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One or more keywords matched the following items that are connected to Knipe, David
Item TypeName
Academic Article Th1-associated immune responses to beta-galactosidase expressed by a replication-defective herpes simplex virus.
Academic Article Potential role for herpes simplex virus ICP8 DNA replication protein in stimulation of late gene expression.
Academic Article Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus.
Academic Article Herpes simplex virus gene products required for viral inhibition of expression of G1-phase functions.
Academic Article C-terminal region of herpes simplex virus ICP8 protein needed for intranuclear localization.
Academic Article Herpes simplex virus infection blocks events in the G1 phase of the cell cycle.
Academic Article Herpes simplex virus-induced keratitis: evaluation of the role of molecular mimicry in lesion pathogenesis.
Academic Article Comparison of the intranuclear distributions of herpes simplex virus proteins involved in various viral functions.
Academic Article An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection.
Academic Article Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: Potential role in blocking IFN-beta induction.
Academic Article Construction and characterization of a replication-defective herpes simplex virus 2 ICP8 mutant strain and its use in immunization studies in a guinea pig model of genital disease.
Academic Article The role of herpes simplex virus ICP27 in the regulation of UL24 gene expression by differential polyadenylation.
Academic Article Herpes simplex virus as a tool to define the role of complement in the immune response to peripheral infection.
Academic Article Herpes simplex virus 1 ICP27 is required for transcription of two viral late (gamma 2) genes in infected cells.
Academic Article Herpes simplex virus.
Academic Article Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme.
Academic Article Herpes simplex virus and toll-like receptors.
Academic Article Optimal long-term humoral responses to replication-defective herpes simplex virus require CD21/CD35 complement receptor expression on stromal cells.
Academic Article Genetic evidence for two distinct transactivation functions of the herpes simplex virus alpha protein ICP27.
Academic Article Immunization with a replication-deficient mutant of herpes simplex virus type 1 (HSV-1) induces a CD8+ cytotoxic T-lymphocyte response and confers a level of protection comparable to that of wild-type HSV-1.
Academic Article Herpes simplex virus vaccines.
Academic Article Stages in the nuclear association of the herpes simplex virus transcriptional activator protein ICP4.
Academic Article Effect of immunization on herpes simplex virus type 1 latent infection in the trigeminal ganglion.
Academic Article Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2.
Academic Article Association between the herpes simplex virus major DNA-binding protein and alkaline nuclease.
Academic Article The role of viral and cellular nuclear proteins in herpes simplex virus replication.
Academic Article Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling.
Academic Article Latent herpes simplex virus infection of sensory neurons alters neuronal gene expression.
Academic Article Herpes simplex virus 1 microRNAs expressed abundantly during latent infection are not essential for latency in mouse trigeminal ganglia.
Academic Article A LAT-associated function reduces productive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1.
Academic Article Molecular genetics of herpes simplex virus. II. Mapping of the major viral glycoproteins and of the genetic loci specifying the social behavior of infected cells.
Academic Article Assembly of herpes simplex virus replication proteins at two distinct intranuclear sites.
Academic Article [Application of herpes simplex virus to HIV vaccine vector].
Academic Article Proteomics of herpes simplex virus infected cell protein 27: association with translation initiation factors.
Academic Article ICP22 is required for wild-type composition and infectivity of herpes simplex virus type 1 virions.
Academic Article Chromatin control of herpes simplex virus lytic and latent infection.
Academic Article Herpes simplex virus ICP0 promotes both histone removal and acetylation on viral DNA during lytic infection.
Academic Article Construction and properties of a herpes simplex virus 2 dl5-29 vaccine candidate strain encoding an HSV-1 virion host shutoff protein.
Academic Article The use of green fluorescent fusion proteins to monitor herpes simplex virus replication.
Academic Article Viral replication is required for induction of ocular immunopathology by herpes simplex virus.
Academic Article Comparative efficacy and immunogenicity of replication-defective, recombinant glycoprotein, and DNA vaccines for herpes simplex virus 2 infections in mice and guinea pigs.
Academic Article Molecular genetics of herpes simplex virus: the terminal a sequences of the L and S components are obligatorily identical and constitute a part of a structural gene mapping predominantly in the S component.
Academic Article Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus.
Academic Article Contributions of antibody and T cell subsets to protection elicited by immunization with a replication-defective mutant of herpes simplex virus type 1.
Academic Article Biological properties of herpes simplex virus 2 replication-defective mutant strains in a murine nasal infection model.
Academic Article Persistent elevated expression of cytokine transcripts in ganglia latently infected with herpes simplex virus in the absence of ganglionic replication or reactivation.
Academic Article A genetic test for expression of a functional herpes simplex virus DNA-binding protein from a transfected plasmid.
Academic Article Mutations in the major DNA-binding protein gene of herpes simplex virus type 1 result in increased levels of viral gene expression.
Academic Article ICP27 selectively regulates the cytoplasmic localization of a subset of viral transcripts in herpes simplex virus type 1-infected cells.
Academic Article Identification and functional evaluation of cellular and viral factors involved in the alteration of nuclear architecture during herpes simplex virus 1 infection.
Academic Article “Herpes Simplex Viruses and Their Replication” Chapter 72
Academic Article Molecular genetics of herpes simplex virus: demonstration of regions of obligatory and nonobligatory identity within diploid regions of the genome by sequence replacement and insertion.
Academic Article Inhibitors of the sodium potassium ATPase that impair herpes simplex virus replication identified via a chemical screening approach.
Academic Article Herpes simplex virus vectors elicit durable immune responses in the presence of preexisting host immunity.
Academic Article Genetic engineering of a modified herpes simplex virus 1 vaccine vector.
Academic Article Comparison of immunogenicity and protective efficacy of genital herpes vaccine candidates herpes simplex virus 2 dl5-29 and dl5-29-41L in mice and guinea pigs.
Academic Article Evidence for differences in immunologic and pathogenesis properties of herpes simplex virus 2 strains from the United States and South Africa.
Academic Article The potential significance of late herpes simplex virus functions expressed early in replication: The tale of a temperature-sensitive mutant
Academic Article Genetic and molecular in vivo analysis of herpes simplex virus assembly in murine visual system neurons.
Academic Article Herpes simplex virus 1 immediate-early and early gene expression during reactivation from latency under conditions that prevent infectious virus production.
Academic Article Humoral response to herpes simplex virus is complement-dependent.
Academic Article Proteomics of herpes simplex virus replication compartments: association of cellular DNA replication, repair, recombination, and chromatin remodeling proteins with ICP8.
Academic Article Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection.
Academic Article Roles of the nuclear lamina in stable nuclear association and assembly of a herpesviral transactivator complex on viral immediate-early genes.
Academic Article Functional order of assembly of herpes simplex virus DNA replication proteins into prereplicative site structures.
Academic Article Stimulation of expression of a herpes simplex virus DNA-binding protein by two viral functions.
Academic Article Molecular genetics of herpes simplex virus. VII. Characterization of a temperature-sensitive mutant produced by in vitro mutagenesis and defective in DNA synthesis and accumulation of gamma polypeptides.
Academic Article Immunization with replication-defective mutants of herpes simplex virus type 1: sites of immune intervention in pathogenesis of challenge virus infection.
Academic Article Herpes simplex virus ICP27 increases translation of a subset of viral late mRNAs.
Academic Article Simian TRIM5alpha proteins reduce replication of herpes simplex virus.
Academic Article Cellular SNF2H chromatin-remodeling factor promotes herpes simplex virus 1 immediate-early gene expression and replication.
Academic Article Formation of DNA replication structures in herpes virus-infected cells requires a viral DNA binding protein.
Academic Article Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors.
Academic Article A mutant herpesvirus protein leads to a block in nuclear localization of other viral proteins.
Academic Article Cell growth transformation by herpes simplex virus.
Academic Article Characterization of the major mRNAs transcribed from the genes for glycoprotein B and DNA-binding protein ICP8 of herpes simplex virus type 1.
Academic Article A dominant mutant form of the herpes simplex virus ICP8 protein decreases viral late gene transcription.
Academic Article Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.
Academic Article Genetic identification of a portion of the herpes simplex virus ICP8 protein required for DNA-binding.
Academic Article Herpes simplex virus 1 glycoprotein B and US3 collaborate to inhibit CD1d antigen presentation and NKT cell function.
Academic Article An immunoassay for the study of DNA-binding activities of herpes simplex virus protein ICP8.
Academic Article Genetic studies on murine susceptibility to herpes simplex keratitis.
Academic Article Replication-defective mutants of herpes simplex virus (HSV) induce cellular immunity and protect against lethal HSV infection.
Academic Article Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis.
Academic Article Identification of a divalent metal cation binding site in herpes simplex virus 1 (HSV-1) ICP8 required for HSV replication.
Academic Article “The replication of herpes simplex virus”
Academic Article Immunization against genital herpes with a vaccine virus that has defects in productive and latent infection.
Academic Article Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells.
Academic Article Neither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virus.
Academic Article Nuclear localization of herpesvirus proteins: potential role for the cellular framework.
Academic Article Herpes simplex virus 1 has multiple mechanisms for blocking virus-induced interferon production.
Academic Article Characterization of two conformational forms of the major DNA-binding protein encoded by herpes simplex virus 1.
Academic Article Characterization of herpes simplex virus 2 temperature-sensitive mutants whose lesions map in or near the coding sequences for the major DNA-binding protein.
Academic Article Vaccine protection against simian immunodeficiency virus by recombinant strains of herpes simplex virus.
Academic Article Immunization with a replication-defective herpes simplex virus 2 mutant reduces herpes simplex virus 1 infection and prevents ocular disease.
Academic Article Disruption of the U(L)41 gene in the herpes simplex virus 2 dl5-29 mutant increases its immunogenicity and protective capacity in a murine model of genital herpes.
Academic Article Conformational changes in the herpes simplex virus ICP8 DNA-binding protein coincident with assembly in viral replication structures.
Academic Article Transcription of the herpes simplex virus latency-associated transcript promotes the formation of facultative heterochromatin on lytic promoters.
Academic Article Correct intranuclear localization of herpes simplex virus DNA polymerase requires the viral ICP8 DNA-binding protein.
Academic Article Herpes simplex virus VP16, but not ICP0, is required to reduce histone occupancy and enhance histone acetylation on viral genomes in U2OS osteosarcoma cells.
Academic Article Thermolabile in vivo DNA-binding activity associated with a protein encoded by mutants of herpes simplex virus type 1.
Academic Article Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site.
Academic Article Previous immunization of mice with herpes simplex virus type-1 strain MP protects against secondary corneal infection.
Academic Article Properties of a herpes simplex virus multiple immediate-early gene-deleted recombinant as a vaccine vector.
Academic Article Mapping of the transcriptional initiation site of the herpes simplex virus type 1 ICP8 gene in infected and transfected cells.
Academic Article Herpes simplex virus 1 U(L)31 and U(L)34 gene products promote the late maturation of viral replication compartments to the nuclear periphery.
Academic Article Identification of a herpes simplex virus function that represses late gene expression from parental viral genomes.
Academic Article Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons.
Academic Article Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency.
Academic Article Herpes simplex virus alpha protein ICP27 possesses separable positive and negative regulatory activities.
Academic Article A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency.
Academic Article Herpes simplex virus alpha protein ICP27 can inhibit or augment viral gene transactivation.
Academic Article Genetic evidence for multiple nuclear functions of the herpes simplex virus ICP8 DNA-binding protein.
Academic Article Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2.
Academic Article Definition of a series of stages in the association of two herpesviral proteins with the cell nucleus.
Academic Article Altered properties of the herpes simplex virus ICP8 DNA-binding protein in cells infected with ICP27 mutant viruses.
Academic Article Protection from herpes simplex virus (HSV)-2 infection with replication-defective HSV-2 or glycoprotein D2 vaccines in HSV-1-seropositive and HSV-1-seronegative guinea pigs.
Academic Article Herpes simplex virus-1 infection causes the secretion of a type I interferon-antagonizing protein and inhibits signaling at or before Jak-1 activation.
Academic Article Herpes simplex virus US3 tegument protein inhibits Toll-like receptor 2 signaling at or before TRAF6 ubiquitination.
Academic Article Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex viral genome during establishment of latent infection.
Academic Article "A gene function of herpes simplex virus required for expression of all early viral genes. Animal Virus Genetics"
Academic Article The acidic amino-terminal region of herpes simplex virus type 1 alpha protein ICP27 is required for an essential lytic function.
Academic Article Gene transfer to sensory neurons using herpes virus vectors.
Academic Article On the structure, functional equivalence, and replication of the four arrangements of herpes simplex virus DNA.
Academic Article Restricted expression of herpes simplex virus lytic genes during establishment of latent infection by thymidine kinase-negative mutant viruses.
Academic Article The intranuclear location of a herpes simplex virus DNA-binding protein is determined by the status of viral DNA replication.
Academic Article Role for herpes simplex virus 1 ICP27 in the inhibition of type I interferon signaling.
Academic Article Intragenic complementation of herpes simplex virus ICP8 DNA-binding protein mutants.
Academic Article Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replication.
Academic Article Mechanisms of immunization with a replication-defective mutant of herpes simplex virus 1.
Academic Article Gene-specific transactivation by herpes simplex virus type 1 alpha protein ICP27.
Academic Article Role of specific innate immune responses in herpes simplex virus infection of the central nervous system.
Academic Article Construction, phenotypic analysis, and immunogenicity of a UL5/UL29 double deletion mutant of herpes simplex virus 2.
Academic Article Myeloid C3 determines induction of humoral responses to peripheral herpes simplex virus infection.
Academic Article Molecular genetics of herpes simplex virus. VI. Characterization of a temperature-sensitive mutant defective in the expression of all early viral gene products.
Academic Article Alternative mechanisms for activation of human immunodeficiency virus enhancer in T cells.
Academic Article Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia.
Academic Article Herpes simplex virus replication compartments can form by coalescence of smaller compartments.
Academic Article Molecular genetics of herpes simplex virus. III. Fine mapping of a genetic locus determining resistance to phosphonoacetate by two methods of marker transfer.
Academic Article Analysis of phosphorylation sites of herpes simplex virus type 1 ICP4.
Concept Herpes Simplex Virus Protein Vmw65
Concept Herpes Simplex Virus Vaccines
Concept Simplexvirus
Academic Article Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA.
Academic Article Genomic sequences of a low passage herpes simplex virus 2 clinical isolate and its plaque-purified derivative strain.
Academic Article Summary and recommendations from a National Institute of Allergy and Infectious Diseases (NIAID) workshop on "Next Generation Herpes Simplex Virus Vaccines".
Academic Article A targeted RNA interference screen reveals novel epigenetic factors that regulate herpesviral gene expression.
Academic Article HIV integrase inhibitors block replication of alpha-, beta-, and gammaherpesviruses.
Academic Article Identification of TRIM27 as a novel degradation target of herpes simplex virus 1 ICP0.
Academic Article Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses.
Academic Article cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection.
Academic Article Barrier-to-Autointegration Factor 1 (BAF/BANF1) Promotes Association of the SETD1A Histone Methyltransferase with Herpes Simplex Virus Immediate-Early Gene Promoters.
Academic Article Nuclear sensing of viral DNA, epigenetic regulation of herpes simplex virus infection, and innate immunity.
Academic Article Proteomic analysis of the herpes simplex virus 1 virion protein 16 transactivator protein in infected cells.
Academic Article Genome Sequencing and Analysis of Geographically Diverse Clinical Isolates of Herpes Simplex Virus 2.
Academic Article Inhibition of O-Linked N-Acetylglucosamine Transferase Reduces Replication of Herpes Simplex Virus and Human Cytomegalovirus.
Academic Article Combined cytotoxic activity of an infectious, but non-replicative herpes simplex virus type 1 and plasmacytoid dendritic cells against tumour cells.
Academic Article History and genomic sequence analysis of the herpes simplex virus 1 KOS and KOS1.1 sub-strains.
Academic Article Production of immunogenic West Nile virus-like particles using a herpes simplex virus 1 recombinant vector.
Academic Article Relative Contributions of Herpes Simplex Virus 1 ICP0 and vhs to Loss of Cellular IFI16 Vary in Different Human Cell Types.
Grant Genetics of Herpesvirus Transformation
Grant International Herpes Vaccine Project
Grant GENETICS OF HERPESVIRUS TRANSFORMATION
Grant GENETICS OF HERPESVIRUS TRANSFORMATION
Grant VIral and host mechanisms that tilt the HSV lytic/latent balance
Grant Epigenetic Regulation of HSV Infection of Oral Cells
Grant MATURATION OF HERPESVIRAL NUCLEAR PROTEINS
Grant Nuclear Sensing of Herpesviral DNA
Grant International Herpes Vaccine Project
Grant Chromatin and Herpes Simplex Virus Latency
Grant Herpesviruses as Vaccine Vectors for AIDS
Grant Mechanism of Latency of Herpes Simplex Virus
Academic Article Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease.
Academic Article Role of Herpes Simplex Virus 1 ?34.5 in the Regulation of IRF3 Signaling.
Academic Article Intramuscular delivery of replication-defective herpes simplex virus gives antigen expression in muscle syncytia and improved protection against pathogenic HSV-2 strains.
Academic Article Mechanisms of Host IFI16, PML, and Daxx Protein Restriction of Herpes Simplex Virus 1 Replication.
Academic Article ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress.
Academic Article Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA.
Academic Article Herpes Simplex Virus 1 Lytic Infection Blocks MicroRNA (miRNA) Biogenesis at the Stage of Nuclear Export of Pre-miRNAs.
Academic Article Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity.
Academic Article Vaccination Route as a Determinant of Protective Antibody Responses against Herpes Simplex Virus.
Academic Article Tripartite Motif 22 (TRIM22) protein restricts herpes simplex virus 1 by epigenetic silencing of viral immediate-early genes.
Academic Article Herpes Simplex Virus 1 Manipulates Host Cell Antiviral and Proviral DNA Damage Responses.
Academic Article Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency.
Academic Article Screening Method for CRISPR/Cas9 Inhibition of a Human DNA Virus: Herpes Simplex Virus.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.