LTT2LinusTsaiLinus Tzu-Yen Tsai, M.D.,Ph.D.42.34022770000000-71.1058540000000076921Tsai, LinusTzu-Yen617/667-7060Assistant Professor of Medicinecatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 1059214229657031Roh HC, Tsai LTY, Shao M, Tenen D, Shen Y, Kumari M, Lyubetskaya A, Jacobs C, Dawes B, Gupta RK, Rosen EDCell metabolismWarming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity. Cell Metab. 2018 May 01; 27(5):1121-1137.e5.Cell Metab2018-04-12T00:00:002018Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity.30078553Kong X, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T, Rosen EDCell metabolismBrown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin. Cell Metab. 2018 10 02; 28(4):631-643.e3.Cell Metab2018-08-02T00:00:002018Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin.D002001Anatomy2347540.631272Adipose Tissue, BrownD008473Anatomy30370.978143Median EminenceD047495Chemicals & Drugs3134940.767605PPAR gammaD022722Physiology1554280.717362ThermogenesisD017667Anatomy46011710.587088AdipocytesCell BiologyGeneticsMedicineHematology/OncologyGeneral MedicineVA Med CentersJoslinEndocrinologyBeth Israel Deaconess Medical CenterBrigham and Women's HospitalDana-Farber Cancer InstituteHarvard Medical SchoolJoslin Diabetes CenterVeterans Affairs Boston Healthcare SystemSK198ShingoKajimuraShingo Kajimura, Ph.D.42.33789600000000-71.1072493000000040157Kajimura, ShingoProfessor of MedicineACB12AnthonyBreuAnthony Charles Breu, M.D.42.34022770000000-71.1058540000000073536Breu, AnthonyAssistant Professor of MedicineEDR1EvanRosenEvan David Rosen, M.D., Ph.D.42.34620670000000-71.0997834000000084973Rosen, EvanProfessor of MedicineKKP4KavithaPrakashKavitha Prakash, M.D.42.34022770000000-71.1058540000000030624Prakash, KavithaAssistant Professor of MedicineCSM3ChristosMantzorosChristos Mantzoros, M.D.42.34022770000000-71.1058540000000061846Mantzoros, ChristosProfessor of Medicine31161155Kazak L, Rahbani JF, Samborska B, Lu GZ, Jedrychowski MP, Lajoie M, Zhang S, Ramsay L, Dou FY, Tenen D, Chouchani ET, Dzeja P, Watson IR, Tsai L, Rosen ED, Spiegelman BMNature metabolismAblation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity. Nat Metab. 2019; 1(3):360-370.Nat Metab2019-02-25T00:00:002019Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity.SHC17SharonChouSharon Hsiao-Han Chou, M.D.42.34022770000000-71.1058540000000038455Chou, SharonAssistant Professor of MedicineARW2AmyWeinsteinAmy Weinstein, M.D.42.34022770000000-71.1058540000000049705Weinstein, AmyAssistant Professor of MedicineCRK3C.KahnC. Ronald Kahn, M.D.42.33839600000000-71.1084030000000084269Kahn, C.Mary K. Iacocca Professor of MedicineBBL1BradfordLowellBradford Barr Lowell, M.D.,Ph.D.42.34022770000000-71.1058540000000015636Lowell, BradfordProfessor of MedicineCCS3CharlesSmithCharles Christopher Smith, M.D.42.34022770000000-71.1058540000000078213Smith, CharlesAssociate Professor of MedicineBMS5BruceSpiegelmanBruce Michael Spiegelman, Ph.D.42.33789600000000-71.1072493000000015280Spiegelman, BruceStanley J. Korsmeyer Professor of Cell Biology and MedicineNP7NorbertPerrimonNorbert Perrimon, Ph.D.42.33837200000000-71.103269000000006247Perrimon, NorbertJames Stillman Professor of Developmental BiologyDGT1DanielTenenDaniel Geoffrey Tenen, M.D.42.33837200000000-71.1032690000000063164Tenen, DanielProfessor of Medicine1134selected publications0.5966290.00231328213research areas2.024390.033266577coauthor of20.2192.5314860similar totrue1Assistant Professor of MedicineAssistant Professor of Medicinetrue1Assistant Professor of MedicineAssistant Professor of Medicinetrue1Professor of MedicineProfessor of Medicinetrue1Assistant Professor of MedicineAssistant Professor of Medicinetrue1James Stillman Professor of Developmental BiologyJames Stillman Professor of Developmental Biologytrue1Mary K. Iacocca Professor of MedicineMary K. Iacocca Professor of Medicinetrue1Professor of MedicineProfessor of Medicinetrue1Professor of MedicineProfessor of Medicinetrue1Stanley J. Korsmeyer Professor of Cell Biology and MedicineStanley J. Korsmeyer Professor of Cell Biology and Medicinetrue1Assistant Professor of MedicineAssistant Professor of Medicinetrue1Associate Professor of MedicineAssociate Professor of Medicinetrue1Professor of MedicineProfessor of MedicineAuthorship 12845021932941798Hall JA, Ramachandran D, Roh HC, DiSpirito JR, Belchior T, Zushin PH, Palmer C, Hong S, Mina AI, Liu B, Deng Z, Aryal P, Jacobs C, Tenen D, Brown CW, Charles JF, Shulman GI, Kahn BB, Tsai LTY, Rosen ED, Spiegelman BM, Banks ASCell metabolismObesity-Linked PPAR? S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3. Cell Metab. 2020 10 06; 32(4):665-675.e6.Cell Metab2020-09-16T00:00:002020Obesity-Linked PPAR? S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3.Authorship 1291750732992037Roh HC, Kumari M, Taleb S, Tenen D, Jacobs C, Lyubetskaya A, Tsai LT, Rosen EDMolecular metabolismAdipocytes fail to maintain cellular identity during obesity due to reduced PPAR? activity and elevated TGFß-SMAD signaling. Mol Metab. 2020 12; 42:101086.Mol Metab2020-09-28T00:00:002020Adipocytes fail to maintain cellular identity during obesity due to reduced PPAR? activity and elevated TGFß-SMAD signaling.33597756Rahbani JF, Roesler A, Hussain MF, Samborska B, Dykstra CB, Tsai L, Jedrychowski MP, Vergnes L, Reue K, Spiegelman BM, Kazak LNatureCreatine kinase B controls futile creatine cycling in thermogenic fat. Nature. 2021 02; 590(7846):480-485.Nature2021-02-17T00:00:002021Creatine kinase B controls futile creatine cycling in thermogenic fat.33655247Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe A, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, Jagadeesh KA, Dey KK, Sen P, Slyper M, Pita-Juárez YH, Phillips D, Bloom-Ackerman Z, Barkas N, Ganna A, Gomez J, Normandin E, Naderi P, Popov YV, Raju SS, Niezen S, Tsai LT, Siddle KJ, Sud M, Tran VM, Vellarikkal SK, Amir-Zilberstein L, Atri DS, Beechem J, Brook OR, Chen J, Divakar P, Dorceus P, Engreitz JM, Essene A, Fitzgerald DM, Fropf R, Gazal S, Gould J, Grzyb J, Harvey T, Hecht J, Hether T, Jane-Valbuena J, Leney-Greene M, Ma H, McCabe C, McLoughlin DE, Miller EM, Muus C, Niemi M, Padera R, Pan L, Pant D, Pe'er C, Pfiffner-Borges J, Pinto CJ, Plaisted J, Reeves J, Ross M, Rudy M, Rueckert EH, Siciliano M, Sturm A, Todres E, Waghray A, Warren S, Zhang S, Zollinger DR, Cosimi L, Gupta RM, Hacohen N, Hide W, Price AL, Rajagopal J, Tata PR, Riedel S, Szabo G, Tickle TL, Hung D, Sabeti PC, Novak R, Rogers R, Ingber DE, Jiang ZG, Juric D, Babadi M, Farhi SL, Stone JR, Vlachos IS, Solomon IH, Ashenberg O, Porter CBM, Li B, Shalek AK, Villani AC, Rozenblatt-Rosen O, Regev AbioRxiv : the preprint server for biologyA single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2. bioRxiv. 2021 Feb 25.bioRxiv2021-02-25T00:00:002021A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2.33915569Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe Å, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, Jagadeesh KA, Dey KK, Sen P, Slyper M, Pita-Juárez YH, Phillips D, Biermann J, Bloom-Ackermann Z, Barkas N, Ganna A, Gomez J, Melms JC, Katsyv I, Normandin E, Naderi P, Popov YV, Raju SS, Niezen S, Tsai LT, Siddle KJ, Sud M, Tran VM, Vellarikkal SK, Wang Y, Amir-Zilberstein L, Atri DS, Beechem J, Brook OR, Chen J, Divakar P, Dorceus P, Engreitz JM, Essene A, Fitzgerald DM, Fropf R, Gazal S, Gould J, Grzyb J, Harvey T, Hecht J, Hether T, Jané-Valbuena J, Leney-Greene M, Ma H, McCabe C, McLoughlin DE, Miller EM, Muus C, Niemi M, Padera R, Pan L, Pant D, Pe'er C, Pfiffner-Borges J, Pinto CJ, Plaisted J, Reeves J, Ross M, Rudy M, Rueckert EH, Siciliano M, Sturm A, Todres E, Waghray A, Warren S, Zhang S, Zollinger DR, Cosimi L, Gupta RM, Hacohen N, Hibshoosh H, Hide W, Price AL, Rajagopal J, Tata PR, Riedel S, Szabo G, Tickle TL, Ellinor PT, Hung D, Sabeti PC, Novak R, Rogers R, Ingber DE, Jiang ZG, Juric D, Babadi M, Farhi SL, Izar B, Stone JR, Vlachos IS, Solomon IH, Ashenberg O, Porter CBM, Li B, Shalek AK, Villani AC, Rozenblatt-Rosen O, Regev ANatureCOVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets. Nature. 2021 07; 595(7865):107-113.Nature2021-04-29T00:00:002021COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.Authorship 134800229Authorship 13535966Authorship 135359714Authorship 13535988Authorship 1360676334077742Tao J, Campbell JN, Tsai LT, Wu C, Liberles SD, Lowell BBNeuronHighly selective brain-to-gut communication via genetically defined vagus neurons. Neuron. 2021 07 07; 109(13):2106-2115.e4.Neuron2021-06-01T00:00:002021Highly selective brain-to-gut communication via genetically defined vagus neurons.true1Assistant Professor of MedicineAssistant Professor of Medicinetrue1Instructor in MedicineInstructor in MedicineAuthorship 14421813735296864Emont MP, Jacobs C, Essene AL, Pant D, Tenen D, Colleluori G, Di Vincenzo A, Jørgensen AM, Dashti H, Stefek A, McGonagle E, Strobel S, Laber S, Agrawal S, Westcott GP, Kar A, Veregge ML, Gulko A, Srinivasan H, Kramer Z, De Filippis E, Merkel E, Ducie J, Boyd CG, Gourash W, Courcoulas A, Lin SJ, Lee BT, Morris D, Tobias A, Khera AV, Claussnitzer M, Pers TH, Giordano A, Ashenberg O, Regev A, Tsai LT, Rosen EDNatureA single-cell atlas of human and mouse white adipose tissue. Nature. 2022 03; 603(7903):926-933.Nature2022-03-16T00:00:002022A single-cell atlas of human and mouse white adipose tissue.Authorship 15031323636324805Pita-Juarez Y, Karagkouni D, Kalavros N, Melms JC, Niezen S, Delorey TM, Essene AL, Brook OR, Pant D, Skelton-Badlani D, Naderi P, Huang P, Pan L, Hether T, Andrews TS, Ziegler CGK, Reeves J, Myloserdnyy A, Chen R, Nam A, Phelan S, Liang Y, Amin AD, Biermann J, Hibshoosh H, Veregge M, Kramer Z, Jacobs C, Yalcin Y, Phillips D, Slyper M, Subramanian A, Ashenberg O, Bloom-Ackermann Z, Tran VM, Gomez J, Sturm A, Zhang S, Fleming SJ, Warren S, Beechem J, Hung D, Babadi M, Padera RF, MacParland SA, Bader GD, Imad N, Solomon IH, Miller E, Riedel S, Porter CBM, Villani AC, Tsai LT, Hide W, Szabo G, Hecht J, Rozenblatt-Rosen O, Shalek AK, Izar B, Regev A, Popov Y, Jiang ZG, Vlachos ISbioRxiv : the preprint server for biologyA single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients. bioRxiv. 2022 Oct 28.bioRxiv2022-10-28T00:00:002022A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients.36334589Xiao H, Bozi LHM, Sun Y, Riley CL, Philip VM, Chen M, Li J, Zhang T, Mills EL, Emont MP, Sun W, Reddy A, Garrity R, Long J, Becher T, Vitas LP, Laznik-Bogoslavski D, Ordonez M, Liu X, Chen X, Wang Y, Liu W, Tran N, Liu Y, Zhang Y, Cypess AM, White AP, He Y, Deng R, Schöder H, Paulo JA, Jedrychowski MP, Banks AS, Tseng YH, Cohen P, Tsai LT, Rosen ED, Klein S, Chondronikola M, McAllister FE, Van Bruggen N, Huttlin EL, Spiegelman BM, Churchill GA, Gygi SP, Chouchani ETCellArchitecture of the outbred brown fat proteome defines regulators of metabolic physiology. Cell. 2022 11 23; 185(24):4654-4673.e28.Cell2022-11-04T00:00:002022Architecture of the outbred brown fat proteome defines regulators of metabolic physiology.true1Professor of MedicineProfessor of MedicineAuthorship 15603403737495702Emont MP, Jacobs C, Essene AL, Pant D, Tenen D, Colleluori G, Di Vincenzo A, Jørgensen AM, Dashti H, Stefek A, McGonagle E, Strobel S, Laber S, Agrawal S, Westcott GP, Kar A, Veregge ML, Gulko A, Srinivasan H, Kramer Z, De Filippis E, Merkel E, Ducie J, Boyd CG, Gourash W, Courcoulas A, Lin SJ, Lee BT, Morris D, Tobias A, Khera AV, Claussnitzer M, Pers TH, Giordano A, Ashenberg O, Regev A, Tsai LT, Rosen EDNatureAuthor Correction: A single-cell atlas of human and mouse white adipose tissue. Nature. 2023 Aug; 620(7973):E14.Nature2023-08-01T00:00:002023Author Correction: A single-cell atlas of human and mouse white adipose tissue.Authorship 160027926Authorship 15996305338014113Nardone S, De Luca R, Zito A, Klymko N, Nicoloutsopoulos D, Amsalem O, Brannigan C, Resch JM, Jacobs CL, Pant D, Veregge M, Srinivasan H, Grippo RM, Yang Z, Zeidel ML, Andermann ML, Harris KD, Tsai LT, Arrigoni E, Verstegen AMJ, Saper CB, Lowell BBbioRxiv : the preprint server for biologyA spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution. bioRxiv. 2023 Nov 17.bioRxiv2023-11-17T00:00:002023A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution.Authorship 161226718Authorship 16298761138416649Gulko A, Essene A, Belmont-Rausch DM, Veregge M, Pant D, Tenen D, Kapel BS, Emont MP, Pers TH, Rosen ED, Tsai LTSTAR protocolsProtocol for flow cytometry-assisted single-nucleus RNA sequencing of human and mouse adipose tissue with sample multiplexing. STAR Protoc. 2024 Feb 27; 5(1):102893.STAR Protoc2024-02-27T00:00:002024Protocol for flow cytometry-assisted single-nucleus RNA sequencing of human and mouse adipose tissue with sample multiplexing.Authorship 16343241838438345Nardone S, De Luca R, Zito A, Klymko N, Nicoloutsopoulos D, Amsalem O, Brannigan C, Resch JM, Jacobs CL, Pant D, Veregge M, Srinivasan H, Grippo RM, Yang Z, Zeidel ML, Andermann ML, Harris KD, Tsai LT, Arrigoni E, Verstegen AMJ, Saper CB, Lowell BBNature communicationsA spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution. Nat Commun. 2024 Mar 04; 15(1):1966.Nat Commun2024-03-04T00:00:002024A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution.23925113Ziller MJ, Gu H, Müller F, Donaghey J, Tsai LT, Kohlbacher O, De Jager PL, Rosen ED, Bennett DA, Bernstein BE, Gnirke A, Meissner ANatureCharting a dynamic DNA methylation landscape of the human genome. Nature. 2013 Aug 22; 500(7463):477-81.Nature2013-08-07T00:00:002013Charting a dynamic DNA methylation landscape of the human genome.Authorship 689945524288132Ramadoss P, Abraham BJ, Tsai L, Zhou Y, Costa-e-Sousa RH, Ye F, Bilban M, Zhao K, Hollenberg ANThe Journal of biological chemistryNovel mechanism of positive versus negative regulation by thyroid hormone receptor ß1 (TRß1) identified by genome-wide profiling of binding sites in mouse liver. J Biol Chem. 2014 Jan 17; 289(3):1313-28.J Biol Chem2013-11-27T00:00:002013Novel mechanism of positive versus negative regulation by thyroid hormone receptor ß1 (TRß1) identified by genome-wide profiling of binding sites in mouse liver.24709624Long JZ, Svensson KJ, Tsai L, Zeng X, Roh HC, Kong X, Rao RR, Lou J, Lokurkar I, Baur W, Castellot JJ, Rosen ED, Spiegelman BMCell metabolismA smooth muscle-like origin for beige adipocytes. Cell Metab. 2014 May 06; 19(5):810-20.Cell Metab2014-04-04T00:00:002014A smooth muscle-like origin for beige adipocytes.Authorship 778543225503565Kang S, Tsai LT, Zhou Y, Evertts A, Xu S, Griffin MJ, Issner R, Whitton HJ, Garcia BA, Epstein CB, Mikkelsen TS, Rosen EDNature cell biologyIdentification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis. Nat Cell Biol. 2015 Jan; 17(1):44-56.Nat Cell Biol2014-12-15T00:00:002014Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis.25693563Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis MNatureIntegrative analysis of 111 reference human epigenomes. Nature. 2015 Feb 19; 518(7539):317-30.Nature2015-02-19T00:00:002015Integrative analysis of 111 reference human epigenomes.Authorship 878818226822036Kang S, Tsai LT, Rosen EDTrends in cell biologyNuclear Mechanisms of Insulin Resistance. Trends Cell Biol. 2016 05; 26(5):341-351.Trends Cell Biol2016-01-25T00:00:002016Nuclear Mechanisms of Insulin Resistance.2Assistant Professor1Associate Professor0Full Professor4InstructorAuthorship 93737082Authorship 9373713Authorship 9373723Authorship 9373732Authorship 9373742Authorship 9373754Authorship 9373762Authorship 9373771Authorship 9373783Authorship 9373802Authorship 9373816Authorship 937382312486199Wolf FW, Rodan AR, Tsai LT, Heberlein UThe Journal of neuroscience : the official journal of the Society for NeuroscienceHigh-resolution analysis of ethanol-induced locomotor stimulation in Drosophila. J Neurosci. 2002 Dec 15; 22(24):11035-44.J Neurosci2002-12-15T00:00:002002High-resolution analysis of ethanol-induced locomotor stimulation in Drosophila.21248138King I, Tsai LT, Pflanz R, Voigt A, Lee S, Jäckle H, Lu B, Heberlein UThe Journal of neuroscience : the official journal of the Society for NeuroscienceDrosophila tao controls mushroom body development and ethanol-stimulated behavior through par-1. J Neurosci. 2011 Jan 19; 31(3):1139-48.J Neurosci2011-01-19T00:00:002011Drosophila tao controls mushroom body development and ethanol-stimulated behavior through par-1.18694769Heberlein U, Tsai LT, Kapfhamer D, Lasek AWNeuropharmacologyDrosophila, a genetic model system to study cocaine-related behaviors: a review with focus on LIM-only proteins. Neuropharmacology. 2009; 56 Suppl 1:97-106.Neuropharmacology2008-07-24T00:00:002008Drosophila, a genetic model system to study cocaine-related behaviors: a review with focus on LIM-only proteins.16213219Bainton RJ, Tsai LT, Schwabe T, DeSalvo M, Gaul U, Heberlein UCellmoody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability in Drosophila. Cell. 2005 Oct 07; 123(1):145-56.Cell2005-10-07T00:00:002005moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability in Drosophila.9371783Luo L, Lee T, Tsai L, Tang G, Jan LY, Jan YNProceedings of the National Academy of Sciences of the United States of AmericaGenghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):12963-8.Proc Natl Acad Sci U S A1997-11-25T00:00:001997Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization.8060613Salzberg A, D'Evelyn D, Schulze KL, Lee JK, Strumpf D, Tsai L, Bellen HJNeuronMutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development. Neuron. 1994 Aug; 13(2):269-87.Neuron1994-08-01T00:00:001994Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development.17018286Rothenfluh A, Threlkeld RJ, Bainton RJ, Tsai LT, Lasek AW, Heberlein UCellDistinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms. Cell. 2006 Oct 06; 127(1):199-211.Cell2006-10-06T00:00:002006Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms.10704411Bainton RJ, Tsai LT, Singh CM, Moore MS, Neckameyer WS, Heberlein UCurrent biology : CBDopamine modulates acute responses to cocaine, nicotine and ethanol in Drosophila. Curr Biol. 2000 Feb 24; 10(4):187-94.Curr Biol2000-02-24T00:00:002000Dopamine modulates acute responses to cocaine, nicotine and ethanol in Drosophila.15550987Tsai LT, Bainton RJ, Blau J, Heberlein UPLoS biologyLmo mutants reveal a novel role for circadian pacemaker neurons in cocaine-induced behaviors. PLoS Biol. 2004 Dec; 2(12):e408.PLoS Biol2004-11-23T00:00:002004Lmo mutants reveal a novel role for circadian pacemaker neurons in cocaine-induced behaviors.330 Brookline AveBeth Israel Deaconess Medical CenterMedicine - CLS 728330 Brookline AveBoston02215MA28122230Roh HC, Tsai LT, Lyubetskaya A, Tenen D, Kumari M, Rosen EDCell reportsSimultaneous Transcriptional and Epigenomic Profiling from Specific Cell Types within Heterogeneous Tissues In Vivo. Cell Rep. 2017 01 24; 18(4):1048-1061.Cell Rep2017-01-24T00:00:002017Simultaneous Transcriptional and Epigenomic Profiling from Specific Cell Types within Heterogeneous Tissues In Vivo.Authorship 9540482Authorship 9571761328166221Campbell JN, Macosko EZ, Fenselau H, Pers TH, Lyubetskaya A, Tenen D, Goldman M, Verstegen AM, Resch JM, McCarroll SA, Rosen ED, Lowell BB, Tsai LTNature neuroscienceA molecular census of arcuate hypothalamus and median eminence cell types. Nat Neurosci. 2017 Mar; 20(3):484-496.Nat Neurosci2017-02-06T00:00:002017A molecular census of arcuate hypothalamus and median eminence cell types.Authorship 1014857828957668Resch JM, Fenselau H, Madara JC, Wu C, Campbell JN, Lyubetskaya A, Dawes BA, Tsai LT, Li MM, Livneh Y, Ke Q, Kang PM, Fejes-Tóth G, Náray-Fejes-Tóth A, Geerling JC, Lowell BBNeuronAldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling. Neuron. 2017 Sep 27; 96(1):190-206.e7.Neuron2017-09-27T00:00:002017Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling.MPE4MargoEmontMargo Preminger Emont, Ph.D.165911Emont, MargoInstructor in Medicine