Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Henning Willers, M.D.

Title
Institution
Department
Address
Phone

Overview
I am a laboratory-based clinician-scientist in Radiation Oncology with an interest in basic, translational, and clinical lung cancer research. I spent at least 50% of my time in laboratory based-research and dedicate my clinical time to the management of patients with lung cancer.

The goal of cancer therapy using ionizing radiation and/or chemotherapeutic agents is to selectively kill tumor cells while sparing surrounding normal tissues. In order to achieve such therapeutic gain, pre-existing genetic differences between tumors and normal tissues have to be exploited. To this end, in the Laboratory of Cellular & Molecular Radiation Oncology, we have two main research interests:
1. To detect and characterize altered recombinational DNA repair that may render the affected tumors hypersensitive to DNA damaging agents.
2. To identify and disrupt altered signal transduction pathways, which may sensitize tumors to radiation.
Research in our laboratory is both basic and translational focusing on various tumor entities, including lung and breast cancer, with the long-term goal of contributing to the realization of "personalized" or "individualized" cancer therapy.

The Role of the Tumor Suppressor Gene p53 in DNA Double-Strand Break (DSB) Repair:

DSBs represent the most important type of DNA damage inflicted by radiation or various chemotherapeutic agents. If DSBs are not properly repaired, they can either lead to cell death or produce genetic changes in the surviving cells, which may promote cancer development. Over the past few years, it has become clear that perturbations of DSB repair are a frequent cause of genomic instability in cancer cells. Conversely, these cells may also be more sensitive to DNA damaging agents. Thus, the DSB repair defects that promote carcinogenesis by causing genetic instability may also be the weakness of the tumors that arise in this setting. This concept has been referred to as the "Achilles' Heel of Cancers" and holds great promise for the advancement of cancer treatment in the not-too-distant future. The p53 tumor suppressor is inactivated in the majority of human cancers. In normal cells, p53 suppresses malignant cell transformation through several mechanisms. We recently established a novel role of p53 in the downregulation of homologous recombination (HR), which is a major DSB repair pathway.
A major goal of our current work is to determine how upregulated HR in cells with non-functional p53 contributes to tumor formation and affects cellular sensitivity to DNA damaging agents. We are particularly interested in identifying the upstream proteins that control this effect of p53, including ATR (in collaboration with Lee Zou, Center for Cancer Research). In addition, more recently we described a role of p53 in the control of non-homologous end-joining (NHEJ), which represents another major DSB repair pathway. In the context of these projects, our laboratory has developed a special expertise in the design and application of plasmid substrates that integrate into the genome and allow the study of HR and NHEJ in living cells.

Functional Biomarkers of Radio- and Chemosensitivity:

Many proteins involved in the response to damaged DNA form subnuclear foci that can be detected by immunofluorescence microscopy. These foci represent potentially powerful biomarkers for the activity of a particular repair pathway. We are particularly interested in detecting disruptions of the Fanconi Anemia/BRCA pathway in breast, lung, and other cancer types, which may render the affected tumors hypersensitive to various DNA damaging agents. Ultimately, genotyping and phenotyping of cancers for the integrity of DNA repair pathways will lead to a better prediction of how a given tumor will respond to treatment, and this will allow us to tailor therapy to the individual cancer and patient. We are conducting this research in collaboration with Lisa Kachnic and Carol Rosenberg, Boston University.

Molecularly Targeted Radiation Therapy:

Ionizing radiation not only causes damage to DNA but also affects intra- and inter-cellular signaling pathways in a complex manner. Many of these alterations constitute cytoprotective responses that help cells to survive radiation exposure. In collaboration with Jeff Settleman, Center for Molecular Therapeutics in the Center for Cancer Research, we are seeking to identify signaling alterations in lung cancers that can be targeted in order to overcome the resistance of these tumors to radiation.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01CA220714 (HATA, AARON N;WILLERS, HENNING) Jul 1, 2018 - Jun 30, 2024
    NIH
    High-Throughput Screening and Validation of Molecular Targeted Chemoradiosensitizers
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Updating...
This operation might take several minutes to complete. Please do not close your browser.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Willers's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (371)
Explore
_
Co-Authors (135)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.