cancer metastasis in mice.
Concept Colonic Neoplasms
Concept Breast Neoplasms
Concept Stomach Neoplasms
Concept Chemotherapy, Cancer, Regional Perfusion
Concept Head and Neck Neoplasms
Concept Bile Duct Neoplasms
Concept Neoplasms, Experimental
Concept Colorectal Neoplasms
Concept Pancreatic Neoplasms
Concept Ovarian Neoplasms
Concept Mammary Neoplasms, Experimental
Concept Esophageal Neoplasms
Concept Brain Neoplasms
Concept Lung Neoplasms
Concept Rectal Neoplasms
Concept Gastrointestinal Neoplasms
Concept Neoplasms
Concept Lymphatic Metastasis
Concept Biliary Tract Neoplasms
Concept Liver Neoplasms, Experimental
Concept Soft Tissue Neoplasms
Concept Liver Neoplasms
Concept Prostatic Neoplasms
Concept Neoplasm Metastasis
Concept Cerebellar Neoplasms
Academic Article Magnetic resonance imaging biomarkers in hepatocellular carcinoma: association with response and circulating biomarkers after sunitinib therapy.
Academic Article Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma.
Academic Article Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression.
Academic Article Can we identify predictive biomarkers for antiangiogenic therapy of cancer using mathematical modeling?
Academic Article Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation.
Academic Article Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers.
Academic Article Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice.
Academic Article A phase II and biomarker study of ramucirumab, a human monoclonal antibody targeting the VEGF receptor-2, as first-line monotherapy in patients with advanced hepatocellular cancer.
Academic Article Benefits of vascular normalization are dose and time dependent--letter.
Academic Article Characterization of functional transient receptor potential melastatin 8 channels in human pancreatic ductal adenocarcinoma cells.
Academic Article A phase 1/2 and biomarker study of preoperative short course chemoradiation with proton beam therapy and capecitabine followed by early surgery for resectable pancreatic ductal adenocarcinoma.
Academic Article Seeds and soil: unraveling the role of local tumor stroma in distant metastasis.
Academic Article Immune checkpoint blockade in hepatocellular carcinoma: current progress and future directions.
Academic Article CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice.
Academic Article Lessons From 30 Years of Teaching About the Microenvironment of Tumors.
Academic Article Epigenetic Silencing of GNMT Gene in Pancreatic Adenocarcinoma.
Academic Article Lessons from anti-vascular endothelial growth factor and anti-vascular endothelial growth factor receptor trials in patients with glioblastoma.
Academic Article Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases.
Academic Article Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer.
Academic Article Reply to Ciccolini et al.: Using mathematical modeling to predict response to antiangiogenic therapy in cancer patients.
Academic Article An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis.
Academic Article From the Guest Editors: Role of Tumor Microenvironment in Tumor Progression and Treatment Response: A 30 Years' Journey.
Academic Article Chemotherapy and antiangiogenics in biliary tract cancer.
Academic Article A Multicenter, Phase II, Randomized, Noncomparative Clinical Trial of Radiation and Temozolomide with or without Vandetanib in Newly Diagnosed Glioblastoma Patients.
Academic Article A phase I study of cediranib in combination with cilengitide in patients with recurrent glioblastoma.
Academic Article Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment.
Academic Article Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients.
Academic Article Familial Gastric Cancers.
Academic Article Rationally combining anti-VEGF therapy with checkpoint inhibitors in hepatocellular carcinoma.
Academic Article Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival.
Academic Article PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity.
Academic Article Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages.
Academic Article Exploration of Imaging Biomarkers for Predicting Survival of Patients With Advanced Non-Small Cell Lung Cancer Treated With Antiangiogenic Chemotherapy.
Academic Article A protein and mRNA expression-based classification of gastric cancer.
Academic Article Molecular Biomarkers of Response to Antiangiogenic Therapy for Cancer.
Academic Article Tissue Microbiome Profiling Identifies an Enrichment of Specific Enteric Bacteria in Opisthorchis viverrini Associated Cholangiocarcinoma.
Academic Article Role of stromal cell-derived factor 1a pathway in bone metastatic prostate cancer.
Academic Article Immune modulation by hypofractionated stereotactic radiation therapy: Therapeutic implications.
Grant Visualizing Immune Responses in vivo: a systems biology approach
Grant Role of SDF1a pathway in prostate cancer relapse and metastasis post-radiotherapy
Grant Integrative Pathophysiology of Solid Tumors
Academic Article Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases.
Academic Article Phase II and Biomarker Study of Cabozantinib in Metastatic Triple-Negative Breast Cancer Patients.
Academic Article Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma.
Academic Article Corrigendum: Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.
Academic Article A phase 2 and biomarker study of cabozantinib in patients with advanced cholangiocarcinoma.
Academic Article Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors.
Academic Article Correlation of blood and physiologic markers with effect of bevacizumab (BV) with chemoradiation therapy in rectal cancer (RC).
Academic Article Feasibility, phase I, and phase II studies of tandutinib, an oral platelet-derived growth factor receptor-ß tyrosine kinase inhibitor, in patients with recurrent glioblastoma.
Academic Article Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.
Academic Article Anti-angiogenesis for cancer revisited: Is there a role for combinations with immunotherapy?
Academic Article Genomic and proteomic characterization of ARID1A chromatin remodeller in ampullary tumors.
Academic Article Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.
Academic Article Can smart nanomedicine deliver effective targeted cytotoxic treatments to hepatocellular carcinomas while reducing the liver damage?
Academic Article The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation.
Academic Article Phase 2 and biomarker study of trebananib, an angiopoietin-blocking peptibody, with and without bevacizumab for patients with recurrent glioblastoma.
Academic Article New Perspective on the Treatment of Intractable Gastrointestinal Cancers: Role of Combination Therapies.
Academic Article Combined delivery of sorafenib and a MEK inhibitor using CXCR4-targeted nanoparticles reduces hepatic fibrosis and prevents tumor development.
Academic Article Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.
Academic Article Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2.
Academic Article Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer.
Academic Article Phase I and Biomarker Study of Plerixafor and Bevacizumab in Recurrent High-Grade Glioma.
Academic Article A Phase II and Biomarker Study of Sorafenib Combined with Modified FOLFOX in Patients with Advanced Hepatocellular Carcinoma.
Academic Article Dual endothelin receptor inhibition enhances T-DM1 efficacy in brain metastases from HER2-positive breast cancer.
Academic Article FOLFOX plus ziv-aflibercept or placebo in first-line metastatic esophagogastric adenocarcinoma: A double-blind, randomized, multicenter phase 2 trial.
Academic Article Role of Apelin in Glioblastoma Vascularization and Invasion after Anti-VEGF Therapy: What Is the Impact on the Immune System?
Academic Article Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial.
Academic Article Changes in tumor vascularity depicted by contrast-enhanced EUS as a predictor of prognosis and treatment efficacy in patients with unresectable pancreatic cancer (PEACE): A study protocol.
Academic Article Dual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma.
Academic Article Phase II trial of ponatinib in patients with bevacizumab-refractory glioblastoma.
Academic Article A phase II study of cabozantinib alone or in combination with trastuzumab in breast cancer patients with brain metastases.
Academic Article Bevacizumab Reduces Permeability and Concurrent Temozolomide Delivery in a Subset of Patients with Recurrent Glioblastoma.
Academic Article Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition.
Academic Article Overcoming sorafenib treatment-resistance in hepatocellular carcinoma: A future perspective at a time of rapidly changing treatment paradigms.
Academic Article Combining microenvironment normalization strategies to improve cancer immunotherapy.
Academic Article Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy.
Academic Article Lack of Targetable FGFR2 Fusions in Endemic Fluke-Associated Cholangiocarcinoma.
Academic Article Potential Circulating Biomarkers of Recurrence after Hepatic Resection or Liver Transplantation in Hepatocellular Carcinoma Patients.
Academic Article Optimizing Radiation Therapy to Boost Systemic Immune Responses in Breast Cancer: A Critical Review for Breast Radiation Oncologists.
Academic Article Oncolytic Virus with Attributes of Vesicular Stomatitis Virus and Measles Virus in Hepatobiliary and Pancreatic Cancers.
Academic Article Going Beyond VEGF Pathway Inhibition for Antiangiogenic Cancer Therapy: Is Inhibition of the PP2A/B55a Complex the Answer?
Academic Article Phase I and Biomarker Study of the Wnt Pathway Modulator DKN-01 in Combination with Gemcitabine/Cisplatin in Advanced Biliary Tract Cancer.
Academic Article Impact of Integrating Insulin-Like Growth Factor 1 Levels into Model for End-Stage Liver Disease Score for Survival Prediction in Hepatocellular Carcinoma Patients.
Academic Article Randomized Phase II and Biomarker Study of Pembrolizumab plus Bevacizumab versus Pembrolizumab Alone for Patients with Recurrent Glioblastoma.
Academic Article Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma.
Academic Article Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model.
Grant Multiplexed time domain fluorescence tomography of tumor biomarkers during immunotherapy
Grant A Phase II and Biomarker Study of Dual VEGF/PD-L1 Blockade in Neoadjuvant Setting in Resectable HCC Patients
Academic Article Toward Personalized Radiation Therapy of Liver Metastasis: Importance of Serial Blood Biomarkers.
Award or Honor Receipt Fellow
Award or Honor Receipt Honoree of the One Hundred
Grant Vascularized tumor explants for drug testing
Grant Radiation and CSPG4-specifc CAR T cell based combinatorial therapy for the in vivo treatment of TNBC
Search Criteria
  • Cancer
  • metastasis
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.