Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Edit functionality is currently unavailable.

Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following items that are connected to Selkoe, Dennis
Item TypeName
Academic Article Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF.
Academic Article Translating cell biology into therapeutic advances in Alzheimer's disease.
Academic Article gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins.
Academic Article Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein.
Academic Article Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities.
Academic Article Permeability and residual plasma volume of human, Dutch variant, and rat amyloid beta-protein 1-40 at the blood-brain barrier.
Academic Article Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42.
Academic Article Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
Academic Article A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.
Academic Article Toward a remembrance of things past: deciphering Alzheimer disease.
Academic Article Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease.
Academic Article A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils.
Academic Article Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays.
Academic Article Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides.
Academic Article The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum.
Academic Article Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.
Academic Article Effects of the amyloid precursor protein Glu693-->Gln 'Dutch' mutation on the production and stability of amyloid beta-protein.
Academic Article Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases.
Academic Article Purification and characterization of the human gamma-secretase complex.
Academic Article Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
Academic Article Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.
Academic Article Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex.
Academic Article Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein.
Academic Article Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.
Academic Article The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid.
Academic Article Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells.
Academic Article Mass spectrometry of purified amyloid beta protein in Alzheimer's disease.
Academic Article Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner.
Academic Article [Biochemistry of Alzheimer's disease].
Academic Article Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes.
Academic Article Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease.
Academic Article Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S.
Academic Article Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin.
Academic Article The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.
Academic Article Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals.
Academic Article gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons.
Academic Article Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
Academic Article Heparin-binding properties of the amyloidogenic peptides Abeta and amylin. Dependence on aggregation state and inhibition by Congo red.
Academic Article Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria.
Academic Article Protein chemical and immunocytochemical studies of meningovascular beta-amyloid protein in Alzheimer's disease and normal aging.
Academic Article Generation of amyloid beta protein from its precursor is sequence specific.
Academic Article Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.
Academic Article Deciphering the genetic basis of Alzheimer's disease.
Academic Article The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments.
Academic Article Production of amyloid-beta-peptide by cultured cells: no evidence for internal initiation of translation at Met596.
Academic Article Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase.
Academic Article Identification of beta-secretase (BACE1) substrates using quantitative proteomics.
Academic Article Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease.
Academic Article An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments.
Academic Article Alzheimer's disease: genes, proteins, and therapy.
Academic Article Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth.
Academic Article Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules.
Academic Article The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein.
Academic Article Normal and abnormal biology of the beta-amyloid precursor protein.
Academic Article The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking.
Academic Article Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide.
Academic Article Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity.
Academic Article alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins.
Academic Article The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.
Academic Article Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein.
Academic Article Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease.
Academic Article Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor.
Concept Amino Acid Sequence
Concept Repetitive Sequences, Amino Acid
Academic Article KTKEGV repeat motifs are key mediators of normal a-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity.
Academic Article Loss of native a-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.
Search Criteria
  • Amino Acid Sequence
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.