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One or more keywords matched the following items that are connected to Manning, Brendan
Item TypeName
Academic Article The LKB1 tumor suppressor negatively regulates mTOR signaling.
Academic Article Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.
Academic Article Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.
Academic Article The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor.
Academic Article Targeting the PI3K-Akt pathway in human cancer: rationale and promise.
Academic Article mTOR links oncogenic signaling to tumor cell metabolism.
Academic Article The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.
Academic Article Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2.
Academic Article United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling.
Academic Article Common corruption of the mTOR signaling network in human tumors.
Academic Article AKT/PKB signaling: navigating downstream.
Academic Article TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.
Academic Article Transcriptional control of cellular metabolism by mTOR signaling.
Academic Article Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
Academic Article Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.
Academic Article Rheb fills a GAP between TSC and TOR.
Academic Article Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.
Academic Article Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis.
Academic Article Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
Academic Article Challenges and opportunities in defining the essential cancer kinome.
Academic Article Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.
Academic Article Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways.
Academic Article NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth.
Academic Article Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.
Academic Article mTOR couples cellular nutrient sensing to organismal metabolic homeostasis.
Academic Article Oncogenic EGFR signaling activates an mTORC2-NF-?B pathway that promotes chemotherapy resistance.
Academic Article Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors.
Academic Article Comment on "A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation": building a model of the mTOR signaling network with a potentially faulty tool.
Concept Signal Transduction
Academic Article Adaptation to starvation: translating a matter of life or death.
Academic Article Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling.
Academic Article Cell signalling: nutrient sensing lost in cancer.
Academic Article Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.
Academic Article A growing role for mTOR in promoting anabolic metabolism.
Academic Article mTORC1 status dictates tumor response to targeted therapeutics.
Academic Article Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Academic Article Coordinated regulation of protein synthesis and degradation by mTORC1.
Academic Article mTORC1 signaling activates NRF1 to increase cellular proteasome levels.
Academic Article Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP.
Academic Article Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation.
Academic Article CASTORing New Light on Amino Acid Sensing.
Academic Article Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex.
Academic Article mTORC1 signaling and the metabolic control of cell growth.
Academic Article AKT/PKB Signaling: Navigating the Network.
Academic Article The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels.
Academic Article Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase.
Academic Article The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism.
Academic Article Molecular logic of mTORC1 signalling as a metabolic rheostat.
Search Criteria
  • Pathway Signal Transduction
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.