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Lixia He, Ph.D.

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Biography
education and training
BIDMC, Harvard Medical School, BostonPostdoctoral Research Fellow3/2019Nutrition&Metabolic Disease, mainly focus on diabetes, obesity, cognitive decline, kidney disease
Peking University, BeijingPhD7/2016Nutrition&Disease, mainly on Immunosuppression, Intestinal Barrier Dysfunction, Radiotherapy Damage

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Stransky LA, Gao W, Schmidt LS, Bi K, Ricketts CJ, Ramesh V, James A, Difilippantonio S, Ileva L, Kalen JD, Karim B, Jeon A, Morgan T, Warner AC, Turan S, Unite J, Tran B, Choudhari S, Zhao Y, Linn DE, Yun C, Dhandapani S, Parab V, Pinheiro EM, Morris N, He L, Vigeant SM, Pignon JC, Sticco-Ivins M, Signoretti S, Van Allen EM, Linehan WM, Kaelin WG. Toward a CRISPR-based mouse model of Vhl-deficient clear cell kidney cancer: Initial experience and lessons learned. Proc Natl Acad Sci U S A. 2024 Oct 08; 121(41):e2408549121. PMID: 39365820; PMCID: PMC11474080.
    Citations: 1
    Fields: SciScienceTranslation:HumansAnimals
  2. Lampson BL†, Ramirez AS†, Baro M, He L, Hegde M, Koduri S, Pfaff JL, Hanna RE, Shirole N, He Y, Kowal J, Doench JG, Contessa JN, Locher KP, Kaelin WG. Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-?B. Cell. 2024; 187(9):2209-2223.View Publication.
  3. Lampson BL, Ram?rez AS, Baro M, He L, Hegde M, Koduri V, Pfaff JL, Hanna RE, Kowal J, Shirole NH, He Y, Doench JG, Contessa JN, Locher KP, Kaelin WG. Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-?B. Cell. 2024 Apr 25; 187(9):2209-2223.e16. PMID: 38670073; PMCID: PMC11149550.
    Citations: 2
    Fields: CelCell BiologyTranslation:HumansAnimalsCells
  4. Liu Y, Zang B, Shao J, Ning N, He L, Ma Y. Predictor of cognitive impairment: metabolic syndrome or circadian syndrome. BMC Geriatr. 2023 07 04; 23(1):408. PMID: 37403015; PMCID: PMC10318700.
    Citations: 5
    Fields: GerGeriatricsTranslation:Humans
  5. Halimulati M, Wang R, Aihemaitijiang S, Huang X, Ye C, Zhang Z, Li L, Zhu W, Zhang Z, He L. Anti-Hyperuricemic Effect of Anserine Based on the Gut-Kidney Axis: Integrated Analysis of Metagenomics and Metabolomics. Nutrients. 2023 Feb 15; 15(4). PMID: 36839325; PMCID: PMC9964072.
    Citations: 8
    Fields: NutNutritional SciencesTranslation:Animals
  6. Tan X, Yang Q, Cai X, Tao Y, Gao S, He L, Zhan S, Cheng H, Song H, Sun F. Analysis on the medication rule of traditional Chinese medicine in the treatment of COVID-19 patients. Acupuncture and Herbal Medicine. 2022; 2(2):91-98.View Publication.
  7. Wang Y, Liu Y, Hu J, Guan H, Wang Y, Liu M, He L, Sun N, Yang W, Ma Y. Association of handgrip strength with all-cause mortality: a nationally longitudinal cohort study in China. J Sci Med Sport. 2022 Nov; 25(11):878-883. PMID: 36064503.
    Citations: 6
    Fields: SpoSports MedicineTranslation:Humans
  8. Zang BY, He LX, Xue L. Intermittent Fasting: Potential Bridge of Obesity and Diabetes to Health? Nutrients. 2022 Feb 25; 14(5). PMID: 35267959.
    Citations: 10
    Fields: NutNutritional SciencesTranslation:HumansAnimals
  9. Li D, Ren J, He L, Sun J, Liu P, Li Y. Combined Effects of Oligopeptides Isolated from Panax ginseng C.A. Meyer and Ostrea gigas Thunberg on Sexual Function in Male Mice. Int J Environ Res Public Health. 2021 02 28; 18(5). PMID: 33670840; PMCID: PMC7967744.
    Citations: 2
    Fields: EnvEnvironmental HealthPubPublic HealthTranslation:HumansAnimals
  10. He LX, Abdolmaleky HM, Yin S, Wang Y, Zhou JR. Dietary Fermented Soy Extract and Oligo-Lactic Acid Alleviate Chronic Kidney Disease in Mice via Inhibition of Inflammation and Modulation of Gut Microbiota. Nutrients. 2020 Aug 08; 12(8). PMID: 32784477; PMCID: PMC7468970.
    Citations: 19
    Fields: NutNutritional SciencesTranslation:AnimalsCells
  11. Liu J, Zhang Y, Lavie CJ, Tabung FK, Xu J, Hu Q, He L, Zhang Y. Associations of C-reactive protein and fibrinogen with mortality from all-causes, cardiovascular disease and cancer among U.S. adults. Prev Med. 2020 10; 139:106044. PMID: 32097752.
    Citations: 11
    Fields: PubPublic HealthTranslation:Humans
  12. He LX. Current Developments in Nutrition. Cow milk and goat milk alleviate glucose intolerance in high-fat induced obesity mice and db/db mice. 2019; 3(Suppl_1):nzz044.
  13. Pettinato G, Lehoux S, Ramanathan R, Salem MM, He LX, Muse O, Flaumenhaft R, Thompson MT, Rouse EA, Cummings RD, Wen X, Fisher RA. Generation of fully functional hepatocyte-like organoids from human induced pluripotent stem cells mixed with Endothelial Cells. Sci Rep. 2019 06 20; 9(1):8920. PMID: 31222080; PMCID: PMC6586904.
    Citations: 72
    Fields: SciScienceTranslation:HumansCells
  14. He LX. Current Developments in Nutrition. Dietary fermented soy extract and active lactic acid alleviate chronic kidney disease in mice via inhibition of inflammation and modulation of gut microbiota. 2019; 3(Suppl_1):nzz031.
  15. Zhu N, Liu R, He LX, Mao RX, Liu XR, Zhang T, Hao YT, Fan R, Xu MH, Li Y. Radioprotective Effect of Walnut Oligopeptides Against Gamma Radiation-Induced Splenocyte Apoptosis and Intestinal Injury in Mice. Molecules. 2019 Apr 22; 24(8). PMID: 31013611; PMCID: PMC6515242.
    Citations: 14
    Fields: BioBiologyTranslation:AnimalsPHPublic Health
  16. He LX, Zhang ZF, Zhao J, Li L, Xu T, Ren JW, Liu R, Chen QH, Wang JB, Salem MM, Pettinato G, Zhou JR, Li Y. Ginseng oligopeptides protect against irradiation-induced immune dysfunction and intestinal injury. Sci Rep. 2018 09 17; 8(1):13916. PMID: 30224720; PMCID: PMC6141576.
    Citations: 12
    Fields: SciScienceTranslation:HumansAnimalsCellsPHPublic Health
  17. He LX, Ren JW, Liu R, Chen QH, Zhao J, Wu X, Zhang ZF, Wang JB, Pettinato G, Li Y. Ginseng (Panax ginseng Meyer) oligopeptides regulate innate and adaptive immune responses in mice via increased macrophage phagocytosis capacity, NK cell activity and Th cells secretion. Food Funct. 2017 Oct 01; 8(10):3523-3532. PMID: 28875201.
    Citations: 23
    Fields: BioBiochemistryCheChemistryNutNutritional SciencesPhyPhysiologyTranslation:AnimalsCells
  18. He LX, Wang JB, Sun B, Zhao J, Li L, Xu T, Li H, Sun JQ, Ren J, Liu R, Chen QH, Zhang ZF, Li Y. Suppression of TNF-a and free radicals reduces systematic inflammatory and metabolic disorders: Radioprotective effects of ginseng oligopeptides on intestinal barrier function and antioxidant defense. J Nutr Biochem. 2017 02; 40:53-61. PMID: 27863345.
    Citations: 20
    Fields: BioBiochemistryNutNutritional SciencesTranslation:AnimalsPHPublic Health
  19. He LX, Zhao J, Huang YS, Li Y. The difference between oats and beta-glucan extract intake in the management of HbA1c, fasting glucose and insulin sensitivity: a meta-analysis of randomized controlled trials. Food Funct. 2016 Mar; 7(3):1413-28. PMID: 26840185.
    Citations: 26
    Fields: BioBiochemistryCheChemistryNutNutritional SciencesPhyPhysiologyTranslation:HumansAnimals
  20. He LX, Zhang ZF, Sun B, Chen QH, Liu R, Ren JW, Wang JB, Li Y. Sea cucumber (Codonopsis pilosula) oligopeptides: immunomodulatory effects based on stimulating Th cells, cytokine secretion and antibody production. Food Funct. 2016 Feb; 7(2):1208-16. PMID: 26838796.
    Citations: 15
    Fields: BioBiochemistryCheChemistryNutNutritional SciencesPhyPhysiologyTranslation:AnimalsCells
  21. Guo QY, He LX, Zhu H, Shang JL, Zhu LY, Wang JB, Li Y. Effects of 90-Day Feeding of Transgenic Maize BT799 on the Reproductive System in Male Wistar Rats. Int J Environ Res Public Health. 2015 Dec 02; 12(12):15309-20. PMID: 26633453; PMCID: PMC4690922.
    Citations: 5
    Fields: EnvEnvironmental HealthPubPublic HealthTranslation:AnimalsCellsPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.