JP6JorgePlutzkyJorge Plutzky, M.D.42.33837200000000-71.103269000000003927Plutzky, Jorge6175254360, 4361Associate Professor of Medicinecatalyst:advisorInMentoringCompletedStudentProjectcompleted student projectscatalyst:eCommonsLogineCommons LoginMentoring - Completed Student Projectprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:overviewoverviewvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 104590313Authorship 1046912129464513Plutzky J, Liao KPCurrent rheumatology reportsLipids in RA: Is Less Not Necessarily More? Curr Rheumatol Rep. 2018 02 21; 20(2):8.Curr Rheumatol Rep2018-02-21T00:00:002018Lipids in RA: Is Less Not Necessarily More?29444854Brown JD, Feldman ZB, Doherty SP, Reyes JM, Rahl PB, Lin CY, Sheng Q, Duan Q, Federation AJ, Kung AL, Haldar SM, Young RA, Plutzky J, Bradner JEProceedings of the National Academy of Sciences of the United States of AmericaBET bromodomain proteins regulate enhancer function during adipogenesis. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):2144-2149.Proc Natl Acad Sci U S A2018-02-14T00:00:002018BET bromodomain proteins regulate enhancer function during adipogenesis.12663371Ridker PM, Cook NR, Cheng S, Erlich HA, Lindpaintner K, Plutzky J, Zee RYArteriosclerosis, thrombosis, and vascular biologyAlanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction. Arterioscler Thromb Vasc Biol. 2003 May 01; 23(5):859-63.Arterioscler Thromb Vasc Biol2003-03-27T00:00:002003Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction.Plutzky J. PPARs and diabetic atherosclerosis. PPARs and diabetic atherosclerosis. 2001.2001-01-01T00:00:002001PPARs and diabetic atherosclerosisAuthorship 1053402229567104Zhang H, Plutzky J, Ge W, Shubina M, Turchin AJournal of clinical lipidologyPredictors of a successful statin reattempt after an adverse reaction. J Clin Lipidol. 2018 May - Jun; 12(3):643-651.J Clin Lipidol2018-02-14T00:00:002018Predictors of a successful statin reattempt after an adverse reaction.19065047Kanda T, Brown JD, Orasanu G, Vogel S, Gonzalez FJ, Sartoretto J, Michel T, Plutzky JThe Journal of clinical investigationPPARgamma in the endothelium regulates metabolic responses to high-fat diet in mice. J Clin Invest. 2009 Jan; 119(1):110-24.J Clin Invest2008-12-08T00:00:002008PPARgamma in the endothelium regulates metabolic responses to high-fat diet in mice.17179034Dzau VJ, Antman EM, Black HR, Hayes DL, Manson JE, Plutzky J, Popma JJ, Stevenson WCirculationThe cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part I: Pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease). Circulation. 2006 Dec 19; 114(25):2850-70.Circulation2006-12-19T00:00:002006The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part I: Pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease).11934839Marx N, Kehrle B, Kohlhammer K, Grüb M, Koenig W, Hombach V, Libby P, Plutzky JCirculation researchPPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis. Circ Res. 2002 Apr 05; 90(6):703-10.Circ Res2002-04-05T00:00:002002PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis.Authorship 10581831229652762Muiru AN, Bibangambah P, Hemphill L, Sentongo R, Kim JH, Triant VA, Bangsberg DR, Tsai AC, Martin JN, Haberer JE, Boum Y, Plutzky J, Hunt PW, Okello S, Siedner MJJournal of acquired immune deficiency syndromes (1999)Distribution and Performance of Cardiovascular Risk Scores in a Mixed Population of HIV-Infected and Community-Based HIV-Uninfected Individuals in Uganda. J Acquir Immune Defic Syndr. 2018 08 01; 78(4):458-464.J Acquir Immune Defic Syndr2018-08-01T00:00:002018Distribution and Performance of Cardiovascular Risk Scores in a Mixed Population of HIV-Infected and Community-Based HIV-Uninfected Individuals in Uganda.Plutzky J. Harrison’s Principles of Internal Medicine Self-Assessment and Review. Disorders of the heart and vascular system. Harrison’s Principles of Internal Medicine Self-Assessment and Review. 1998; 49-90. .1998-01-01T00:00:001998Disorders of the heart and vascular system18755353Orasanu G, Ziouzenkova O, Devchand PR, Nehra V, Hamdy O, Horton ES, Plutzky JJournal of the American College of CardiologyThe peroxisome proliferator-activated receptor-gamma agonist pioglitazone represses inflammation in a peroxisome proliferator-activated receptor-alpha-dependent manner in vitro and in vivo in mice. J Am Coll Cardiol. 2008 Sep 02; 52(10):869-81.J Am Coll Cardiol2008-07-02T00:00:002008The peroxisome proliferator-activated receptor-gamma agonist pioglitazone represses inflammation in a peroxisome proliferator-activated receptor-alpha-dependent manner in vitro and in vivo in mice.Authorship 1067976229802688Ganda OP, Plutzky J, Sanganalmath SK, Bujas-Bobanovic M, Koren A, Mandel J, Letierce A, Leiter LADiabetes, obesity & metabolismEfficacy and safety of alirocumab among individuals with diabetes mellitus and atherosclerotic cardiovascular disease in the ODYSSEY phase 3 trials. Diabetes Obes Metab. 2018 10; 20(10):2389-2398.Diabetes Obes Metab2018-07-02T00:00:002018Efficacy and safety of alirocumab among individuals with diabetes mellitus and atherosclerotic cardiovascular disease in the ODYSSEY phase 3 trials.21750705Brown JD, Oligino E, Rader DJ, Saghatelian A, Plutzky JPloS oneVLDL hydrolysis by hepatic lipase regulates PPARd transcriptional responses. PLoS One. 2011; 6(7):e21209.PLoS One2011-07-05T00:00:002011VLDL hydrolysis by hepatic lipase regulates PPARd transcriptional responses.15192437Ziouzenkova O, Plutzky JCurrent opinion in clinical nutrition and metabolic careLipolytic PPAR activation: new insights into the intersection of triglycerides and inflammation? Curr Opin Clin Nutr Metab Care. 2004 Jul; 7(4):369-75.Curr Opin Clin Nutr Metab Care2004-07-01T00:00:002004Lipolytic PPAR activation: new insights into the intersection of triglycerides and inflammation?15470904Plutzky JClinical cardiologyPPARs: altering clinical responses in Type 2 diabetes and atherosclerosis. Introduction. Clin Cardiol. 2004 Jul; 27(7 Suppl 4):IV1-2.Clin Cardiol2004-07-01T00:00:002004PPARs: altering clinical responses in Type 2 diabetes and atherosclerosis. Introduction.11561170Plutzky JCurrent opinion in lipidologyPeroxisome proliferator-activated receptors in endothelial cell biology. Curr Opin Lipidol. 2001 Oct; 12(5):511-8.Curr Opin Lipidol2001-10-01T00:00:002001Peroxisome proliferator-activated receptors in endothelial cell biology.Libby P, Aikawa M, Schönbeck U, Sukhova G, Mach F, Marx N, Plutzky J. Inflammation and plaque stability. 2000.2000-01-01T00:00:002000Inflammation and plaque stability18502305Mazzone T, Chait A, Plutzky JLancet (London, England)Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies. Lancet. 2008 May 24; 371(9626):1800-9.Lancet2008-05-24T00:00:002008Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies.22730451de Ferranti SD, Daniels SR, Gillman M, Vernacchio L, Plutzky J, Baker ALClinical chemistryNHLBI Integrated Guidelines on Cardiovascular Disease Risk Reduction: can we clarify the controversy about cholesterol screening and treatment in childhood? Clin Chem. 2012 Dec; 58(12):1626-30.Clin Chem2012-06-22T00:00:002012NHLBI Integrated Guidelines on Cardiovascular Disease Risk Reduction: can we clarify the controversy about cholesterol screening and treatment in childhood?23546564Zhang H, Plutzky J, Skentzos S, Morrison F, Mar P, Shubina M, Turchin AAnnals of internal medicineDiscontinuation of statins in routine care settings: a cohort study. Ann Intern Med. 2013 Apr 02; 158(7):526-34.Ann Intern Med2013-04-02T00:00:002013Discontinuation of statins in routine care settings: a cohort study.Authorship 1183811222195188Skentzos S, Shubina M, Plutzky J, Turchin AAMIA ... Annual Symposium proceedings. AMIA SymposiumStructured vs. unstructured: factors affecting adverse drug reaction documentation in an EMR repository. AMIA Annu Symp Proc. 2011; 2011:1270-9.AMIA Annu Symp Proc2011-10-22T00:00:002011Structured vs. unstructured: factors affecting adverse drug reaction documentation in an EMR repository.22927471Kiefer FW, Cohen P, Plutzky JCirculationFifty shades of brown: perivascular fat, thermogenesis, and atherosclerosis. Circulation. 2012 Aug 28; 126(9):1012-5.Circulation2012-08-28T00:00:002012Fifty shades of brown: perivascular fat, thermogenesis, and atherosclerosis.20299477Chutkow WA, Birkenfeld AL, Brown JD, Lee HY, Frederick DW, Yoshioka J, Patwari P, Kursawe R, Cushman SW, Plutzky J, Shulman GI, Samuel VT, Lee RTDiabetesDeletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity. Diabetes. 2010 Jun; 59(6):1424-34.Diabetes2010-03-18T00:00:002010Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity.21802576Davidson MH, Plutzky JThe American journal of cardiologyThe role of cardiologists in the management of patients with diabetes is evolving owing to the close relationship between diabetes and CAD. Introduction. Am J Cardiol. 2011 Aug 02; 108(3 Suppl):1B-2B.Am J Cardiol2011-08-02T00:00:002011The role of cardiologists in the management of patients with diabetes is evolving owing to the close relationship between diabetes and CAD. Introduction.21802578Plutzky JThe American journal of cardiologyMacrovascular effects and safety issues of therapies for type 2 diabetes. Am J Cardiol. 2011 Aug 02; 108(3 Suppl):25B-32B.Am J Cardiol2011-08-02T00:00:002011Macrovascular effects and safety issues of therapies for type 2 diabetes.22577210Lo J, Plutzky JThe Journal of infectious diseasesThe biology of atherosclerosis: general paradigms and distinct pathogenic mechanisms among HIV-infected patients. J Infect Dis. 2012 Jun; 205 Suppl 3:S368-74.J Infect Dis2012-06-01T00:00:002012The biology of atherosclerosis: general paradigms and distinct pathogenic mechanisms among HIV-infected patients.Ahmed W, Ziouzenkova O, Orasanu G, Marchadier D, Rader D, Plutzky J. American Heart Association Scientific Sessions, New Orleans, LAEndothelial lipase acts on HDL to activate PPAR?. American Heart Association Scientific Sessions, New Orleans, LA. 2004.2004-01-01T00:00:002004Endothelial lipase acts on HDL to activate PPAR?16709944Han CY, Chiba T, Campbell JS, Fausto N, Chaisson M, Orasanu G, Plutzky J, Chait AArteriosclerosis, thrombosis, and vascular biologyReciprocal and coordinate regulation of serum amyloid A versus apolipoprotein A-I and paraoxonase-1 by inflammation in murine hepatocytes. Arterioscler Thromb Vasc Biol. 2006 Aug; 26(8):1806-13.Arterioscler Thromb Vasc Biol2006-05-18T00:00:002006Reciprocal and coordinate regulation of serum amyloid A versus apolipoprotein A-I and paraoxonase-1 by inflammation in murine hepatocytes.17645586Ahmed W, Ziouzenkova O, Brown J, Devchand P, Francis S, Kadakia M, Kanda T, Orasanu G, Sharlach M, Zandbergen F, Plutzky JJournal of internal medicinePPARs and their metabolic modulation: new mechanisms for transcriptional regulation? J Intern Med. 2007 Aug; 262(2):184-98.J Intern Med2007-08-01T00:00:002007PPARs and their metabolic modulation: new mechanisms for transcriptional regulation?3511471Plutzky J, Hoskins JA, Long GL, Crabtree GRProceedings of the National Academy of Sciences of the United States of AmericaEvolution and organization of the human protein C gene. Proc Natl Acad Sci U S A. 1986 Feb; 83(3):546-50.Proc Natl Acad Sci U S A1986-02-01T00:00:001986Evolution and organization of the human protein C gene.22105195Plutzky JCirculationThe incretin axis in cardiovascular disease. Circulation. 2011 Nov 22; 124(21):2285-9.Circulation2011-11-22T00:00:002011The incretin axis in cardiovascular disease.Plutzky J. Peroxisome proliferator-activated receptors in diabetes, vascular inflammation, and atherosclerosis (DVD, audio tape). Peroxisome proliferator-activated receptors in diabetes, vascular inflammation, and atherosclerosis (DVD, audio tape). 2005.2005-01-01T00:00:002005Peroxisome proliferator-activated receptors in diabetes, vascular inflammation, and atherosclerosis (DVD, audio tape)Plutzky J. In: Duttaroy AK, Spener F, editors. Cellular proteins and their fatty acids in health and disease. PPARs and atherosclerosis. In: Duttaroy AK, Spener F, editors. Cellular proteins and their fatty acids in health and disease. 2003; Chapter 23.2003-05-01T00:00:002003PPARs and atherosclerosisPlutzky J. Insulin resistance and atherosclerosis. Insulin resistance and atherosclerosis. 2001.2001-01-01T00:00:002001Insulin resistance and atherosclerosisAuthorship 11126101130445605Cosentino F, Ceriello A, Baeres FMM, Fioretto P, Garber A, Stough WG, George JT, Grant PJ, Khunti K, Langkilde AM, Plutzky J, Rydén L, Scheen A, Standl E, Tuomilehto J, Zannad FEuropean heart journalAddressing cardiovascular risk in type 2 diabetes mellitus: a report from the European Society of Cardiology Cardiovascular Roundtable. Eur Heart J. 2019 09 07; 40(34):2907-2919.Eur Heart J2019-09-07T00:00:002019Addressing cardiovascular risk in type 2 diabetes mellitus: a report from the European Society of Cardiology Cardiovascular Roundtable.Gornik HL, Plutzky J. In: Gaziano JM, editor. Atlas of Cardiovascular Risk Factors. Dyslipidemia. In: Gaziano JM, editor. Atlas of Cardiovascular Risk Factors. 2005; 97-114.2005-10-01T00:00:002005Dyslipidemia12606719Ziouzenkova O, Perrey S, Asatryan L, Hwang J, MacNaul KL, Moller DE, Rader DJ, Sevanian A, Zechner R, Hoefler G, Plutzky JProceedings of the National Academy of Sciences of the United States of AmericaLipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2730-5.Proc Natl Acad Sci U S A2003-02-26T00:00:002003Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase.14678867Plutzky JThe American journal of medicineThe vascular biology of atherosclerosis. Am J Med. 2003 Dec 08; 115 Suppl 8A:55S-61S.Am J Med2003-12-08T00:00:002003The vascular biology of atherosclerosis.15855580McMahon GT, Plutzky J, Daher E, Bhattacharyya T, Grunberger G, DiCarli MFDiabetes careEffect of a peroxisome proliferator-activated receptor-gamma agonist on myocardial blood flow in type 2 diabetes. Diabetes Care. 2005 May; 28(5):1145-50.Diabetes Care2005-05-01T00:00:002005Effect of a peroxisome proliferator-activated receptor-gamma agonist on myocardial blood flow in type 2 diabetes.20609666Fonseca VA, Zinman B, Nauck MA, Goldfine AB, Plutzky JThe American journal of medicineConfronting the type 2 diabetes epidemic: the emerging role of incretin-based therapies. Am J Med. 2010 Jul; 123(7):S2-S10.Am J Med2010-07-01T00:00:002010Confronting the type 2 diabetes epidemic: the emerging role of incretin-based therapies. Plutzky J. Am J Cardiol The role of high-density lipoprotein (HDL) cholesterol in the prevention and treatment of coronary heart disease. Am J Cardiol. 2002; 90(7 ): 139-143.2002-01-01T00:00:002002The role of high-density lipoprotein (HDL) cholesterol in the prevention and treatment of coronary heart diseasePlutzky J. Proceedings from the Second Annual US/Japanese Dialogue on Lipids and Atherosclerosis.Atherosclerosis: an insulin resistance disorder. Proceedings from the Second Annual US/Japanese Dialogue on Lipids and Atherosclerosis. 2000; 245:49-58.2000-01-01T00:00:002000Atherosclerosis: an insulin resistance disorderOligino E, Ziouzenkova O, Plutzky J. Sarnoff Endowment, Washington, DC VLDL hydrolysis by hepatic lipase is a distinct mechanism for PPAR-delta activation. Sarnoff Endowment, Washington, DC. 2006.2006-01-01T00:00:002006VLDL hydrolysis by hepatic lipase is a distinct mechanism for PPAR-delta activation11157683Plutzky J, Ridker PMCirculationStatins for stroke: the second story? Circulation. 2001 Jan 23; 103(3):348-50.Circulation2001-01-23T00:00:002001Statins for stroke: the second story?11208679Marx N, Mackman N, Schönbeck U, Yilmaz N, Hombach V, Libby P, Plutzky JCirculationPPARalpha activators inhibit tissue factor expression and activity in human monocytes. Circulation. 2001 Jan 16; 103(2):213-9.Circulation2001-01-16T00:00:002001PPARalpha activators inhibit tissue factor expression and activity in human monocytes.17631413Zandbergen F, Plutzky JBiochimica et biophysica actaPPARalpha in atherosclerosis and inflammation. Biochim Biophys Acta. 2007 Aug; 1771(8):972-82.Biochim Biophys Acta2007-05-21T00:00:002007PPARalpha in atherosclerosis and inflammation.18068127Ziouzenkova O, Plutzky JFEBS lettersRetinoid metabolism and nuclear receptor responses: New insights into coordinated regulation of the PPAR-RXR complex. FEBS Lett. 2008 Jan 09; 582(1):32-8.FEBS Lett2007-12-07T00:00:002007Retinoid metabolism and nuclear receptor responses: New insights into coordinated regulation of the PPAR-RXR complex.19667619Plutzky JPostgraduate medicineDiabetes as a vascular disease. Dyslipidemia as a target. Postgrad Med. 2003 Apr; 113(4 Suppl):15-23.Postgrad Med2003-04-01T00:00:002003Diabetes as a vascular disease. Dyslipidemia as a target.21493923Plutzky JCirculation researchThe PPAR-RXR transcriptional complex in the vasculature: energy in the balance. Circ Res. 2011 Apr 15; 108(8):1002-16.Circ Res2011-04-15T00:00:002011The PPAR-RXR transcriptional complex in the vasculature: energy in the balance.Oberg K, Cannon C, Plutzky J.FormularyFocus on reteplase: a newly approved third-generation thrombolytic agent for the treatment of acute myocardial infarction. Formulary. 1997; 32:37-45.1997-01-01T00:00:001997Focus on reteplase: a newly approved third-generation thrombolytic agent for the treatment of acute myocardial infarctionD045162Chemicals & Drugs2624740.759045ThiazolidinedionesD018160Chemicals & Drugs4498620.684236Receptors, Cytoplasmic and NuclearD047492Chemicals & Drugs46640.952472Peroxisome Proliferator-Activated ReceptorsD003925Disorders3218210.658696Diabetic AngiopathiesD001161Disorders35610920.689191ArteriosclerosisAuthorship 1151998531075399Zhang M, Wang B, Urabe G, Huang Y, Plutzky J, Kent KC, Guo LWCellular signallingThe BD2 domain of BRD4 is a determinant in EndoMT and vein graft neointima formation. Cell Signal. 2019 09; 61:20-29.Cell Signal2019-05-07T00:00:002019The BD2 domain of BRD4 is a determinant in EndoMT and vein graft neointima formation.MedicineNutritionRheumatologyCardiologyCardiovascular MedicineBrigham and Women's HospitalHarvard T.H. Chan School of Public HealthRB101RonBlanksteinRon Blankstein, M.D.42.33510370000000-71.1061649000000080639Blankstein, RonProfessor of MedicinePL2PeterLibbyPeter Libby, M.D.42.33510370000000-71.1061649000000058636Libby, PeterMallinckrodt Professor of MedicineAuthorship 1154162931097165Singh A, Gupta A, Collins BL, Qamar A, Monda KL, Biery D, Lopez JAG, de Ferranti SD, Plutzky J, Cannon CP, Januzzi JL, Di Carli MF, Nasir K, Bhatt DL, Blankstein RJournal of the American College of CardiologyFamilial Hypercholesterolemia Among Young Adults With Myocardial Infarction. J Am Coll Cardiol. 2019 05 21; 73(19):2439-2450.J Am Coll Cardiol2019-05-21T00:00:002019Familial Hypercholesterolemia Among Young Adults With Myocardial Infarction.ER4ElenaAikawaElena Aikawa, M.D., Ph.D.42.33837200000000-71.1032690000000079704Aikawa, ElenaProfessor of MedicineDLB20DeepakBhattDeepak L. Bhatt, M.D.42.33510370000000-71.1061649000000081016Bhatt, DeepakVisiting Professor of MedicinePMR3PaulRidkerPaul M. Ridker, M.D.42.35195210000000-71.1243705000000041982Ridker, PaulEugene Braunwald Professor of MedicineMWF1MarkFeinbergMark W. Feinberg, M.D.42.33837200000000-71.1032690000000019817Feinberg, MarkAssociate Professor of MedicineGW42GeraldWattsGerald Watts, M.Sc.97111Watts, GeraldResearch Associate in MedicineAuthorship 11594862931164165Fruchart JC, Santos RD, Aguilar-Salinas C, Aikawa M, Al Rasadi K, Amarenco P, Barter PJ, Ceska R, Corsini A, Després JP, Duriez P, Eckel RH, Ezhov MV, Farnier M, Ginsberg HN, Hermans MP, Ishibashi S, Karpe F, Kodama T, Koenig W, Krempf M, Lim S, Lorenzatti AJ, McPherson R, Nuñez-Cortes JM, Nordestgaard BG, Ogawa H, Packard CJ, Plutzky J, Ponte-Negretti CI, Pradhan A, Ray KK, Reiner Ž, Ridker PM, Ruscica M, Sadikot S, Shimano H, Sritara P, Stock JK, Su TC, Susekov AV, Tartar A, Taskinen MR, Tenenbaum A, Tokgözoglu LS, Tomlinson B, Tybjærg-Hansen A, Valensi P, Vrablík M, Wahli W, Watts GF, Yamashita S, Yokote K, Zambon A, Libby PCardiovascular diabetologyThe selective peroxisome proliferator-activated receptor alpha modulator (SPPARMa) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation. Cardiovasc Diabetol. 2019 06 04; 18(1):71.Cardiovasc Diabetol2019-06-04T00:00:002019The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMa) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation.CES5ChristineSeidmanChristine Edry Seidman, M.D.42.33837200000000-71.1032690000000029608Seidman, ChristineThomas W. Smith Professor of MedicineBMS1BenjaminSciricaBenjamin Morgan Scirica, M.D.42.33510370000000-71.1061649000000063097Scirica, BenjaminAssociate Professor of MedicineSCT3StephanieTribunaStephanie Carol Tribuna42.33837200000000-71.1032690000000025956Tribuna, StephanieAssociate in MedicineFBH1FrankHuFrank B. Hu, M.D., Ph.D.42.33546850000000-71.1015102000000039913Hu, FrankFredrick J. Stare Professor of Nutrition and EpidemiologyDEH8DianeHandyDiane Elizabeth Handy, Ph.D.42.33837200000000-71.1032690000000076190Handy, DianeAssistant Professor of Medicine11210selected publications2.897610.00105189643research areas1.686740.0139726133coauthor of142.95725.126560similar toAuthorship 1282689Authorship 1183497931451236Mitchell S, Malanda B, Damasceno A, Eckel RH, Gaita D, Kotseva K, Januzzi JL, Mensah G, Plutzky J, Prystupiuk M, Ryden L, Thierer J, Virani SS, Sperling LGlobal heartA Roadmap on the Prevention of Cardiovascular Disease Among People Living With Diabetes. Glob Heart. 2019 09; 14(3):215-240.Glob Heart2019-09-01T00:00:002019A Roadmap on the Prevention of Cardiovascular Disease Among People Living With Diabetes.31548242Divakaran S, Singh A, Biery D, Yang J, DeFilippis EM, Collins BL, Ramsis M, Qamar A, Hainer J, Klein J, Cannon CP, Polk DM, Plutzky J, Nasir K, Januzzi JL, Di Carli MF, Bhatt DL, Blankstein RDiabetes careDiabetes Is Associated With Worse Long-term Outcomes in Young Adults After Myocardial Infarction: The Partners YOUNG-MI Registry. Diabetes Care. 2020 08; 43(8):1843-1850.Diabetes Care2019-09-23T00:00:002019Diabetes Is Associated With Worse Long-term Outcomes in Young Adults After Myocardial Infarction: The Partners YOUNG-MI Registry.Authorship 119223113true1Research Associate in MedicineResearch Associate in Medicinetrue1Associate Professor of MedicineAssociate Professor of Medicinetrue1Mallinckrodt Professor of MedicineMallinckrodt Professor of Medicinetrue1Associate Professor of MedicineAssociate Professor of Medicinetrue1Assistant Professor of MedicineAssistant Professor of Medicinetrue1Associate Professor of MedicineAssociate Professor of MedicineAuthorship 1418061Authorship 1209393331802265Chang LS, Vaduganathan M, Plutzky J, Aroda VRCurrent diabetes reportsBridging the Gap for Patients with Diabetes and Cardiovascular Disease Through Cardiometabolic Collaboration. Curr Diab Rep. 2019 12 04; 19(12):157.Curr Diab Rep2019-12-04T00:00:002019Bridging the Gap for Patients with Diabetes and Cardiovascular Disease Through Cardiometabolic Collaboration.Authorship 12115691031852220Rogers MA, Chen J, Nallamshetty S, Pham T, Goto S, Muehlschlegel JD, Libby P, Aikawa M, Aikawa E, Plutzky JArteriosclerosis, thrombosis, and vascular biologyRetinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects. Arterioscler Thromb Vasc Biol. 2020 03; 40(3):656-669.Arterioscler Thromb Vasc Biol2019-12-19T00:00:002019Retinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects.Authorship 12239611Authorship 1694011Authorship 1625092Authorship 1235545132219361Plutzky JJAMAEpigenetic Therapeutics for Cardiovascular Disease: Writing, Erasing, Reading, and Maybe Forgetting. JAMA. 2020 04 28; 323(16):1557-1558.JAMA2020-04-28T00:00:002020Epigenetic Therapeutics for Cardiovascular Disease: Writing, Erasing, Reading, and Maybe Forgetting.Authorship 1238775732257155Yang IT, Hemphill LC, Kim JH, Bibangambah P, Sentongo R, Kakuhire B, Plutzky J, Boum Y, Tsai AC, Okello S, Siedner MJJournal of global healthTo fast or not to fast: Lipid measurement and cardiovascular disease risk estimation in rural sub-Saharan Africa. J Glob Health. 2020 Jun; 10(1):010407.J Glob Health2020-06-01T00:00:002020To fast or not to fast: Lipid measurement and cardiovascular disease risk estimation in rural sub-Saharan Africa.32324495Borck PC, Guo LW, Plutzky JCirculation researchBET Epigenetic Reader Proteins in Cardiovascular Transcriptional Programs. Circ Res. 2020 04 24; 126(9):1190-1208.Circ Res2020-04-23T00:00:002020BET Epigenetic Reader Proteins in Cardiovascular Transcriptional Programs.Authorship 12404603Authorship 1731391Authorship 17540717Authorship 1366251Authorship 127602832539451Berman AN, Biery DW, Singh A, Wu WY, Divakaran S, DeFilippis EM, Hainer J, Blaha MJ, Cannon C, Polk DM, Plutzky J, Natarajan P, Nasir K, Di Carli MF, Bhatt DL, Blankstein REuropean journal of preventive cardiologyAtherosclerotic cardiovascular disease risk and elevated lipoprotein(a) among young adults with myocardial infarction: The Partners YOUNG-MI Registry. Eur J Prev Cardiol. 2021 07 23; 28(8):e12-e14.Eur J Prev Cardiol2021-07-23T00:00:002021Atherosclerotic cardiovascular disease risk and elevated lipoprotein(a) among young adults with myocardial infarction: The Partners YOUNG-MI Registry.Authorship 12550301132584928Honigberg MC, Chang LS, McGuire DK, Plutzky J, Aroda VR, Vaduganathan MJAMA cardiologyUse of Glucagon-Like Peptide-1 Receptor Agonists in Patients With Type 2 Diabetes and Cardiovascular Disease: A Review. JAMA Cardiol. 2020 10 01; 5(10):1182-1190.JAMA Cardiol2020-10-01T00:00:002020Use of Glucagon-Like Peptide-1 Receptor Agonists in Patients With Type 2 Diabetes and Cardiovascular Disease: A Review.Authorship 12587774Authorship 156687Authorship 12877399Authorship 12884441232936209Desai AS, Maclean T, Blood AJ, Bosque-Hamilton J, Dunning J, Fischer C, Fera L, Smith KV, Wagholikar K, Zelle D, Gaziano T, Plutzky J, Scirica B, MacRae CAJAMA cardiologyRemote Optimization of Guideline-Directed Medical Therapy in Patients With Heart Failure With Reduced Ejection Fraction. JAMA Cardiol. 2020 12 01; 5(12):1430-1434.JAMA Cardiol2020-12-01T00:00:002020Remote Optimization of Guideline-Directed Medical Therapy in Patients With Heart Failure With Reduced Ejection Fraction.32916609Ryan DH, Lingvay I, Colhoun HM, Deanfield J, Emerson SS, Kahn SE, Kushner RF, Marso S, Plutzky J, Brown-Frandsen K, Gronning MOL, Hovingh GK, Holst AG, Ravn H, Lincoff AMAmerican heart journalSemaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity (SELECT) rationale and design. Am Heart J. 2020 11; 229:61-69.Am Heart J2020-07-17T00:00:002020Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity (SELECT) rationale and design.Authorship 12911521032992038Fenzl A, Kulterer OC, Spirk K, Mitulovic G, Marculescu R, Bilban M, Baumgartner-Parzer S, Kautzky-Willer A, Kenner L, Plutzky J, Quadro L, Kiefer FWMolecular metabolismIntact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis. Mol Metab. 2020 12; 42:101088.Mol Metab2020-09-28T00:00:002020Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis.Authorship 130257813Authorship 1302947833234676Shen H, Li J, Xie X, Yang H, Zhang M, Wang B, Kent KC, Plutzky J, Guo LWLife science allianceBRD2 regulation of sigma-2 receptor upon cholesterol deprivation. Life Sci Alliance. 2021 01; 4(1).Life Sci Alliance2020-11-24T00:00:002020BRD2 regulation of sigma-2 receptor upon cholesterol deprivation.33201729Scirica BM, Cannon CP, Fisher NDL, Gaziano TA, Zelle D, Chaney K, Miller A, Nichols H, Matta L, Gordon WJ, Murphy S, Wagholikar KB, Plutzky J, MacRae CACirculationDigital Care Transformation: Interim Report From the First 5000 Patients Enrolled in a Remote Algorithm-Based Cardiovascular Risk Management Program to Improve Lipid and Hypertension Control. Circulation. 2021 02 02; 143(5):507-509.Circulation2020-11-17T00:00:002020Digital Care Transformation: Interim Report From the First 5000 Patients Enrolled in a Remote Algorithm-Based Cardiovascular Risk Management Program to Improve Lipid and Hypertension Control.Authorship 1322175933470195Nicholls S, Lincoff AM, Bays HE, Cho L, Grobbee DE, Kastelein JJ, Libby P, Moriarty PM, Plutzky J, Ray KK, Thompson PD, Sasiela W, Mason D, McCluskey J, Davey D, Wolski K, Nissen SEAmerican heart journalRationale and design of the CLEAR-outcomes trial: Evaluating the effect of bempedoic acid on cardiovascular events in patients with statin intolerance. Am Heart J. 2021 05; 235:104-112.Am Heart J2020-10-24T00:00:002020Rationale and design of the CLEAR-outcomes trial: Evaluating the effect of bempedoic acid on cardiovascular events in patients with statin intolerance.Authorship 1985492Authorship 133305812Authorship 13334871133615723Weber B, He Z, Yang N, Playford MP, Weisenfeld D, Iannaccone C, Coblyn J, Weinblatt M, Shadick N, Di Carli M, Mehta NN, Plutzky J, Liao KPArthritis & rheumatology (Hoboken, N.J.)Divergence of Cardiovascular Biomarkers of Lipids and Subclinical Myocardial Injury Among Rheumatoid Arthritis Patients With Increased Inflammation. Arthritis Rheumatol. 2021 06; 73(6):970-979.Arthritis Rheumatol2021-05-09T00:00:002021Divergence of Cardiovascular Biomarkers of Lipids and Subclinical Myocardial Injury Among Rheumatoid Arthritis Patients With Increased Inflammation.33611447Berman AN, Biery DW, Singh A, Wu WY, Divakaran S, DeFilippis EM, Hainer J, Blaha MJ, Cannon C, Polk DM, Plutzky J, Natarajan P, Nasir K, Di Carli MF, Bhatt DL, Blankstein REuropean journal of preventive cardiologyAtherosclerotic cardiovascular disease risk and elevated lipoprotein(a) among young adults with myocardial infarction: The Partners YOUNG-MI Registry. Eur J Prev Cardiol. 2020 Jun 23.Eur J Prev Cardiol2020-06-23T00:00:002020Atherosclerotic cardiovascular disease risk and elevated lipoprotein(a) among young adults with myocardial infarction: The Partners YOUNG-MI Registry.34009238Berman AN, Biery DW, Ginder C, Singh A, Baek J, Wadhera RK, Wu WY, Divakaran S, DeFilippis EM, Hainer J, Cannon CP, Plutzky J, Polk DM, Nasir K, Di Carli MF, Ash AS, Bhatt DL, Blankstein RJAMA cardiologyAssociation of Socioeconomic Disadvantage With Long-term Mortality After Myocardial Infarction: The Mass General Brigham YOUNG-MI Registry. JAMA Cardiol. 2021 08 01; 6(8):880-888.JAMA Cardiol2021-08-01T00:00:002021Association of Socioeconomic Disadvantage With Long-term Mortality After Myocardial Infarction: The Mass General Brigham YOUNG-MI Registry.Authorship 135577112Authorship 1374382534247329Achhra AC, Lyass A, Borowsky L, Bogorodskaya M, Plutzky J, Massaro JM, D'Agostino RB, Triant VACurrent HIV/AIDS reportsAssessing Cardiovascular Risk in People Living with HIV: Current Tools and Limitations. Curr HIV/AIDS Rep. 2021 08; 18(4):271-279.Curr HIV/AIDS Rep2021-07-11T00:00:002021Assessing Cardiovascular Risk in People Living with HIV: Current Tools and Limitations.Authorship 1896712Authorship 1391942134481756Plutzky J, Benson MD, Chaney K, Bui TV, Kraft M, Matta L, McPartlin M, Zelle D, Cannon CP, Dodek A, Gaziano TA, Desai AS, MacRae CA, Scirica BMAmerican heart journalPopulation health management of low-density lipoprotein cholesterol via a remote, algorithmic, navigator-executed program. Am Heart J. 2022 01; 243:15-27.Am Heart J2021-09-03T00:00:002021Population health management of low-density lipoprotein cholesterol via a remote, algorithmic, navigator-executed program.Authorship 1415748434746903Bays HE, Baum SJ, Brinton EA, Plutzky J, Hanselman JC, Teng R, Ballantyne CMAmerican journal of preventive cardiologyEffect of bempedoic acid plus ezetimibe fixed-dose combination vs ezetimibe or placebo on low-density lipoprotein cholesterol in patients with type 2 diabetes and hypercholesterolemia not treated with statins. Am J Prev Cardiol. 2021 Dec; 8:100278.Am J Prev Cardiol2021-10-04T00:00:002021Effect of bempedoic acid plus ezetimibe fixed-dose combination vs ezetimibe or placebo on low-density lipoprotein cholesterol in patients with type 2 diabetes and hypercholesterolemia not treated with statins.Authorship 14191042734922811Handelsman Y, Anderson JE, Bakris GL, Ballantyne CM, Beckman JA, Bhatt DL, Bloomgarden ZT, Bozkurt B, Budoff MJ, Butler J, Dagogo-Jack S, de Boer IH, DeFronzo RA, Eckel RH, Einhorn D, Fonseca VA, Green JB, Grunberger G, Guerin C, Inzucchi SE, Jellinger PS, Kosiborod MN, Kushner P, Lepor N, Mende CW, Michos ED, Plutzky J, Taub PR, Umpierrez GE, Vaduganathan M, Weir MRJournal of diabetes and its complicationsDCRM Multispecialty Practice Recommendations for the management of diabetes, cardiorenal, and metabolic diseases. J Diabetes Complications. 2022 02; 36(2):108101.J Diabetes Complications2021-12-07T00:00:002021DCRM Multispecialty Practice Recommendations for the management of diabetes, cardiorenal, and metabolic diseases.34998708Wu WY, Biery DW, Berman AN, Hsieh G, Divakaran S, Gupta S, Steigner ML, Aghayev A, Skali H, Polk DM, Plutzky J, Cannon CP, Di Carli MF, Blankstein RJournal of cardiovascular computed tomographyImpact of coronary artery calcium testing on patient management. J Cardiovasc Comput Tomogr. 2022 Jul-Aug; 16(4):303-308.J Cardiovasc Comput Tomogr2021-12-17T00:00:002021Impact of coronary artery calcium testing on patient management.Authorship 142611311Authorship 1427736235080899Gupta RM, Plutzky JArteriosclerosis, thrombosis, and vascular biologyThe Aging Aorta: Are We Only as Old as Our Endothelium? Arterioscler Thromb Vasc Biol. 2022 02; 42(2):172-174.Arterioscler Thromb Vasc Biol2022-01-26T00:00:002022The Aging Aorta: Are We Only as Old as Our Endothelium?Authorship 14486161135440172Zhuang R, Chen J, Cheng HS, Assa C, Jamaiyar A, Pandey AK, Pérez-Cremades D, Zhang B, Tzani A, Khyrul Wara A, Plutzky J, Barrera V, Bhetariya P, Mitchell RN, Liu Z, Feinberg MWCirculation researchPerivascular Fibrosis Is Mediated by a KLF10-IL-9 Signaling Axis in CD4+ T Cells. Circ Res. 2022 05 27; 130(11):1662-1681.Circ Res2022-04-20T00:00:002022Perivascular Fibrosis Is Mediated by a KLF10-IL-9 Signaling Axis in CD4+ T Cells.Authorship 36343411Authorship 14610159Authorship 1459311235715883Pilvar A, Plutzky J, Pierce M, Roblyer DJournal of biomedical opticsShortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties. J Biomed Opt. 2022 06; 27(6).J Biomed Opt2022-06-01T00:00:002022Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties.35657008Weber B, Weisenfeld D, Seyok T, Huang S, Massarotti E, Barrett L, Bibbo C, Solomon DH, Plutzky J, Bolster M, Di Carli M, Liao KPJournal of the American Heart AssociationRelationship Between Risk of Atherosclerotic Cardiovascular Disease, Inflammation, and Coronary Microvascular Dysfunction in Rheumatoid Arthritis. J Am Heart Assoc. 2022 06 07; 11(11):e025467.J Am Heart Assoc2022-06-03T00:00:002022Relationship Between Risk of Atherosclerotic Cardiovascular Disease, Inflammation, and Coronary Microvascular Dysfunction in Rheumatoid Arthritis.Authorship 14887225Authorship 15009092035929959Ventura P, Sardh E, Longo N, Balwani M, Plutzky J, Gouya L, Phillips J, Rhyee S, Fanelli MJ, Sweetser MT, Petrides PEExpert review of gastroenterology & hepatologyHyperhomocysteinemia in acute hepatic porphyria (AHP) and implications for treatment with givosiran. Expert Rev Gastroenterol Hepatol. 2022 Sep; 16(9):879-894.Expert Rev Gastroenterol Hepatol2022-08-25T00:00:002022Hyperhomocysteinemia in acute hepatic porphyria (AHP) and implications for treatment with givosiran.36350612Blood AJ, Cannon CP, Gordon WJ, Mailly C, MacLean T, Subramaniam S, Tucci M, Crossen J, Nichols H, Wagholikar KB, Zelle D, McPartlin M, Matta LS, Oates M, Aronson S, Murphy S, Landman A, Fisher NDL, Gaziano TA, Plutzky J, Scirica BMJAMA cardiologyResults of a Remotely Delivered Hypertension and Lipid Program in More Than 10?000 Patients Across a Diverse Health Care Network. JAMA Cardiol. 2023 01 01; 8(1):12-21.JAMA Cardiol2023-01-01T00:00:002023Results of a Remotely Delivered Hypertension and Lipid Program in More Than 10?000 Patients Across a Diverse Health Care Network.Authorship 15107101436502289Lingvay I, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, Hardt-Lindberg S, Hovingh GK, Kahn SE, Kushner RF, Lincoff AM, Marso SP, Fries TM, Plutzky J, Ryan DHObesity (Silver Spring, Md.)Semaglutide for cardiovascular event reduction in people with overweight or obesity: SELECT study baseline characteristics. Obesity (Silver Spring). 2023 01; 31(1):111-122.Obesity (Silver Spring)2022-12-10T00:00:002022Semaglutide for cardiovascular event reduction in people with overweight or obesity: SELECT study baseline characteristics.23723371Tatematsu S, Francis SA, Natarajan P, Rader DJ, Saghatelian A, Brown JD, Michel T, Plutzky JArteriosclerosis, thrombosis, and vascular biologyEndothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. Arterioscler Thromb Vasc Biol. 2013 Aug; 33(8):1788-94.Arterioscler Thromb Vasc Biol2013-05-30T00:00:002013Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium.Authorship 1527102936821386Cheng HS, Zhuang R, Pérez-Cremades D, Chen J, Jamaiyar A, Wu W, Sausen G, Tzani A, Plutzky J, Henao-Mejia J, Goodney PP, Creager MA, Sabatine MS, Bonaca MP, Feinberg MWJCI insightA miRNA/CXCR4 signaling axis impairs monopoiesis and angiogenesis in diabetic critical limb ischemia. JCI Insight. 2023 04 10; 8(7).JCI Insight2023-04-10T00:00:002023A miRNA/CXCR4 signaling axis impairs monopoiesis and angiogenesis in diabetic critical limb ischemia.Authorship 15317851036876740Nissen SE, Lincoff AM, Brennan D, Ray KK, Mason D, Kastelein JJP, Thompson PD, Libby P, Cho L, Plutzky J, Bays HE, Moriarty PM, Menon V, Grobbee DE, Louie MJ, Chen CF, Li N, Bloedon L, Robinson P, Horner M, Sasiela WJ, McCluskey J, Davey D, Fajardo-Campos P, Petrovic P, Fedacko J, Zmuda W, Lukyanov Y, Nicholls SJThe New England journal of medicineBempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients. N Engl J Med. 2023 Apr 13; 388(15):1353-1364.N Engl J Med2023-03-04T00:00:002023Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients.37137588Gilliland TC, Liu Y, Mohebi R, Miksenas H, Haidermota S, Wong M, Hu X, Cristino JR, Browne A, Plutzky J, Tsimikas S, Januzzi JL, Natarajan PJournal of the American College of CardiologyLipoprotein(a), Oxidized Phospholipids, and Coronary Artery Disease Severity and Outcomes. J Am Coll Cardiol. 2023 05 09; 81(18):1780-1792.J Am Coll Cardiol2023-05-09T00:00:002023Lipoprotein(a), Oxidized Phospholipids, and Coronary Artery Disease Severity and Outcomes.Authorship 1971031true1Associate in MedicineAssociate in MedicineAuthorship 15570593Authorship 155594910Authorship 1552190937305780Pilvar A, Smith DW, Plutzky J, Roblyer DJournal of biomedical opticsFeasibility of postprandial optical scattering of lipoproteins in blood as an optical marker of cardiovascular disease risk: modeling and experimental validation. J Biomed Opt. 2023 06; 28(6):065002.J Biomed Opt2023-06-08T00:00:002023Feasibility of postprandial optical scattering of lipoproteins in blood as an optical marker of cardiovascular disease risk: modeling and experimental validation.37097749Cheng HS, Pérez-Cremades D, Zhuang R, Jamaiyar A, Wu W, Chen J, Tzani A, Stone L, Plutzky J, Ryan TE, Goodney PP, Creager MA, Sabatine MS, Bonaca MP, Feinberg MWJCI insightImpaired angiogenesis in diabetic critical limb ischemia is mediated by a miR-130b/INHBA signaling axis. JCI Insight. 2023 05 22; 8(10).JCI Insight2023-05-22T00:00:002023Impaired angiogenesis in diabetic critical limb ischemia is mediated by a miR-130b/INHBA signaling axis.Authorship 3388822Authorship 15901981037640175Jafri SH, Hushcha P, Dorbala P, Bousquet G, Lutfy C, Mellett L, Sonis L, Blankstein R, Cannon C, Plutzky J, Polk D, Skali HCurrent problems in cardiologyUse of Optimal Medical Therapy in Patients With Cardiovascular Disease Undergoing Cardiac Rehabilitation. Curr Probl Cardiol. 2024 Jan; 49(1 Pt A):102058.Curr Probl Cardiol2023-08-26T00:00:002023Use of Optimal Medical Therapy in Patients With Cardiovascular Disease Undergoing Cardiac Rehabilitation.Authorship 4065173true1Research Fellow in MedicineResearch Fellow in Medicinetrue1Professor of MedicineProfessor of Medicinetrue1Thomas W. Smith Professor of MedicineThomas W. Smith Professor of Medicinetrue1Visiting Professor of MedicineVisiting Professor of MedicineAuthorship 16055291337942611Tzani A, Haemmig S, Cheng HS, Pérez-Cremades D, Heuschkel MA, Jamaiyar A, Singh SA, Aikawa M, Yu PB, Wang T, Sun Y, Feinberg MW, Plutzky JArteriosclerosis, thrombosis, and vascular biologyFAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis-Brief Report. Arterioscler Thromb Vasc Biol. 2024 01; 44(1):143-155.Arterioscler Thromb Vasc Biol2023-11-09T00:00:002023FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis-Brief Report.Authorship 4904785Authorship 16097521437952131Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, Hardt-Lindberg S, Hovingh GK, Kahn SE, Kushner RF, Lingvay I, Oral TK, Michelsen MM, Plutzky J, Tornøe CW, Ryan DHThe New England journal of medicineSemaglutide and Cardiovascular Outcomes in Obesity without Diabetes. N Engl J Med. 2023 Dec 14; 389(24):2221-2232.N Engl J Med2023-11-11T00:00:002023Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes.Authorship 4977789Authorship 5028621Authorship 16156117Authorship 16136841038095068Gallagher KA, Mills JL, Armstrong DG, Conte MS, Kirsner RS, Minc SD, Plutzky J, Southerland KW, Tomic-Canic MCirculationCurrent Status and Principles for the Treatment and Prevention of Diabetic Foot Ulcers in the Cardiovascular Patient Population: A Scientific Statement From the American Heart Association. Circulation. 2024 Jan 23; 149(4):e232-e253.Circulation2023-12-14T00:00:002023Current Status and Principles for the Treatment and Prevention of Diabetic Foot Ulcers in the Cardiovascular Patient Population: A Scientific Statement From the American Heart Association.38135330Cho J, Noonan SH, Fay R, Apovian CM, McCarthy AC, Blood AJ, Samal L, Fisher N, Orav JE, Plutzky J, Block JP, Bates DW, Rozenblum R, Tucci M, McPartlin M, Gordon WJ, McManus KD, Morrison-Deutsch C, Scirica BM, Baer HJBMJ openImplementation of a Scalable Online Weight Management Programme in Clinical Settings: Protocol for the PROPS 2.0 Programme (Partnerships for Reducing Overweight and Obesity with Patient-Centered Strategies 2.0). BMJ Open. 2023 12 21; 13(12):e077520.BMJ Open2023-12-21T00:00:002023Implementation of a Scalable Online Weight Management Programme in Clinical Settings: Protocol for the PROPS 2.0 Programme (Partnerships for Reducing Overweight and Obesity with Patient-Centered Strategies 2.0).true1Professor of MedicineProfessor of MedicineAuthorship 16252141638302335Blood AJ, Chang LS, Colling C, Stern G, Gabovitch D, Feldman G, Adan A, Waterman F, Durden E, Hamersky C, Noone J, Aronson SJ, Liberatore P, Gaziano TA, Matta LS, Plutzky J, Cannon CP, Wexler DJ, Scirica BMPrimary care diabetesMethods, rationale, and design for a remote pharmacist and navigator-driven disease management program to improve guideline-directed medical therapy in patients with type 2 diabetes at elevated cardiovascular and/or kidney risk. Prim Care Diabetes. 2024 Jan 31.Prim Care Diabetes2024-01-31T00:00:002024Methods, rationale, and design for a remote pharmacist and navigator-driven disease management program to improve guideline-directed medical therapy in patients with type 2 diabetes at elevated cardiovascular and/or kidney risk.Authorship 578700Authorship 58335038418000Berman AN, Biery DW, Besser SA, Singh A, Shiyovich A, Weber BN, Huck DM, Divakaran S, Hainer J, Kaur G, Blaha MJ, Cannon CP, Plutzky J, Januzzi JL, Booth JN, López JAG, Kent ST, Nasir K, Di Carli MF, Bhatt DL, Blankstein RJournal of the American College of CardiologyLipoprotein(a) and Major Adverse Cardiovascular Events in Patients With or Without Baseline Atherosclerotic Cardiovascular Disease. J Am Coll Cardiol. 2024 Mar 05; 83(9):873-886.J Am Coll Cardiol2024-03-05T00:00:002024Lipoprotein(a) and Major Adverse Cardiovascular Events in Patients With or Without Baseline Atherosclerotic Cardiovascular Disease.Authorship 162997713Authorship 16291111638428421Chen J, Jamaiyar A, Wu W, Hu Y, Zhuang R, Sausen G, Cheng HS, de Oliveira Vaz C, Pérez-Cremades D, Tzani A, McCoy MG, Assa C, Eley S, Randhawa V, Lee K, Plutzky J, Hamburg NM, Sabatine MS, Feinberg MWCell reportsDeficiency of lncRNA MERRICAL abrogates macrophage chemotaxis and diabetes-associated atherosclerosis. Cell Rep. 2024 Feb 26; 113815.Cell Rep2024-02-26T00:00:002024Deficiency of lncRNA MERRICAL abrogates macrophage chemotaxis and diabetes-associated atherosclerosis.Authorship 52590010true1Fredrick J. Stare Professor of Nutrition and EpidemiologyFredrick J. Stare Professor of Nutrition and Epidemiologytrue1Eugene Braunwald Professor of MedicineEugene Braunwald Professor of MedicineAuthorship 582936Authorship 586821Authorship 603290Authorship 2374002Authorship 348941Authorship 441064Authorship 2535621Authorship 6496842Authorship 64717913Authorship 6485212Authorship 6530778Authorship 6603621023911322Anand P, Brown JD, Lin CY, Qi J, Zhang R, Artero PC, Alaiti MA, Bullard J, Alazem K, Margulies KB, Cappola TP, Lemieux M, Plutzky J, Bradner JE, Haldar SMCellBET bromodomains mediate transcriptional pause release in heart failure. Cell. 2013 Aug 01; 154(3):569-82.Cell2013-08-01T00:00:002013BET bromodomains mediate transcriptional pause release in heart failure.23951127Nallamshetty S, Wang H, Rhee EJ, Kiefer FW, Brown JD, Lotinun S, Le P, Baron R, Rosen CJ, Plutzky JPloS oneDeficiency of retinaldehyde dehydrogenase 1 induces BMP2 and increases bone mass in vivo. PLoS One. 2013; 8(8):e71307.PLoS One2013-08-09T00:00:002013Deficiency of retinaldehyde dehydrogenase 1 induces BMP2 and increases bone mass in vivo.23817716Zhang H, Plutzky J, Turchin AAnnals of internal medicineDiscontinuation of statins in routine care settings. Ann Intern Med. 2013 Jul 02; 159(1):75-6.Ann Intern Med2013-07-02T00:00:002013Discontinuation of statins in routine care settings.23817482Khera AV, Plutzky JCirculationManagement of low levels of high-density lipoprotein-cholesterol. Circulation. 2013 Jul 02; 128(1):72-8.Circulation2013-07-02T00:00:002013Management of low levels of high-density lipoprotein-cholesterol.Authorship 625968Authorship 822867Authorship 1914312Authorship 5055965Authorship 578550Authorship 6811761324153306Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CHNatureA diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature. 2013 Oct 24; 502(7472):550-4.Nature2013-10-24T00:00:002013A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use.Authorship 3368034Authorship 2565201Authorship 3816991Authorship 24335514Authorship 2409931Authorship 2480205Authorship 612316Authorship 4097755Authorship 621175Authorship 7228993Authorship 7195492524460800Fruchart JC, Davignon J, Hermans MP, Al-Rubeaan K, Amarenco P, Assmann G, Barter P, Betteridge J, Bruckert E, Cuevas A, Farnier M, Ferrannini E, Fioretto P, Genest J, Ginsberg HN, Gotto AM, Hu D, Kadowaki T, Kodama T, Krempf M, Matsuzawa Y, Núñez-Cortés JM, Monfil CC, Ogawa H, Plutzky J, Rader DJ, Sadikot S, Santos RD, Shlyakhto E, Sritara P, Sy R, Tall A, Tan CE, Tokgözoglu L, Toth PP, Valensi P, Wanner C, Zambon A, Zhu J, Zimmet PCardiovascular diabetologyResidual macrovascular risk in 2013: what have we learned? Cardiovasc Diabetol. 2014 Jan 24; 13:26.Cardiovasc Diabetol2014-01-24T00:00:002014Residual macrovascular risk in 2013: what have we learned?24315787Chamarthi B, Zafrir B, Plutzky J, Givertz MMThe Journal of heart and lung transplantation : the official publication of the International Society for Heart TransplantationImpact of pre-diabetes on heart transplant outcomes in patients with advanced heart failure. J Heart Lung Transplant. 2014 Feb; 33(2):215-7.J Heart Lung Transplant2013-10-20T00:00:002013Impact of pre-diabetes on heart transplant outcomes in patients with advanced heart failure.Authorship 2452863Authorship 726855624561125Fonseca VA, Devries JH, Henry RR, Donsmark M, Thomsen HF, Plutzky JJournal of diabetes and its complicationsReductions in systolic blood pressure with liraglutide in patients with type 2 diabetes: insights from a patient-level pooled analysis of six randomized clinical trials. J Diabetes Complications. 2014 May-Jun; 28(3):399-405.J Diabetes Complications2014-01-21T00:00:002014Reductions in systolic blood pressure with liraglutide in patients with type 2 diabetes: insights from a patient-level pooled analysis of six randomized clinical trials.Authorship 735178224920686Zhang H, Plutzky J, Turchin ABMJ (Clinical research ed.)(Mis)interpreting studies on the adverse effects of statins. BMJ. 2014 Jun 11; 348:g3652.BMJ2014-06-11T00:00:002014(Mis)interpreting studies on the adverse effects of statins.Authorship 1992381Authorship 2545255Authorship 2098918Authorship 3438192Authorship 4639531Authorship 74863110Authorship 7539701025064526Nallamshetty S, Le PT, Wang H, Issacsohn MJ, Reeder DJ, Rhee EJ, Kiefer FW, Brown JD, Rosen CJ, Plutzky JBoneRetinaldehyde dehydrogenase 1 deficiency inhibits PPAR?-mediated bone loss and marrow adiposity. Bone. 2014 Oct; 67:281-91.Bone2014-07-24T00:00:002014Retinaldehyde dehydrogenase 1 deficiency inhibits PPAR?-mediated bone loss and marrow adiposity.25060886Halter JB, Musi N, McFarland Horne F, Crandall JP, Goldberg A, Harkless L, Hazzard WR, Huang ES, Kirkman MS, Plutzky J, Schmader KE, Zieman S, High KPDiabetesDiabetes and cardiovascular disease in older adults: current status and future directions. Diabetes. 2014 Aug; 63(8):2578-89.Diabetes2014-08-01T00:00:002014Diabetes and cardiovascular disease in older adults: current status and future directions.25263595Brown JD, Lin CY, Duan Q, Griffin G, Federation A, Paranal RM, Bair S, Newton G, Lichtman A, Kung A, Yang T, Wang H, Luscinskas FW, Croce K, Bradner JE, Plutzky JMolecular cellNF-?B directs dynamic super enhancer formation in inflammation and atherogenesis. Mol Cell. 2014 Oct 23; 56(2):219-231.Mol Cell2014-09-25T00:00:002014NF-?B directs dynamic super enhancer formation in inflammation and atherogenesis.Authorship 610180Authorship 37365311Authorship 76763316Authorship 5277816Authorship 7786411Authorship 779154625518042Plutzky JCirculation. Cardiovascular geneticsEmerging epigenetic maps in atherosclerosis. Circ Cardiovasc Genet. 2014 Oct; 7(5):573-5.Circ Cardiovasc Genet2014-10-01T00:00:002014Emerging epigenetic maps in atherosclerosis.25095746Pande RL, Brown J, Buck S, Redline W, Doyle J, Plutzky J, Creager MAJournal of vascular surgeryAssociation of monocyte tumor necrosis factor a expression and serum inflammatory biomarkers with walking impairment in peripheral artery disease. J Vasc Surg. 2015 Jan; 61(1):155-61.J Vasc Surg2014-08-02T00:00:002014Association of monocyte tumor necrosis factor a expression and serum inflammatory biomarkers with walking impairment in peripheral artery disease.Authorship 2585812Authorship 610053Authorship 717192Authorship 605929Authorship 615991Authorship 944415Authorship 3896102Authorship 4097931Authorship 3884707Authorship 4289255Authorship 4293262Authorship 438291Authorship 3406188Authorship 5122241Authorship 3700581Authorship 5212562Authorship 182398Authorship 4948283Authorship 5545682Authorship 5731552Authorship 590478Authorship 622801Authorship 633727Authorship 4991548Authorship 5082901Authorship 3206811Authorship 616704Authorship 1173091Authorship 2625043Authorship 31405511Authorship 4759345Authorship 5452481Authorship 618230Authorship 623369Authorship 3680622Authorship 38774910Authorship 4611411Authorship 2508153Authorship 4357202Authorship 4577133Authorship 5418102Authorship 2779155Authorship 456945Authorship 7911031Authorship 800023825998594Plutzky J, Garber A, Falahati A, Toft AD, Poulter NRCanadian journal of diabetesReductions in lipids and CV risk markers in patients with type 2 diabetes treated with liraglutide: a meta-analysis. Can J Diabetes. 2009; 33(3):209-10.Can J Diabetes2012-12-10T00:00:002012Reductions in lipids and CV risk markers in patients with type 2 diabetes treated with liraglutide: a meta-analysis.25818250Rhee EJ, Park SE, Oh HG, Park CY, Oh KW, Park SW, Blankstein R, Plutzky J, Lee WYAtherosclerosisStatin eligibility and cardiovascular risk burden assessed by coronary artery calcium score: comparing the two guidelines in a large Korean cohort. Atherosclerosis. 2015 May; 240(1):242-9.Atherosclerosis2015-03-07T00:00:002015Statin eligibility and cardiovascular risk burden assessed by coronary artery calcium score: comparing the two guidelines in a large Korean cohort.Authorship 581574Authorship 750965Authorship 3866094Authorship 4399692Authorship 3736453Authorship 3780116Authorship 45186212Authorship 5028334Authorship 588232Authorship 812467626034041Milstone DS, Ilyama M, Chen M, O'Donnell P, Davis VM, Plutzky J, Brown JD, Haldar SM, Siu A, Lau AC, Zhu SN, Basheer MF, Collins T, Jongstra-Bilen J, Cybulsky MICirculation researchDifferential role of an NF-?B transcriptional response element in endothelial versus intimal cell VCAM-1 expression. 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Lancet HIV. 2015 Feb; 2(2):e52-63.Lancet HIV2015-01-09T00:00:002015Effects of statin therapy on coronary artery plaque volume and high-risk plaque morphology in HIV-infected patients with subclinical atherosclerosis: a randomised, double-blind, placebo-controlled trial.Authorship 49766712Authorship 602888Authorship 614900Authorship 867713226912151Kim SH, Plutzky JDiabetes & metabolism journalBrown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders. Diabetes Metab J. 2016 Feb; 40(1):12-21.Diabetes Metab J2016-02-01T00:00:002016Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders.Authorship 620782Authorship 31796372002-04-30T00:00:002001-07-01T00:00:00Characterization of b-apo-14’-carotenal as an Inhibitor of PPARa and PPARgAuthorship 8748251326855180Duan Q, Mao X, Xiao Y, Liu Z, Wang Y, Zhou H, Zhou Z, Cai J, Xia K, Zhu Q, Qi J, Huang H, Plutzky J, Yang TBiochimica et biophysica actaSuper enhancers at the miR-146a and miR-155 genes contribute to self-regulation of inflammation. Biochim Biophys Acta. 2016 Apr; 1859(4):564-71.Biochim Biophys Acta2016-02-05T00:00:002016Super enhancers at the miR-146a and miR-155 genes contribute to self-regulation of inflammation.Authorship 8770311126948948Liu Z, Xiao Y, Zhou Z, Mao X, Cai J, Xiong L, Liao C, Huang F, Liu Z, Ali Sheikh MS, Plutzky J, Huang H, Yang T, Duan QMolecular and cellular endocrinologyExtensive metabolic disorders are present in APC(min) tumorigenesis mice. Mol Cell Endocrinol. 2016 May 15; 427:57-64.Mol Cell Endocrinol2016-03-04T00:00:002016Extensive metabolic disorders are present in APC(min) tumorigenesis mice.2002-08-23T00:00:002002-06-17T00:00:00The Effect of PPARæ Activation on Tissue Factor Expression and Activity in Human Endothelial CellsSummer2002-04-30T00:00:002001-07-01T00:00:00Characterization of b-apo-14’-carotenal as an Inhibitor of
PPARa and PPARgAuthorship 879905227148965Zhang H, Plutzky J, Shubina M, Turchin APloS oneDrivers of the Sex Disparity in Statin Therapy in Patients with Coronary Artery Disease: A Cohort Study. PLoS One. 2016; 11(5):e0155228.PLoS One2016-05-05T00:00:002016Drivers of the Sex Disparity in Statin Therapy in Patients with Coronary Artery Disease: A Cohort Study.2008-08-08T00:00:002008-06-23T00:00:00The Role of HNF4(alpha)in the Regulation of Fgl2 Expression in Macrophages
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Circ Res. 2016 May 27; 118(11):1706-22.Circ Res2016-05-27T00:00:002016Epigenetic Changes in Diabetes and Cardiovascular Risk.Authorship 595372Authorship 6252362Assistant Professor1Associate Professor6Fellow or Post Doc0Full Professor5Other FacultyAuthorship 5688131Authorship 6181782009-12-31PLUTZKY, JORGE2004-01-01Lipolytic Mechanisms of PPAR ActivationR01HL0717452017-08-31PLUTZKY, JORGE2015-09-08Epigenetic Control of Endothelial and T Cell States By BET Reader ProteinsR56HL1258941999-06-30PLUTZKY, JORGE1994-07-01SH2-CONTAINING PROTEINS AND PDGF SIGNALINGK08HL0031072017-03-31MICHEL, THOMAS1992-09-30Arterial Dysfunction: Basic and Clinical MechanismsP01HL0487432005-12-31PLUTZKY, JORGE2005-01-01Endogenous Mechanisms of PPAR ModulationR01HL079117Co-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 615541Authorship 6492111Authorship 594768Authorship 596926Authorship 2739143Authorship 2744013Authorship 409226Authorship 42360614Authorship 9563271127544600Duan Q, Mao X, Liao C, Zhou H, Sun Z, Deng X, Hu Q, Qi J, Zhang G, Huang H, Plutzky J, Yang TInternational journal of cardiologyInhibition of BET bromodomain attenuates angiotensin II induced abdominal aortic aneurysm in ApoE-/- mice. Int J Cardiol. 2016 Nov 15; 223:428-432.Int J Cardiol2016-08-14T00:00:002016Inhibition of BET bromodomain attenuates angiotensin II induced abdominal aortic aneurysm in ApoE-/- mice.1280823Freeman RM, Plutzky J, Neel BGProceedings of the National Academy of Sciences of the United States of AmericaIdentification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. Proc Natl Acad Sci U S A. 1992 Dec 01; 89(23):11239-43.Proc Natl Acad Sci U S A1992-12-01T00:00:001992Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.10843708Marx N, Mach F, Sauty A, Leung JH, Sarafi MN, Ransohoff RM, Libby P, Plutzky J, Luster ADJournal of immunology (Baltimore, Md. : 1950)Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells. J Immunol. 2000 Jun 15; 164(12):6503-8.J Immunol2000-06-15T00:00:002000Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells.15591235Devchand PR, Ziouzenkova O, Plutzky JCirculation researchOxidative stress and peroxisome proliferator-activated receptors: reversing the curse? Circ Res. 2004 Dec 10; 95(12):1137-9.Circ Res2004-12-10T00:00:002004Oxidative stress and peroxisome proliferator-activated receptors: reversing the curse?16439686Ahmed W, Orasanu G, Nehra V, Asatryan L, Rader DJ, Ziouzenkova O, Plutzky JCirculation researchHigh-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion. Circ Res. 2006 Mar 03; 98(4):490-8.Circ Res2006-01-26T00:00:002006High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion.Authorship 966193227919358Zhang H, Plutzky J, Shubina M, Turchin AJournal of clinical lipidologyRisk factors for lack of statin therapy in patients with diabetes and coronary artery disease. J Clin Lipidol. 2016 Nov - Dec; 10(6):1406-1413.J Clin Lipidol2016-09-17T00:00:002016Risk factors for lack of statin therapy in patients with diabetes and coronary artery disease.9537338Laufs U, La Fata V, Plutzky J, Liao JKCirculationUpregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation. 1998 Mar 31; 97(12):1129-35.Circulation1998-03-31T00:00:001998Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors.Authorship 971282728291835Carroll SH, Zhang E, Wang BF, LeClair KB, Rahman A, Cohen DE, Plutzky J, Patwari P, Lee RTPloS oneAdipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in ß-adrenergic receptor signaling. PLoS One. 2017; 12(3):e0173823.PLoS One2017-03-14T00:00:002017Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in ß-adrenergic receptor signaling.11772424Ziouzenkova O, Perrey S, Marx N, Bacqueville D, Plutzky JCurrent atherosclerosis reportsPeroxisome proliferator-activated receptors. 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Arterioscler Thromb Vasc Biol. 1999 Mar; 19(3):546-51.Arterioscler Thromb Vasc Biol1999-03-01T00:00:001999PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease.12450998Libby P, Plutzky JCirculationDiabetic macrovascular disease: the glucose paradox? Circulation. 2002 Nov 26; 106(22):2760-3.Circulation2002-11-26T00:00:002002Diabetic macrovascular disease: the glucose paradox?14642685Plutzky JJournal of the American College of CardiologyPeroxisome proliferator-activated receptors as therapeutic targets in inflammation. J Am Coll Cardiol. 2003 Nov 19; 42(10):1764-6.J Am Coll Cardiol2003-11-19T00:00:002003Peroxisome proliferator-activated receptors as therapeutic targets in inflammation.15211097Plutzky JReviews in endocrine & metabolic disordersInflammation in atherosclerosis and diabetes mellitus. Rev Endocr Metab Disord. 2004 Aug; 5(3):255-9.Rev Endocr Metab Disord2004-08-01T00:00:002004Inflammation in atherosclerosis and diabetes mellitus.12878589Ziouzenkova O, Asatryan L, Sahady D, Orasanu G, Perrey S, Cutak B, Hassell T, Akiyama TE, Berger JP, Sevanian A, Plutzky JThe Journal of biological chemistryDual roles for lipolysis and oxidation in peroxisome proliferation-activator receptor responses to electronegative low density lipoprotein. J Biol Chem. 2003 Oct 10; 278(41):39874-81.J Biol Chem2003-07-23T00:00:002003Dual roles for lipolysis and oxidation in peroxisome proliferation-activator receptor responses to electronegative low density lipoprotein.11122762Plutzky JCurrent atherosclerosis reportsPeroxisome proliferator-activated receptors in vascular biology and atherosclerosis: emerging insights for evolving paradigms. Curr Atheroscler Rep. 2000 Jul; 2(4):327-35.Curr Atheroscler Rep2000-07-01T00:00:002000Peroxisome proliferator-activated receptors in vascular biology and atherosclerosis: emerging insights for evolving paradigms.12957325Plutzky JThe American journal of cardiologyThe potential role of peroxisome proliferator-activated receptors on inflammation in type 2 diabetes mellitus and atherosclerosis. Am J Cardiol. 2003 Aug 18; 92(4A):34J-41J.Am J Cardiol2003-08-18T00:00:002003The potential role of peroxisome proliferator-activated receptors on inflammation in type 2 diabetes mellitus and atherosclerosis.77 Avenue Louis PasteurBrigham & Women's HospitalCardiovascular Medicine, NRB 74277 Avenue Louis PasteurBoston02115MA12149216Sethi S, Ziouzenkova O, Ni H, Wagner DD, Plutzky J, Mayadas TNBloodOxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPAR alpha. Blood. 2002 Aug 15; 100(4):1340-6.Blood2002-08-15T00:00:002002Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPAR alpha.1736296Plutzky J, Neel BG, Rosenberg RDProceedings of the National Academy of Sciences of the United States of AmericaIsolation of a src homology 2-containing tyrosine phosphatase. Proc Natl Acad Sci U S A. 1992 Feb 01; 89(3):1123-7.Proc Natl Acad Sci U S A1992-02-01T00:00:001992Isolation of a src homology 2-containing tyrosine phosphatase.11550998Marx N, Libby P, Plutzky JJournal of cardiovascular riskPeroxisome proliferator-activated receptors (PPARs) and their role in the vessel wall: possible mediators of cardiovascular risk? J Cardiovasc Risk. 2001 Aug; 8(4):203-10.J Cardiovasc Risk2001-08-01T00:00:002001Peroxisome proliferator-activated receptors (PPARs) and their role in the vessel wall: possible mediators of cardiovascular risk?17008383Ziouzenkova O, Orasanu G, Sukhova G, Lau E, Berger JP, Tang G, Krinsky NI, Dolnikowski GG, Plutzky JMolecular endocrinology (Baltimore, Md.)Asymmetric cleavage of beta-carotene yields a transcriptional repressor of retinoid X receptor and peroxisome proliferator-activated receptor responses. Mol Endocrinol. 2007 Jan; 21(1):77-88.Mol Endocrinol2006-09-28T00:00:002006Asymmetric cleavage of beta-carotene yields a transcriptional repressor of retinoid X receptor and peroxisome proliferator-activated receptor responses.10534139Ginsberg H, Plutzky J, Sobel BEJournal of cardiovascular riskA review of metabolic and cardiovascular effects of oral antidiabetic agents: beyond glucose-level lowering. J Cardiovasc Risk. 1999 Oct; 6(5):337-46.J Cardiovasc Risk1999-10-01T00:00:001999A review of metabolic and cardiovascular effects of oral antidiabetic agents: beyond glucose-level lowering.17179035Dzau VJ, Antman EM, Black HR, Hayes DL, Manson JE, Plutzky J, Popma JJ, Stevenson WCirculationThe cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part II: Clinical trial evidence (acute coronary syndromes through renal disease) and future directions. Circulation. 2006 Dec 19; 114(25):2871-91.Circulation2006-12-19T00:00:002006The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part II: Clinical trial evidence (acute coronary syndromes through renal disease) and future directions.17192512Buse JB, Ginsberg HN, Bakris GL, Clark NG, Costa F, Eckel R, Fonseca V, Gerstein HC, Grundy S, Nesto RW, Pignone MP, Plutzky J, Porte D, Redberg R, Stitzel KF, Stone NJCirculationPrimary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association. Circulation. 2007 Jan 02; 115(1):114-26.Circulation2006-12-27T00:00:002006Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association.16391165Lee CH, Plutzky JCirculationLiver X receptor activation and high-density lipoprotein biology: a reversal of fortune? Circulation. 2006 Jan 03; 113(1):5-8.Circulation2006-01-03T00:00:002006Liver X receptor activation and high-density lipoprotein biology: a reversal of fortune?10418853Plutzky JThe American journal of cardiologyAtherosclerotic plaque rupture: emerging insights and opportunities. Am J Cardiol. 1999 Jul 08; 84(1A):15J-20J.Am J Cardiol1999-07-08T00:00:001999Atherosclerotic plaque rupture: emerging insights and opportunities.14563997Plutzky JScience (New York, N.Y.)Medicine. PPARs as therapeutic targets: reverse cardiology? Science. 2003 Oct 17; 302(5644):406-7.Science2003-10-17T00:00:002003Medicine. 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Diabetes Care. 2007 Jan; 30(1):162-72.Diabetes Care2007-01-01T00:00:002007Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association.18370723Drexler AJ, Nesto RW, Abrahamson MJ, Bakris G, Bell D, Brunzell J, Dandona P, Davidson J, Fonseca V, Fowler M, Frye R, Giles T, Haffner S, Hollenberg N, Hsueh W, Law R, Plutzky J, Ratner R, Reusch J, Selwyn A, Sowers J, Wyne K, Young LHMetabolic syndrome and related disordersEvaluating the cardiovascular effects of the thiazolidinediones and their place in the management of type 2 diabetes in relation to the metabolic syndrome. Metab Syndr Relat Disord. 2005; 3(2):147-73.Metab Syndr Relat Disord2005-01-01T00:00:002005Evaluating the cardiovascular effects of the thiazolidinediones and their place in the management of type 2 diabetes in relation to the metabolic syndrome.9831704Marx N, Schönbeck U, Lazar MA, Libby P, Plutzky JCirculation researchPeroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells. Circ Res. 1998 Nov 30; 83(11):1097-103.Circ Res1998-11-30T00:00:001998Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells.10980848Kinlay S, Plutzky JCurrent cardiology reportsEffect of lipid-lowering therapy on vasomotion and endothelial function. Curr Cardiol Rep. 1999 Sep; 1(3):238-43.Curr Cardiol Rep1999-09-01T00:00:001999Effect of lipid-lowering therapy on vasomotion and endothelial function.12379175Raji A, Plutzky JCurrent cardiology reportsInsulin resistance, diabetes, and atherosclerosis: thiazolidinediones as therapeutic interventions. Curr Cardiol Rep. 2002 Nov; 4(6):514-21.Curr Cardiol Rep2002-11-01T00:00:002002Insulin resistance, diabetes, and atherosclerosis: thiazolidinediones as therapeutic interventions.12477625Plutzky J, Viberti G, Haffner SJournal of diabetes and its complicationsAtherosclerosis in type 2 diabetes mellitus and insulin resistance: mechanistic links and therapeutic targets. J Diabetes Complications. 2002 Nov-Dec; 16(6):401-15.J Diabetes Complications2002-11-01T00:00:002002Atherosclerosis in type 2 diabetes mellitus and insulin resistance: mechanistic links and therapeutic targets.20185618Brown J, Nallamshetty S, Plutzky JClinical chemistryIntersecting vectors of basic science research and clinical medicine: LOX-1? Clin Chem. 2010 Apr; 56(4):499-501.Clin Chem2010-02-25T00:00:002010Intersecting vectors of basic science research and clinical medicine: LOX-1?22555438Kiefer FW, Orasanu G, Nallamshetty S, Brown JD, Wang H, Luger P, Qi NR, Burant CF, Duester G, Plutzky JEndocrinologyRetinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism. Endocrinology. 2012 Jul; 153(7):3089-99.Endocrinology2012-05-03T00:00:002012Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism.23137497Rosenson RS, Wright RS, Farkouh M, Plutzky JAmerican heart journalModulating peroxisome proliferator-activated receptors for therapeutic benefit? Biology, clinical experience, and future prospects. Am Heart J. 2012 Nov; 164(5):672-80.Am Heart J2012-10-16T00:00:002012Modulating peroxisome proliferator-activated receptors for therapeutic benefit? Biology, clinical experience, and future prospects.19068318Fruchart JC, Sacks F, Hermans MP, Assmann G, Brown WV, Ceska R, Chapman MJ, Dodson PM, Fioretto P, Ginsberg HN, Kadowaki T, Lablanche JM, Marx N, Plutzky J, Reiner Z, Rosenson RS, Staels B, Stock JK, Sy R, Wanner C, Zambon A, Zimmet PThe American journal of cardiologyThe Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in patients with dyslipidemia. Am J Cardiol. 2008 Nov 17; 102(10 Suppl):1K-34K.Am J Cardiol2008-11-17T00:00:002008The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in patients with dyslipidemia.20689078Chang K, Francis SA, Aikawa E, Figueiredo JL, Kohler RH, McCarthy JR, Weissleder R, Plutzky J, Jaffer FAArteriosclerosis, thrombosis, and vascular biologyPioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging. Arterioscler Thromb Vasc Biol. 2010 Oct; 30(10):1933-9.Arterioscler Thromb Vasc Biol2010-08-05T00:00:002010Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging.Plutzky J, Davidson J. Diabetes and cardiovascular disease in the Hispanic population, (CD-ROM)Diabetes and cardiovascular disease in the Hispanic population, (CD-ROM). 2001.2001-06-01T00:00:002001Diabetes and cardiovascular disease in the Hispanic population, (CD-ROM)Plutzky J, Libby P. Diabetes and cardiovascular disease (DVD)Diabetes and cardiovascular disease (DVD). 2002.2002-01-01T00:00:002002Diabetes and cardiovascular disease (DVD)Authorship 994018728700749Carroll SH, Zhang E, Wang BF, LeClair KB, Rahman A, Cohen DE, Plutzky J, Patwari P, Lee RTPloS oneCorrection: Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in ß-adrenergic receptor signaling. 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