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One or more keywords matched the following properties of Sorger, Peter
overview Research in the Sorger Lab focuses on signal transduction networks controlling cell proliferation and death, dysregulation of these networks in cancer and inflammation and mechanisms of action of therapeutic drugs targeting signaling proteins. His group uses mathematical and experimental approaches to construct and test computational models of oncogenic and signaling networks in cell lines, patient-derived cells and murine disease models. The Sorger Lab also develops open-source software for analyzing biological networks and drug mechanism of action and it participates in multiple collaborative programs working to improve data access and reproducibility. Recent research extends a systems pharmacology approach to high-dimensional analysis of biopsy samples and the interpretation of clinical trials. As founding head of the Harvard Program in Therapeutic Science (HiTS) and its Laboratory Systems Pharmacology (LSP) Peter leads a multi-institutional effort to advance the basic and translational science used to develop new medicines, create novel drug combinations and identify responsive patients. The LSP applies systems approaches to understanding and mitigating adverse drug effects and to designing new clinical trials. The recently established Harvard-MIT Center of Regulatory Sciences focuses on improving how drugs are evaluated, brought to market and used in patients. HiTS includes faculty from seven institutions.
One or more keywords matched the following items that are connected to Sorger, Peter
Item TypeName
Academic Article Probing the architecture of a simple kinetochore using DNA-protein crosslinking.
Academic Article Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells.
Academic Article A dual role for Bub1 in the spindle checkpoint and chromosome congression.
Academic Article Tracing the pathway of spindle assembly checkpoint signaling.
Academic Article Properties of cell death models calibrated and compared using Bayesian approaches.
Academic Article Bayesian network approach to cell signaling pathway modeling.
Academic Article Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour.
Academic Article Flexible informatics for linking experimental data to mathematical models via DataRail.
Academic Article Studying chromosome instability in the mouse.
Academic Article Modeling a snap-action, variable-delay switch controlling extrinsic cell death.
Academic Article Systematic calibration of a cell signaling network model.
Academic Article Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics.
Academic Article Structure and assembly of turnip crinkle virus. II. Mechanism of reassembly in vitro.
Academic Article Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction.
Academic Article Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis.
Academic Article A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.
Academic Article Comparative autoregressive moving average analysis of kinetochore microtubule dynamics in yeast.
Academic Article Phenotypic clustering of yeast mutants based on kinetochore microtubule dynamics.
Academic Article A data-driven computational model of the ErbB receptor signaling network.
Academic Article Molecular structures and interactions in the yeast kinetochore.
Academic Article The response of human epithelial cells to TNF involves an inducible autocrine cascade.
Academic Article Quantitative analysis of pathways controlling extrinsic apoptosis in single cells.
Academic Article Measuring and modeling apoptosis in single cells.
Academic Article Physicochemical modelling of cell signalling pathways.
Academic Article The logic of EGFR/ErbB signaling: theoretical properties and analysis of high-throughput data.
Academic Article New approaches to modeling complex biochemistry.
Academic Article Logic-based models for the analysis of cell signaling networks.
Academic Article Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation.
Academic Article Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks.
Academic Article Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.
Academic Article Coupling cell division and cell death to microtubule dynamics.
Academic Article Chromosome movement: kinetochores motor along.
Academic Article Crystal structure of the yeast inner kinetochore subunit Cep3p.
Academic Article Collecting and organizing systematic sets of protein data.
Academic Article Systems biology and combination therapy in the quest for clinical efficacy.
Academic Article Towards a rigorous assessment of systems biology models: the DREAM3 challenges.
Academic Article Classic and contemporary approaches to modeling biochemical reactions.
Academic Article Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networks.
Academic Article A reductionist's systems biology: opinion.
Academic Article Programming biological models in Python using PySB.
Academic Article Comparing signaling networks between normal and transformed hepatocytes using discrete logical models.
Academic Article Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding.
Academic Article Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data.
Academic Article Training signaling pathway maps to biochemical data with constrained fuzzy logic: quantitative analysis of liver cell responses to inflammatory stimuli.
Academic Article The Open Microscopy Environment (OME) Data Model and XML file: open tools for informatics and quantitative analysis in biological imaging.
Academic Article Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling.
Academic Article Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis.
Concept Models, Molecular
Concept Models, Theoretical
Concept Models, Animal
Concept Models, Genetic
Concept Linear Models
Concept Disease Models, Animal
Concept Models, Statistical
Concept Models, Biological
Concept Xenograft Model Antitumor Assays
Academic Article Real-time imaging of the dynamics of death receptors and therapeutics that overcome TRAIL resistance in tumors.
Academic Article Decision-tree based model analysis for efficient identification of parameter relations leading to different signaling states.
Academic Article Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis.
Academic Article A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks.
Academic Article Fractional killing arises from cell-to-cell variability in overcoming a caspase activity threshold.
Academic Article Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs.
Grant Systems Biology of cell Decision Processes
Grant Cell and tumor genetics of mitotic arrest checkpoints
Grant Computation and Mechanical Modeling of Chromosome Dynamics
Grant Molecular analysis of chromosome segregation in yeast
Grant Pharmaco Response Signatures and Disease Mechanism
Grant The HMS Laboratory of Systems Pharmacology
Academic Article Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation.
Academic Article Structure-guided development of covalent TAK1 inhibitors.
Academic Article Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state.
Academic Article Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.
Academic Article Fundamental trade-offs between information flow in single cells and cellular populations.
Academic Article From word models to executable models of signaling networks using automated assembly.
Grant Systems Pharmacology of Therapeutic and Adverse Responses to ImmuneCheckpoint and Small Molecule Drugs
Grant Harnessing Diverse BioInformatic Approaches to Repurpose Drugs for Alzheimers Disease
Academic Article INDRA-IPM: interactive pathway modeling using natural language with automated assembly.
Academic Article Inferring reaction network structure from single-cell, multiplex data, using toric systems theory.
Academic Article Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity.
Academic Article Receptor-based mechanism of relative sensing and cell memory in mammalian signaling networks.
Academic Article SARS-CoV-2 infection protects against rechallenge in rhesus macaques.
Academic Article Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing.
Academic Article A Proof of Concept for Biomarker-Guided Targeted Therapy against Ovarian Cancer Based on Patient-Derived Tumor Xenografts.
Academic Article Comparing the Efficacy of Cancer Therapies between Subgroups in Basket Trials.
Academic Article Differentiable biology: using deep learning for biophysics-based and data-driven modeling of molecular mechanisms.
Search Criteria
  • Modelling
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.