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One or more keywords matched the following items that are connected to Gray, Nathanael
Item TypeName
Academic Article p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol.
Academic Article Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.
Academic Article Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors.
Academic Article Chemical and biological profile of dual Cdk1 and Cdk2 inhibitors.
Academic Article Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins.
Academic Article Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
Academic Article A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts.
Academic Article ATP-site directed inhibitors of cyclin-dependent kinases.
Academic Article CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation.
Academic Article Identification of homeodomain proteins, PBX1 and PREP1, involved in the transcription of murine leukemia virus.
Academic Article Systematic kinome shRNA screening identifies CDK11 (PITSLRE) kinase expression is critical for osteosarcoma cell growth and proliferation.
Academic Article Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.
Academic Article DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.
Concept Cyclin B
Concept Cyclin-Dependent Kinase 2
Concept Cyclin-Dependent Kinase 8
Concept Cyclin D1
Concept Cyclin-Dependent Kinase 6
Concept Cyclin A
Concept Cyclin-Dependent Kinase 9
Concept Cyclin-Dependent Kinase 4
Concept Cyclin D3
Concept Cyclin-Dependent Kinases
Academic Article Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.
Academic Article CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.
Academic Article Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor.
Academic Article CDK7-dependent transcriptional addiction in triple-negative breast cancer.
Academic Article YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers.
Academic Article Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors.
Academic Article THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors.
Academic Article Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma.
Academic Article BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.
Academic Article Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.
Academic Article Enhancer profiling identifies critical cancer genes and characterizes cell identity in adult T-cell leukemia.
Academic Article Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors.
Academic Article CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation.
Academic Article Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.
Academic Article EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma.
Academic Article High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma.
Academic Article Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13.
Academic Article A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification.
Academic Article Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML.
Academic Article Small-molecule targeting of brachyury transcription factor addiction in chordoma.
Academic Article Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6.
Academic Article CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation.
Academic Article Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity.
Academic Article Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype.
Academic Article A kinase-independent role for CDK8 in BCR-ABL1+ leukemia.
Academic Article CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer.
Academic Article Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13.
Search Criteria
  • Cyclin E
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.