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One or more keywords matched the following items that are connected to Hafler, David
Item TypeName
Mentoring - Completed Student Project Antigen Specificity of Immunoglobulin Isolated from the CSF of 5 Patients with Multiple Sclerosis
Academic Article Autoreactive T cells in multiple sclerosis.
Academic Article TCR usage in human and experimental demyelinating disease.
Academic Article Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease.
Academic Article Human and murine CD4 T cell reactivity to a complex antigen: recognition of the synthetic random polypeptide glatiramer acetate.
Academic Article Decreases in interleukin-4 secretion by invariant CD4(-)CD8(-)V alpha 24J alpha Q T cells in peripheral blood of patientswith relapsing-remitting multiple sclerosis.
Academic Article The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis.
Academic Article Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein.
Academic Article Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping.
Academic Article Suppressor T cells in human diseases.
Academic Article Dysregulated T cell expression of TIM3 in multiple sclerosis.
Academic Article Treatment of progressive multiple sclerosis with pulse cyclophosphamide/methylprednisolone: response to therapy is linked to the duration of progressive disease.
Academic Article Common T-cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis.
Academic Article Ubiquitous pathogens: links between infection and autoimmunity in MS?
Academic Article Oral administration of myelin induces antigen-specific TGF-beta 1 secreting T cells in patients with multiple sclerosis.
Academic Article Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: increased interleukin-4 production and associated eosinophilia.
Academic Article CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trial.
Academic Article Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses.
Academic Article T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis.
Academic Article Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis.
Academic Article T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions.
Academic Article Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions.
Academic Article New therapeutic approaches for multiple sclerosis.
Academic Article Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands.
Academic Article Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation.
Academic Article Degeneracy, as opposed to specificity, in immunotherapy.
Academic Article Role of Th1 and Th2 cells in neurologic disorders.
Academic Article Multiple sclerosis.
Academic Article A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility.
Academic Article Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease.
Academic Article Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human antimouse responses.
Academic Article Immunosuppression in progressive multiple sclerosis with high dose intravenous cyclophosphamide and monoclonal antibodies.
Academic Article Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis.
Academic Article Molecular pathogenesis of multiple sclerosis.
Academic Article T cell vaccination in multiple sclerosis: a preliminary report.
Academic Article Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain.
Academic Article Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis.
Academic Article Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis.
Academic Article CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls.
Academic Article T helper cell differentiation in multiple sclerosis and autoimmunity.
Academic Article Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score.
Academic Article Regulatory T cells in the central nervous system.
Academic Article Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments.
Academic Article Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein.
Academic Article Three-year open protocol continuation study of oral tolerization with myelin antigens in multiple sclerosis and design of a phase III pivotal trial.
Academic Article A high-density screen for linkage in multiple sclerosis.
Academic Article Myelin basic protein and proteolipid protein reactivity of brain- and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis.
Academic Article Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid.
Academic Article Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis.
Academic Article A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis.
Academic Article Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis.
Academic Article Oral administration of myelin induces antigen-specific TGF-beta 1-secreting T cells in multiple sclerosis patients.
Academic Article Changes in cytokine secretion induced by altered peptide ligands of myelin basic protein peptide 85-99.
Academic Article Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
Academic Article Risk alleles for multiple sclerosis identified by a genomewide study.
Academic Article Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells.
Academic Article Fingolimod for multiple sclerosis.
Academic Article Altered blood T-cell subsets in patients with multiple sclerosis.
Academic Article Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.
Academic Article Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis.
Academic Article Antigen-specific immunosuppression: oral tolerance for the treatment of autoimmune disease.
Academic Article Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions.
Academic Article Pulse cyclophosphamide plus methylprednisolone induces myelin-antigen-specific IL-4-secreting T cells in multiple sclerosis patients.
Academic Article The role of the CD58 locus in multiple sclerosis.
Academic Article Variation within DNA repair pathway genes and risk of multiple sclerosis.
Academic Article Multiple sclerosis.
Academic Article Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand.
Academic Article In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.
Academic Article Immunotherapy of multiple sclerosis.
Academic Article Genetic analysis of multiple sclerosis.
Academic Article Applying a new generation of genetic maps to understand human inflammatory disease.
Academic Article The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus.
Academic Article Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein.
Academic Article Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS.
Academic Article The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation.
Academic Article Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4+ 2H4+) T cells in multiple sclerosis.
Academic Article Gene expression profiling in MS: what is the clinical relevance?
Academic Article A novel population of B7-1+ T cells producing intracellular IL-4 is decreased in patients with multiple sclerosis.
Academic Article Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility.
Academic Article The potential of restricted T cell recognition of myelin basic protein epitopes in the therapy of multiple sclerosis.
Academic Article A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis.
Academic Article Lack of TIM-3 immunoregulation in multiple sclerosis.
Academic Article Phenotypic and functional analysis of T cells cloned directly from the blood and cerebrospinal fluid of patients with multiple sclerosis.
Academic Article Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses.
Academic Article A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.
Academic Article Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis.
Academic Article Decrease of suppressor inducer (CD4+2H4+) T cells in multiple sclerosis cerebrospinal fluid.
Academic Article Immunosuppression with high-dose i.v. cyclophosphamide and ACTH in progressive multiple sclerosis: cumulative 6-year experience in 164 patients.
Academic Article The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions.
Academic Article CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis.
Academic Article Abnormal Tr1 differentiation in multiple sclerosis.
Academic Article T cells in multiple sclerosis and inflammatory central nervous system diseases.
Academic Article T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans.
Academic Article Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients.
Academic Article Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
Academic Article The distinction blurs between an autoimmune versus microbial hypothesis in multiple sclerosis.
Academic Article Interleukin-1 corrects the defective autologous mixed lymphocyte response in multiple sclerosis.
Academic Article CTLA4 is associated with susceptibility to multiple sclerosis.
Academic Article In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosis.
Academic Article Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis.
Academic Article Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis.
Academic Article MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination.
Academic Article A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility.
Academic Article A review of T-cell receptors in multiple sclerosis: clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide.
Academic Article Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination.
Academic Article Multiple sclerosis and regulatory T cells.
Academic Article Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
Academic Article Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.
Academic Article A randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis.
Academic Article Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data.
Academic Article Immunoregulation in multiple sclerosis.
Academic Article CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis.
Academic Article T cell subsets in patients with multiple sclerosis. An overview.
Academic Article The development of antigen specific therapies for autoimmune diseases; investigations in multiple sclerosis as a paradigm for rheumatoid arthritis.
Academic Article Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis.
Academic Article Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex.
Academic Article Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin.
Academic Article Multiple sclerosis.
Academic Article Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis.
Academic Article In vitro evidence that immunuaffinity-purified MOG contains immunogenic quantities of contaminating mouse IgG; techniques for producing Ig-free MOG.
Academic Article Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis.
Academic Article An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity.
Academic Article T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis.
Academic Article Cross-reactive TCR responses to self antigens presented by different MHC class II molecules.
Academic Article Comprehensive phenotyping in multiple sclerosis: discovery based proteomics and the current understanding of putative biomarkers.
Academic Article A second major histocompatibility complex susceptibility locus for multiple sclerosis.
Academic Article Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis.
Academic Article Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.
Academic Article Reactivity of normal T-cell lines to MBP isolated from normal and multiple sclerosis white matter.
Academic Article Immunosuppression with monoclonal antibodies in multiple sclerosis.
Academic Article In vivo labeling of blood T cells: rapid traffic into cerebrospinal fluid in multiple sclerosis.
Academic Article Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases.
Academic Article Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis.
Academic Article Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonß therapy in multiple sclerosis.
Academic Article Immunohistochemical analysis of suppressor-inducer and helper-inducer T cells in multiple sclerosis brain tissue.
Academic Article Immunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12.
Academic Article Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin.
Academic Article Loss of functional suppression is linked to decreases in circulating suppressor-inducer (CD4+ 2H4+) T cells in multiple sclerosis.
Academic Article Decreased autologous mixed lymphocyte reaction in multiple sclerosis.
Academic Article Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells.
Academic Article HLA B*44: protective effects in MS susceptibility and MRI outcome measures.
Academic Article Cumulative experience with high-dose intravenous cyclophosphamide and ACTH therapy in chronic progressive multiple sclerosis.
Academic Article Selective loss of the suppressor-inducer T-cell subset in progressive multiple sclerosis. Analysis with anti-2H4 monoclonal antibody.
Academic Article Increased frequency of gamma delta T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. Reactivity, cytotoxicity, and T cell receptor V gene rearrangements.
Academic Article Therapy for multiple sclerosis.
Academic Article Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report of the Northeast Cooperative Multiple Sclerosis Treatment Group.
Academic Article High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model.
Academic Article Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis.
Academic Article The use of cyclophosphamide in the treatment of multiple sclerosis.
Academic Article Immunologic mechanisms and therapy in multiple sclerosis.
Academic Article IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.
Academic Article T-cell recognition of myelin basic protein.
Academic Article Re: GAMES issue study: Are international genetic consortia functional?
Academic Article Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response.
Academic Article Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor.
Academic Article T-cells in multiple sclerosis.
Academic Article Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis.
Academic Article Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals.
Academic Article Antigen-specific TGF-beta1 secretion with bovine myelin oral tolerization in multiple sclerosis.
Concept Multiple Sclerosis
Concept Multiple Sclerosis, Chronic Progressive
Concept Multiple Sclerosis, Relapsing-Remitting
Academic Article PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis.
Academic Article Specific peripheral B cell tolerance defects in patients with multiple sclerosis.
Academic Article Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis.
Academic Article Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
Academic Article Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing-remitting multiple sclerosis.
Academic Article Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects.
Academic Article Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus.
Academic Article The plasticity of human Treg and Th17 cells and its role in autoimmunity.
Academic Article Regulatory T cells in autoimmune neuroinflammation.
Academic Article Small-molecule ROR?t antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.
Academic Article Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.
Academic Article Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.
Academic Article B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes.
Academic Article Multiple sclerosis-a quiet revolution.
Academic Article Genetic variants associated with autoimmunity drive NF?B signaling and responses to inflammatory stimuli.
Academic Article Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis.
Academic Article Corrigendum: multiple sclerosis-a quiet revolution.
Academic Article Biomarkers in multiple sclerosis.
Academic Article Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived Immunoglobulins.
Academic Article The Link Between CD6 and Autoimmunity: Genetic and Cellular Associations.
Academic Article Evaluation of KIR4.1 as an Immune Target in Multiple Sclerosis.
Academic Article Multiple sclerosis: genetics, biomarkers, treatments.
Academic Article Linking Genotype to Clinical Phenotype in Multiple Sclerosis: In Search of the Holy Grail.
Grant CELLULAR IMMUNOLOGIC STUDIES IN CNS INFLAMMTORY DISEASE
Grant T CELL RECOGNITION OF MYELIN IN MULTIPLE SCLEROSIS
Grant TIM family of genes: Role in T cell immunity and tolerance
Grant ACE: Investigation of Innate Immunity in Multiple Sclerosis
Grant Role of regulatory CD4+CD25+ T cells in diabetes
Grant Regulatory T Cells in Autoimmune Disease
Grant ORAL TOLERANCE IN MURINE AND HUMAN AUTOIMMUNE DISEASES
Grant The role of the innate immune system on Treg reprogramming in human autoimmune di
Grant Antigen Presentation and T cell Programming in Human Autoimmune Diseases
Grant Treatment of Autoimmune Disease by Costimulatory Signal*
Grant Antigen Specific Therapy in CNS Autoimmune Diseases
Grant IMMUNE MONITORING OF ANTIGEN SPECIFIC THERAPY
Grant T Cell Recognition of Myelin in Multiple Sclerosis
Grant FEDERATION OF CLINICAL IMMUNOLOGY SOCIETIES MEETING
Grant The Role of Rare Variants in Multiple Sclerosis Risk
Academic Article Class II HLA interactions modulate genetic risk for multiple sclerosis.
Academic Article Regulatory T Cells: From Discovery to Autoimmunity.
Academic Article Multiple sclerosis.
Academic Article Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo.
Academic Article Activated ß-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity.
Academic Article Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis.
Academic Article Multiple sclerosis enters a grey area.
Academic Article Siponimod Chips Away at Progressive MS.
Academic Article Differential expression of the T-cell inhibitor TIGIT in glioblastoma and MS.
Academic Article CXCR3+ T cells in multiple sclerosis correlate with reduced diversity of the gut microbiome.
Academic Article Two genetic variants explain the association of European ancestry with multiple sclerosis risk in African-Americans.
Academic Article Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis.
Academic Article 23Na imaging: Worth its salt for understanding multiple sclerosis.
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  • Sclerosis
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.