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One or more keywords matched the following items that are connected to Knipe, David
Item TypeName
Academic Article Herpes simplex virus gene products required for viral inhibition of expression of G1-phase functions.
Academic Article The role of toll-like receptors in herpes simplex infection in neonates.
Academic Article Herpes simplex virus-induced keratitis: evaluation of the role of molecular mimicry in lesion pathogenesis.
Academic Article Comparison of the intranuclear distributions of herpes simplex virus proteins involved in various viral functions.
Academic Article An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection.
Academic Article Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: Potential role in blocking IFN-beta induction.
Academic Article Construction and characterization of a replication-defective herpes simplex virus 2 ICP8 mutant strain and its use in immunization studies in a guinea pig model of genital disease.
Academic Article Herpes simplex virus 1 ICP27 is required for transcription of two viral late (gamma 2) genes in infected cells.
Academic Article Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme.
Academic Article Optimal long-term humoral responses to replication-defective herpes simplex virus require CD21/CD35 complement receptor expression on stromal cells.
Academic Article Immunization with a replication-deficient mutant of herpes simplex virus type 1 (HSV-1) induces a CD8+ cytotoxic T-lymphocyte response and confers a level of protection comparable to that of wild-type HSV-1.
Academic Article RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities.
Academic Article Effect of immunization on herpes simplex virus type 1 latent infection in the trigeminal ganglion.
Academic Article Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2.
Academic Article A dominant-negative herpesvirus protein inhibits intranuclear targeting of viral proteins: effects on DNA replication and late gene expression.
Academic Article Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling.
Academic Article Cutting edge: myeloid complement C3 enhances the humoral response to peripheral viral infection.
Academic Article Herpes simplex virus 1 microRNAs expressed abundantly during latent infection are not essential for latency in mouse trigeminal ganglia.
Academic Article A LAT-associated function reduces productive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1.
Academic Article Assembly of herpes simplex virus replication proteins at two distinct intranuclear sites.
Academic Article Role for A-type lamins in herpesviral DNA targeting and heterochromatin modulation.
Academic Article ICP22 is required for wild-type composition and infectivity of herpes simplex virus type 1 virions.
Academic Article Herpes simplex virus ICP0 promotes both histone removal and acetylation on viral DNA during lytic infection.
Academic Article Construction and properties of a herpes simplex virus 2 dl5-29 vaccine candidate strain encoding an HSV-1 virion host shutoff protein.
Academic Article Decreasing herpes simplex viral infectivity in solution by surface-immobilized and suspended N,N-dodecyl,methyl-polyethylenimine.
Academic Article Viral replication is required for induction of ocular immunopathology by herpes simplex virus.
Academic Article Comparative efficacy and immunogenicity of replication-defective, recombinant glycoprotein, and DNA vaccines for herpes simplex virus 2 infections in mice and guinea pigs.
Academic Article Influence of mucosal and parenteral immunization with a replication-defective mutant of HSV-2 on immune responses and protection from genital challenge.
Academic Article Biological properties of herpes simplex virus 2 replication-defective mutant strains in a murine nasal infection model.
Academic Article Persistent elevated expression of cytokine transcripts in ganglia latently infected with herpes simplex virus in the absence of ganglionic replication or reactivation.
Academic Article Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein.
Academic Article Mechanism of virus-induced Ig subclass shifts.
Academic Article ICP27 selectively regulates the cytoplasmic localization of a subset of viral transcripts in herpes simplex virus type 1-infected cells.
Academic Article Identification and functional evaluation of cellular and viral factors involved in the alteration of nuclear architecture during herpes simplex virus 1 infection.
Academic Article CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2.
Academic Article HSV-1-mediated modulation of cytokine gene expression in a permissive cell line: selective upregulation of IL-6 gene expression.
Academic Article Comparison of different forms of herpes simplex replication-defective mutant viruses as vaccines in a mouse model of HSV-2 genital infection.
Academic Article Herpes simplex virus vectors elicit durable immune responses in the presence of preexisting host immunity.
Academic Article Genetic engineering of a modified herpes simplex virus 1 vaccine vector.
Academic Article Comparison of immunogenicity and protective efficacy of genital herpes vaccine candidates herpes simplex virus 2 dl5-29 and dl5-29-41L in mice and guinea pigs.
Academic Article Evidence for differences in immunologic and pathogenesis properties of herpes simplex virus 2 strains from the United States and South Africa.
Academic Article Herpes simplex virus 1 immediate-early and early gene expression during reactivation from latency under conditions that prevent infectious virus production.
Academic Article Humoral response to herpes simplex virus is complement-dependent.
Academic Article Proteomics of herpes simplex virus replication compartments: association of cellular DNA replication, repair, recombination, and chromatin remodeling proteins with ICP8.
Academic Article Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection.
Academic Article Roles of the nuclear lamina in stable nuclear association and assembly of a herpesviral transactivator complex on viral immediate-early genes.
Academic Article Functional order of assembly of herpes simplex virus DNA replication proteins into prereplicative site structures.
Academic Article Immunization with replication-defective mutants of herpes simplex virus type 1: sites of immune intervention in pathogenesis of challenge virus infection.
Academic Article Herpes simplex ICP27 mutant viruses exhibit reduced expression of specific DNA replication genes.
Academic Article Herpes simplex virus ICP27 increases translation of a subset of viral late mRNAs.
Academic Article Simian TRIM5alpha proteins reduce replication of herpes simplex virus.
Academic Article Cellular SNF2H chromatin-remodeling factor promotes herpes simplex virus 1 immediate-early gene expression and replication.
Academic Article Cell growth transformation by herpes simplex virus.
Academic Article Preexisting nuclear architecture defines the intranuclear location of herpesvirus DNA replication structures.
Academic Article A dominant mutant form of the herpes simplex virus ICP8 protein decreases viral late gene transcription.
Academic Article Herpes simplex virus 1 glycoprotein B and US3 collaborate to inhibit CD1d antigen presentation and NKT cell function.
Academic Article Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis.
Academic Article Identification of a divalent metal cation binding site in herpes simplex virus 1 (HSV-1) ICP8 required for HSV replication.
Academic Article Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells.
Academic Article Neither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virus.
Academic Article Herpes simplex virus 1 has multiple mechanisms for blocking virus-induced interferon production.
Academic Article Immunization with a replication-defective herpes simplex virus 2 mutant reduces herpes simplex virus 1 infection and prevents ocular disease.
Academic Article Disruption of the U(L)41 gene in the herpes simplex virus 2 dl5-29 mutant increases its immunogenicity and protective capacity in a murine model of genital herpes.
Academic Article Conformational changes in the herpes simplex virus ICP8 DNA-binding protein coincident with assembly in viral replication structures.
Academic Article Transcription of the herpes simplex virus latency-associated transcript promotes the formation of facultative heterochromatin on lytic promoters.
Academic Article Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein.
Academic Article Herpes simplex virus VP16, but not ICP0, is required to reduce histone occupancy and enhance histone acetylation on viral genomes in U2OS osteosarcoma cells.
Academic Article Herpes simplex virus 1 U(L)31 and U(L)34 gene products promote the late maturation of viral replication compartments to the nuclear periphery.
Academic Article Evidence for a direct interaction between HSV-1 ICP27 and ICP8 proteins.
Academic Article Discovery of a novel TLR2 signaling inhibitor with anti-viral activity.
Academic Article Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2.
Academic Article Protection from herpes simplex virus (HSV)-2 infection with replication-defective HSV-2 or glycoprotein D2 vaccines in HSV-1-seropositive and HSV-1-seronegative guinea pigs.
Academic Article Herpes simplex virus-1 infection causes the secretion of a type I interferon-antagonizing protein and inhibits signaling at or before Jak-1 activation.
Academic Article Herpes simplex virus US3 tegument protein inhibits Toll-like receptor 2 signaling at or before TRAF6 ubiquitination.
Academic Article Role for herpes simplex virus 1 ICP27 in the inhibition of type I interferon signaling.
Academic Article Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replication.
Academic Article Mechanisms of immunization with a replication-defective mutant of herpes simplex virus 1.
Academic Article Role of specific innate immune responses in herpes simplex virus infection of the central nervous system.
Academic Article Construction, phenotypic analysis, and immunogenicity of a UL5/UL29 double deletion mutant of herpes simplex virus 2.
Academic Article Myeloid C3 determines induction of humoral responses to peripheral herpes simplex virus infection.
Academic Article Herpes simplex virus replication compartments can form by coalescence of smaller compartments.
Academic Article Herpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection.
Concept Herpesvirus 2, Human
Concept Herpesvirus 1, Human
Concept Herpesvirus 4, Human
Concept Herpesvirus 8, Human
Academic Article Genomic sequences of a low passage herpes simplex virus 2 clinical isolate and its plaque-purified derivative strain.
Academic Article HIV integrase inhibitors block replication of alpha-, beta-, and gammaherpesviruses.
Academic Article Identification of TRIM27 as a novel degradation target of herpes simplex virus 1 ICP0.
Academic Article HSV-1 remodels host telomeres to facilitate viral replication.
Academic Article Barrier-to-Autointegration Factor 1 (BAF/BANF1) Promotes Association of the SETD1A Histone Methyltransferase with Herpes Simplex Virus Immediate-Early Gene Promoters.
Academic Article Proteomic analysis of the herpes simplex virus 1 virion protein 16 transactivator protein in infected cells.
Academic Article Global Diversity within and between Human Herpesvirus 1 and 2 Glycoproteins.
Academic Article Genome Sequencing and Analysis of Geographically Diverse Clinical Isolates of Herpes Simplex Virus 2.
Academic Article Combined cytotoxic activity of an infectious, but non-replicative herpes simplex virus type 1 and plasmacytoid dendritic cells against tumour cells.
Academic Article Clues to mechanisms of herpesviral latent infection and potential cures.
Academic Article History and genomic sequence analysis of the herpes simplex virus 1 KOS and KOS1.1 sub-strains.
Academic Article Protection from genital herpes disease, seroconversion and latent infection in a non-lethal murine genital infection model by immunization with an HSV-2 replication-defective mutant virus.
Academic Article A Herpesviral Lytic Protein Regulates the Structure of Latent Viral Chromatin.
Academic Article HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression.
Academic Article Production of immunogenic West Nile virus-like particles using a herpes simplex virus 1 recombinant vector.
Academic Article Relative Contributions of Herpes Simplex Virus 1 ICP0 and vhs to Loss of Cellular IFI16 Vary in Different Human Cell Types.
Grant MECHANISMS OF VIRAL MEDIATED IMMUNE EVASION
Academic Article A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation.
Academic Article Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease.
Academic Article Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation.
Academic Article Role of Herpes Simplex Virus 1 ?34.5 in the Regulation of IRF3 Signaling.
Academic Article Intramuscular delivery of replication-defective herpes simplex virus gives antigen expression in muscle syncytia and improved protection against pathogenic HSV-2 strains.
Academic Article Mechanisms of Host IFI16, PML, and Daxx Protein Restriction of Herpes Simplex Virus 1 Replication.
Academic Article CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection.
Academic Article ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress.
Academic Article Role for a Filamentous Nuclear Assembly of IFI16, DNA, and Host Factors in Restriction of Herpesviral Infection.
Academic Article Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA.
Academic Article Herpes Simplex Virus 1 Lytic Infection Blocks MicroRNA (miRNA) Biogenesis at the Stage of Nuclear Export of Pre-miRNAs.
Academic Article Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity.
Academic Article Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9.
Academic Article Tripartite Motif 22 (TRIM22) protein restricts herpes simplex virus 1 by epigenetic silencing of viral immediate-early genes.
Academic Article Expression of SARS coronavirus 1 spike protein from a herpesviral vector induces innate immune signaling and neutralizing antibody responses.
Search Criteria
  • Herpesvirus 6 Human
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.