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It's a good year for Blimp-1 (and plasma cells).
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation.
XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells.
The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response.
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.
XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development.
Plasma cell differentiation requires the transcription factor XBP-1.
Transcriptional Regulation of the Immune Response
Arming the Immune System Against Pathogens
XBP-1 and the unfolded protein response (UPR).