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Viral Shailesh Shah, M.D., Ph.D.

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Biography
University of Iowa, Iowa City, IAMD05/2017Medicine
University of Iowa, Iowa City, IAPhD05/2017Physiology and Biophysics
Massachusetts General Hospital, Boston, MA05/2019Internal Medicine Residency
Harvard Combined Fellowship, Boston, MA03/2021Pulmonary and Critical Care
2024
American Society for Clinical Investigation Emerging-Generation Award

Overview
My ultimate career goal is to be a physician-scientist who devotes 80% of my focus on research in my own independent lab with 20% of time dedicated to clinical care. The focus of my research is "Physiologic Regeneration". This is a fusion of my expertise developed in graduate school studying airway surface physiology with Dr. Michael Welsh and during my postdoc training on airway regeneration with Dr. Jay Rajagopal.

The overall objective of this work is to deduce, decipher and define how the airway epithelial surface restores its critical physiologic functions after severe infectious, chemical, and physical injury. By leveraging mouse genetics, stem cell biology, human and murine in vitro and ex vivo models, numerous airway surface physiology assays, and novel live microscopy techniques, I aim to dissect the pathways that become aberrant in a variety of diseases like Cystic Fibrosis, COPD, bronchiectasis, and post-viral pneumonia.

My long term goal is that upon understanding the fundamental biology that has gone awry, we will be able to identify actionable therapeutic targets to improve disease. Team Science with collaborators of various expertise is essential to this vision and a major aspect of my scientific philosophy. Through this cross-disciplinary effort we can uncover the mechanisms of disease and may be able to develop something meaningful to help improve people's lives.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 003338L121 (Viral Shah) Jul 1, 2022 - Jun 30, 2026
    Cystic Fibrosis Foundation
    Defining the Role of the Ionocyte in Cystic Fibrosis
    Role Description: LeRoy Mathews Physician Scientist Award
    Role: Principal Investigator
  2. 5U24HL148865-04/OS00000379 (Viral Shah) Jul 1, 2022 - Jun 30, 2023
    NIH/NHLBI
    Defining the Gene Expression and Function of Human Hillocks in the Airway Epithelium
    Role Description: LungMap 2 Pilot Grant
    Role: Sub Contract PI
  3. 5T32HL116275 (Viral Shah) Jul 1, 2021 - Jun 30, 2022
    NIH/NHLBI
    Understanding the role of ionocytes as cellular sensors on the airway epithelium
    Role Description: T32 Training Grant
    Role: Principal Investigator
  4. F30HL123239 (SHAH, VIRAL SHAILESH) May 1, 2014 - Apr 30, 2018
    NIH
    Mechanisms Controlling Airway Surface Liquid pH
    Role: Principal Investigator

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Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.