Harvard Catalyst Profiles

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Amar Sahay, Ph.D.

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Overview
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The incidence and complexity of mental illnesses and cognitive impairments associated with ageing and Alzheimer’s disease underscores the need to develop novel treatments. Our mission is to improve hippocampal functions in cognition.

Given the centrality of hippocampal dysfunction in neurological and psychiatric disorders and our efforts targeting convergent mechanisms (eg: PV mediated GABAergic inhibition, neuroinflammation), we aspire to develop strategies with broad therapeutic impact that improve cognition in not only Age-related cognitive decline and Mild Cognitive Impairment (MCI, Alzheimer’s disease) but also social cognition impairments in Autism spectrum disorders and overgeneralization of traumatic memories in PTSD. Take a look at our Research Page and DM me (Amar) to discuss ongoing efforts to de-risk preclinical gene therapy assets for translation.

For more information, please go to http://www.sahaylab.com/

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01MH131652 (SAHAY, AMAR) Aug 1, 2023 - May 31, 2028
    NIH
    Hippocampal synaptic and circuit mechanisms mediating Dyrk1a functions in social cognition
    Role: Principal Investigator
  2. 1R01AG076612-01 (Sahay) Jun 1, 2022 - Mar 31, 2027
    NIA
    Targeting neurogenesis-inhibition coupling to improve memory in aging
    Role: PI
  3. R01AG076612 (SAHAY, AMAR) Jun 1, 2022 - Mar 31, 2027
    NIH
    Targeting neurogenesis-inhibition coupling to improve memory in aging
    Role: Principal Investigator
  4. R56NS117529 (SAHAY, AMAR) Sep 1, 2020 - Aug 31, 2021
    NIH
    Transcriptional Control of adult hippocampal neural stem cell homeostasis
    Role: Principal Investigator
  5. R01MH111729 (SAHAY, AMAR) Nov 15, 2017 - Oct 31, 2023
    NIH
    Contributions of hippocampal oxytocin receptors to social recognition
    Role: Principal Investigator

Bibliographic
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© 2024 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.