VKK1VijayKuchrooVijay Kumar Kuchroo, Ph.D.42.33837200000000-71.1032690000000061468Kuchroo, VijayKumar617/525-5350Samuel L. Wasserstrom Professor of Neurologycatalyst:advisorInMentoringCompletedStudentProjectcompleted student projectscatalyst:eCommonsLogineCommons LoginMentoring - Completed Student Projectprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:overviewoverviewvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson10973273Nicholson LB, Kuchroo VKNature immunologySelecting killers: the line between life and death. Nat Immunol. 2000 Sep; 1(3):192-4.Nat Immunol2000-09-01T00:00:002000Selecting killers: the line between life and death.11102774Encinas JA, Kuchroo VKCurrent opinion in immunologyMapping and identification of autoimmunity genes. Curr Opin Immunol. 2000 Dec; 12(6):691-7.Curr Opin Immunol2000-12-01T00:00:002000Mapping and identification of autoimmunity genes.11222494Encinas JA, Lees MB, Sobel RA, Symonowicz C, Weiner HL, Seidman CE, Seidman JG, Kuchroo VKInternational immunologyIdentification of genetic loci associated with paralysis, inflammation and weight loss in mouse experimental autoimmune encephalomyelitis. Int Immunol. 2001 Mar; 13(3):257-64.Int Immunol2001-03-01T00:00:002001Identification of genetic loci associated with paralysis, inflammation and weight loss in mouse experimental autoimmune encephalomyelitis.Authorship 104706823Authorship 10490681329500245Dixon KO, Schorer M, Nevin J, Etminan Y, Amoozgar Z, Kondo T, Kurtulus S, Kassam N, Sobel RA, Fukumura D, Jain RK, Anderson AC, Kuchroo VK, Joller NJournal of immunology (Baltimore, Md. : 1950)Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity. J Immunol. 2018 04 15; 200(8):3000-3007.J Immunol2018-03-02T00:00:002018Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity.11306603Theien BE, Vanderlugt CL, Eagar TN, Nickerson-Nutter C, Nazareno R, Kuchroo VK, Miller SDThe Journal of clinical investigationDiscordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis. J Clin Invest. 2001 Apr; 107(8):995-1006.J Clin Invest2001-04-01T00:00:002001Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis.Authorship 10278873594486Nelson M, Nelson DS, Kuchroo VK, Spradbrow PB, Jennings PACancer immunology, immunotherapy : CIIDepression of cell-mediated immunity by tumour cell products: induction of resistance by immunotherapeutically active extracts of bovine ocular squamous cell carcinoma. Cancer Immunol Immunother. 1987; 24(3):231-6.Cancer Immunol Immunother1987-01-01T00:00:001987Depression of cell-mediated immunity by tumour cell products: induction of resistance by immunotherapeutically active extracts of bovine ocular squamous cell carcinoma.Authorship 1050940429511029Nakashima H, Nguyen T, Kasai K, Passaro C, Ito H, Goins WF, Shaikh I, Erdelyi R, Nishihara R, Nakano I, Reardon DA, Anderson AC, Kuchroo V, Chiocca EAClinical cancer research : an official journal of the American Association for Cancer ResearchToxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma. Clin Cancer Res. 2018 06 01; 24(11):2574-2584.Clin Cancer Res2018-03-06T00:00:002018Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma.29505031Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IMNature medicineNociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia. Nat Med. 2018 05; 24(4):417-426.Nat Med2018-03-05T00:00:002018Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia.29531164Sage PT, Schildberg FA, Sobel RA, Kuchroo VK, Freeman GJ, Sharpe AHJournal of immunology (Baltimore, Md. : 1950)Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function. J Immunol. 2018 04 15; 200(8):2592-2602.J Immunol2018-03-12T00:00:002018Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function.Authorship 1053266919015529Korn T, Mitsdoerffer M, Croxford AL, Awasthi A, Dardalhon VA, Galileos G, Vollmar P, Stritesky GL, Kaplan MH, Waisman A, Kuchroo VK, Oukka MProceedings of the National Academy of Sciences of the United States of AmericaIL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18460-5.Proc Natl Acad Sci U S A2008-11-17T00:00:002008IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells.29562202Meyer Zu Horste G, Przybylski D, Schramm MA, Wang C, Schnell A, Lee Y, Sobel R, Regev A, Kuchroo VKImmunityFas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1. Immunity. 2018 03 20; 48(3):556-569.e7.Immunity2018-03-20T00:00:002018Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1.Authorship 109944517632405Degauque N, Mariat C, Kenny J, Sanchez-Fueyo A, Alexopoulos SP, Kuchroo V, Zheng XX, Strom TBTransplantationRegulation of T-cell immunity by T-cell immunoglobulin and mucin domain proteins. Transplantation. 2007 Jul 15; 84(1 Suppl):S12-6.Transplantation2007-07-15T00:00:002007Regulation of T-cell immunity by T-cell immunoglobulin and mucin domain proteins.11536181Stremmel C, Exley M, Balk S, Hohenberger W, Kuchroo VKEuropean journal of immunologyCharacterization of the phenotype and function of CD8(+), alpha / beta(+) NKT cells from tumor-bearing mice that show a natural killer cell activity and lyse multiple tumor targets. Eur J Immunol. 2001 Sep; 31(9):2818-28.Eur J Immunol2001-09-01T00:00:002001Characterization of the phenotype and function of CD8(+), alpha / beta(+) NKT cells from tumor-bearing mice that show a natural killer cell activity and lyse multiple tumor targets.11725301McIntire JJ, Umetsu SE, Akbari O, Potter M, Kuchroo VK, Barsh GS, Freeman GJ, Umetsu DT, DeKruyff RHNature immunologyIdentification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol. 2001 Dec; 2(12):1109-16.Nat Immunol2001-12-01T00:00:002001Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family.12152031Freeman GJ, Sharpe AH, Kuchroo VKNature medicineProtect the killer: CTLs need defenses against the tumor. Nat Med. 2002 Aug; 8(8):787-9.Nat Med2002-08-01T00:00:002002Protect the killer: CTLs need defenses against the tumor.12776205Kuchroo VK, Umetsu DT, DeKruyff RH, Freeman GJNature reviews. ImmunologyThe TIM gene family: emerging roles in immunity and disease. Nat Rev Immunol. 2003 Jun; 3(6):454-62.Nat Rev Immunol2003-06-01T00:00:002003The TIM gene family: emerging roles in immunity and disease.19015312Hafler DA, Kuchroo VThe Journal of experimental medicineTIMs: central regulators of immune responses. J Exp Med. 2008 Nov 24; 205(12):2699-701.J Exp Med2008-11-17T00:00:002008TIMs: central regulators of immune responses.19479722Mitsdoerffer M, Kuchroo VAnnals of neurologyNew pieces in the puzzle: how does interferon-beta really work in multiple sclerosis? Ann Neurol. 2009 May; 65(5):487-8.Ann Neurol2009-05-01T00:00:002009New pieces in the puzzle: how does interferon-beta really work in multiple sclerosis?19879742Bluestone JA, Kuchroo VCurrent opinion in immunologyAutoimmunity. Curr Opin Immunol. 2009 Dec; 21(6):579-81.Curr Opin Immunol2009-10-30T00:00:002009Autoimmunity.Authorship 10380116259003Illes Z, Stern JN, Keskin DB, Reddy J, Brosnan CF, Waldner H, Santambrogio L, Kuchroo VK, Strominger JLEuropean journal of immunologyCopolymer effects on microglia and T cells in the central nervous system of humanized mice. Eur J Immunol. 2005 Dec; 35(12):3683-93.Eur J Immunol2005-12-01T00:00:002005Copolymer effects on microglia and T cells in the central nervous system of humanized mice.19017931Anderson AC, Chandwaskar R, Lee DH, Kuchroo VKJournal of immunology (Baltimore, Md. : 1950)Cutting edge: the Idd3 genetic interval determines regulatory T cell function through CD11b+CD11c- APC. J Immunol. 2008 Dec 01; 181(11):7449-52.J Immunol2008-12-01T00:00:002008Cutting edge: the Idd3 genetic interval determines regulatory T cell function through CD11b+CD11c- APC.19017954Nagahara K, Arikawa T, Oomizu S, Kontani K, Nobumoto A, Tateno H, Watanabe K, Niki T, Katoh S, Miyake M, Nagahata S, Hirabayashi J, Kuchroo VK, Yamauchi A, Hirashima MJournal of immunology (Baltimore, Md. : 1950)Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions. J Immunol. 2008 Dec 01; 181(11):7660-9.J Immunol2008-12-01T00:00:002008Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions.22427644Lozano E, Dominguez-Villar M, Kuchroo V, Hafler DAJournal of immunology (Baltimore, Md. : 1950)The TIGIT/CD226 axis regulates human T cell function. J Immunol. 2012 Apr 15; 188(8):3869-75.J Immunol2012-03-16T00:00:002012The TIGIT/CD226 axis regulates human T cell function.23203389Ichinose K, Zhang Z, Koga T, Juang YT, Kis-Tóth K, Sharpe AH, Kuchroo V, Crispín JC, Tsokos GCArthritis and rheumatismBrief report: increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice. Arthritis Rheum. 2013 Mar; 65(3):764-9.Arthritis Rheum2013-03-01T00:00:002013Brief report: increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice.29725003Biswas A, Shouval DS, Griffith A, Goettel JA, Field M, Kang YH, Konnikova L, Janssen E, Redhu NS, Thrasher AJ, Chatila T, Kuchroo VK, Geha RS, Notarangelo LD, Pai SY, Horwitz BH, Snapper SBNature communicationsWASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nat Commun. 2018 05 03; 9(1):1779.Nat Commun2018-05-03T00:00:002018WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis.17581588Korn T, Bettelli E, Gao W, Awasthi A, Jäger A, Strom TB, Oukka M, Kuchroo VKNatureIL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature. 2007 Jul 26; 448(7152):484-487.Nature2007-06-20T00:00:002007IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.16670339Espinosa A, Zhou W, Ek M, Hedlund M, Brauner S, Popovic K, Horvath L, Wallerskog T, Oukka M, Nyberg F, Kuchroo VK, Wahren-Herlenius MJournal of immunology (Baltimore, Md. : 1950)The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death. J Immunol. 2006 May 15; 176(10):6277-85.J Immunol2006-05-15T00:00:002006The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death.Authorship 1048051219155484Mariat C, Degauque N, Balasubramanian S, Kenny J, DeKruyff RH, Umetsu DT, Kuchroo V, Zheng XX, Strom TBJournal of immunology (Baltimore, Md. : 1950)Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation. J Immunol. 2009 Feb 01; 182(3):1379-85.J Immunol2009-02-01T00:00:002009Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation.19676072Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VKEuropean journal of immunologyTIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol. 2009 Sep; 39(9):2492-501.Eur J Immunol2009-09-01T00:00:002009TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines.20679213Jin HT, Anderson AC, Tan WG, West EE, Ha SJ, Araki K, Freeman GJ, Kuchroo VK, Ahmed RProceedings of the National Academy of Sciences of the United States of AmericaCooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14733-8.Proc Natl Acad Sci U S A2010-08-02T00:00:002010Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection.22227671Kuchroo VK, Ohashi PS, Sartor RB, Vinuesa CGNature medicineDysregulation of immune homeostasis in autoimmune diseases. Nat Med. 2012 Jan 06; 18(1):42-7.Nat Med2012-01-06T00:00:002012Dysregulation of immune homeostasis in autoimmune diseases.12910246Robinson WH, Fontoura P, Lee BJ, de Vegvar HE, Tom J, Pedotti R, DiGennaro CD, Mitchell DJ, Fong D, Ho PP, Ruiz PJ, Maverakis E, Stevens DB, Bernard CC, Martin R, Kuchroo VK, van Noort JM, Genain CP, Amor S, Olsson T, Utz PJ, Garren H, Steinman LNature biotechnologyProtein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nat Biotechnol. 2003 Sep; 21(9):1033-9.Nat Biotechnol2003-08-10T00:00:002003Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis.22427931Fowler KD, Kuchroo VK, Chakraborty AKPloS oneA model for how signal duration can determine distinct outcomes of gene transcription programs. PLoS One. 2012; 7(3):e33018.PLoS One2012-03-13T00:00:002012A model for how signal duration can determine distinct outcomes of gene transcription programs.22949318Kuchroo VK, Awasthi AEuropean journal of immunologyEmerging new roles of Th17 cells. Eur J Immunol. 2012 Sep; 42(9):2211-4.Eur J Immunol2012-09-01T00:00:002012Emerging new roles of Th17 cells.22961052Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VKNature immunologyInduction and molecular signature of pathogenic TH17 cells. Nat Immunol. 2012 Oct; 13(10):991-9.Nat Immunol2012-09-09T00:00:002012Induction and molecular signature of pathogenic TH17 cells.14971042Petersen TR, Bettelli E, Sidney J, Sette A, Kuchroo V, Bäckström BTEuropean journal of immunologyCharacterization of MHC- and TCR-binding residues of the myelin oligodendrocyte glycoprotein 38-51 peptide. Eur J Immunol. 2004 Jan; 34(1):165-73.Eur J Immunol2004-01-01T00:00:002004Characterization of MHC- and TCR-binding residues of the myelin oligodendrocyte glycoprotein 38-51 peptide.15657286Bettelli E, Kuchroo VKThe Journal of experimental medicineIL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together. J Exp Med. 2005 Jan 17; 201(2):169-71.J Exp Med2005-01-17T00:00:002005IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together.Authorship 108568516924248Haynes L, Pfeffer S, Boss JM, Kavathas P, Kuchroo VNature immunologyLab management: insights for the new investigator. Nat Immunol. 2006 Sep; 7(9):895-7.Nat Immunol2006-09-01T00:00:002006Lab management: insights for the new investigator.18035554Korn T, Oukka M, Kuchroo V, Bettelli ESeminars in immunologyTh17 cells: effector T cells with inflammatory properties. Semin Immunol. 2007 Dec; 19(6):362-71.Semin Immunol2007-11-26T00:00:002007Th17 cells: effector T cells with inflammatory properties.Authorship 105967923630250Wu C, Pot C, Apetoh L, Thalhamer T, Zhu B, Murugaiyan G, Xiao S, Lee Y, Rangachari M, Yosef N, Kuchroo VKProceedings of the National Academy of Sciences of the United States of AmericaMetallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):7802-7.Proc Natl Acad Sci U S A2013-04-29T00:00:002013Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation.Authorship 10738882129899446Chihara N, Madi A, Kondo T, Zhang H, Acharya N, Singer M, Nyman J, Marjanovic ND, Kowalczyk MS, Wang C, Kurtulus S, Law T, Etminan Y, Nevin J, Buckley CD, Burkett PR, Buenrostro JD, Rozenblatt-Rosen O, Anderson AC, Regev A, Kuchroo VKNatureInduction and transcriptional regulation of the co-inhibitory gene module in T cells. Nature. 2018 06; 558(7710):454-459.Nature2018-06-13T00:00:002018Induction and transcriptional regulation of the co-inhibitory gene module in T cells.23467089Yosef N, Shalek AK, Gaublomme JT, Jin H, Lee Y, Awasthi A, Wu C, Karwacz K, Xiao S, Jorgolli M, Gennert D, Satija R, Shakya A, Lu DY, Trombetta JJ, Pillai MR, Ratcliffe PJ, Coleman ML, Bix M, Tantin D, Park H, Kuchroo VK, Regev ANatureDynamic regulatory network controlling TH17 cell differentiation. Nature. 2013 Apr 25; 496(7446):461-8.Nature2013-03-06T00:00:002013Dynamic regulatory network controlling TH17 cell differentiation.8552644Chen Y, Inobe J, Kuchroo VK, Baron JL, Janeway CA, Weiner HLProceedings of the National Academy of Sciences of the United States of AmericaOral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. Proc Natl Acad Sci U S A. 1996 Jan 09; 93(1):388-91.Proc Natl Acad Sci U S A1996-01-09T00:00:001996Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells.22052881Sharma S, Sundararajan A, Suryawanshi A, Kumar N, Veiga-Parga T, Kuchroo VK, Thomas PG, Sangster MY, Rouse BTProceedings of the National Academy of Sciences of the United States of AmericaT cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses. Proc Natl Acad Sci U S A. 2011 Nov 22; 108(47):19001-6.Proc Natl Acad Sci U S A2011-11-03T00:00:002011T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses.2966194Jaureguiberry B, Liao L, Kuchroo V, Dorf ME, Diamond BJournal of immunology (Baltimore, Md. : 1950)Monoclonal anti-idiotypic antibodies to an I-J interacting molecule inhibit suppression in an H-2 restricted way. J Immunol. 1988 May 15; 140(10):3286-9.J Immunol1988-05-15T00:00:001988Monoclonal anti-idiotypic antibodies to an I-J interacting molecule inhibit suppression in an H-2 restricted way.22814351Vignali DA, Kuchroo VKNature immunologyIL-12 family cytokines: immunological playmakers. Nat Immunol. 2012 Jul 19; 13(8):722-8.Nat Immunol2012-07-19T00:00:002012IL-12 family cytokines: immunological playmakers.22884313Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJImmunityPodoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity. 2012 Aug 24; 37(2):276-89.Immunity2012-08-09T00:00:002012Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2.2023-06-30KUCHROO, VIJAY K.2018-07-01Neuroimmune interactions regulate development of allergic inflammationR01AI139536Principal Investigator15153541Khademi M, Illés Z, Gielen AW, Marta M, Takazawa N, Baecher-Allan C, Brundin L, Hannerz J, Martin C, Harris RA, Hafler DA, Kuchroo VK, Olsson T, Piehl F, Wallström EJournal of immunology (Baltimore, Md. : 1950)T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. J Immunol. 2004 Jun 01; 172(11):7169-76.J Immunol2004-06-01T00:00:002004T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis.15265898Mycko MP, Waldner H, Anderson DE, Bourcier KD, Wucherpfennig KW, Kuchroo VK, Hafler DAJournal of immunology (Baltimore, Md. : 1950)Cross-reactive TCR responses to self antigens presented by different MHC class II molecules. J Immunol. 2004 Aug 01; 173(3):1689-98.J Immunol2004-08-01T00:00:002004Cross-reactive TCR responses to self antigens presented by different MHC class II molecules.16002337Meyers JH, Sabatos CA, Chakravarti S, Kuchroo VKTrends in molecular medicineThe TIM gene family regulates autoimmune and allergic diseases. Trends Mol Med. 2005 Aug; 11(8):362-9.Trends Mol Med2005-08-01T00:00:002005The TIM gene family regulates autoimmune and allergic diseases.Authorship 10541217182553Carrier Y, Yuan J, Kuchroo VK, Weiner HLJournal of immunology (Baltimore, Md. : 1950)Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic mice. J Immunol. 2007 Jan 01; 178(1):179-85.J Immunol2007-01-01T00:00:002007Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic mice.18563156Bettelli E, Korn T, Oukka M, Kuchroo VKNatureInduction and effector functions of T(H)17 cells. Nature. 2008 Jun 19; 453(7198):1051-7.Nature2008-06-19T00:00:002008Induction and effector functions of T(H)17 cells.2466892Steele JK, Kuchroo VK, Kawasaki H, Jayaraman S, Iwata M, Ishizaka K, Dorf MEJournal of immunology (Baltimore, Md. : 1950)A monoclonal antibody raised to lipomodulin recognizes T suppressor factors in two independent hapten-specific suppressor networks. J Immunol. 1989 Apr 01; 142(7):2213-20.J Immunol1989-04-01T00:00:001989A monoclonal antibody raised to lipomodulin recognizes T suppressor factors in two independent hapten-specific suppressor networks.30013196Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IMNature medicineAuthor Correction: Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia. Nat Med. 2018 Oct; 24(10):1625-1626.Nat Med2018-10-01T00:00:002018Author Correction: Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia.16622013Waldner H, Sobel RA, Price N, Kuchroo VKJournal of immunology (Baltimore, Md. : 1950)The autoimmune diabetes locus Idd9 regulates development of type 1 diabetes by affecting the homing of islet-specific T cells. J Immunol. 2006 May 01; 176(9):5455-62.J Immunol2006-05-01T00:00:002006The autoimmune diabetes locus Idd9 regulates development of type 1 diabetes by affecting the homing of islet-specific T cells.Authorship 110262417579036Greve B, Weissert R, Hamdi N, Bettelli E, Sobel RA, Coyle A, Kuchroo VK, Rajewsky K, Schmidt-Supprian MJournal of immunology (Baltimore, Md. : 1950)I kappa B kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis. 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J Exp Med. 2007 Jul 09; 204(7):1691-702.J Exp Med2007-07-02T00:00:002007Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.2246502Gallina MJ, Kuchroo VK, Steele JKJournal of immunology (Baltimore, Md. : 1950)Serologic, biologic, and western blot analysis of a T suppressor factor with specificity for the hapten 4-hydroxy-3-nitrophenyl acetyl derived from serum-free medium. J Immunol. 1990 Dec 01; 145(11):3570-7.J Immunol1990-12-01T00:00:001990Serologic, biologic, and western blot analysis of a T suppressor factor with specificity for the hapten 4-hydroxy-3-nitrophenyl acetyl derived from serum-free medium.17994022Awasthi A, Carrier Y, Peron JP, Bettelli E, Kamanaka M, Flavell RA, Kuchroo VK, Oukka M, Weiner HLNature immunologyA dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. 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Hafler, M.D.42.33837200000000-71.1032690000000082929Hafler, DavidJack, Sadie and David Breakstone Professor of Neurology, EmeritusAuthorship 1155660729016728Brauner S, Jiang X, Thorlacius GE, Lundberg AM, Östberg T, Yan ZQ, Kuchroo VK, Hansson GK, Wahren-Herlenius MCardiovascular researchAugmented Th17 differentiation in Trim21 deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content. Cardiovasc Res. 2018 01 01; 114(1):158-167.Cardiovasc Res2018-01-01T00:00:002018Augmented Th17 differentiation in Trim21 deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content.DMW2DominicWalshDominic M. Walsh, Ph.D.42.33837200000000-71.1032690000000028637Walsh, DominicLecturer on NeurologyACA5AnaAndersonAna Carrizosa Anderson, Ph.D.42.33837200000000-71.103269000000009079Anderson, AnaAlbert H. Coons Associate Professor of Neurology in the Field of Immunologic DiseasesGT33GeorgeTsokosGeorge C. Tsokos, M.D.42.34022770000000-71.1058540000000037050Tsokos, GeorgeProfessor of MedicineCAL10CynthiaLemereCynthia Ann Lemere, Ph.D.42.33837200000000-71.1032690000000060772Lemere, CynthiaProfessor of Neurology11433selected publications12.00870.00240918986research areas9.990870.00898443171coauthor of486.59864.869760similar toAHS1ArleneSharpeArlene Helen Sharpe, M.D., Ph.D.42.33837200000000-71.1032690000000068774Sharpe, ArleneKolokotrones University ProfessorHLW2HowardWeinerHoward Lee Weiner, M.D.42.33837200000000-71.1032690000000069565Weiner, HowardRobert L. Kroc Professor of NeurologySST7ShahamatTauhidShahamat Syed Tauhid, M.B.,B.S.42.33837200000000-71.1032690000000078414Tauhid, ShahamatResearch Fellow in NeurologyFJQ1FranciscoQuintanaFrancisco Javier Quintana, Ph.D.42.33837200000000-71.1032690000000082105Quintana, FranciscoProfessor of NeurologyAuthorship 1368851Authorship 1280198Authorship 1419793Authorship 1188387631477921Clement RL, Daccache J, Mohammed MT, Diallo A, Blazar BR, Kuchroo VK, Lovitch SB, Sharpe AH, Sage PTNature immunologyFollicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses. Nat Immunol. 2019 10; 20(10):1360-1371.Nat Immunol2019-09-02T00:00:002019Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses.Authorship 1463696Authorship 1567871Authorship 11965873Authorship 119778617Authorship 11966991931604535Tang R, Rangachari M, Kuchroo VKSeminars in immunologyTim-3: A co-receptor with diverse roles in T cell exhaustion and tolerance. Semin Immunol. 2019 04; 42:101302.Semin Immunol2019-04-01T00:00:002019Tim-3: A co-receptor with diverse roles in T cell exhaustion and tolerance.31618654Xu H, Ding J, Porter CBM, Wallrapp A, Tabaka M, Ma S, Fu S, Guo X, Riesenfeld SJ, Su C, Dionne D, Nguyen LT, Lefkovith A, Ashenberg O, Burkett PR, Shi HN, Rozenblatt-Rosen O, Graham DB, Kuchroo VK, Regev A, Xavier RJImmunityTranscriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide a-CGRP Modulates Group 2 Innate Lymphoid Cell Responses. Immunity. 2019 10 15; 51(4):696-708.e9.Immunity2019-10-15T00:00:002019Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide a-CGRP Modulates Group 2 Innate Lymphoid Cell Responses.31604686Wallrapp A, Burkett PR, Riesenfeld SJ, Kim SJ, Christian E, Abdulnour RE, Thakore PI, Schnell A, Lambden C, Herbst RH, Khan P, Tsujikawa K, Xavier RJ, Chiu IM, Levy BD, Regev A, Kuchroo VKImmunityCalcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses. Immunity. 2019 10 15; 51(4):709-723.e6.Immunity2019-10-08T00:00:002019Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses.Authorship 12004303Authorship 1201396231676122Zhang H, Kuchroo VSeminars in immunologyEpigenetic and transcriptional mechanisms for the regulation of IL-10. Semin Immunol. 2019 08; 44:101324.Semin Immunol2019-10-30T00:00:002019Epigenetic and transcriptional mechanisms for the regulation of IL-10.31676858Wolf Y, Anderson AC, Kuchroo VKNature reviews. ImmunologyTIM3 comes of age as an inhibitory receptor. Nat Rev Immunol. 2020 03; 20(3):173-185.Nat Rev Immunol2019-11-01T00:00:002019TIM3 comes of age as an inhibitory receptor.Authorship 1362271231757673Wang W, Cohen JA, Wallrapp A, Trieu KG, Barrios J, Shao F, Krishnamoorthy N, Kuchroo VK, Jones MR, Fine A, Bai Y, Ai XImmunityAge-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung. Immunity. 2019 12 17; 51(6):1102-1118.e7.Immunity2019-11-19T00:00:002019Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung.true1Samuel L. Wasserstrom Professor of NeurologySamuel L. Wasserstrom Professor of Neurologytrue1Professor of NeurologyProfessor of Neurologytrue1Jack, Sadie and David Breakstone Professor of Neurology, EmeritusJack, Sadie and David Breakstone Professor of Neurology, Emeritustrue1Professor of MedicineProfessor of Medicinetrue1Robert L. Kroc Professor of NeurologyRobert L. Kroc Professor of Neurologytrue1Lecturer on NeurologyLecturer on NeurologyAuthorship 1429405Authorship 1450974Authorship 1286279Authorship 1402646Authorship 1357849Authorship 12717315Authorship 1328257Authorship 1608437Authorship 1350831231813624Lai NY, Musser MA, Pinho-Ribeiro FA, Baral P, Jacobson A, Ma P, Potts DE, Chen Z, Paik D, Soualhi S, Yan Y, Misra A, Goldstein K, Lagomarsino VN, Nordstrom A, Sivanathan KN, Wallrapp A, Kuchroo VK, Nowarski R, Starnbach MN, Shi H, Surana NK, An D, Wu C, Huh JR, Rao M, Chiu IMCellGut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense. Cell. 2020 01 09; 180(1):33-49.e22.Cell2019-12-05T00:00:002019Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense.Authorship 13937110Authorship 167021631974523Schnell A, Bod L, Madi A, Kuchroo VKCell researchThe yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity. Cell Res. 2020 04; 30(4):285-299.Cell Res2020-01-23T00:00:002020The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity.Authorship 1267912025-01-31KUCHROO, VIJAY K.2020-02-03Role of Tim-3:Bat-3 pathway in inducing tolerogenic DCs and peripheral toleranceR01AI144166Principal Investigator32086475Schnell A, Bod L, Madi A, Kuchroo VKCell researchAuthor Correction: The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity. Cell Res. 2020 Apr; 30(4):366.Cell Res2020-04-01T00:00:002020Author Correction: The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity.Authorship 18745112Authorship 2035026Authorship 1467474Authorship 1465653Authorship 1377064Authorship 1394021Authorship 16090810Authorship 1481221232668241Xiao S, Bod L, Pochet N, Kota SB, Hu D, Madi A, Kilpatrick J, Shi J, Ho A, Zhang H, Sobel R, Weiner HL, Strom TB, Quintana FJ, Joller N, Kuchroo VKCell reportsCheckpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation. Cell Rep. 2020 07 14; 32(2):107892.Cell Rep2020-07-14T00:00:002020Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation.Authorship 1852201132937153Acharya N, Madi A, Zhang H, Klapholz M, Escobar G, Dulberg S, Christian E, Ferreira M, Dixon KO, Fell G, Tooley K, Mangani D, Xia J, Singer M, Bosenberg M, Neuberg D, Rozenblatt-Rosen O, Regev A, Kuchroo VK, Anderson ACImmunityEndogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment. Immunity. 2020 09 15; 53(3):658-671.e6.Immunity2020-09-15T00:00:002020Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment.Authorship 2280363Authorship 195431733039897Pawlak M, Ho AW, Kuchroo VKCurrent opinion in immunologyCytokines and transcription factors in the differentiation of CD4+ T helper cell subsets and induction of tissue inflammation and autoimmunity. Curr Opin Immunol. 2020 12; 67:57-67.Curr Opin Immunol2020-10-08T00:00:002020Cytokines and transcription factors in the differentiation of CD4+ T helper cell subsets and induction of tissue inflammation and autoimmunity.true1Albert H. Coons Associate Professor of Neurology in the Field of Immunologic DiseasesAlbert H. Coons Associate Professor of Neurology in the Field of Immunologic DiseasesAuthorship 23169733238123Zhang H, Madi A, Yosef N, Chihara N, Awasthi A, Pot C, Lambden C, Srivastava A, Burkett PR, Nyman J, Christian E, Etminan Y, Lee A, Stroh H, Xia J, Karwacz K, Thakore PI, Acharya N, Schnell A, Wang C, Apetoh L, Rozenblatt-Rosen O, Anderson AC, Regev A, Kuchroo VKCell reportsAn IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets. Cell Rep. 2020 11 24; 33(8):108433.Cell Rep2020-11-24T00:00:002020An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets.33168576Sungnak W, Wagner A, Kowalczyk MS, Bod L, Kye YC, Sage PT, Sharpe AH, Sobel RA, Quintana FJ, Rozenblatt-Rosen O, Regev A, Wang C, Yosef N, Kuchroo VKJournal of immunology (Baltimore, Md. : 1950)T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity. J Immunol. 2020 12 15; 205(12):3247-3262.J Immunol2020-11-09T00:00:002020T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity.33203678Hu D, Tjon EC, Andersson KM, Molica GM, Pham MC, Healy B, Murugaiyan G, Pochet N, Kuchroo VK, Bokarewa MI, Weiner HLProceedings of the National Academy of Sciences of the United States of AmericaAberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells. Proc Natl Acad Sci U S A. 2020 12 01; 117(48):30639-30648.Proc Natl Acad Sci U S A2020-11-17T00:00:002020Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells.Authorship 152962Authorship 243725127798153Suzuki E, Maverakis E, Sarin R, Bouchareychas L, Kuchroo VK, Nestle FO, Adamopoulos IEJournal of immunology (Baltimore, Md. : 1950)T Cell-Independent Mechanisms Associated with Neutrophil Extracellular Trap Formation and Selective Autophagy in IL-17A-Mediated Epidermal Hyperplasia. J Immunol. 2016 12 01; 197(11):4403-4412.J Immunol2016-10-24T00:00:002016T Cell-Independent Mechanisms Associated with Neutrophil Extracellular Trap Formation and Selective Autophagy in IL-17A-Mediated Epidermal Hyperplasia.33742094Gandhi AK, Sun ZJ, Kim WM, Huang YH, Kondo Y, Bonsor DA, Sundberg EJ, Wagner G, Kuchroo VK, Petsko GA, Blumberg RSCommunications biologyStructural basis of the dynamic human CEACAM1 monomer-dimer equilibrium. Commun Biol. 2021 03 19; 4(1):360.Commun Biol2021-03-19T00:00:002021Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium.33931442Zhu C, Dixon KO, Newcomer K, Gu G, Xiao S, Zaghouani S, Schramm MA, Wang C, Zhang H, Goto K, Christian E, Rangachari M, Rosenblatt-Rosen O, Okada H, Mak T, Singer M, Regev A, Kuchroo VScience advancesTim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion. Sci Adv. 2021 04; 7(18).Sci Adv2021-04-30T00:00:002021Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion.33951465Mori Y, Ajay AK, Chang JH, Mou S, Zhao H, Kishi S, Li J, Brooks CR, Xiao S, Woo HM, Sabbisetti VS, Palmer SC, Galichon P, Li L, Henderson JM, Kuchroo VK, Hawkins J, Ichimura T, Bonventre JVCell metabolismKIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease. Cell Metab. 2021 05 04; 33(5):1042-1061.e7.Cell Metab2021-05-04T00:00:002021KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease.34108686Dixon KO, Tabaka M, Schramm MA, Xiao S, Tang R, Dionne D, Anderson AC, Rozenblatt-Rosen O, Regev A, Kuchroo VKNatureTIM-3 restrains anti-tumour immunity by regulating inflammasome activation. Nature. 2021 07; 595(7865):101-106.Nature2021-06-09T00:00:002021TIM-3 restrains anti-tumour immunity by regulating inflammasome activation.34219003Anderson AC, Kuchroo VKSeminars in immunologyIntroduction to the Special Issue: Immuno-oncology. Semin Immunol. 2021 02; 52:101483.Semin Immunol2021-07-01T00:00:002021Introduction to the Special Issue: Immuno-oncology.34216539Wagner A, Wang C, Fessler J, DeTomaso D, Avila-Pacheco J, Kaminski J, Zaghouani S, Christian E, Thakore P, Schellhaass B, Akama-Garren E, Pierce K, Singh V, Ron-Harel N, Douglas VP, Bod L, Schnell A, Puleston D, Sobel RA, Haigis M, Pearce EL, Soleimani M, Clish C, Regev A, Kuchroo VK, Yosef NCellMetabolic modeling of single Th17 cells reveals regulators of autoimmunity. Cell. 2021 08 05; 184(16):4168-4185.e21.Cell2021-07-02T00:00:002021Metabolic modeling of single Th17 cells reveals regulators of autoimmunity.34287641Chen Z, Luo J, Li J, Kim G, Chen ES, Xiao S, Snapper SB, Bao B, An D, Blumberg RS, Lin CH, Wang S, Zhong J, Liu K, Li Q, Wu C, Kuchroo VKThe Journal of experimental medicineFoxo1 controls gut homeostasis and commensalism by regulating mucus secretion. J Exp Med. 2021 09 06; 218(9).J Exp Med2021-07-21T00:00:002021Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion.Authorship 1529177Authorship 154770534450029Pelka K, Hofree M, Chen JH, Sarkizova S, Pirl JD, Jorgji V, Bejnood A, Dionne D, Ge WH, Xu KH, Chao SX, Zollinger DR, Lieb DJ, Reeves JW, Fuhrman CA, Hoang ML, Delorey T, Nguyen LT, Waldman J, Klapholz M, Wakiro I, Cohen O, Albers J, Smillie CS, Cuoco MS, Wu J, Su MJ, Yeung J, Vijaykumar B, Magnuson AM, Asinovski N, Moll T, Goder-Reiser MN, Applebaum AS, Brais LK, DelloStritto LK, Denning SL, Phillips ST, Hill EK, Meehan JK, Frederick DT, Sharova T, Kanodia A, Todres EZ, Jané-Valbuena J, Biton M, Izar B, Lambden CD, Clancy TE, Bleday R, Melnitchouk N, Irani J, Kunitake H, Berger DL, Srivastava A, Hornick JL, Ogino S, Rotem A, Vigneau S, Johnson BE, Corcoran RB, Sharpe AH, Kuchroo VK, Ng K, Giannakis M, Nieman LT, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen NCellSpatially organized multicellular immune hubs in human colorectal cancer. Cell. 2021 09 02; 184(18):4734-4752.e20.Cell2021-08-26T00:00:002021Spatially organized multicellular immune hubs in human colorectal cancer.Authorship 1711265Authorship 17686316Authorship 2038192Authorship 156840134875227Schnell A, Huang L, Singer M, Singaraju A, Barilla RM, Regan BML, Bollhagen A, Thakore PI, Dionne D, Delorey TM, Pawlak M, Meyer Zu Horste G, Rozenblatt-Rosen O, Irizarry RA, Regev A, Kuchroo VKCellStem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity. Cell. 2021 12 22; 184(26):6281-6298.e23.Cell2021-12-06T00:00:002021Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity.Authorship 142159017Authorship 14216293Authorship 14217989Authorship 14216075Authorship 142163416Authorship 142180912Authorship 14219602Authorship 142226163Authorship 142226414Authorship 14227454Authorship 14216327Authorship 14228828Authorship 142294316Authorship 142295219Authorship 142179417Authorship 14221514Authorship 14223182Authorship 14223292Authorship 142360217Authorship 142214915Authorship 142222410Authorship 142233120Authorship 142241021Authorship 142238925Authorship 142240523Authorship 142274318Authorship 142359416Authorship 14236043Authorship 14221454Authorship 142215325Authorship 14222306Authorship 142227214Authorship 14223859Authorship 142359917Authorship 14221239Authorship 142212413Authorship 14223979Authorship 14229331828760805Brauner S, Folkersen L, Kvarnström M, Meisgen S, Petersen S, Franzén-Malmros M, Mofors J, Brokstad KA, Klareskog L, Jonsson R, Westerberg LS, Trollmo C, Malmström V, Ambrosi A, Kuchroo VK, Nordmark G, Wahren-Herlenius MAnnals of the rheumatic diseasesH1N1 vaccination in Sjögren's syndrome triggers polyclonal B cell activation and promotes autoantibody production. Ann Rheum Dis. 2017 Oct; 76(10):1755-1763.Ann Rheum Dis2017-07-31T00:00:002017H1N1 vaccination in Sjögren's syndrome triggers polyclonal B cell activation and promotes autoantibody production.31657111Delaney C, Schnell A, Cammarata LV, Yao-Smith A, Regev A, Kuchroo VK, Singer MMolecular systems biologyCombinatorial prediction of marker panels from single-cell transcriptomic data. Mol Syst Biol. 2019 10; 15(10):e9005.Mol Syst Biol2019-10-01T00:00:002019Combinatorial prediction of marker panels from single-cell transcriptomic data.31758534Schorer M, Kuchroo VK, Joller NAdvances in experimental medicine and biologyRole of Co-stimulatory Molecules in T Helper Cell Differentiation. Adv Exp Med Biol. 2019; 1189:153-177.Adv Exp Med Biol2019-01-01T00:00:002019Role of Co-stimulatory Molecules in T Helper Cell Differentiation.34216540Puleston DJ, Baixauli F, Sanin DE, Edwards-Hicks J, Villa M, Kabat AM, Kaminski MM, Stanckzak M, Weiss HJ, Grzes KM, Piletic K, Field CS, Corrado M, Haessler F, Wang C, Musa Y, Schimmelpfennig L, Flachsmann L, Mittler G, Yosef N, Kuchroo VK, Buescher JM, Balabanov S, Pearce EJ, Green DR, Pearce ELCellPolyamine metabolism is a central determinant of helper T cell lineage fidelity. Cell. 2021 08 05; 184(16):4186-4202.e20.Cell2021-07-02T00:00:002021Polyamine metabolism is a central determinant of helper T cell lineage fidelity.28900677Joller N, Kuchroo VKCurrent topics in microbiology and immunologyTim-3, Lag-3, and TIGIT. Curr Top Microbiol Immunol. 2017; 410:127-156.Curr Top Microbiol Immunol2017-01-01T00:00:002017Tim-3, Lag-3, and TIGIT.28848066Ding Q, Mohib K, Kuchroo VK, Rothstein DMJournal of immunology (Baltimore, Md. : 1950)TIM-4 Identifies IFN-?-Expressing Proinflammatory B Effector 1 Cells That Promote Tumor and Allograft Rejection. J Immunol. 2017 10 01; 199(7):2585-2595.J Immunol2017-08-28T00:00:002017TIM-4 Identifies IFN-?-Expressing Proinflammatory B Effector 1 Cells That Promote Tumor and Allograft Rejection.Authorship 1931815Authorship 2105384Authorship 1430651235142369Krovi SH, Kuchroo VKImmunological reviewsActivation pathways that drive CD4+ T cells to break tolerance in autoimmune diseases. Immunol Rev. 2022 05; 307(1):161-190.Immunol Rev2022-02-10T00:00:002022Activation pathways that drive CD4+ T cells to break tolerance in autoimmune diseases.35275752Tang R, Acharya N, Subramanian A, Purohit V, Tabaka M, Hou Y, He D, Dixon KO, Lambden C, Xia J, Rozenblatt-Rosen O, Sobel RA, Wang C, Regev A, Anderson AC, Kuchroo VKScience immunologyTim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function. Sci Immunol. 2022 03 11; 7(69):eabm0631.Sci Immunol2022-03-11T00:00:002022Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function.Authorship 144183223Authorship 14363451Authorship 14405161635316223Pagliano O, Morrison RM, Chauvin JM, Banerjee H, Davar D, Ding Q, Tanegashima T, Gao W, Chakka SR, DeBlasio R, Lowin A, Kara K, Ka M, Zidi B, Amin R, Raphael I, Zhang S, Watkins SC, Sander C, Kirkwood JM, Bosenberg M, Anderson AC, Kuchroo VK, Kane LP, Korman AJ, Rajpal A, West SM, Han M, Bee C, Deng X, Schebye XM, Strop P, Zarour HMThe Journal of clinical investigationTim-3 mediates T cell trogocytosis to limit antitumor immunity. J Clin Invest. 2022 05 02; 132(9).J Clin Invest2022-05-02T00:00:002022Tim-3 mediates T cell trogocytosis to limit antitumor immunity.35263566Kuchroo VK, Weiner HLImmunityHow does Epstein-Barr virus trigger MS? Immunity. 2022 03 08; 55(3):390-392.Immunity2022-03-08T00:00:002022How does Epstein-Barr virus trigger MS?Authorship 27563613Authorship 287631Authorship 1446493535359977Song Z, Yuan W, Zheng L, Wang X, Kuchroo VK, Mohib K, Rothstein DMFrontiers in immunologyB Cell IL-4 Drives Th2 Responses In Vivo, Ameliorates Allograft Rejection, and Promotes Allergic Airway Disease. Front Immunol. 2022; 13:762390.Front Immunol2022-03-14T00:00:002022B Cell IL-4 Drives Th2 Responses In Vivo, Ameliorates Allograft Rejection, and Promotes Allergic Airway Disease.Authorship 1464648735636144Douna H, Smit V, van Puijvelde GHM, Kiss MG, Binder CJ, Bot L, Kuchroo VK, Lichtman AH, Kuiper J, Foks ACAtherosclerosisTim-1 mucin domain-mutant mice display exacerbated atherosclerosis. Atherosclerosis. 2022 07; 352:1-9.Atherosclerosis2022-05-21T00:00:002022Tim-1 mucin domain-mutant mice display exacerbated atherosclerosis.Authorship 4051829Authorship 4141917Authorship 14864412Authorship 14871362036068310Spiljar M, Kuchroo VKSeminars in immunopathologyMetabolic regulation and function of T helper cells in neuroinflammation. Semin Immunopathol. 2022 09; 44(5):581-598.Semin Immunopathol2022-09-06T00:00:002022Metabolic regulation and function of T helper cells in neuroinflammation.36070768Pawlak M, DeTomaso D, Schnell A, Meyer Zu Horste G, Lee Y, Nyman J, Dionne D, Regan BML, Singh V, Delorey T, Schramm MA, Wang C, Wallrapp A, Burkett PR, Riesenfeld SJ, Anderson AC, Regev A, Xavier RJ, Yosef N, Kuchroo VKImmunityInduction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling. Immunity. 2022 09 13; 55(9):1663-1679.e6.Immunity2022-09-06T00:00:002022Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling.Authorship 1512329336596896Schnell A, Littman DR, Kuchroo VKNature immunologyTH17 cell heterogeneity and its role in tissue inflammation. Nat Immunol. 2023 01; 24(1):19-29.Nat Immunol2023-01-03T00:00:002023TH17 cell heterogeneity and its role in tissue inflammation.36893254Wheeler MA, Clark IC, Lee HG, Li Z, Linnerbauer M, Rone JM, Blain M, Akl CF, Piester G, Giovannoni F, Charabati M, Lee JH, Kye YC, Choi J, Sanmarco LM, Srun L, Chung EN, Flausino LE, Andersen BM, Rothhammer V, Yano H, Illouz T, Zandee SEJ, Daniel C, Artis D, Prinz M, Abate AR, Kuchroo VK, Antel JP, Prat A, Quintana FJScience (New York, N.Y.)Droplet-based forward genetic screening of astrocyte-microglia cross-talk. 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Nat Immunol. 2023 Nov; 24(11):1908-1920.Nat Immunol2023-10-12T00:00:002023Targeting PGLYRP1 promotes antitumor immunity while inhibiting autoimmune neuroinflammation.true1Kolokotrones University ProfessorKolokotrones University Professortrue1Research Fellow in ImmunologyResearch Fellow in Immunologytrue1Research Fellow in NeurologyResearch Fellow in Neurologytrue1Professor of NeurologyProfessor of NeurologyAuthorship 428424Authorship 15990877Authorship 1603060937909848Akbar I, Tang R, Baillargeon J, Roy AP, Doss PMIA, Zhu C, Kuchroo VK, Rangachari MJournal of immunology (Baltimore, Md. : 1950)Cutting Edge: Serpine1 Negatively Regulates Th1 Cell Responses in Experimental Autoimmune Encephalomyelitis. 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Ann N Y Acad Sci. 2013 Apr; 1283:57-66.Ann N Y Acad Sci2013-04-01T00:00:002013Immunology of neuromyelitis optica: a T cell-B cell collaboration.23836225Baeten DL, Kuchroo VKNature medicineHow Cytokine networks fuel inflammation: Interleukin-17 and a tale of two autoimmune diseases. Nat Med. 2013 Jul; 19(7):824-5.Nat Med2013-07-01T00:00:002013How Cytokine networks fuel inflammation: Interleukin-17 and a tale of two autoimmune diseases.Authorship 3652732ImmunologyAuthorship 54836923979159Humphreys BD, Xu F, Sabbisetti V, Grgic I, Movahedi Naini S, Wang N, Chen G, Xiao S, Patel D, Henderson JM, Ichimura T, Mou S, Soeung S, McMahon AP, Kuchroo VK, Bonventre JVThe Journal of clinical investigationChronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. 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Nature. 2015 01 15; 517(7534):386-90.Nature2014-10-26T00:00:002014CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.Authorship 5383279Authorship 5217613Authorship 5604443Authorship 564570325539814Krishnamoorthy N, Burkett PR, Dalli J, Abdulnour RE, Colas R, Ramon S, Phipps RP, Petasis NA, Kuchroo VK, Serhan CN, Levy BDJournal of immunology (Baltimore, Md. : 1950)Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation. J Immunol. 2015 Feb 01; 194(3):863-7.J Immunol2014-12-24T00:00:002014Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation.25614966Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan DJ, Wu C, Rangachari M, Pertel T, Jin HT, Ahmed R, Anderson AC, Kuchroo VKNature communicationsAn IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction. 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Immunity. 2015 Feb 17; 42(2):201-203.Immunity2015-02-17T00:00:002015Ezh2 lines up the chromatin in T regulatory cells.Authorship 2719823Authorship 275082Authorship 5074872Authorship 3905143Authorship 3924905Authorship 4026592Authorship 56207110Authorship 5903313Authorship 739171Authorship 8060412Authorship 3856922Authorship 42878611Authorship 1663823Authorship 48887810Authorship 45008Authorship 466937Authorship 5370884Authorship 3909616Authorship 5655702Authorship 5507302Authorship 4089853Authorship 799462Authorship 24305511Authorship 615655Authorship 5538998Authorship 706858Authorship 975211Authorship 23605524Authorship 2497618Authorship 1031934Authorship 3010252Authorship 31468412Authorship 2494288Authorship 2711749Authorship 2367163Authorship 2099225Authorship 2125117Authorship 3075051Authorship 3141573Authorship 3567512Authorship 3297709Authorship 330486Authorship 275802Authorship 39117513Authorship 5160727Authorship 4409486Authorship 2329058Authorship 52547Authorship 804757Authorship 879811Authorship 251761Authorship 2668313Authorship 320194Authorship 3386821Authorship 3538862Authorship 4504723Authorship 2120753Authorship 44447217Authorship 3978598Authorship 4008446Authorship 2345672Authorship 2869012Authorship 3029545Authorship 365493Authorship 2877185Authorship 4011091Authorship 4759039Authorship 4965565Authorship 56709910AW183AntoniaWallrappAntonia Wallrapp, Ph.D.138811Wallrapp, AntoniaResearch Fellow in ImmunologyAuthorship 3394810Authorship 3486364Authorship 3951299Authorship 4649532Authorship 5060656Authorship 5445981Authorship 7906749Authorship 80421017Authorship 5741632Authorship 7971413Authorship 8054808Authorship 8010397Authorship 7954085Authorship 8044283Authorship 8057349Authorship 7998294Authorship 7899863Authorship 7931453Authorship 78911423Authorship 7926989Authorship 8026441525450716Liu Y, Ji H, Zhang Y, Shen X, Gao F, He X, Li GA, Busuttil RW, Kuchroo VK, Kupiec-Weglinski JWJournal of hepatologyRecipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury. 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