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One or more keywords matched the following items that are connected to Selkoe, Dennis
Item TypeName
Academic Article Amyloid beta-protein and the genetics of Alzheimer's disease.
Academic Article Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization.
Academic Article Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody.
Academic Article Translating cell biology into therapeutic advances in Alzheimer's disease.
Academic Article Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.
Academic Article Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage.
Academic Article The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.
Academic Article Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Academic Article In search of gamma-secretase: presenilin at the cutting edge.
Academic Article Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Academic Article Alzheimer's disease is a synaptic failure.
Academic Article Alzheimer disease: mechanistic understanding predicts novel therapies.
Academic Article Toward a remembrance of things past: deciphering Alzheimer disease.
Academic Article Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease.
Academic Article Alzheimer's disease: genotypes, phenotypes, and treatments.
Academic Article Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes.
Academic Article FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
Academic Article Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Academic Article Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.
Academic Article Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.
Academic Article Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.
Academic Article Cell surface amyloid beta-protein precursor colocalizes with beta 1 integrins at substrate contact sites in neural cells.
Academic Article Cell biology of the beta-amyloid precursor protein and the genetics of Alzheimer's disease.
Academic Article Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
Academic Article Alzheimer's disease. A technical KO of amyloid-beta peptide.
Academic Article Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides.
Academic Article The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum.
Academic Article Purification and characterization of the human gamma-secretase complex.
Academic Article Skeletal and CNS defects in Presenilin-1-deficient mice.
Academic Article Subcellular distribution and turnover of presenilins in transfected cells.
Academic Article Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
Academic Article Alzheimer's disease. Missense on the membrane.
Academic Article Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein.
Academic Article Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.
Academic Article Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells.
Academic Article Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
Academic Article Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
Academic Article Biochemistry. Intramembrane proteases--mixing oil and water.
Academic Article Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.
Academic Article Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Academic Article Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.
Academic Article Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
Academic Article The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease.
Academic Article The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
Academic Article The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.
Academic Article Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation.
Academic Article The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.
Academic Article Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease.
Academic Article Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
Academic Article The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins.
Academic Article Deciphering the genetic basis of Alzheimer's disease.
Academic Article The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments.
Academic Article Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease.
Academic Article Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin.
Academic Article Identification of beta-secretase (BACE1) substrates using quantitative proteomics.
Academic Article Peroxisome proliferator-activated receptor gamma enhances the activity of an insulin degrading enzyme-like metalloprotease for amyloid-beta clearance.
Academic Article Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates.
Academic Article Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.
Academic Article Alzheimer's disease: genes, proteins, and therapy.
Academic Article Antisera to an amino-terminal peptide detect the amyloid protein precursor of Alzheimer's disease and recognize senile plaques.
Academic Article Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates.
Academic Article Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.
Academic Article Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
Academic Article Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration.
Academic Article Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.
Academic Article Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins.
Academic Article Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.
Concept Membrane Proteins
Academic Article Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein.
Academic Article Functional analysis and purification of a Pen-2 fusion protein for ?-secretase structural studies.
Academic Article Complement and microglia mediate early synapse loss in Alzheimer mouse models.
Grant Aging in the Brain: The Role of the Fibrous Proteins
Search Criteria
  • Membrane Proteins
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.