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One or more keywords matched the following properties of Sorger, Peter
PropertyValue
keywords Cancer Biology, Systems Pharmacology, Single-Cell Imaging, Clinical Trials
overview Research in the Sorger Lab focuses on signal transduction networks controlling cell proliferation and death, dysregulation of these networks in cancer and inflammation and mechanisms of action of therapeutic drugs targeting signaling proteins. His group uses mathematical and experimental approaches to construct and test computational models of oncogenic and signaling networks in cell lines, patient-derived cells and murine disease models. The Sorger Lab also develops open-source software for analyzing biological networks and drug mechanism of action and it participates in multiple collaborative programs working to improve data access and reproducibility. Recent research extends a systems pharmacology approach to high-dimensional analysis of biopsy samples and the interpretation of clinical trials. As founding head of the Harvard Program in Therapeutic Science (HiTS) and its Laboratory Systems Pharmacology (LSP) Peter leads a multi-institutional effort to advance the basic and translational science used to develop new medicines, create novel drug combinations and identify responsive patients. The LSP applies systems approaches to understanding and mitigating adverse drug effects and to designing new clinical trials. The recently established Harvard-MIT Center of Regulatory Sciences focuses on improving how drugs are evaluated, brought to market and used in patients. HiTS includes faculty from seven institutions.
preferred title Otto Krayer Professor of Systems Pharmacology
One or more keywords matched the following items that are connected to Sorger, Peter
Item TypeName
Academic Article Yeast kinetochore microtubule dynamics analyzed by high-resolution three-dimensional microscopy.
Academic Article Flexible informatics for linking experimental data to mathematical models via DataRail.
Academic Article Microfluidics closes in on point-of-care assays.
Academic Article Systematic calibration of a cell signaling network model.
Academic Article Adaptive informatics for multifactorial and high-content biological data.
Academic Article Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008).
Academic Article A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.
Academic Article Comparative autoregressive moving average analysis of kinetochore microtubule dynamics in yeast.
Academic Article Phenotypic clustering of yeast mutants based on kinetochore microtubule dynamics.
Academic Article Physicochemical modelling of cell signalling pathways.
Academic Article Snapshots of protein dynamics and post-translational modifications in one experiment--beta-catenin and its functions.
Academic Article Coupling cell division and cell death to microtubule dynamics.
Academic Article Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.
Academic Article Collecting and organizing systematic sets of protein data.
Academic Article Systems biology and combination therapy in the quest for clinical efficacy.
Academic Article Towards a rigorous assessment of systems biology models: the DREAM3 challenges.
Academic Article A reductionist's systems biology: opinion.
Academic Article Dissecting variability in responses to cancer chemotherapy through systems pharmacology.
Academic Article Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data.
Concept Systems Biology
Concept Database Management Systems
Concept Drug Delivery Systems
Concept Point-of-Care Systems
Concept Systems Theory
Concept MAP Kinase Signaling System
Academic Article Real-time imaging of the dynamics of death receptors and therapeutics that overcome TRAIL resistance in tumors.
Academic Article Metrics other than potency reveal systematic variation in responses to cancer drugs.
Academic Article Decision-tree based model analysis for efficient identification of parameter relations leading to different signaling states.
Academic Article Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis.
Academic Article Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway.
Grant Systems Biology of cell Decision Processes
Grant Cancer Center Support (Core) Grant
Grant Cell and tumor genetics of mitotic arrest checkpoints
Grant Pharmaco Response Signatures and Disease Mechanism
Grant Computation and Mechanical Modeling of Chromosome Dynamics
Grant Molecular analysis of chromosome segregation in yeast
Grant A Proteomics Research Resource for Integrative Biology
Grant High Performance Clustered Storage for Image Management
Grant Pharmaco Response Signatures and Disease Mechanism
Grant The HMS Laboratory of Systems Pharmacology
Grant Biochemical and Genetic Analysis of Yeast Kinetochores
Academic Article Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state.
Academic Article Fundamental trade-offs between information flow in single cells and cellular populations.
Grant Harnessing Diverse BioInformatic Approaches to Repurpose Drugs for Alzheimer's Disease
Academic Article The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.
Academic Article Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy.
Grant Systems Pharmacology of Therapeutic and Adverse Responses to ImmuneCheckpoint and Small Molecule Drugs
Academic Article Encoding Growth Factor Identity in the Temporal Dynamics of FOXO3 under the Combinatorial Control of ERK and AKT Kinases.
Grant Pre-cancer atlases of cutaneous and hematologic origin (PATCH Center)
Grant Harnessing Diverse BioInformatic Approaches to Repurpose Drugs for Alzheimers Disease
Academic Article Facetto: Combining Unsupervised and Supervised Learning for Hierarchical Phenotype Analysis in Multi-Channel Image Data.
Academic Article Inferring reaction network structure from single-cell, multiplex data, using toric systems theory.
Academic Article SYLARAS: A Platform for the Statistical Analysis and Visual Display of Systemic Immunoprofiling Data and Its Application to Glioblastoma.
Academic Article Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells.
Search Criteria
  • System
  • dynamics
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.