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Dongyao Wang, Ph.D.

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Biography
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Harvard Medical School, United StatesResearch fellowTumor immnology
University of Science and Technology of China, ChinaAssociate research fellowTumor immnology
University of Science and Technology of China, ChinaPostdoc12/2022Tumor immnology
University of Science and Technology of China, ChinaPhD06/2019Tumor immnology
Jilin University, ChinaBachelor of Medicine06/2013Medicine

Overview
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Dongyao Wang received his PhD degree and completed postdoctoral work in immunology from the University of Science and Technology of China (USTC). His work demonstrated that pharmacologic inhibition of GARP-mediated active TGF signaling could restore NK cell-mediated graft-versus leukemia (GVL) activity. In addition, he demonstrated that sequential low-dose IL-2 therapy increased the frequency and function of HBV-specific CD8+ T cells, which contributed to HBeAg seroconversion, among the non-responder chronic hepatitis B patients after IFN therapy. Furthermore, he found that the inhibition of IL-11-STAT3 signaling could significantly suppress postsurgical recurrence of liver cancer. Dongyao is interested in the role of NK cells and in different kinds of tumors.
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Research
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  1. 82370217 (Dongyao Wang) Jan 1, 2024 - Jan 31, 2027
    Natural Science Foundation of China
    The Mechanistic Study on L-Arginine Reversing Autophagy of NK Cells in the Bone Marrow Microenvironment of AML after Allogeneic Hematopoietic Stem Cell Transplantation and Restoring the GvL Effect
    Role: Investigator
  2. 82100230 (Dongyao Wang) Jan 1, 2022 - Dec 31, 2024
    Natural Science Foundation of China
    The Mechanistic Study on GARP Activation of TGF-ß1 Inhibiting the GvL Effect of Bone Marrow NK Cells after Allogeneic Hematopoietic Stem Cell Transplantation.
    Role: Investigator

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© 2024 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.