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Henry Herce, Ph.D.

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  • Cell-Penetrating Antibodies Design

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Prew MS, Camara CM, Botzanowski T, Moroco JA, Bloch NB, Levy HR, Seo HS, Dhe-Paganon S, Bird GH, Herce HD, Gygi MA, Escudero S, Wales TE, Engen JR, Walensky LD. Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency. Nat Commun. 2022 06 27; 13(1):3669. PMID: 35760926; PMCID: PMC9237092.
    Citations: 3 Article has an altmetric score of 5
    Fields: BioBiologySciScienceTranslation:Humans
  2. Gorgulla C, Padmanabha Das KM, Leigh KE, Cespugli M, Fischer PD, Wang ZF, Tesseyre G, Pandita S, Shnapir A, Calderaio A, Gechev M, Rose A, Lewis N, Hutcheson C, Yaffe E, Luxenburg R, Herce HD, Durmaz V, Halazonetis TD, Fackeldey K, Patten JJ, Chuprina A, Dziuba I, Plekhova A, Moroz Y, Radchenko D, Tarkhanova O, Yavnyuk I, Gruber C, Yust R, Payne D, Näär AM, Namchuk MN, Davey RA, Wagner G, Kinney J, Arthanari H. A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening. iScience. 2021 Feb 19; 24(2):102021. PMID: 33426509; PMCID: PMC7783459.
    Citations: 44 Article has an altmetric score of 48
  3. Cathcart AM, Bird GH, Wales TE, Herce HD, Harvey EP, Hauseman ZJ, Newman CE, Adhikary U, Prew MS, Oo T, Lee S, Engen JR, Walensky LD. Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer. Nat Chem Biol. 2020 11; 16(11):1218-1226. PMID: 32807965.
    Citations: 4
    Fields: BioBiologyCheChemistryTranslation:HumansCells
  4. Gorgulla C, Padmanabha Das KM, Leigh KE, Cespugli M, Fischer PD, Wang ZF, Tesseyre G, Pandita S, Shnapir A, Calderaio A, Gechev M, Rose A, Lewis N, Hutcheson C, Yaffe E, Luxenburg R, Herce HD, Durmaz V, Halazonetis TD, Fackeldey K, Patten JJ, Chuprina A, Dziuba I, Plekhova A, Moroz Y, Radchenko D, Tarkhanova O, Yavnyuk I, Gruber C, Yust R, Payne D, Näär AM, Namchuk MN, Davey RA, Wagner G, Kinney J, Arthanari H. A Multi-Pronged Approach Targeting SARS-CoV-2 Proteins Using Ultra-Large Virtual Screening. ChemRxiv. 2020 Jul 24. PMID: 33200116; PMCID: PMC7668741.
    Citations: 1 Article has an altmetric score of 5
  5. Hauseman ZJ, Harvey EP, Newman CE, Wales TE, Bucci JC, Mintseris J, Schweppe DK, David L, Fan L, Cohen DT, Herce HD, Mourtada R, Ben-Nun Y, Bloch NB, Hansen SB, Wu H, Gygi SP, Engen JR, Walensky LD. Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization. Mol Cell. 2020 07 02; 79(1):68-83.e7. PMID: 32533918; PMCID: PMC7472837.
    Citations: 18 Article has an altmetric score of 26
    Fields: CelCell BiologyMolMolecular BiologyTranslation:HumansAnimalsCells
  6. Mourtada R, Herce HD, Yin DJ, Moroco JA, Wales TE, Engen JR, Walensky LD. Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice. Nat Biotechnol. 2019 10; 37(10):1186-1197. PMID: 31427820; PMCID: PMC7437984.
    Citations: 104 Article has an altmetric score of 62
    Fields: BioBiotechnologyTranslation:HumansAnimalsCells
  7. Herce HD, Schumacher D, Schneider AFL, Ludwig AK, Mann FA, Fillies M, Kasper MA, Reinke S, Krause E, Leonhardt H, Cardoso MC, Hackenberger CPR. Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells. Nat Chem. 2017 08; 9(8):762-771. PMID: 28754949.
    Citations: 96
    Fields: CheChemistryTranslation:HumansAnimalsCells
  8. Ludwig AK, Zhang P, Hastert FD, Meyer S, Rausch C, Herce HD, Müller U, Lehmkuhl A, Hellmann I, Trummer C, Storm C, Leonhardt H, Cardoso MC. Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise. Nucleic Acids Res. 2017 03 17; 45(5):2438-2457. PMID: 27923996; PMCID: PMC5389475.
    Citations: 22
    Fields: BioBiochemistryTranslation:HumansAnimalsCells
  9. Martin RM, Herce HD, Ludwig AK, Cardoso MC. Visualization of the Nucleolus in Living Cells with Cell-Penetrating Fluorescent Peptides. Methods Mol Biol. 2016; 1455:71-82. PMID: 27576711.
    Citations: 1 Article has an altmetric score of 1
    Fields: MolMolecular BiologyTranslation:HumansAnimalsCells
  10. Neale C, Herce HD, Pomès R, García AE. Can Specific Protein-Lipid Interactions Stabilize an Active State of the Beta 2 Adrenergic Receptor? Biophys J. 2015 Oct 20; 109(8):1652-62. PMID: 26488656; PMCID: PMC4624154.
    Citations: 35 Article has an altmetric score of 1
    Fields: BioBiophysicsTranslation:HumansCells
  11. Hreha TN, Mezic KG, Herce HD, Duffy EB, Bourges A, Pryshchep S, Juarez O, Barquera B. Complete topology of the RNF complex from Vibrio cholerae. Biochemistry. 2015 Apr 21; 54(15):2443-55. PMID: 25831459.
    Citations: 11
    Fields: BioBiochemistryTranslation:Cells
  12. Martin RM, Ter-Avetisyan G, Herce HD, Ludwig AK, Lättig-Tünnemann G, Cardoso MC. Principles of protein targeting to the nucleolus. Nucleus. 2015; 6(4):314-25. PMID: 26280391.
    Citations: 60
    Fields: CelCell BiologyMolMolecular BiologyTranslation:HumansAnimalsCells
  13. Nischan N, Herce HD, Natale F, Bohlke N, Budisa N, Cardoso MC, Hackenberger CP. Covalent attachment of cyclic TAT peptides to GFP results in protein delivery into live cells with immediate bioavailability. Angew Chem Int Ed Engl. 2015 Feb 02; 54(6):1950-3. PMID: 25521313.
    Citations: 85 Article has an altmetric score of 55
    Fields: CheChemistry
  14. Herce HD, Garcia AE, Cardoso MC. Fundamental molecular mechanism for the cellular uptake of guanidinium-rich molecules. J Am Chem Soc. 2014 Dec 17; 136(50):17459-67. PMID: 25405895; PMCID: PMC4277769.
    Citations: 65 Article has an altmetric score of 52
    Fields: CheChemistryTranslation:HumansCells
  15. Herce HD, Rajan M, Lättig-Tünnemann G, Fillies M, Cardoso MC. A novel cell permeable DNA replication and repair marker. Nucleus. 2014; 5(6):590-600. PMID: 25484186.
    Citations: 10
    Fields: CelCell BiologyMolMolecular BiologyTranslation:HumansAnimalsCells
  16. Kind B, Muster B, Staroske W, Herce HD, Sachse R, Rapp A, Schmidt F, Koss S, Cardoso MC, Lee-Kirsch MA. Altered spatio-temporal dynamics of RNase H2 complex assembly at replication and repair sites in Aicardi-Goutières syndrome. Hum Mol Genet. 2014 Nov 15; 23(22):5950-60. PMID: 24986920.
    Citations: 24 Article has an altmetric score of 1
    Fields: GenGenetics, MedicalMolMolecular BiologyTranslation:HumansCells
  17. Hörner S, Fabritz S, Herce HD, Avrutina O, Dietz C, Stark RW, Cardoso MC, Kolmar H. Cube-octameric silsesquioxane-mediated cargo peptide delivery into living cancer cells. Org Biomol Chem. 2013 Apr 14; 11(14):2258-65. PMID: 23250285.
    Citations: 2
    Fields: BioBiochemistryCheChemistryTranslation:HumansCells
  18. Becker A, Allmann L, Hofstätter M, Casà V, Weber P, Lehmkuhl A, Herce HD, Cardoso MC. Direct homo- and hetero-interactions of MeCP2 and MBD2. PLoS One. 2013; 8(1):e53730. PMID: 23335972.
    Citations: 17
    Fields: MedMedicine (General)SciScienceTranslation:HumansAnimalsCells
  19. Herce HD, Deng W, Helma J, Leonhardt H, Cardoso MC. Visualization and targeted disruption of protein interactions in living cells. Nat Commun. 2013; 4:2660. PMID: 24154492; PMCID: PMC3826628.
    Citations: 73 Article has an altmetric score of 13
    Fields: BioBiologySciScienceTranslation:HumansAnimalsCells
  20. Casas-Delucchi CS, van Bemmel JG, Haase S, Herce HD, Nowak D, Meilinger D, Stear JH, Leonhardt H, Cardoso MC. Histone hypoacetylation is required to maintain late replication timing of constitutive heterochromatin. Nucleic Acids Res. 2012 Jan; 40(1):159-69. PMID: 21908399.
    Citations: 41
    Fields: BioBiochemistryTranslation:AnimalsCells
  21. Lättig-Tünnemann G, Prinz M, Hoffmann D, Behlke J, Palm-Apergi C, Morano I, Herce HD, Cardoso MC. Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides. Nat Commun. 2011 Aug 30; 2:453. PMID: 21878907; PMCID: PMC3265364.
    Citations: 100 Article has an altmetric score of 6
    Fields: BioBiologySciScienceTranslation:AnimalsCells
  22. Herce HD, Garcia AE. Cell penetrating peptides: how do they do it? J Biol Phys. 2007 Dec; 33(5-6):345-56. PMID: 19669523.
    Citations: 31
    Fields: BioBiophysicsPhyPhysics
  23. Herce HD, Garcia AE. Molecular dynamics simulations suggest a mechanism for translocation of the HIV-1 TAT peptide across lipid membranes. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20805-10. PMID: 18093956.
    Citations: 146
    Fields: SciScienceTranslation:HumansCells
  24. Herce HD, Garcia AE, Darden T. The electrostatic surface term: (I) periodic systems. J Chem Phys. 2007 Mar 28; 126(12):124106. PMID: 17411107.
    Citations: 10
    Fields: BioBiophysicsCheChemistryPhyPhysics
  25. Herce HD, Garcia AE. Correction of apparent finite size effects in the area per lipid of lipid membranes simulations. J Chem Phys. 2006 Dec 14; 125(22):224711. PMID: 17176158.
    Citations: 5
    Fields: BioBiophysicsCheChemistryPhyPhysics
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.