Harvard Catalyst Profiles

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Alex Kostic, Ph.D.

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Biography
Broad Institute of MIT & Harvard, Cambridge, MAPostdoctoral Fellowship08/2016Microbiome-Immune Interfaces
Harvard University, Cambridge, MAPh.D.05/2013Biological & Biomedical Sciences
University of Toronto, Toronto, ONHon.B.Sc.05/2008Molecular Biology
2017 - 2022
Pathway to Stop Diabetes Initiator Award
2017 - 2019
Smith Family Awards Program for Excellence in Biomedical Research
2015 - 2016
Merck Fellow of the Helen Hay Whitney Foundation
2014 - 2016
The Lawrence H. Summers Postdoctoral Fellowship

Overview
Our research combines computational and experimental expertise to probe the relationship between the human microbiome and type 1 diabetes. We strive to generate a high-level understanding of how the molecular interactions between the immune system and our indigenous microbiome regulate human health. We have worked to characterize the developing infant gut microbiome in dense, longitudinal metagenomic analyses of birth cohorts at risk for type 1 diabetes, including mechanistic evidence by which the human microbiome may directly influence immune development and progression to type 1 diabetes. The ultimate goal of our lab is to develop new methods to diagnose and treat type 1 diabetes by deepening our understanding of the immunomodulatory effects of the diverse constituents of the symbiotic microbiota and their impact on autoimmunity.

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.